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33篇 您的检索式:作者名="HA Baba"
    题名 作者 年代 出处 被引量
1AKT and ERK1/2 signaling in intrahepatic cholangiocarcinoma显示文摘Intrahepatic cholangiocarcinomas (ICC) are neoplasms that originate from cholangiocytes and can occur at any level of the biliary tree. Surgical resection is the current therapy of choice for this highly aggressive cancer. However, the 5-year survival still is poor, with high recurrence rates. Due to the intrahepatic growth a signifi cant proportion of patients present with advanced disease and are not candidates for curative surgery or transplantation. The existing palliative options are of limited benefit and there is a great necessity for novel therapeutic options. In this article we review the role of the phosphoinositide 3-kinase(PI3K)/ AKT and extracellular regulated kinase (ERK) signaling pathways in ICC and present new data on the prognostic value of these protein kinases. Finally, we discuss future upcoming therapeutic options based on targeting these signaling pathways.KJ Schmitz H Lang J Wohlschlaeger GC Sotiropoulos H Reis KW Schmid HA Baba 2007World Journal of Gastroenterology2007,13,48:8
2Heart-directed expression of a human cardiac isoform of cAMP-response element modulator in transgenic mice显示文摘Muller FU Lewin G Baba HA 2005J Biol Chem2005,280,8:1
3Inducible heat shock protein 70 in rat cardiac allograft and its immunohistochemical localization in cardiac myocytes 显示文摘Baba HA Schmid C Wilhelm MJ 1997Transplantation1997,64,7:1
4Metallothionein: localization in hunan transplant endomvocarium,relation to cytokines and allografi function显示文摘Baba HA Schmid KW Takeda A 1999J Heart Lung Transplant1999,18,10:1
5Differential effects of angiotensin Ⅱ receptor blockade on pressure induced left ven tricular hypertrophy and fibrosis in rats显示文摘Baba HA Iwai T Bauer M 1999J Mol Cell Cardiol1999,31,:1
6Heat shock protein 72 and apoptosis indicate cardiac decompensation during early multiple organ failure in sheep显示文摘Baba HA Wohlschlaeger J Stubbe HD 2004Intensive Care Med2004,30,7:1
7Possible relationship between heat shock protein 70,cardiac hemodynamics,and survival in the early period after heart transplantation显示文摘 Schmid KW Schmid C 1998Transplantation1998,65,6:1
8Uniform long-term gene expression using adeno-associated virus (AAV) by ex vivo recirculation in rat-cardiac isografts显示文摘Asfour B Baba HA Scheld HH 2002Thorac Cardiovasc Surg2002,50,6:1
9Inducible heat shock protein 70 in rat cardiac allograft and its immunohistochemical localization in cardiac myocytes显示文摘Baba HA Schmid C 1997Transplanation1997,64,7:1
10Modulation of SR Ca2+release by the triadin-to-calsequestrin ratio in ventricular myo-cytes显示文摘KucerováD Baba HA Bokník P 2012Am J Physiol Heart Circ Physiol2012,302,10:1
11Progressive cardiac hypertrophy and dysfunction in atrial natriuretic peptide receptor (GC-A)deficient mice显示文摘Kuhn M Holtwick R Baba HA 2002Heart2002,87,:1
12Increased expression ofα-methylacyl-coenzyme A racemase(AMACR;p504s)and p16in distal hyperplastic polyps显示文摘Dayi N Baba HA Schmid KW 2013Diagn Pathol2013,23,8:1
13Dynamic regulation of MEK/Erks and Akt/GSK-3beta in human end-stage heart failure af- ter left ventricular mechanical support: myocardial mechanotransduc- tion-sensitivity as a possible molecular mechanism 显示文摘Baba HA Stypmann J Grabellus F 2003Cardiovasc Res2003,59,2:1
14Inducible heat shock protein 70 in rat cardiac allograft and its immunohistochemical localization in cardiac myocytes 显示文摘Baba HA Schmid C Wilhelm MJ 1997Transplantation1997,64,7:1
15Phosphorylation of p70S6 kinase predicts overall survival in patients with clear margin- resected hepatocellular carcinoma显示文摘Baba HA Wohlschlaeger J Cicinnati VR 2009Liver lnt2009,29,3:1
16Heat shock pro- tein 72 and apoptosis indicate cardiac decompensation during ear- ly multiple organ failure in sheep 显示文摘Baba HA Wohlschlaeger J Stubbe HD 2004Intensive Care Med2004,30,7:1
17Inducible heat shock protein 70 in rat cardiac allograft and its immunohistochemical localization in cardiac myocytes显示文摘Baba HA Schmid C Wilhelm MJ etal 1997Transplantation1997,64,7:1
18Dynamic regulation of MEK/Erks and Akt/GSK-3beta in human end-stage heart failure after left ventricular mechanical support: myocardial mechanotransduction -sensitivity as a possible molecular mechanism 显示文摘Baba HA Stypmann J Grabellus F 2003Cardiovasc Res2003,59,2:1
19Effective gene transfer in the rat myocardium via adenovirus vectors using a coronary recirculation model显示文摘Asfour B Byrne BJ Baba HA 1999Thorac Cardiovasc Surg1999,47,5:1
20Right atrial metastasis as primary clinical manifestation of hepatocellular carcinoma显示文摘Baba HA Engers R Heintzen MP 1995Int J Cardiol1995,47,3:1
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