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| 1 | Biodiversity and Sequence of the Middle Triassic Panxian Marine Reptile Fauna,Guizhou Province,China显示文摘中间的三叠纪的 Panxian 动物志是一个物理标记和在结束以后跟随早三叠纪的停滞阶段的三叠纪的海洋的生态系统的快速的恢复的代表性的记录 -- 二叠的集体扑灭。十海洋的爬行动物税一在 Guanling 形成的上面的成员从 1.82 2.10 m 厚的含化石的水平被发现了,它能在石块爬行动物的 stratigraphic 分布上通过分析被细分进三张海洋的爬行动物床。更低的爬行动物床产出 sauropterygians Placodus inexpectatus 江等, 2008 并且 Lariosaurus hongguoensis 江等, 2006, ichthyopterygians Xinminosaurus catactes 江等, 2008 并且 Phalarodon cf。Phalarodon fraasi Merriam, 1910,与 Mixosaurus panxianensis 江等联系了, 2006,代表 durophagous 的优势的一个阶段税一。在这张床上,大完全的骨骼可以在长度到达多达 2.3 m,并且岩相和 chemostratigraphic 分析在底部,以及升起的海水平附近与 oxic 水环境显示一个相对深的碳酸盐平台。中间的爬行动物床产出 sauropterygian Nothosaurus yangjuanensis 江等, 2006 并且祖龙 Qianosuchus mixtus 李等, 2006,把等与 Mixosaurus panxianensis 江联系了, 2006。在这张床上的石块被它的大头针 cering 出牙和大全面身体尺寸描绘,与最大可能在长度超过 3 m。这张床可能在底部附近与相对缺氧的状况代表最深的盆的一时间。上面的爬行动物床产出 sauropterygians Wumengosaurus delicatomandibularis 江等, 2008, Keichousaurus sp, protorosaur Dinocephalosaurus 东方人是李, 2003,并且 ichthyopterygian Mixosaurus panxianensis 江等, 2006。在这张床上,爬虫税一由吸喂描绘了出现,并且最长是不到 1 m。这张床对应于减少的水深度的一个时期。 | JIANG Dayong Ryosuke MOTANI HAO Weicheng Olivier RIEPPEL SUN Yuanlin Andrea TINTORI SUN Zuoyu Lars SCHMITZ | 2009 | Acta Geologica Sinica(English Edition)2009，83，3： | 17 |
| 2 | New primitive ichthyosaurian (Reptilia,Diapsida) from the Middle Triassic of Panxian,Guizhou,southwestern China and its position in the Triassic biotic recovery显示文摘一张新原始 ichthyopterygian Xinminosaurus catactes 情报。et sp。nov。在 Panxian 从 Guanling 形成的中间的三叠纪的上面的成员基于一架完全的骨骼被树立,贵州,西南的中国。它在它的出牙,尺骨,腕骨和 tarsals 有特别地导出的人物的一间套房。它类似于在保留伸长的手足骨头的原始 ichthyopterygians。新税在上和多种水兵在 Panxian 动物志的爬行动物是中间的三叠纪的关於生命的放射的物理标记。这动物志的详细研究将在差异,迁居和中间的三叠纪的 ichthyopterygians 的 paleobiogeographic 亲密关系上供应必要知识。 | Dayong Jiang Ryosuke Motani Weicheng Hao Lars Schmitz Olivier Rieppel Yuanlin Sun Zuoyu Sun | 2008 | Progress in Natural Science:Materials International2008，18，10： | 13 |
| 3 | Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis显示文摘AIM: To study susceptibility genes which may play a potential role in the pathogenesis and etiology of inflammatory bowel disease (IBD). METHODS: To identify potential susceptibility genes we performed global gene expression profiling in patients with IBD and control specimens. For determination of an intrinsic gene expression profile in ulcerative colitis (UC) and Crohn’s disease (CD) compared to normal subjects, mucosal biopsies of non-inflamed regions of the colon and the terminal ileum were subjected to DNA microarray analysis. Real-time RT-PCR and immunohistochemistry were used for verification of selected regulated candidate genes and a genetic analysis was performed. RESULTS: We could show that aquaporin-8 (AQP8) mRNA and protein levels were significantly increased in the colon of UC patients compared to controls. Genetic analysis of the six exons and the promoter region of AQP8, however, revealed no mutations or polymorphisms in IBD patients. CONCLUSION: Our results suggest that upregulation of AQP8 in the colon of UC patients represents a secondary phenomenon which may, due to altered water exchange of the distal intestinal mucosa, disturb the physiologic colonic mucus barrier and thus lead to chronic infla- mmation and ulceration. | Alexandra Zahn Christoph Moehle Thomas Langmann Robert Ehehalt Frank Autschbach Wolfgang Stremmel Gerd Schmitz | 2007 | World Journal of Gastroenterology2007，13，11： | 13 |
