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| 1 | Chemotherapy for gastric cancer显示文摘变形胃的癌症仍然是非药品疾病。没有生活妥协的质量,辩解的化疗被表明了延长幸存。单个代理人的许多和联合被证实了在变形疾病的治疗活跃。客观反应率为综合化学疗法为单个代理人的治疗和 30-60% 从 10-30%。阶段 II 和 III 研究的结果在这篇论文以及新药的潜在的功效被考察。为有局部性的疾病的病人,助手和 neoadjuvant 化疗和放射治疗的角色被讨论。辅助化疗上的大多数研究没能表明一个幸存优点,因此,它没在大多数中心被看作标准疗法。辅助免疫化疗在朝鲜和日本根本上被开发了。有 OK-432 的阶段 III 试用的元分析建议那免疫化疗可以改进病人的幸存与 curatively resected 胃的癌症。基于美国的结果团体之间 0116 学习,手术后的 chemoradiation 与 resected 在病人作为标准照顾被接受了在北美洲的胃的癌症。然而,结果被病人们经历了的事实有点惊讶不到推荐 D1 淋巴节点解剖和复发的模式建议没有任何效果,积极效果在微变形疾病上源于本地放射疗法。Neoadjuvant 化疗或 chemoradiation 治疗仍然保持试验性,但是几阶段 II 学习正在显示出有希望的结果。阶段 III 试用被需要。 | Javier Sastre Jose Angel García-Saenz Eduardo Díaz-Rubio | 2006 | World Journal of Gastroenterology2006，12，2： | 22 |
| 2 | Effect of calcination temperature on structural properties and catalytic activity in oxidation reactions of LaNiO_3 perovskite prepared by Pechini method显示文摘The study presented the preparation of the perovskite oxide LaNiO3 by the complex citrate method, paying particular attention to evolution of its formation from the amorphous precursor with varied calcination temperatures. The products obtained after heat treatment under air between 200 and 800 ℃ were characterized by X-ray diffraction (XRD), thermogravimetric and differential thermal analysis (TG-DTA), Fourier transform infrared spectroscopy (FTIR), SBET measurements and X-ray photoelectron spectroscopy (XPS). The results showed the formation of a single phase with perovskite structure from ca. 550 ℃. Tests on the two catalytic oxidation reactions of C3H6 and CO over the system calcined between mentioned temperatures were examined on the basis of characterization results and showed that optimum catalytic properties for such reactions were achieved for the perovskite calcined at 600 ℃. In turn, correlations between redox and catalytic properties were established on the basis of thermogravimetric temperature programmed reduction (TPR) analysis. | K. Rida M.A. Pea E. Sastre A. Martínez-Arias | 2012 | Journal of Rare Earths2012，30，3： | 11 |
| 3 | Ductal adenocarcinoma of the pancreatic head:A focus on current diagnostic and surgical concepts显示文摘Complete surgical resection still remains the only possibility of curing pancreatic cancer,however,only 10% of patients undergo curative surgery.Pancreatic resection currently remains the only method of curing patients,and has a 5-year overall survival rate between 7%-34% compared to a median survival of 3-11 mo for unresected cancer.Pancreatic surgery is a technically demanding procedure requiring highly standardized surgical techniques.Nevertheless,even in experienced hands,perioperative morbidity rates(delayed gastric emptying,pancreatic fistula etc.) are as high as 50%.Different strategies to reduce postoperative morbidity,such as different techniques of gastroenteric reconstruction(pancreatico-jejunostomy vs pancreatico-gastrostomy),intraoperative placement of a pancreatic main duct stent or temporary sealing of the main pancreatic duct with fibrin glue have not led to a significant improvement in clinical outcome.The perioperative application of somatostatin or its analogues may decrease the incidence of pancreatic fistulas in cases with soft pancreatic tissue and a small main pancreatic duct(< 3 mm).The positive effects of external pancreatic main duct drainage and antecolic gastrointestinal reconstruction have been observed to decrease the rate of pancreatic fistulas and delayed gastric emptying,respectively.Currently,the concept of extended radical lymphadenectomy has been found to be associated with higher perioperative morbidity,but without any positive impact on overall survival.However,there is growing evidence that portal vein resections can be performed with acceptable low perioperative morbidity and mortality but does not achieve a cure. | Mehdi Ouassi Urs Giger Guillaume Louis Igor Sielezneff Bernard Sastre Olivier Farges | 2012 | World Journal of Gastroenterology2012，18，24： | 7 |
| 4 | Role of cetuximab in first-line treatment of metastatic colorectal cancer显示文摘The treatment of metastatic colorectal cancer(mCRC)has evolved considerably in the last decade,currently allowing most mCRC patients to live more than two years.Monoclonal antibodies targeting the epidermal growth factor receptor(EGFR)and vascular endothelial growth factor play an important role in the current treatment of these patients.However,only antibodies directed against EGFR have a predictive marker of response,which is the mutation status of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS).Cetuximab has been shown to be effective in patients with KRAS wild-type mCRC.The CRYSTAL study showed that adding cetuximab to FOLFIRI(regimen of irinotecan,infusional fluorouracil and leucovorin)significantly improved results in the first-line treatment of KRAS wildtype mCRC.However,results that evaluate the efficacy of cetuximab in combination with oxaliplatin-based chemotherapy in this setting are contradictory.On the other hand,recent advances in the management of colorectal liver metastases have improved survival in these patients.Adding cetuximab to standard chemotherapy increases the response rate in patients with wild-type KRAS and can thus increase the resectability rate of liver metastases in this group of patients.In this paper we review the different studies assessing the efficacy of cetuximab in the first-line treatment of mCRC. | Miguel Jhonatan Sotelo Beatriz García-Paredes Carlos Aguado Javier Sastre Eduardo Díaz-Rubio | 2014 | World Journal of Gastroenterology2014，20，15： | 7 |
