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| 1 | How antibiotic resistances could change Helicobacter pylori treatment:A matter of geography?显示文摘Therapeutic management of Helicobacter pylori(H.pylori)remains an unsolved issue.Indeed,no therapeutic regimen is able to cure the infection in all treated patients,and in many the infection persists despite the administration of several consecutive standard therapies.Although antibiotic resistance reports describe alarming results,the outcome of therapeutic regimens does not seem to parallel this scenario in most cases,since a successful performance is often reached in more than 80%of cases.However,the phenomenon of increasing antibiotic resistance is being closely studied,and the results show controversial aspects even in the same geographic area.For the continents of Europe,America,Asia,Africa,and Oceania,minimal and maximal values of resistance to the main antibiotics(clarithromycin,amoxicillin,metronidazole,and levofloxacin)feature wide ranges in different countries.The real enigma is therefore linked to the several different therapeutic regimens,which show results that often do not parallel the in vitro findings even in the same areas.A first aspect to be emphasized is that some regimens are limited by their use in very small geographic districts.Moreover,not all therapeutic trials have considered bacterial and host factors affecting the therapeutic outcome.The additional use of probiotics may help to reduce adverse events,but their therapeutic impact is doubtful.In conclusion,the'ideal therapy',paradoxically,appears to be a'utopia',despite the unprecedented volume of studies in the field and the real breakthrough in medical practice made by the discovery and treatment of H.pylori.The ample discrepancies observed in the different areas do not encourage the development of therapeutic guidelines that could be valid worldwide.On these bases,one of the main challenges for the future might be identifying a successful solution to overcome antibiotic resistances.In this context,geography must be considered a relevant matter. | Enzo Ierardi Floriana Giorgio Giuseppe Losurdo Alfredo Di Leo Mariabeatrice Principi | 2013 | World Journal of Gastroenterology2013，19，45： | 23 |
| 2 | Prevention of Helicobacter pylori infection in childhood显示文摘Helicobacter pylori(H.pylori)infection is one of the most common infections worldwide.Although infection rates are falling in the developed and developing countries,H.pylori is still widespread in the world.This article has reviewed the important publications on H.pylori in childhood with a focus on its evolving transmission route and the source of infection and preventive strategies in childhood,PubMed was searched up to identify eligible studies.Relevant publications were searched using the following. | Oya Yucel | 2014 | World Journal of Gastroenterology2014，20，30： | 12 |
| 3 | Blood pressure and stature in Helicobacter pylori positive and negative persons显示文摘To evaluate vital signs and body indices in Helicobacter pylori(H.pylori)positive and negative persons.A total of 22 centres entered the study.They were spread over the whole country,corresponding well to the geographical distribution of the Czech population.A total of 1818 subjects(aged 5-98 years)took part in the study,randomly selected out of 38147 subjects.H.pylori infection was investigated by means of a 13Curea breath test.Data on height,weight,systolic and diastolic blood pressure and heart rate were collected at the clinics of general practitioners.The overall prevalence of H.pylori infection was 30.4%(402/1321)in adults(≥18 year-old)and 5.2%(26/497)in children and adolescents(≤17 year-old).Once adjusted for age and gender,only a difference in body mass index remained statistically significant with H.pylori positive adults showing an increase of 0.6 kg/m2 in body mass index.Once adjusted for age and gender,we found a difference in height between H.pylori positive and H.pylori negative children and adolescents.On