| 4 | 长效胰岛素类似物的应用现状显示文摘 | Ole Schmitz | 2006 | 国际内分泌代谢杂志2006，26，3： | 12 |
| 5 | Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function显示文摘AIM: To test the hypothesis that hydrolysis of sphingomyelin to ceramide changes the composition of tight junctions (TJs) with increasing permeability of the intestinal epithelium. METHODS: Monolayers of Caco-2 cells were used as an in vitro model for the intestinal barrier. Permeability was determined by quantifi cation of transepithelialflux and transepithelial resistance. Sphingolipid-rich membrane microdomains were isolated by a discontinuous sucrose gradient and characterized by Western-blot. Lipid content of microdomains was analysed by tandem mass spectrometry. Ceramide was subcellularly localized by immunofluorescent staining.RESULTS: Exogenous sphingomyelinase increased transepithelial permeability and decreased transepithelial resistance at concentrations as low as 0.01 U/mL. Lipid analysis showed rapid accumulation of ceramide in the membrane fractions containing occludin and claudin-4, representing TJs. In these fractions we observed a concomitant decrease of sphingomyelin and cholesterol with increasing concentrations of ceramide. Immunofluorescent staining confirmed clustering of ceramide at the sites of cell-cell contacts. Neutralization of surface ceramide prevented the permeability-increase induced by platelet activating factor. CONCLUSION: Our findings indicate that changes in lipid composition of TJs impair epithelial barrier functions. Generation of ceramide by sphingomyelinases might contribute to disturbed barrier function seen in diseases such as inflammatory, infectious, toxic or radiogenic bowel disease. | Jürgen Bock Gerhard Liebisch Joachim Schweimer Gerd Schmitz Gerhard Rogler | 2007 | World Journal of Gastroenterology2007，13，39： | 11 |
| 6 | Guanling Biota: A Marker of Triassic Biotic Recovery from the end-Permian Extinction in the Ancient Guizhou Sea显示文摘After a slow recovery from the end-Permian extinction during the Early Triassic and rapid radiation in the Middle Triassic, evolution of organisms reached a new peak phase in the Late Triassic. The Guanling Biota from the Wayao Member (conodont Paragondolella polygnathiformis Zone), Falang Formation, Xinpu, Guanling County, Guizhou Province, southwestern China corresponds to this peak that marks the full recovery from the end-Permian extinction of marine ecosystems. The biota is of high diversity, containing well preserved and completely articulated skeletons of vertebrates comprising marine reptiles, fishes, and invertebrates including crinoids, ammonites, bivalves, and other fossils, and is one of the best examples of marine ecosystem records in life history. The fossil marine reptiles and crinoids are most significant in this biota, especially the marine reptiles, which provide an important link between the Triassic Pacific and Tethys, and between Triassic basal forms and the Jurassic-Cretaceous marine top predators. The most remarkable fossils are the large completely articulated ichthyosaur skeletons up to and more than 10 m, and the first recorded thalattosaurs and placodonts in China. Following our review, of the 17 named reptilian taxa the eight listed here are considered to be valid: three ichthyosaurs (Qianichthyosaurus zhoui Li, 1999; Guizhouichthyosaurus tangae Cao and Luo in Yin et al., 2000, Guanlingsaurus liangae Yin in Yin et