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| 1 | Overview of milling techniques for improving the solubility of poorly water-soluble drugs显示文摘Milling involves the application of mechanical energy to physically break down coarse particles to finer ones and is regarded as a“topedown”approach in the production of fine particles.Fine drug particulates are especially desired in formulations designed for parenteral,respiratory and transdermal use.Most drugs after crystallization may have to be comminuted and this physical transformation is required to various extents,often to enhance processability or solubility especially for drugs with limited aqueous solubility.The mechanisms by which milling enhances drug dissolution and solubility include alterations in the size,specific surface area and shape of the drug particles as well as millinginduced amorphization and/or structural disordering of the drug crystal(mechanochemical activation).Technology advancements in milling now enable the production of drug micro-and nano-particles on a commercial scale with relative ease.This review will provide a background on milling followed by the introduction of common milling techniques employed for the micronization and nanonization of drugs.Salient information contained in the cited examples are further extracted and summarized for ease of reference by researchers keen on employing these techniques for drug solubility and bioavailability enhancement. | Zhi Hui Loh Asim Kumar Samanta Paul Wan Sia Heng | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，4： | 7 |
| 2 | 菲律宾大马尼拉市气候因素与登革热发病率的相关性分析显示文摘在菲律宾大马尼拉,登革热是一个严重的公共卫生问题。持续攀升的登革热发病率已被归因于气候变化;然而,与之相矛盾的报告称,登革热与气候因素之间的显著的相关关系并不存在。为了进一步说明此二者的关系,本研究考察了1996~2005年,大马尼拉市地区的气温和降水两个气候因素对登革热发病率的影响。收集了10年间(1996~2005)大马尼拉地区登革热月发病率和气候数据。对温度和降水两个气候因素与登革热发病率之间的联系进行回归分析。预测模型(登革热发病率为Y,降水为X)显示,降水与登革热发病率显著相关(r^2=0.377,p<0.05);而温度与登革热发病率之间不存在显著的相关关系(p>0.05)。有证据显示,大马尼拉地区登革热发病率随着降水模式的改变而变化。建议加强降水丰富期对蚊子的监控。 | Glenn L. Sia Su 哈艳梅(译) 马泽清(译) | 2008 | AMBIO-人类环境杂志2008，37，4： | 5 |
| 3 | Avian influenza virus directly infects human natural killer cells and inhibits cell activity显示文摘Natural killer(NK) cell is a key component of innate immunity and plays an important role in host defense against virus infection by directly destroying infected cells. Influenza is a respiratory disease transmitted in the early phase of virus infection. Evasion of host innate immunity including NK cells is critical for the virus to expand and establish a successful acute infection. Previously,we showed that human influenza H1N1 virus infects NK cells and induces cell apoptosis, as well as inhibits NK cell activity. In this study, we further demonstrated that avian influenza virus also directly targeted NK cells as an immunoevasion strategy. The avian virus infected human NK cells and induced cell apoptosis. In addition, avian influenza virion and HA protein inhibited NK cell cytotoxicity. This novel strategy has obvious advantages for avian influenza virus, allowing the virus sufficient time to expand and subsequent spread before the onset of the specific immune response. Our findings provide an important clue for the immunopathogenesis of avian influenza,and also suggest that direct targeting NK cells may be a common strategy used by both human and avian influenza viruses to evade NK cell immunity. | Huawei Mao Yinping Liu Sin Fun Sia JS Malik Peiris Yu-Lung Lau Wenwei Tu | 2017 | Virologica Sinica2017，32，2： | 4 |
| 4 | Efficiency of HAART in the prevention of mother to children HIV-1 transmission at Saint Camille medical centre in Burkina Faso,West Africa显示文摘Objective:To evaluate efficiency of HAART in the prevention of mother to child HIV transmission.Methods:A longitudinal study was conducted on 1 300 women attending the antenatal service at Saint Camille Medical Centre from September 2010 to July 2011.The HIV status of mothers was determined by rapid tests and EUSA.Discordant results were confirmed by real-time PCR.PCR was used to determine HIV status of children born from HIV-positive mothers.Results:Among 1 300 pregnant women tested for HIV,378 were seropositive.Mothers were predominantly housewives(69.7%),and their mean age was(28.32±0.15) years.The overall prevalence of HIV transmission from mother to child was 4.8%(18/378).This