|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical features and management of primary biliary cirrhosis显示文摘Primary biliary cirrhosis(PBC),which is characterised by progressive destruction of intrahepatic bile ducts,is not a rare disease since both prevalence and incidence are increasing during the last years mainly due to the improvement of case finding strategies.The prognosis of the disease has improved due to both the recognition of earlier and indolent cases,and to the wide use of ursodeoxycholic acid(UDCA).New indicators of prog-nosis are available that will be useful especially for the growing number of patients with less severe disease.Most patients are asymptomatic at presentation.Pruri-tus may represent the most distressing symptom and,when UDCA is ineffective,cholestyramine represents the mainstay of treatment.Complications of long-standing cholestasis may be clinically relevant only in very ad-vanced stages.Available data on the effects of UDCA on clinically relevant end points clearly indicate that the drug is able to slow but not to halt the progression of the disease while,in advanced stages,the only thera-peutic option remains liver transplantation. | Andrea Crosignani Pier Maria Battezzati Pietro Invernizzi Carlo Selmi Elena Prina Mauro Podda | 2008 | World Journal of Gastroenterology2008，14，21： | 23 |
| 2 | The microbiome and autoimmunity: a paradigm from the gut–liver axis显示文摘Microbial cells significantly outnumber human cells in the body,and the microbial flora at mucosal sites are shaped by environmental factors and,less intuitively,act on host immune responses,as demonstrated by experimental data in germ-free and gnotobiotic studies.Our understanding of this link stems from the established connection between infectious bacteria and immune tolerance breakdown,as observed in rheumatic fever triggered by Streptococci via molecular mimicry,epitope spread and bystander effects.The availability of high-throughput techniques has significantly advanced our capacity to sequence the microbiome and demonstrated variable degrees of dysbiosis in numerous autoimmune diseases,including rheumatoid arthritis,type 1 diabetes,multiple sclerosis and autoimmune liver disease.It remains unknown whether the observed differences are related to the disease pathogenesis or follow the therapeutic and inflammatory changes and are thus mere epiphenomena.In fact,there are only limited data on the molecular mechanisms linking the microbiota to autoimmunity,and microbial therapeutics is being investigated to prevent or halt autoimmune diseases.As a putative mechanism,it is of particular interest that the apoptosis of intestinal epithelial cells in response to microbial stimuli enables the presentation of self-antigens,giving rise to the differentiation of autoreactive Th17 cells and other T helper cells.This comprehensive review will illustrate the data demonstrating the crosstalk between intestinal microbiome and host innate and adaptive immunity,with an emphasis on how dysbiosis may influence systemic autoimmunity.In particular,a gut–liver axis involving the intestinal microbiome and hepatic autoimmunity is elucidated as a paradigm,considering its anatomic and physiological connections. | Bo Li Carlo Selmi Ruqi Tang ME Gershwin Xiong Ma | 2018 | Cellular & Molecular Immunology2018，15，6： | 15 |
| 3 | Experimental evidence on the immunopathogenesis of primary biliary cirrhosis显示文摘Primary biliary cirrhosis(PBC)is a chronic cholestatic liver disease for which an autoimmune pathogenesis is supported by clinical and experimental data,including the presence of autoantibodies and autoreactive T cells.The etiology remains to be determined,yet data suggest that both a susceptible genetic background and unknown environmental factors determine disease onset.Multiple infectious and chemical candidates have been proposed to trigger the disease in a genetically susceptible host,mostly by molecular mimicry.Most recently,several murine models have been reported,including genetically determined models as well as models induced by immunization with xenobiotics and bacteria. | Carlo Selmi Francesca Meda Anaid Kasangian Pietro Invernizzi Zhigang Tian Zhexiong Lian Mauro Podda M Eric Gershwin | 2010 | Cellular & Molecular Immunology2010，7，1： | 14 |
| 4 | The epigenetics of autoimmunity显示文摘The etiology of autoimmune diseases remains largely unknown.Concordance rates in monozygotic twins are lower than 50% while genome-wide association studies propose numerous significant associations representing only a minority of patients.These lines of evidence strongly support other complementary mechanisms involved in the regulation of genes expression ultimately causing overt autoimmunity.Alterations in the post-translational modification of histones and DNA methylation are the two major epigenetic mechanisms that may potentially cause a breakdown of immune tolerance and the perpetuation of autoimmune diseases.In recent years,several studies both in clinical settings and experimental models proposed that the epigenome may hold the key to a better understanding of autoimmunity initiation and perpetuation.More specifically,data support the impact of epigenetic changes in systemic lupus erythematosus,rheumatoid arthritis,multiple sclerosis and other autoimmune diseases,in some cases based on mechanistical observations.We herein discuss what we currently know and what we expect will come in the next future.Ultimately,epigenetic treatments already being used in oncology may soon prove beneficial also in autoimmune diseases. | Francesca Meda Marco Folci Andrea Baccarelli Carlo Selmi | 2011 | Cellular & Molecular Immunology2011，8，3： | 8 |