al., 2000), three thalattosaurs (Anshunsaurus huangguoshuensis Liu, 1999, Xinpusaurus suni Yin in Yin et al., 2000, Xinpusaurus kohi Jiang et al., 2004), and two placodonts (Sinocyamodus xinpuensis Li, 2000, Psephochelys polyosteoderma Li and Rieppel, 2002). Mixosaurus guanlingensis Cao in Yin et al., 2000 might be a junior synonym of Qianichthyosaurus zhoui Li, 1999, and Cymbospondylus asiaticus Li and You, 2002 and Panjiangsaurus epicharis Chen and Cheng, 2003 might be junior synonyms of Guizhouichthyosaurus tangae Cao and Luo in Yin et al., 2000. It needs to re-describe the holotypes after a complete preparation for clarifying the taxonomic status of Typicusichthyosaurus tsaihuae Yu in Yin et al., 2000, Xinpusaurus bamaolinensis Cheng, 2003, Neosinosaurus hoangi (Zhou in Yin et al., 2000), Wayaosaurus geei Zhou in Yin et al., 2000, Wayaosaurus bellus Zhou in Yin et al., 2000 and Placochelys ? minutus Yin and Luo in Yin et al., 2000. | JIANG Dayong Ryosuke MOTAN LI Chun HAO Weicheng SUN Yuanlin SUN Zuoyu Lars SCHMITZ | 2005 | Acta Geologica Sinica(English Edition)2005，79，6： | 11 |
| 7 | 104例老年骨质疏松性骨盆骨折的治疗——骨水泥型经髂骨螺钉内固定系统介绍显示文摘目的探讨骨水泥型经髂骨螺钉内固定系统(TIFI)治疗老年骨质疏松性骨盆骨折的方法。方法回顾性分析2004年1月至2014年11月期间收治的104例年龄≥59岁的骨盆骨折患者资料。男11例,女93例;年龄为59~94岁,平均(77.5±7.6)岁。骨折根据Ptommens分型:I型31例,Ⅱ型39例,Ⅲ型19例,Ⅳ型15例。致伤原因:平地摔伤89例,从低于3m高处摔伤8例,无明确外伤史7例。保守治疗65例;手术治疗39例,其中17例患者采用骨水泥型TIFI固定治疗,将宁心钉和SchalIZ钉从髂后卜棘到髂前下棘置入,并固定于髋臼上方。结果65例保守治疗患者出院当天活动度:坐轮椅1例,平地行走26例,可上下楼8例,未记录30例。39例手术治疗患者出院当天活动度:坐轮椅6例,平地行走26例,可上下楼1例,未记录6例。34例Schanz钉固定患者中,有2例固定髂骨时出现螺钉穿透骶髂关节。16例Schanz钉结合骨水泥固定患者中,未观察到骨水泥溢出至骶髂关节。Schanz钉髂骨置钉深度平均为(100±20)mm,连接杆的长度平均为(62±16)mm。17例采用TIFI固定的患者中,2例术后出现血肿,I例出现浅表伤口感染,未出现深层组织感染或内固定感染。结论老午骨质疏松性骨盆骨折可根据Rommens分型来选择治疗方式。骨水泥型TIFI固定是~一种治疗老年骨质疏松性骨笳骨折的微创、可靠方法。 | Paul Schmitz Stephan Luedeek 王博炜 Rupert Schupfner Michael Worlieek Michael Nerlich Michael Bernhard Muller | 2017 | 中华创伤骨科杂志2017，19，5： | 10 |
| 8 | Receptance Coupling for Tool Point Dynamics Prediction on Machine Tools显示文摘Chatter has been a primary obstacle to the successful implementation of high speed machining.The frequency response function(FRF) of the tool point is crucial for identification of chatter free cutting conditions.In order to quickly acquire the FRF of the different components combinations of machine tool,the assembly of machine tool was always decomposed into several parts,where the fluted portion of tool,however,was always treated as a uniform beam,and the associated discrepancy was ignored.This paper presents a new method to predict the dynamic response of the machine-spindle-holder-tool assembly using the receptance coupling substructure analysis technique,where the assembly is divided into three parts:machine-spindle,holder and tool shank,and tool's fluted portion.Impact testing is used to measure the receptance of machine-spindle,the Timoshenko beam model is employed to analyze the dynamics of holder and tool shank,and the finite element method(FEM) is used to calculate the receptance of the tool's fluted portion.The approximation of the fluted portion cross section using an equivalent diameter is also addressed.All the individual receptances are coupled by using substructure method.The predicted assembly receptance is experimentally verified for three different tool overhang lengths.The results also show that the equivalent diameter beam model reaches an acceptable accuracy.The proposed approach is helpful to predict the tool point dynamics rapidly in industry. | ZHANG Jun SCHMITZ Tony ZHAO Wanhua LU Bingheng | 2011 | Chinese Journal of Mechanical Engineering2011，24，3： | 9 |