prevalence differed significantly from 0.0%(0/114) to 6.8%(18/264) in children born from mothers under HAART and those with mothers under New Prophylactic Protocol(ACT + 3TC + NVP),respectively(P< 0.01).Children’s mortality rate during the medical follow up was 1.3%(5/378).Among 16 women with HIV dubious status by ELISA,the Real Time PCR confirmed 2/16(12.5%) as HIV positive. Conclusions:The protocol of prevention of mother to children HIV transmission(PMTCT) is effective.The rate of HIV vertical transmission is significantly reduced.Early diagnosis determined by PCR of children born from HIV- positive mother is necessary and recommended in the context of PMTCT in Burkina Faso.We also found that PCR is an effective tool to confirm HIV status in pregnant women. | Laure Stella Ghoma Linguissi Cyrille Bisseye Tani Sagna Bolni Marius Nagalo Djeneba Ouermi Florencia W Djigma Salvatore Pignatelli Joseph D Sia Virginio Pietra Remy Moret Jean Baptiste Nikiema Jacques Simpore | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，12： | 4 |
| 5 | Wavefront-optimized surface retreatments of refractive error following previous laser refractive surgery: a retrospective study显示文摘Background:Retreatments are sometimes necessary to correct residual or induced refractive errors following refractive surgery.Many different combinations of primary treatment methods and retreatment techniques have been studied,however,few studies have investigated wavefront-optimized(WFO)technology for retreatment following primary refractive surgery.This study aimed to report the outcomes of WFO photorefractive keratectomy(PRK)retreatments of refractive error following previous laser refractive surgery with PRK,laser in situ keratomileusis(LASIK),or laser-assisted subepithelial keratectomy(LASEK).Methods:We reviewed records of patients who underwent WFO PRK retreatments using the Allegretto Wave Eye-Q 400 Hz Excimer Laser System(Alcon Surgical)between January 2008 and April 2011 at Walter Reed Army Medical Center and Madigan Army Medical Center.Outcomes were recorded in terms of uncorrected distance visual acuity(UDVA),manifest refraction spherical equivalent(MRSE),corrected distance visual acuity(CDVA),and complications at 1 month(M),3 M,and 6 M post-op.Results:Seventy-eight patients(120 eyes)underwent WFO PRK retreatment during the study period.Primary surgery was surface ablation in 87 eyes(78 PRK,9 LASEK)and LASIK in 33 eyes.The mean spherical equivalent before retreatment was−0.79±0.94 D(−3.00 to 1.88 D).UDVA was≥20/20 in 69 eyes(60.0%)at 1 M,54 eyes(71.1%)at 3 M,and 27 eyes(73.0%)at 6 M follow-up.MRSE was within±0.50 D of emmetropia in 78 eyes(67.8%)at 1 M,59 eyes(77.6%)at 3 M,and 25 eyes(67.6%)at 6 M follow-up.CDVA was maintained within±1 line of pre-op in 113 of 115 eyes(98.3%)at 1 M,74 of 76 eyes(97.4%)at 3 M,and 37 eyes(100%)at 6 M follow-up.Conclusion:Although follow-up was limited beyond 3 M,WFO PRK retreatments in patients with residual refractive error may be a safe and effective procedure.Further studies are necessary to determine the long-term safety and stability of outcomes. | Kevin M.Broderick Rose K Sia Denise S.Ryan Richard D.Stutzman Michael J.Mines Travis C.Frazier Mark F.Torres Kraig S.Bower | 2016 | Eye and Vision2016，3，1： | 3 |
| 6 | Elliptical model for surface topography prediction in five-axis flank milling显示文摘In five-axis flank milling operations,the intersecting surfaces of different cutting edges create roughness on the milled surfaces that cannot be ignored in situations with strict requirements,especially in aeronautical manufacturing.To focus on motion problems in milling operations,this paper presents a new model that utilizes elliptical paths as cutting edge trajectories on 3D surface topography machined by peripheral milling.First,the cutter parallel axis offset and location angle are considered,which change the location of the ellipse center and intersection point of the cutting edges.Then,through the proposed model,the predicted surface topography is obtained,and the factors that affect the development tendency of roughness are analyzed.Next,the effects of the cutter location position(CLP)geometric parameters,cutter parallel axis offset and curvature on the roughness are evaluated by a numerical simulation.Finally,machining tests are carried out to validate the model predictions,and the results show that the surface topography predictions correspond well with the experimental results. | Liping WANG Shuyi GE Hao SIa Liwen GUAN Feiyu DUAN Yuzhe LIU | 2020 | Chinese Journal of Aeronautics2020，33，4： | 3 |
