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| 1 | Role of Hox genes in stem cell differentiation显示文摘Hox genes are an evolutionary highly conserved gene family. They determine the anterior-posterior body axis in bilateral organisms and influence the developmental fate of cells. Embryonic stem cells are usually devoidof any Hox gene expression, but these transcription factors are activated in varying spatial and temporal patterns defining the development of various body regions. In the adult body, Hox genes are among others responsible for driving the differentiation of tissue stem cells towards their respective lineages in order to repair and maintain the correct function of tissues and organs. Due to their involvement in the embryonic and adult body, they have been suggested to be useable for improving stem cell differentiations in vitro and in vivo. In many studies Hox genes have been found as driving factors in stem cell differentiation towards adipogenesis, in lineages involved in bone and joint formation, mainly chondrogenesis and osteogenesis, in cardiovascular lineages including endothelial and smooth muscle cell differentiations, and in neurogenesis. As life expectancy is rising, the demand for tissue reconstruction continues to increase. Stem cells have become an increasingly popular choice for creating therapies in regenerative medicine due to their self-renewal and differentiation potential. Especially mesenchymal stem cells are used more and more frequently due to their easy handling and accessibility, combined with a low tumorgenicity and little ethical concerns. This review therefore intends to summarize to date known correlations between natural Hox gene expression patterns in body tissues and during the differentiation of various stem cells towards their respective lineages with a major focus on mesenchymal stem cell differentiations. This overview shall help to understand the complex interactions of Hox genes and differentiation processes all over the body as well as in vitro for further improvement of stem cell treatments in future regenerative medicine approaches. | Anne Seifert David F Werheid Silvana M Knapp Edda Tobiasch | 2015 | World Journal of Stem Cells2015，7，3： | 10 |
| 2 | Fibroblast Growth Factors and Their Receptors in Urological Cancers: Basic Research and Clinical Implications显示文摘 | M.V Cronauer W.A Schulz H.-H Seifert R Ackermann M Burchardt | 2003 | European Urology2003，，3： | 2 |
| 3 | One-stage Soave pull-through for Hirschsprungs disease: a comparison of the transanal and open approaches显示文摘 | Langer JC Seifert M | 2000 | J Pediatr Surg2000，35，： | 1 |
| 4 | Endothelin and subarachnoid hemorrhage: an overview 显示文摘 | Zimmermann M Seifert V | 1998 | Neurosurgery1998，43，4： | 1 |
| 5 | Expression of the nm23 homologues nm23 - H4, nm23 - H6, and nm23 -H7 in human gastric and colon cancer 显示文摘 | Seifert M Welter C Mehraein Y | 2005 | J Pathol2005，205，5： | 1 |
| 6 | Efficacy of sustained low-effi- ciency dialysis in the treatment of salicylate toxicity 显示文摘 | Lund B Seifert S A Mayersohn M | 2005 | Nephrology Dialysis Transplantation2005，20，7： | 1 |
| 7 | Characterization of additional volatile components of tomato 显示文摘 | Buttery R G Seifert R M Guadagni D G | 1971 | J Agr Food Chem1971，19，： | 1 |
| 8 | Anatomic reconstruction of the posterolateral cranial base with titanium micromesh for combined transpetrosal approach:techical note显示文摘 | Seifert V | 1997 | Nerurosurg1997，41，4： | 1 |
| 9 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 10 | Ionogel-templated Synthesis and Organization of Anisotropic Gold Nanoparticles显示文摘 | Firestone M A Dietz M L Seifert S | 2005 | Small2005，1，： | 1 |
| 11 | Serum biomarkers for experimental acute spinal cord injury: rapid elevation of neuron-specific enolase and S-100 显示文摘 | Marquardt G Setzer M Seifert V | 2006 | Neurosurgery2006，58，3： | 1 |
| 12 | Analysis of long term dynamics of crowns of sessile oaks at the stand level by means of spatial statistics 显示文摘 | Longuetaud F Seifert T Leban J M | 2008 | Forest Ecology and Manage- ment2008，256，20： | 1 |
| 13 | The energy expenditure, physical exertion, and time trial performance during mountain bicycling 显示文摘 | Seifert effects J G Luetkemeier M J Spencer M K et of mountain bike suspension system on al | 1997 | International Journal of Sports Medicine1997，18，3： | 1 |
| 14 | Using response time measures to assess' guilty knowledge' 显示文摘 | Seymour T L Seifert C M Shafto M G | 2000 | Journal of Applied Psychology2000，85，1： | 1 |
| 15 | A global view of gene activity and alternative splicing by deep sequen- cing of the human transcriptome 显示文摘 | SULTAN M SEIFERT M YASPO M L | 2008 | Science2008，321，： | 1 |
| 16 | Dynamic Behavior of CO2 Spot Prices 显示文摘 | Seifert J Homburg M U Wagner M | 2008 | Jouriml of Environmental Economics and Management2008，56，2： | 1 |
| 17 | Relationship between petroleum composition and depositional environment of petroleum source rocks显示文摘 | Moldowan J M Seifert W K Gallegos E J | | 0，，08： | 1 |
| 18 | Relationship between petroleum composition and depositional environment of petroleum source rocks显示文摘 | Moldowan J M Seifert W K Gallegos E J | 1985 | AAPG Bulletin1985，69，： | 1 |
| 19 | Microbial CO (2) fixation and sulfur cycling associated with low-temperature emissions at the Lilliput hydrothermal field, southern Mid-Atlantic Ridge (9 degrees S)显示文摘 | Perner M Seifert R Weber S | 2007 | Environ Microbiol2007，9，5： | 1 |
| 20 | Molecular footprints of a germinal center derivation of human IgM+(IgD+) CD27+ B cells and the dynamics of memory B cell generation 显示文摘 | Seifert M Ktippers R | 2009 | J Exp Meal2009，206，12： | 1 |
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