| 9 | Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro显示文摘AIM: Eph receptor tyrosine kinases and their membrane bound receptor-like ligands, the ephrins, represent a bi-directional cell-cell contact signaling system that directs epithelial movements in development. The meaning of this system in the adult human gut is unknown. We investigated the Eph/ephrin mRNA expression in the intestinal epithelium of healthy controls and patients with inflammatory bowel disease (IBD).METHODS: mRNA expression profiles of all Eph/ephrin family members in normal small intestine and colon were established by real-time RT-PCR. In addition, differential expression in IBD was investigated by cDNA array technology, and validated by both real-time RT-PCR and immunohistochemistry. Potential effects of enhanced EphB/ephrin-B signaling were analyzed in an in vitro IEC-6 cell scratch wound model.RESULTS: Human adult intestinal mucosa exhibits a complex pattern of Eph receptors and ephrins. Beside the known prominent co-expression of EphA2 and ephrinA1,we found abundantly co-expressed EphB2 and ephrin-B1/2.Interestingly, cDNA array data, validated by real-time PCR and immunohistochemistry, showed upregulation of ephrin-B2 in both perilesional and lesional intestinal epithelial cells of IBD patients, suggesting a role in epithelial homeostasis. Stimulation of ephrin-B signaling in ephrinB1/2 expressing rat IEC-6-cells with recombinant EphB1Fc resulted in a significant dose-dependent acceleration of wound closure. Furthermore, fluorescence microscopy showed that EphB1-Fc induced coordinated migration of wound edge cells is associated with enhanced formation of lamellipodial protrusions into the wound, increased actin stress fiber assembly and production of laminin at the wound edge.CONCLUSION: EphB/ephrin-B signaling might represent a novel protective mechanism that promotes intestinal epithelial wound healing, with potential impact on epithelial restitution in IBD. | Christian Hafner Stefanie Meyer Thomas Langmann Gerd Schmitz Frauke Bataille Ilja Hagen Bernd Becker Alexander Roesch Gerhard Rogler Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，26： | 9 |
| 10 | AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma显示文摘Intrahepatic cholangiocarcinomas (ICC) are neoplasms that originate from cholangiocytes and can occur at any level of the biliary tree. Surgical resection is the current therapy of choice for this highly aggressive cancer. However, the 5-year survival still is poor, with high recurrence rates. Due to the intrahepatic growth a signifi cant proportion of patients present with advanced disease and are not candidates for curative surgery or transplantation. The existing palliative options are of limited benefit and there is a great necessity for novel therapeutic options. In this article we review the role of the phosphoinositide 3-kinase(PI3K)/ AKT and extracellular regulated kinase (ERK) signaling pathways in ICC and present new data on the prognostic value of these protein kinases. Finally, we discuss future upcoming therapeutic options based on targeting these signaling pathways. | KJ Schmitz H Lang J Wohlschlaeger GC Sotiropoulos H Reis KW Schmid HA Baba | 2007 | World Journal of Gastroenterology2007，13，48： | 8 |