further adjustment for place of residence,this difference became statistically significant,with H.pylori positive children and adolescents being on average 3.5 cm shorter.H.pylori positive adults were significantly older compared to H.pylori negative subjects.Once adjusted for age and gender,H.pylori infection had no impact on body weight,body mass index and vital signs either in adults or children and adolescents.Chronic H.pylori infection appeared to be associated with short stature in children.H.pylori infection did not influence blood pressure,body weight and body mass index either in adults or children and adolescents. | Marcela Kopacova Ilona Koupil Bohumil Seifert Miluska Skodova Fendrichova Jana Spirkova Viktor Vorisek Stanislav Rejchrt Tomas Douda Ilja Tacheci Jan Bures | 2014 | World Journal of Gastroenterology2014，20，19： | 9 |
| 4 | 兰州市健康体检人群幽门螺杆菌感染情况调查显示文摘背景:幽门螺杆菌(Hp)感染与消化性溃疡、胃癌等多种疾病的发生、发展密切相关。我国是Hp感染高发国,平均现症感染率为55%。目的:了解兰州市健康人群的Hp感染情况,为当地Hp感染的防治提供依据。方法:纳入2014年5月—2015年7月在兰州军区兰州总医院参加体检的健康成人3 239例,采用^(13)C-尿素呼气试验检测Hp感染情况。结果:3 239例受检者的Hp总体感染率为51.8%(1 679/3 239),其中男性和女性感染率分别为52.5%(1 197/2 279)和50.2%(482/960),总体和分年龄段男女性感染率差异均无统计学意义(P>0.05)。不同年龄段组间Hp感染率差异显著(P<0.05),41~60岁年龄段组感染率最高。结论:兰州市健康人群Hp现症感染率为51.8%,是一个不容忽视的公共卫生问题。Hp感染率随年龄增长而逐渐增高,与性别则无明显关联。 | 于晓辉 赵红珍 李晓云 高娟 何毅刚 孙延荣 | 2016 | 胃肠病学2016，21，11： | 7 |
| 5 | Helicobacter pylori infection in older people显示文摘Since the discovery of Helicobacter pylori(H.pylori)infection as the major cause of gastroduodenal disorders three decades ago,H.pylori has been the focus of active research and debate in the scientific community.Its linkage to several diseases,such as peptic ulcer disease,gastritis and gastric malignancy is incontestable.In particular,it has been noticed that,as the aged population is increasing worldwide,older people are at increased risk of developing several gastroduodenal diseases and related complications.At the same time,gastric cancer is definitely more frequent in elderly than in adult and young people.In addition,it has been showed that peptic ulcer and related complications occur much more commonly in aged individuals than in young people,resulting in a significantly higher mortality.Although this infection plays a crucial role in gastrointestinal disorders affecting all age groups and in particular older people,only a few studies have been published regarding the latter.This article presents an overview of the epidemiology,diagnosis,clinical manifestations and therapy of H.pylori infection in elderly people. | Alberto Pilotto Marilisa Franceschi | 2014 | World Journal of Gastroenterology2014，20，21： | 6 |
| 6 | 幽门螺旋杆菌检测方法及其应用价值的研究进展显示文摘幽门螺旋杆菌(Hp)是一种定植于人类胃部并对机体造成一定损害的病原菌。多年来针对Hp的各类检测技术不断被研发改进并被应用于临床Hp感染的诊断中,以组织病理切片法为代表的侵入性检测方法因有创性而使其应用范围受限,以^(13/14)C呼气试验为代表的非侵入性检测方法因无创和简便等特点更易被患者接受,但不同检测方法均存在一定的局限性,因此需考虑患者年龄、既往史、当地医疗条件、检测方法的可靠性和检测成本等因素选择适合患者的Hp检测方法,可以帮助临床医生及时并准确地做出诊断。近年来对于Hp检测技术的研究已不仅局限于Hp的定性检测,定量检测、基因检测和分型检测方法也在不断探索和更新,家用检测试剂盒的开发也为Hp检测带来了更多的可能性。现从侵入性和非侵入性2个方面就近年来Hp检测方法的检测原理、检测灵敏度和特异度等进行综述,为Hp感染的临床诊疗和科学研究提供参考。 | 常明珠 李雨澎 母润红 朱建宇 | 2023 | 吉林大学学报(医学版)2023，49，1： | 3 |
| 7 | 长治地区^(14)C尿素呼气试验检测幽门螺杆菌感染分析显示文摘目的:调查长治地区人群幽门螺杆菌(Helicobacler,Hp)的感染现状,分析相关影响因素,为本地区防治Hp感染提供科学依据。方法:选取长治医学院附属和平医院健康体检中心的3 095例常规体检人员,采用14C尿素呼气试验(14 C-urea breath test,14 C-UBT)检测Hp感染状况;对586例有效问卷应用非条件logistic回归分析Hp感染的相关影响因素。结果:受检人群Hp的总感染率为49.5%,40~49岁年龄组Hp感染率最高(56.3%,P<0.05);在外就餐人群Hp感染率高于在家就餐者(61%vs33.9%,P<0.05);月收入<2 000元和2 000~5 000元组Hp感染率高于月收入>5 000元组(48.0%、50.5%vs 29.4%,P<0.05);医护人员和工人组Hp感染率显著高于公务员人群(46.4%、46.6%vs26.9%,P<0.05)。结论:长治地区人群Hp感染形势较严峻。40~49岁中年人群、经常在外就餐、低经济收入和医护人员及工人可能为Hp感染的高危人群,应用14 C-尿素呼气试验对其进行Hp感染筛查,对早期发现并治疗Hp感染具有重要意义。 | 崔瑞芳 张文平 毛华杰 吕壮 窦志勇 郭旭霞 | 2017 | 长治医学院学报2017，31，5： | 3 |
| 8 | 慢性萎缩性胃炎与幽门螺杆菌感染及其主要毒力因子研究进展显示文摘慢性萎缩性胃炎(chronic atrophic gastritis,CAG)是胃黏膜上皮长期遭受致病因子的反复损害而导致的以胃黏膜上皮和腺体萎缩,数目减少,胃黏膜变薄,黏膜基层增厚,或伴幽门腺化生和肠腺化生,或有不典型增生为特征的慢性疾病,是消化系统常见病之一。"正常胃黏膜-炎症-萎缩-肠化-异型增生-胃癌"的假设已被大量的临床和实验研究所证实,CAG作为胃黏膜病变过程的中间环节, | 舒晓霞 黄彬 谢伟昌 张春虹 | 2016 | 中国中西医结合消化杂志2016，24，8： | 2 |
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