| 7 | Association of Helicobacter pylori infection and giardiasis: Results from a study of surrogate markers for fecal exposure among children显示文摘AIM: To investigate whether Helicobacter pylori (H pykori)infection is associated with hepatitis A virus (HAV) infection, presence of enteroparasites, and other surrogates of fecal exposure.METHODS: We conducted a cross-sectional study in 121 children consecutively admitted at a pediatric hospital inSalvador, Brazil.H pylori and HAV infection were identified by the presence of serum antibodies. Stool specimens were examined for the presence of ova and parasites. A structured questionnaire inquiring about sanitary conditions and life style was applied to each subject. RESULTS: Fifty-one of the 121 children (42.1%) werefound to be seropositive for H pylori, and 45 (37.2%) for HAV. The seroprevalence ofHpyloriand HAV both increased significantly with age. Cross-tabulation of data showed that 26 (21.5%) were seropositive and 51 (42.1%) were negative for bothHpyloriand HAV antibodies (χ2 = 7.18,OR = 2.8, CI 1.30-5.97). The age adjusted OR for an HAV-infected child being H pylori positive was 2.3 (CI1.02-5.03). The agreement between H pylori and HAVseropositivity was fair (κ = 0.24). After controlling for possible confounding, the variables remaining independently associated with seropositivity to H pyloriwere age,presence of Giardia lamblia in feces (OR = 3.2, 95%CI, 1.1-9.5) and poor garbage disposal quality (OR = 2.4,95%CI, 1.1-5.1).CONCLUSION: Our data suggest that H pylori infection is associated with surrogate markers of fecal exposure. Thus, we conclude that the fecal-oral route is relevant in the transmission of HP among children in an urban setting of a developing country. The association observed between G. lamblia and H pylori infection may have several explanations. Further studies to investigate this relationship are warranted. | Edson Duarte Moreira Jr Victor Bastos Nassri Rafaela Sousa Santos Junísia Ferraz Matos Wilson Andrade de Carvalho Célia Stolve Silvani Círia Santana e Sant'Ana | 2005 | World Journal of Gastroenterology2005，11，18： | 3 |
| 8 | Combining Clinical, Pathology, and Gene Expression Data to Predict Recurrence of Hepatocellular Carcinoma显示文摘 | Augusto Villanueva Yujin Hoshida Carlo Battiston Victoria Tovar Daniela Sia Clara Alsinet Helena Cornella Arthur Liberzon Masahiro Kobayashi Hiromitsu Kumada Swan N. Thung Jordi Bruix Philippa Newell Craig April Jian–Bing Fan Sasan Roayaie Vincenzo Mazzaf | 2011 | Gastroenterology2011，，5： | 3 |
| 9 | Hemodynamic analysis of intracranial aneurysms using phase-contrast magnetic resonance imaging and computational fluid dynamics显示文摘Additional hemodynamic parameters are highly desirable in the clinical management of intracranial aneurysm rupture as static medical images cannot demonstrate the blood flow within aneurysms. There are two ways of obtaining the hemodynamic information—by phase-contrast magnetic resonance imaging(PCMRI) and computational fluid dynamics(CFD). In this paper, we compared PCMRI and CFD in the analysis of a stable patient's specific aneurysm.The results showed that PCMRI and CFD are in good agreement with each other. An additional CFD study of two stable and two ruptured aneurysms revealed that ruptured aneurysms have a higher statistical average blood velocity,wall shear stress, and oscillatory shear index(OSI) within the aneurysm sac compared to those of stable aneurysms.Furthermore, for ruptured aneurysms, the OSI divides the positive and negative wall shear stress divergence at the aneurysm sac. | Xuemei Zhao Rui Li Yu Chen Sheau Fung Sia Donghai Li Yu Zhang Aihua Liu | 2017 | Acta Mechanica Sinica2017，33，2： | 3 |
| 10 | 基于医学影像的血流动力学分析显示文摘随着计算机成像技术的发展,计算机断层扫描(CT)和核磁共振(MRI)已经广泛应用于临床,特别是血管类疾病的诊断,比如动脉狭窄、血管瘤、血管畸形等.除了可以提供高分辨率的静态图像,先进的MRI技术还可以通过时间序列直接反映血流动力学的变化.而基于计算机成像和三维重建技术,血流动力学的参数又可以通过计算流体力学的方法进行详细的分析.如何将血流动力学参数和临床诊断相结合是近年来在转化医学领域研究的热点.文中将结合文献调研和作者自己的研究工作对基于医学图像的血流动力学分析进行综述,并探讨未来的研究方向. | 陈宇 李睿 赵雪梅 李东海 徐文娟 刘爱华 Sia Sheau Fung Chong Winston 张宇 | 2016 | 力学进展2016，46，1： | 3 |