| 11 | 商用车涂料为水性聚氨酯涂料拓展更广泛的应用领域显示文摘随着环保重要性的不断增加以及法规压力的不断加大,西欧地区形成了各种低排放交通工具涂料的概念。本文着重介绍了双组分水性聚氨酯体系的应用情况,以及相关的原材料、技术和原理。 | Raul Pires Jorg Schmitz Christoph Irle Michael Bulanov 张之涵 李金旗 | 2009 | 涂料工业2009，39，7： | 6 |
| 12 | 2D NMR对Sarcophine所有~1H NMR和^(13)C NMR归属的指定显示文摘从中国南海软珊瑚Sarcophyton molle中分离得到大环二萜内酯Sarcophine(1)。本文利用~1H-~1HCOSY,HMQC,HMBC等二维谱手段首次对Sarcophine所有~1H NMR、^(13)C NMR的信号归属进行了完全的指定。并第一次报道了其^(13)C NMR数据。 | 孟艳辉 苏镜娱 曾陇梅 阎素君 FRANCIS Schmitz | 1997 | 有机化学1997，17，6： | 6 |
| 13 | IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines显示文摘 | Jochen Schmitz Alexander Owyang Elizabeth Oldham Yaoli Song Erin Murphy Terril K. McClanahan Gerard Zurawski Mehrdad Moshrefi Jinzhong Qin Xiaoxia Li Daniel M. Gorman J. Fernando Bazan Robert A. Kastelein | 2005 | Immunity2005，，5： | 6 |
| 14 | Intracellular transport of hepatitis B virus显示文摘For genome multiplication hepadnaviruses use the tran-scriptional machinery of the cell that is found within the nucleus.Thus the viral genome has to be transported through the cytoplasm and nuclear pore.The intracy-tosolic translocation is facilitated by the viral capsid that surrounds the genome and that interacts with cellular microtubules.The subsequent passage through the nu-clear pore complexes(NPC) is mediated by the nuclear transport receptors importin α and β.Importin α binds to the C-terminus of the capsid protein that comprises a nuclear localization signal(NLS).The exposure of the NLS is regulated and depends upon genome maturation and/or phosphorylation of the capsid protein.As for oth-er karyophilic cargos using this pathway importin α inter-acts with importin β that facilitates docking of the import complex to the NPC and the passage through the pore.Being a unique strategy,the import of the viral capsid is incomplete in that it becomes arrested inside the nuclear basket,which is a cage-like structure on the karyoplas-mic face of the NPC.Presumably only this compartment provides the factors that are required for capsid disas-sembly and genome release that is restricted to those capsids comprising a mature viral DNA genome. | Michael Kann André Schmitz Birgit Rabe | 2007 | World Journal of Gastroenterology2007，13，1： | 6 |
| 15 | 氯化锂除湿转轮的性能预测显示文摘对氯化锂除湿转轮的吸附过程进行了分析 ,建立了传热传质模型并得到了数值解 .计算结果与实验数据吻合 ,说明该模型可较好地定量预测氯化锂转轮的除湿效果 .结果有助于推动这一设备在空调系统设计中的应用 . | 秦朝葵 Gerhard Schmitz | 2002 | 同济大学学报(自然科学版)2002，30，7： | 5 |
| 16 | Genevestigator Transcriptome Meta-Analysis and Biomarker Search Using Rice and Barley Gene Expression Databases显示文摘到学习植物 transcriptomes 的 microarray 技术的普遍使用导致了重要发现并且盖住大量不同纸巾,发展阶段,不安,和遗传型到介绍数据的累积。查询很多 microarray 实验能提供不能被分析单个实验获得的卓见。然而,如此的元分析关于数据提出重要挑战相似性和正规化,系统的样品注解,和分析工具。Genevestigator 用一个大 curated 表达式数据库和在因特网上是可存取的一套明确地发达的分析工具处理这些问题。这联合已经证明了基于 Arabidopsis 数据的一个大集合在植物研究的区域有用(Grennan, 2006 ) 。这里,我们在场 Genevestigator 米饭的版本和包含质量控制、好的注解 microarray 的大麦基因表示数据库试验使用本体论。数据库当前从病理,植物营养,不能生活的压力,荷尔蒙处理,遗传型,和空间或时间的分析包括实验,但是被期望作为更试验性的数据盖住研究区域的一个宽广变化变得可得到。模型种类米饭和大麦的 transcriptome 元分析被期望交付能在谷物被用于功能的 genomics 和 biotechnological 应用程序的结果。 | Philip Zimmermann Oliver Laule Josy Schmitz Tomas Hruz Stefan Bleuler Wilhelm Gruissema | 2008 | Molecular Plant2008，1，5： | 5 |
