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| 1 | Structural basis of the Norrin-Frizzled 4 interaction显示文摘 | Guobo Shen Jiyuan Ke Zhizhi Wang Zhihong Cheng Xin Gu Yuquan Wei Karsten Melcher H Eric Xu Wenqing Xu | 2015 | Cell Research2015，25，9： | 3 |
| 2 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 3 | Broadband Fluorescence Guided-Wave in DANS/PMMA Thin Film Waveguides显示文摘The broadband fluorescence guided-waves excited in DANS/PMMA polymer thin film waveguides by an Ar+laser beam were demonstrated in terms of the observation of mlines with colour array.Considering the high brightness of these m-lines observation,we assert that it is a kind of stimulated amplification of fluorescence guided-wave. | WANG Huitian DONG Fengzhong ZHANG Zhanxiang YE Peixian QIU Ling SHEN Jifeng FU Xingfa SHEN Yuquan | 1994 | Chinese Physics Letters1994，11，2： | 0 |
| 4 | Transcriptome Analysis of Pacific White Shrimp (Litopenaeus vannamei) Under Prolonged High-Salinity Stress显示文摘The Pacific white shrimp(Litopenaeus vannamei)is a marine species commonly farmed worldwide.In northern China,it has been increasingly cultured in high-salinity waters(>40),but exhibits poor growth performance.In this study,postlarval shrimps were acclimated to salinity 55,cultivated for 3 months at this salinity,and compared with a control group reared at general salinity 25.Subsequently,high-throughput RNA sequencing was applied to compare the transcriptomic responses in the gills and hepatopancreas of the shrimps in the control group and the treatment group,while the weights of the shrimps in these two groups were significantly different.The results revealed that 11834 and 2115 genes were significantly differentially expressed in the gills and hepatopancreas,respectively.Additionally,enrichment analysis of the differentially expressed genes indicated that osmoregula-tion-associated Gene Ontology terms and KEGG pathways were similar between the two subgroups of the shrimp maintained at high salinity,suggesting that the growth rate of shrimp at high salinity is independent of osmoregulation.Furthermore,examination of the shrimp with different growth rates(i.e.,weights)at high salinity revealed molt-associated processes,namely,increased expression of ecdysone response genes and downstream effector genes in the gills and hepatopancreas of slow-growing shrimp,suggesting a role of the molt-associated processes in the regulation of shrimp growth at high salinity.Thus,we not only report adaptive transcriptomic responses of L.vannamei to prolonged high-salinity stress,but also provide new insights into the shrimp growth regulation at high salinity. | LI Yuquan CHEN Yigeng CUI Yanting SHEN Min WANG Renjie WANG Zhongkai | 2022 | Journal of Ocean University of China2022，21，2： | 0 |
| 5 | Decavanadate-based Transition Metal Hybrids as Bifunctional Catalysts for Sulfide Oxidation and C-C Bond Construction显示文摘The development of bifunctional catalysts has drawn much attention in realizing efficient and feasible catalytic systems to meet the diverse dema nd of pote ntial industrial applications.Desig n of stable and powerful bifun ctional catalysts for various catalysis systems is highly desirable yet largely unmet.Here,three kinds of decavanadate-based transition metal hybrids(DTMH)(i.e.,Co-DTMH,Ni-DTMH and Ag-DTMH)have been successfully synthesized through a pH tuning strategy and further characterized.Specifically,the rare M05N six-coordinated transition metal coordination modes have been detected in Co-DTMH and Ni-DTMH,while Ag atoms in Ag-DTMH exhibited three-and five-coordinated geometries with the tuning of specially selected imidazole ligands.Thus-obtained clusters can serve as powerful bifunctional catalysts for both sulfide oxidation and C-C bond construction.Remarkably,Ag-DTMH dem on st rated excellent heteroge ne ous bifunctional catalytic properties in the selective oxidati on of sulfides and construction of C-C bond(yields up to 99%),which enable successful recycling for three cycles with remained catalytic activities and structure stability.The newly designed decavanadate-based transition metal hybrids with bifunctional property hold high promise in the practical applications like continuous catalysis or flow bed reactions. | Xianqiang Huang Xiaoyu Gu Yuquan Qi Yanru Zhang Guodong Shen Bingchuan Yang Wenzeng Duan Shuwen Gong Zechun Xue Yifa Chen | 2021 | Chinese Journal of Chemistry2021，39，9： | 0 |
| 6 | Ultrafast Optical Response of Phthalocyanine Langmuir-Blodegett Film显示文摘The mechanism of 2,9,16,23-tetra-heptadecylamido substituted vanadyl phthalocyanine Langmuir-Blodegett film was studied with femtosecond laser pulses.An ultrafast decay due to phonon-exciton coupling greatly affected by temperature,and exciton-exciton annihilation leading to the recovery of the ground state(T~lops)and an even slower relaxation were observed. | YUAN Ping XIA Zongju ZOU Yinghua QIU Ling SHEN Jifeng SHEN Yuquan XU Huijun | 1994 | Chinese Physics Letters1994，11，4： | 0 |
