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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Genetic diversity of the pln locus among oenological Lactobacillus plantarum strains显示文摘 | Yolanda Sáenz Beatriz Rojo-Bezares Laura Navarro Lorena Díez Sergio Somalo Myriam Zarazaga Fernanda Ruiz-Larrea Carmen Torres | 2009 | International Journal of Food Microbiology2009，，3： | 1 |
| 3 | On the mechanisms of internalization and intracellular delivery mediated by pH-sensitive liposomes显示文摘 | Sergio S Vladimir S Nejat D | 2001 | Biochim Biophys Acta2001，1515，1： | 1 |
| 4 | Low-resistivity Zn O∶F∶Al Transparent Thin Films显示文摘 | Delia C A Gerardo T D Sergio J S | 2004 | Solar Energy Material&Solar Cells2004，82，1： | 1 |
| 5 | Multiple description wavelet based image coding 显示文摘 | Sergio D S Kannan K Vinary A V | 2000 | IEEE Transactions on Image Processing2000，9，5： | 1 |
| 6 | Lipid coating on polyelectrolyte surface modified colloidal particles and polyelectrolyre capsules 显示文摘 | Sergio M Edwin D Gleb B S | 2000 | Macromolecules2000，33，12： | 1 |
| 7 | Image cod-ing based on a morphological representation of wavelet data显示文摘 | SERGIO D S KANNAN R MICHAEL T O | 1999 | IEEE Transactions on Image Processing1999，8，9： | 1 |
| 8 | Nanostrutured composite materials with improved deformation behavior显示文摘 | JuRGEN E UTA K JAYANTA D SERGIO S N1COLLE R | 2005 | Advanced Engineering Materials2005，7，7： | 1 |
| 9 | Tunneling and op- ileal control in quantum ring molecules 显示文摘 | LUIS D S JOSE M V SERGIO E U | 2007 | Physical Re-view B2007，，76： | 1 |
| 10 | Critical properties of a branehed polymer growth model 显示文摘 | Sergio S Botelho F D A Aarao Reis | 2001 | Phys Rev E2001，63，1： | 1 |
| 11 | Relationships between xylem vessel characteristics,calculated axial hydraulic conductance and size-controlling capacity of peach rootstocks显示文摘 | Sergio T Johnson R S Kevin R D | 2010 | Annals of Botany2010，105，： | 1 |
| 12 | Stress stiffening effects in laminated beams with piezoelectric actuators显示文摘 | Sergio F Jorn S H | 1998 | Journal of Intelligent Material Systems and Structures1998，9，2： | 1 |
| 13 | Rela- tionships between xylem vessel characteristics, calculated axial hy- draulic conductance and size-controlling capacity of peach root- stocks显示文摘 | SERGIO T JOHNSON R S KEVIN R D THEODRE M D | 2010 | Annals of Botany2010，105，： | 1 |
| 14 | Characterisation of electrochemically depositen Ni-Mo alloy coatings 显示文摘 | Luciana S S Sergio H D Claudia E B | 2004 | Electrochemsitry Communications2004，，6： | 1 |
| 15 | Cyclic maximization of non-Gaussianity for blind signal extraction of complex-valued sources 显示文摘 | IVAN D D SERGIO C MARIA A S | 2011 | Neurocomputing2011，74，17： | 1 |
| 16 | Casuarina in Africa : distribution, role and importance of arbuseular mycorrhlzal, ectomy- corrhizal fungi and Frankia on plant development显示文摘 | NATHALIE D DIEGANE D SERGIO S | 2013 | Journal of Envlronme*ztal Management2013，128，： | 1 |
| 17 | Detecting and differentiating white from red coronary thrombus by angiography in angina pectoris and in acute myocardial infarction显示文摘 | George S Abela Joel D Eisenberg Murray A Mittleman Richard W Nesto David Leeman Stuart Zarich Sergio Waxman Alejandro R Prieto Karen S Manzo | 1999 | The American Journal of Cardiology1999，，： | 1 |
| 18 | Failureprocess and hydrologic response of a two layer physical model :Implications for rainfall-induced landslides显示文摘 | SERGIO D N LOURENCO K S HIROSHI F | 2006 | Geomorpholo-gy2006，73，12： | 1 |
| 19 | Pharmacological Modulation of Epithelial Mesenchymal Transition Caused by Angiotensin II. Role of ROCK and MAPK Pathways显示文摘 | Raquel Rodrigues-Díez Gisselle Carvajal-González Elsa Sánchez-López Juan Rodríguez-Vita Raúl Rodrigues Díez Rafael Selgas Alberto Ortiz Jesús Egido Sergio Mezzano Marta Ruiz-Ortega | 2008 | Pharmaceutical Research2008，，10： | 1 |
| 20 | Pharmacological Modulation of Epithelial Mesenchymal Transition Caused by Angiotensin II. Role of ROCK and MAPK Pathways显示文摘 | Raquel Rodrigues-Díez Gisselle Carvajal-González Elsa Sánchez-López Juan Rodríguez-Vita Raúl Rodrigues Díez Rafael Selgas Alberto Ortiz Jesús Egido Sergio Mezzano Marta Ruiz-Ortega | 2008 | Pharmaceutical Research2008，，10： | 1 |
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