| 17 | Different cava reconstruction techniques in liver transplantation:piggyback versus cava resection显示文摘BACKGROUND: Originally, cava reconstruction(CR) in liver transplantation meant complete resection and reinsertion of the donor cava. Alternatively, preservation of the recipients inferior vena cava(IVC) with side-to-side anastomosis(known as 'piggyback') can be performed. Here, partial clamping maintains blood flow of the IVC, which may improve cardiovascular stability, reduce blood loss and stabilize kidney function. The aim of this study was to compare both techniques with particular focus on kidney function.METHODS: A series of 414 patients who had had adult liver transplantations(2006-2009) were included. Among them,176(42.5%) patients had piggyback and 238 had classical CR operation, 112(27.1%) of the patients underwent CR accompanied with veno-venous bypass(CR-B) and 126(30.4%)without a bypass. The choice of either technique was based on the surgeons' individual preference. Kidney function [serum creatinine, calculated glomerular filtration rate(GFR), RIFLE stages] was assessed over 14 days.RESULTS: Lab-MELD scores were significantly higher in CR-B(22.5±11.0) than in CR(17.3±9.0) and piggyback(18.8±10.0)(P=0.008). Unexpectedly, the incidences of arterial stenoses(P=0.045) and biliary leaks(P=0.042) were significantly increased in piggyback. Preoperative serum creatinine levels were the highest in CR-B [1.45±1.17 vs 1.25±0.85(piggyback)and 1.13±0.60 mg/dL(CR); P=0.033]. Although a worsening of postoperative kidney function was observed among all groups,this was most pronounced in CR-B [creatinine day 14: 1.67±1.40 vs 1.35±0.96(piggyback) and 1.45±1.03 mg/dL(CR); P=0.102].Accordingly, the proportion of patients displaying RIFLE stages≥2 was the highest in CR/CR-B(26%/19%) when compared to piggyback(18%).CONCLUSIONS: Piggyback revealed a shorter warm ischemic time, a reduced blood loss, and a decreased risk of acute kidney failure. Thus, piggyback is a useful technique, which should be applied in standard procedures. When piggyback is unfeasible,cava replacement, which displayed a lower incidence of vascular and biliary complications in our study, remains as a safe alternative. | Volker Schmitz Wenzel Schoening Ines Jelkmann Brigitta Globke Andreas Pascher Marcus Bahra Peter Neuhaus Gero Puhl | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，3： | 5 |
| 18 | Arabidopsis FtsZ2-1 and FtsZ2-2 Are Functionally Redundant, But FtsZ-Based Plastid Division Is Not Essential for Chloroplast Partitioning or Plant Growth and Development显示文摘FtsZ1 和 FtsZ2 是在共同本地化到中间质体的戒指的植物的 FtsZ 的种系发生地不同的家庭并且便于叶绿体的分割。在植物,在叶绿体分割改变了 FtsZ1 或 FtsZ2 原因剂量依赖者缺点的层次;因此,在 FtsZ 基因之间的功能的关系上的研究在 vivo 要求 FtsZ 层次的小心的操作。在 Arabidopsis thaliana, FtsZ2-1 和 FtsZ2-2 定义在二 FtsZ2 基因之间的功能的关系,我们在 ftsZ2-2 0 异种表示了 FtsZ2-1,并且反过来也如此,并且决定了叶绿体部门缺点是否在表示 FtsZ2 的不同全部的层次的植物被救。当 FtsZ2-1 或 FtsZ2-2 水平接近了时,完整的营救被观察全部的 FtsZ2 层次在野类型(WT ) 。另外, FtsZ2-2 与 ARC6 交往,为 FtsZ2-1 以前出现。这些数据显示 FtsZ2-1 和 FtsZ2-2 为在 Arabidopsis 的叶绿体分割是机能上地冗余的。严厉地为叶绿体分割验证每个 FtsZ 家庭的要求,我们在 vivo 用 FtsZ2 代替了 FtsZ1,并且反过来也如此,当在转基因的植物维持 FtsZ 水平时,在 WT 等于到全部的水平的。叶绿体部门缺点没被救,决定性地证明 FtsZ1 和 FtsZ2 为 WT 叶绿体数字的维护是非冗余的。最后,我们产生了完全缺乏 FtsZ 蛋白质的植物可行、肥沃的 ftsZ 三元组 0 异种和表演。因为质体是大概必要的细胞器,这些调查结果建议质体划分的一个 FtsZ 独立的模式可以发生在更高的植物。 | Aaron J. Schmitz Jonathan M. Glynn Bradley J.S.C. Olson Kevin D. Stokes Katherine W. Osteryoung | 2009 | Molecular Plant2009，2，6： | 4 |