| 7 | Observation of Optical Bistability Hysteresis Loop with Surface Waves in Doped Polymer Film显示文摘Optical bistability hysteresis loop has been observed experiment ally with a setup using prism excitation of surface wave in a doped polymer thin film.A simple model has been developed to analyze its operation.The observed bistability hysteresis loop can be explained in terms of surface plasmon excitation and laser induced refractive index variations. | YE Peixian YU Zuhe ZHANG Zhanxiang SHEN Yuquan FU Xingfa | 1991 | Chinese Physics Letters1991，8，9： | 0 |
| 8 | Ultrafast Time-Resolved Optical Kerr Effect in Phthalocyanine Langmuir-Blodegett Film显示文摘The resonant optical Kerr effect in the Langmuir-Blodegett film of 2,9,16,23-tetra heptadecylamido substituted vanadyl phthalocyanine was measured with femtosecond laser pulses to determine the relaxation time,and meanwhile slow decay components were observed.The ultrafast nonlinearity of the molecule was also measured. | YUAN Ping XIA Zongju ZOU Yinghua QIU Ling SHEN Jifeng SHEN Yuquan XU Huijun | 1994 | Chinese Physics Letters1994，11，7： | 0 |
| 9 | A Fundamental Study and Applied Exploration of Some Novel Photo-functional Materials显示文摘 | YaoJiannian Fan Meigong Fu Hongbing Ye Cheng Shen Yuquan | 2005 | Bulletin of the Chinese Academy of Sciences2005，19，3： | 0 |
| 10 | Refill Friction Stir Spot Welding Al Alloy to Copper via Pure Metallurgical Joining Mechanism显示文摘The current investigation of refill friction stir spot welding(refill FSSW)Al alloy to copper primarily involved plunging the tool into bottom copper sheet to achieve both metallurgical and mechanical interfacial bonding.Compared to conventional FSSW and pinless FSSW,weld strength can be significantly improved by using this method.Nevertheless,tool wear is a critical issue during refill FSSW.In this study,defect-free Al/copper dissimilar welds were successfully fabricated using refill FSSW by only plunging the tool into top Al alloy sheet.Overall,two types of continuous and ultra-thin intermetallic compounds(IMCs)layers were identified at the whole Al/copper interface.Also,strong evidence of melting and resolidification was observed in the localized region.The peak temperature obtained at the center of Al/copper interface was 591℃,and the heating rate reached up to 916℃/s during the sleeve penetration phase.A softened weld region was produced via refill FSSW process,the hardness profile exhibited a W-shaped appearance along middle thickness of top Al alloy.The weld lap shear load was insensitive to the welding condition,whose scatter was rather small.The fracture path exclusively propagated along the IMCs layer of Cu_(9)Al_(4) under the external lap shear loadings,both CuAl_(2) and Cu_(9)Al_(4) were detected on the fractured surface on the copper side.This research indicated that acceptable weld strength can be achieved via pure metallurgical joining mechanism,which has significant potential for the industrial applications. | Zhikang Shen Yuquan Ding Wei Guo Wentao Hou Xiaochao Liu Haiyan Chen Fenjun Liu Wenya Li Adrian Gerlich | 2021 | Chinese Journal of Mechanical Engineering2021，34，4： | 0 |
| 11 | Observation of Optical Bistabilities in a Doped Polymer Thin Film Quasi-waveguide显示文摘Optical bistability was observed and studied in the output of reflected beam as well as in that of m-lines in a doped polymer thin film quasi-waveguide.The physical origin was demonstrated to be the existence of a mode spectrum and the high third order nonlinearity of the polymer film.It was also observed for the first time that the intensity variation of the reflected beam and the m-line in the hysteresis loops are complementary to each other. | WANG Huitian DONG Fengzhong ZHANG Zhanxiang YE Peixian QIU Ling SHEN Jifeng FU Xingfa SHEN Yuquan | 1995 | Chinese Physics Letters1995，12，4： | 0 |
| 12 | Observation of Optical Bistability Hysteresis Loop with Surface Waves in Doped Polymer Film显示文摘Optical bistability hysteresis loop has been observed experimentally with a setup using prism excitation of surface wave in a doped polymer thin film.A simple model has been developed to analyze its operation.The observed bistability hysteresis loop can be explained in terms of surface plasmon excitation and laser induced refractive index variations. | YE Peixian YU Zuhe ZHANG Zhanxiang SHEN Yuquan FU Xingfa | 1991 | Chinese Physics Letters1991，8，6： | 0 |
| 13 | Microwave-assisted controllable synthesis of 2-acylbenzothiazoles and bibenzo[b][1,4]thiazines from aryl methyl ketones and disulfanediyldianilines显示文摘A condition-controlled strategy for selectively synthesis of 2-acylbenzothiazoles and bibenzo[b][1,4]thiazines from aryl methyl ketones and disulfanediyldianilines was realized using I_(2)/DMSO or I_(2)/MeCN systems,respectively.The desired products were synthesized in only 15 min with moderate to excellent yields(50%-90%)under microwave-assisted,metal-free conditions.The strategy provides a great advantage for selective synthetic applications in the efficient synthesis of benzothiazoles and bibenzothiazines heterocycle compounds. | Yuquan Qi Xiaoyu Gu Xianqiang Huang Guodong Shen Bingchuan Yang Qjngpeng He Zechun Xue Mengcheng Du Lilong Shi Bing Yu | 2021 | Chinese Chemical Letters2021，32，11： | 0 |
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