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| 1 | Significant decrease in prevalence ofHelicobacter pylori in the Czech Republic显示文摘AIM:To study possible decrease in prevalence of Helicobacter pylori(H.pylori) infection in the Czech Republic within a 10-year period.METHODS:A total of 22 centres entered the study.The catchment areas of these centres covered cities and towns with more than 20 000 inhabitants,smaller towns(≤ 20 000 inhabitants) with surrounding villages and rural areas,and were spread over the whole country,corresponding well to the geographical distribution of the Czech population.A total of 1 837 subjects(aged 5-98 years) took part in the study,randomly selected out of 38 147 people from the general population.H.pylori infection was investigated by means of a 13 C-urea breath test.Breath samples in duplicates were analysed using isotope ratio mass spectrometry.The cut-off point was 3.5.Social and demographic characteristics were based on data from self-completed questionnaires.RESULTS:The overall prevalence of H.pylori infection was 23.5%(430/1826),and 4.8%(20/420) in children aged 15 or less.There was no statistically significant difference in prevalence between males(24.3%;208/857) and females(22.9%,222/969,P = 0.494).H.pylori infection was strongly associated with higher age,among subjects aged 55+ years,prevalence of H.pylori infection was 39.8%(252/633,P < 0.001).The highest prevalence of H.pylori infection was found among persons aged 55-64 years(43.9%,97/221) and 75+ years(37.9%,58/153).Among study subjects aged 15+ years,prevalence of H.pylori infection was significantly increased in those with lowest education(odds risk 3.19,95% CI 1.87-5.47).Compared to never married(14.1%),the prevalence of H.pylori infection was statistically significantly higher among married(35.4%,246/694,P < 0.001),divorced(36.8%,49/133,P < 0.001) and widowed study subjects(40.2%,45/112,P < 0.001),both in minimally and fully adjusted analysis.There was no significant difference in the prevalence of H.pylori infection between married and widowed subjects(35.4%,246/694 vs 40.2%,45/112,P = 0.389).There was little variation in smoking prevalence across categories of smoking and there was no evidence of an increased risk ofH.pylori infection among current or past smokers in our data(odds risk 1.04 with 95% CI 0.78-1.40 for current smokers;odds ratio 0.83 with 95% CI 0.60-1.16 for former smokers).The current prevalence of H.pylori in 2011 was significantly lower compared to the prevalence reported from identical geographical areas in 2001(23.5%vs 41.7%,P < 0.001).CONCLUSION:The overall prevalence of H.pylori infection in the general population has fallen substantially in the Czech Republic over the past 10 years. | Jan Bure Marcela Kopáová Ilona Koupil Bohumil Seifert Miluka kodová Fendrichová Jana pirková Viktor Voíek Stanislav Rejchrt TomáDouda Norbert Král Ilja Tachecí | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 2 | Standardization and interlaborato- ry reproducibility assessment of pulsed-field gel electrophoresis-generated fingerprints ofAcinetobacter baumannii显示文摘 | Seifert H Dolzani L Bressan R | 2005 | J Clin Microbiol2005，43，： | 1 |
| 3 | Outcome of pulmonary vascular disease in pregnancy: a systematic overview from 1978 through 1996 显示文摘 | Weiss BM Zemp L Seifert B | 1998 | J Am Coll Cardiol1998，31，： | 1 |
| 4 | An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii显示文摘 | DIJKSHOORN L NEMEC A SEIFERT H | 2007 | Nat Rev Mierobiol2007，5，12： | 1 |
| 5 | Distribution c Acinetobacter species on human skin: comparison of phenotypi and genotypic identification methods显示文摘 | Seifert H Dijkshoorn L Gerner-smidt P | | J Clin Microbiol0，199，35： | 1 |
| 6 | Characterization of a novel bidirectional distraction spinal cord iniury animal model显示文摘 | SEIFERT J L BELL J E ELMER B B | 2011 | J Neurosci Methods2011，197，1： | 1 |
| 7 | Nuclear ribosomal internal transcribed spacer(ITS)region as a universal DNA barcode marker for fungi显示文摘 | SCHOCH C L SEIFERT K A HUHNDORF S | 2012 | Proceedings of the National Academy of Sciences USA2012，109，16： | 1 |
| 8 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 9 | Ionogel-templated Synthesis and Organization of Anisotropic Gold Nanoparticles显示文摘 | Firestone M A Dietz M L Seifert S | 2005 | Small2005，1，： | 1 |
| 10 | Infrared microscopic investigation of skin biopsies after application of implant material for correction of aesthetic deficiencies显示文摘 | Heise HM Seifert L Kuckuk R | 2003 | J Mol Struct2003，，： | 1 |
| 11 | An increasing threat in hospitals:multidrug -resistant Acinetobacter baumannii显示文摘 | Dijkshoom L Nemec A Seifert H | 2007 | Nat Rev Microbiol2007，5，12： | 1 |
| 12 | Acinetobacter baumannii: emergence of a suceessful pathogen 显示文摘 | Peleg A Y Seifert H Paterson D L | 2008 | Clin Microbiol Rev2008，21，： | 1 |
| 13 | Using response time measures to assess' guilty knowledge' 显示文摘 | Seymour T L Seifert C M Shafto M G | 2000 | Journal of Applied Psychology2000，85，1： | 1 |
| 14 | An increasing threat in hospi- tals : muhidrug-resistant Acinetobacter baumannii 显示文摘 | Dijkshoorn L Nemec A Seifert H | 2007 | Nat Rev Mi- crobio2007，5，12： | 1 |
| 15 | A global view of gene activity and alternative splicing by deep sequen- cing of the human transcriptome 显示文摘 | SULTAN M SEIFERT M YASPO M L | 2008 | Science2008，321，： | 1 |
| 16 | An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii 显示文摘 | Dijkshoorn L Nemec A Seifert H | 2007 | Nat Rev Microbiol2007，5，： | 1 |
| 17 | Inter-limb coordination in swimming: Effect of speed and skill level显示文摘 | SEIFERT L LEBLANC H CHOLLET D | 2010 | Human movement sci- ence2010，29，1： | 1 |
| 18 | Outcome of pulmonary, vascular disease in pregnancy: a systematic overview from 1978 through 1996显示文摘 | Weiss BM Zemp L Seifert B | 1998 | J Am Coll Cardiol1998，31，： | 1 |
| 19 | Acinetobacter bau- mannii: emergence of a successful pathogen显示文摘 | Peleg A Y Seifert H Paterson D L | 2008 | Clin Mi- crobiol Rev2008，21，3： | 1 |
| 20 | Nuclear riboso-mal internal transcribed spacer (ITS)region as a universalDNA barcode marker for fungi显示文摘 | Schoch C L Seifert K A Huhndorf S | 2013 | Proceedings of the Nation-al Academy of Sciences of the United States of America2013，109，16： | 1 |
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