| 19 | Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inlammatory bowel disease显示文摘AIM:To determine free and conjugated serum bile acid (BA) levels in in? ammatory bowel disease (IBD) subgroups with defi ned clinical manifestations.METHODS: Comprehensive serum BA profiling was performed in 358 IBD patients and 310 healthy controls by liquid chromatography coupled to electrospray ionization tandem mass spectrometry.RESULTS: Serum levels of hyodeoxycholic acid, the CYP3A4-mediated detoxification product of the secondary BA lithocholic acid (LCA), was increased significantly in Crohn's disease (CD) and ulcerative colitis (UC), while most other serum BA species were decreased significantly. Total BA, total BA conjugate, and total BA glycoconjugate levels were decreased only in CD, whereas total unconjugated BA levels were decreased only in UC. In UC patients with hepatobiliary manifestations, the conjugated primary BAs glycocholic acid, taurocholic acid, and glycochenodeoxycholic acid were as significantly increased as the secondary BAs LCA, ursodeoxycholic acid, and tauroursodeoxycholic acid compared to UC patients without hepatobiliary manifestations. Finally, we found that in ileocecal resected CD patients, the unconjugated primary BAs, cholic acid and chenode-oxycholic acid, were increased significantly compared to controls and patients without surgical interventions.CONCLUSION: Serum BA profiling in IBD patients that indicates impaired intestinal barrier function and increased detoxification is suitable for advanced diagnostic characterization and differentiation of IBD subgroups with defined clinical manifestations. | Carsten Gnewuch Gerhard Liebisch Thomas Langmann Benjamin Dieplinger Thomas Mueller Meinhard Haltmayer Hans Dieplinger Alexandra Zahn Wolfgang Stremmel Gerhard Rogler Gerd Schmitz | 2009 | World Journal of Gastroenterology2009，15，25： | 4 |
| 20 | Evaluating the management of anaphylaxis in US emergency departments:Guidelines vs.practice显示文摘BACKGROUND:Anaphylaxis is characterized by acute episodes of potentially life-threatening symptoms that are often treated in the emergency setting.Current guidelines recommend:1) quick diagnosis using standard criteria;2) first-line treatment with epinephrine;and 3) discharge with a prescription for an epinephrine auto-injector,written instructions regarding long-term management,and a referral(preferably,allergy) for follow-up.However,studies suggest low concordance with guideline recommendations by emergency medicine(EM) providers.The study aimed to evaluate how emergency departments(EDs) in the United States(US) manage anaphylaxis in relation to guideline recommendations.METHODS:This was an online anonymous survey of a random sample of EM health providers in US EDs.RESULTS:Data analysis included 207 EM providers.For respondent EDs,approximately 9%reported using agreed-upon clinical criteria to diagnose anaphylaxis;42%reported administering epinephrine in the ED for most anaphylaxis episodes;and <50%provided patients with a prescription for an epinephrine auto-injector and/or an allergist referral on discharge.Most provided some written materials,and follow-up with a primary care clinician was recommended.CONCLUSIONS:This is the first cross-sectional survey to provide 'real-world' data showing that practice in US EDs is discordant with current guideline recommendations for the diagnosis,treatment,and follow-up of patients with anaphylaxis.The primary gaps are low(or no) utilization of standard criteria for defining anaphylaxis and inconsistent use of epinephrine.Prospective research is recommended. | W.Scott Russell Judith Rosen Farrar Richard Nowak Daniel P.Hays Natalie Schmitz Joseph Wood Judi Miller | 2013 | World Journal of Emergency Medicine2013，4，2： | 4 |
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