| 5 | Immune-mediated bile duct injury:The case of primary biliary cirrhosis显示文摘Autoimmune cholangitis would be the appropriate name to define the immune-mediated bile duct injury following the breakdown of tolerance to mitochondrial proteins and the appearance of serum autoantibodies and autoreactive T cells.Nevertheless,the conditionis universally named primary biliary cirrhosis(PBC).The disease etiology and pathogenesis remain largely unknown despite the proposed lines of evidence.One twin study and numerous epidemiology reportssuggest that both a susceptible genetic background and environmental factors determine disease onsetwhile a recent genome-wide association study proposed highly significant associations with several commongenetic polymorphisms in subgroups of patients.Specific infectious agents and chemicals may contribute to the disease onset and perpetuation in a geneticallysusceptible host,possibly through molecular mimicry.Importantly,several murine models have been proposed and include strains in which PBC is genetically determined or induced by immunization with chemicals and bacteria.From a pathogenetic standpoint,new exciting data have demonstrated the unique apoptotic features of bile duct cells that allow the mitochondrial autoantigens to be taken up in their intact form within apoptotic blebs.We are convinced that the application of the most recent molecular techniques will soon pro-vide developments in PBC etiology and pathogenesis with likely implications in diagnostics and therapeutics. | Carlo Selmi Andrea Affronti Laura Ferrari Pietro Invernizzi | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，4： | 6 |
| 6 | The effects of Spirulina on anemia and immune function in senior citizens显示文摘Anemia and immunological dysfunction(i.e.immunosenescence)are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena.Spirulina is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant effects.We hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of anemia.We enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic diseases.Participants took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the study.Complete cell count(CCC)and indoleamine 2,3-dioxygenase(IDO)enzyme activity,as a sign of immune function,were determined at baseline and weeks 6 and 12 of supplementation.Thirty study participants completed the entire study and the data obtained were analyzed.Over the 12-week study period,there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both sexes.In addition,mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male participants.Older women appeared to benefit more rapidly from Spirulina supplements.Similarly,the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina supplementation.Spirulina may ameliorate anemia and immunosenescence in older subjects.We encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials. | Carlo Selmi Patrick SC Leung Laura Fischer Bruce German Chen-Yen Yang Thomas P Kenny Gerry R Cysewski M Eric Gershwin | 2011 | Cellular & Molecular Immunology2011，8，3： | 2 |
| 7 | Epigenetic considerations and the clinical reevaluation of the overlap syndrome between primary biliary cirrhosis and autoimmune hepatitis显示文摘 | Qixia Wang Carlo Selmi Xinmin Zhou Dekai Qiu Zenshan Li Qi Miao Xiaoyu Chen Jianhong Wang Edward L. Krawitt M. Eric Gershwin Ying Han Xiong Ma | 2012 | Journal of Autoimmunity2012，，： | 2 |
| 8 | Autoimmunity in 2010显示文摘 | Carlo Selmi | 2011 | Autoimmunity Reviews2011，，12： | 1 |
| 9 | Atypical synergetic effect between Te-and V-substituted phosphomolybdic cesium salt and LAMOX-type phases for the oxidation of isobutane into methacrylic acid显示文摘 | Huynh Q Selmi A Corbel G | 2009 | Journal of Catalysis2009，266，1： | 1 |
| 10 | Probiotics and immunity 显示文摘 | Botchers AT Selmi C Meyers FJ | 2009 | J Gastroenterol2009，44，1： | 1 |
| 11 | Primary biliary cirrhosis显示文摘 | Selmi C Bowlus CL Gershwin ME | 2011 | Diag Crit Autoimmun Dis2011，377，9777： | 1 |
| 12 | A clear look at the neuroimmunol ogy ofmuhiple sclerosis and beyond显示文摘 | Selmi C Mix E Zettl UK | 2012 | Autoimmun Rev2012，11，： | 1 |
| 13 | The SAPHO syndrome 显示文摘 | Nguyen MT Borchers A Selmi C | 2012 | Semin Arthritis Rheum2012，42，3： | 1 |
| 14 | Mitochondrial antigens as targets of cellular and humoral auto-immunity in primary biliary cirrhosis显示文摘 | Ichiki Y Selmi C Shimoda S | 2005 | Clin Rev Allergy Immunol2005，28，2： | 1 |
| 15 | The limitations and hidden gems of the epidemiology of primary biliary cirrhosis显示文摘 | Mauro Podda Carlo Selmi Ana Lleo Luca Moroni Pietro Invernizzi | 2013 | Journal of Autoimmunity2013，，： | 1 |
| 16 | Genes and goals: an approach to microarmy analysis in autoimmnnity 显示文摘 | Oertelt S Selmi C Invemizzi P | 2005 | Autoimmun Rev2005，4，7： | 1 |
| 17 | Probiotics and immu- nity 显示文摘 | BORCHERS A T SELMI C MEYERS F J | 2009 | J Gastroentero12009，44，1： | 1 |
| 18 | Genetics and geoepidemiology of primary biliary cirrhosis: following the fovtprints to disease etiology显示文摘 | SELMI C ZNVERNIZZI P ZNIN M | 2005 | Semin Liver Dis2005，25，3： | 1 |
| 19 | The molecular mechanism of muhidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using alphaboranophosphatc nucleotide analogues显示文摘 | Deval J Selmi B Boretto J | 2002 | J Biol Chem2002，277，42： | 1 |
| 20 | Spermatozoa of two Eledone species (Cephalopoda,Octopoda)显示文摘 | SELMI M G | | 0，，28： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员