| 11 | 中医针灸在马来西亚的发展现状分析显示文摘中医针灸自14世纪便传入了马来西亚,经过几个世纪的沉淀与积累,针灸在马来西亚展现出了旺盛的生命力。本文从针灸在马来西亚的全日制教育、协会、马来西亚对针灸的政策支持、针灸的临床应用以及科学研究等方面全方位介绍马来西亚针灸的发展情况。随着马来西亚传统医学界与中国大陆中医界的频繁交流,极大地推动了针灸在马来西亚的传播。 | 沈佳成 RUI XIAO AVRIL SIA SIEN LYNN 杨宗保 | 2019 | 中国针灸2019，39，8： | 2 |
| 12 | Reduction in endotoxemia, oxidative and inflammatory stress, and insulin resistance after Roux-en-Y gastric bypass surgery in patients with morbid obesity and type 2 diabetes mellitus显示文摘 | Scott V. Monte Joseph A. Caruana Husam Ghanim Chang Ling Sia Kelly Korzeniewski Jerome J. Schentag Paresh Dandona | 2012 | Surgery2012，，4： | 2 |
| 13 | Cilostazol for secondary stroke prevention:systematic review and meta-analysis显示文摘Background Stroke is one of the leading causes of death worldwide.Cilostazol,an antiplatelet and phosphodiesterase 3 inhibitor,has not been clearly established for ischaemic stroke use.We aim to determine the efficacy and safety of cilostazol for secondary stroke prevention.Methods MEDLINE,EMBASE,Cochrane Library,Web of Science and ClinicalTrials.gov were searched from inception to 25 September 2020,for randomised trials comparing the efficacy and safety of cilostazol monotherapy or dual therapy with another antiplatelet regimen or placebo,in patients with ischaemic stroke.Version 2 of the Cochrane risk-of-bias tool for randomised trials(RoB 2)was used to assess study quality.This meta-analysis was reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)statement.Results Eighteen randomised trials comprising 11429 participants were included in this meta-analysis.Most trials possessed low risk of bias and were of low heterogeneity.Cilostazol significantly reduced the rate of ischaemic stroke recurrence(risk ratio,RR=0.69,95%CI 0.58 to 0.81),any stroke recurrence(RR=0.64,95%CI 0.54 to 0.74)and major adverse cardiovascular events(RR=0.67,95%CI 0.56 to 0.81).Cilostazol did not significantly decrease mortality(RR=0.90,95%CI 0.64 to 1.25)or increase the rate of good functional outcome(Modified Rankin Scale score of 0–1;RR=1.07,95%CI 0.95 to 1.19).Cilostazol demonstrated favourable safety profile,significantly reducing the risk of intracranial haemorrhage(RR=0.46,95%CI 0.31 to 0.68)and major haemorrhagic events(RR=0.49,95%CI 0.34 to 0.70).Conclusions Cilostazol demonstrated superior efficacy and safety profiles compared with traditional antiplatelet regimens such as aspirin and clopidogrel for secondary stroke prevention but does not appear to affect functional outcomes.Future randomised trials can be conducted outside East Asia,or compare cilostazol with a wider range of antiplatelet agents. | Choon Han Tan Andrew GR Wu Ching-Hui Sia Aloysius ST Leow Bernard PL Chan Vijay Kumar Sharma Leonard LL Yeo Benjamin YQ Tan | 2021 | Stroke & Vascular Neurology2021，6，3： | 2 |
| 14 | Evaluation of interface shear strength of composite liner system and stability analysis for a landfill lining system in Thailand显示文摘 | D.T. Bergado G.V. Ramana H.I. Sia Varun | 2006 | Geotextiles and Geomembranes2006，，6： | 2 |
| 15 | New directions in mechanics显示文摘 | Michael E. Kassner Sia Nemat-Nasser Zhigang Suo Gang Bao J. Charles Barbour L. Catherine Brinson Horacio Espinosa Huajian Gao Steve Granick Peter Gumbsch Kyung-Suk Kim Wolfgang Knauss Ladislas Kubin James Langer Ben C. Larson L. Mahadevan Arun Majumdar Sa | 2004 | Mechanics of Materials2004，，2： | 2 |
| 16 | Protein grafting of an HIV- 1 - in hibiting epitope显示文摘 | Sia S K Kim P S | 2003 | Proc Natl Acad Sci USA2003，100，17： | 1 |
| 17 | Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans显示文摘 | Fox D S Cruz M C Sia R A L | 2001 | Molecular Microbiology2001，39，： | 1 |
| 18 | I mproved post-myocardial infarction survival with probucol in rats:effects on left ventricular function,morphology,cardiac oxidative stress and cytokine expression显示文摘 | Sia YT Parker TG Liu P | 2002 | Am Coll Cardiol2002，39，： | 1 |
| 19 | Volatility And the Institutional Investor显示文摘 | Sias R | 1996 | Finan- cial Analysts Journal1996，52，3： | 1 |
| 20 | Four-injection brachial plexus block using peripheral nerve stimulator:A comparison between axillary and humeral approach显示文摘 | Sia S Lepri A Campolo MC | 2002 | Anesth Analg2002，95，： | 1 |
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