| 5 | Does an association exist between chronic pancreatitis and liver cirrhosis in alcoholic subjects?显示文摘AIM: To study the possible association between chronic pancreatitis (CP) and liver cirrhosis (LC) of alcoholic etiology,after excluding any other causes.METHODS: One hundred and forty consecutive alcoholic patients were subdivided into three groups: CP (n = 53),LC (n = 57),and asymptomatic alcoholic (n = 30).Clinical,biochemical and morphological characteristics,Child-Pugh index,indocyanine green test,and fecal pancreatic elastase-1 test were assessed.RESULTS: In patients with cirrhosis,major clinical manifestations of CP such as pancreatic pain and steatorrhea,as well as imaging alterations of CP such as calcifications,duct dilation and pseudocysts were absent; insulin-dependent diabetes was present in 5.3% of cases,and elastase-1 test was altered in only 7%,and severely altered in none.In patients with CP,clinical characteristics of cirrhosis such as ascites,encephalopathy and gastrointestinal hemorrhage were present in one case,Child-Pugh grade > A in 5.7%,and altered indocyanine green test in 1.9% cases.In asymptomatic alcoholism,there was only a non-coincident alteration of elastase-1 test and indocyanine test in 14.8% and 10%,respectively,but other characteristics of cirrhosis or CP were absent.An inverse correlation (r = -0.746) between elastase-1 test and indocyanine test was found in alcoholic patients.CONCLUSION: There is a scarce coincidence in clinical and morphological alterations among patients with CP or LC of alcoholic etiology,but an inverse correlation between pancreatic and liver function tests.These findings support that these alcoholic diseases evolve in a different manner and have different etiopathogenesis. | Luis Aparisi Luis Sabater Juan Del-Olmo Juan Sastre Miguel-Angel Serra Ricardo Campello Daniel Bautista Abdalla Wassel José-Manuel Rodrigo | 2008 | World Journal of Gastroenterology2008，14，40： | 4 |
| 6 | Should capecitabine replace 5-fluorouracil in the first-line treatment of metastatic colorectal cancer?显示文摘Fluoropyrimidines play a central role in the first-line treatment of metastatic colorectal cancer.Our aim was to review whether capecitabine was a safer,non-inferior,economically superior and more convenient alternative to 5-fluorouracil.Capecitabine has previously been compared to 5-fluorouracil-either as a monotherapy or in combination with oxaliplatin,irinotecan,or biological drugs-and has been found to have comparable efficacy and safety profiles.Furthermore,pharmacoeconomic data and patients’preferences for oral chemotherapy further favor capecitabine.Therefore,capecitabine appears to be an effective and safe alternative to fluorouracil in the first-line treatment of metastatic colorectal cancer. | Carlos Aguado Beatriz García-Paredes Miguel Jhonatan Sotelo Javier Sastre Eduardo Díaz-Rubio | 2014 | World Journal of Gastroenterology2014，20，20： | 4 |
| 7 | First-line single-agent cetuximab in elderly patients with metastatic colorectal cancer. A phase II clinical and molecular study of the Spanish group for digestive tumor therapy (TTD)显示文摘 | J. Sastre E. Aranda C. Grávalos B. Massutí M. Varella-Garcia F. Rivera G. Soler A. Carrato J.L. Manzano E. Díaz-Rubio M. Hidalgo | 2009 | Critical Reviews in Oncology and Hematology2009，，1： | 2 |
| 8 | Medial pancreatectomy: A multi-institutional retrospective study of 53 patients by the French Pancreas Club显示文摘 | Alain Sauvanet Christian Partensky Bernard Sastre Jean-Fran?ois Gigot Pierre-Louis Fagniez Jean-Jacques Tuech Bertrand Millat Stéphane Berdah Bertrand Dousset Daniel Jaeck Yves-Patrice Le Treut Christian Letoublon | 2002 | Surgery2002，，5： | 2 |
| 9 | Humans Are Not Machines—Anthropocentric Human–Machine Symbiosis for Ultra-Flexible Smart Manufacturing显示文摘1.Introduction The real question is not whether machines think but whether men do.Burrhus Frederic Skineer Dedicated manufacturing systems are fading out as future manufacturing(i.e.,Industry 4.0[1])demands ultra-flexible smart manufacturing systems that can self-adapt to production process changes resulting from the varied batch sizes of personalized products[2–4].The manufacturing shop-floor can become an unstructured environment where manufacturing systems and processes change their configurations dynamically via adaptive near-real-time decision-making.One emerging trend to make manufacturing flexible and reconfigurable is to introduce collaborative machines that work alongside humans with high productivity[5-7]. | Yuqian Lu Juvenal Sastre Adrados Saahil Shivneel Chand Lihui Wang | 2021 | Engineering2021，7，6： | 2 |
| 10 | Protein phosphatases and chromatin modifying complexes in the inflammatory cascade in acute pancreatitis显示文摘Acute pancreatitis is an inflammation of the pancreas that may lead to systemic inflammatory response syndrome and death due to multiple organ failure. Acinar cells, together with leukocytes, trigger the inflammatory cascade in response to local damage of the pancreas. Amplification of the inflammatory cascade requires up-regulation of proinflammatory cytokines and this process is mediated not only by nuclear factor κB but also by chromatinmodifying complexes and chromatin remodeling. Among the different families of histone acetyltransferases, the p300/CBP family seems to be particularly associated with the inflammatory process. cAMP activates gene expression via the cAMP-responsive element (CRE) and the transcription factor CRE-binding protein (CREB). CREB can be phosphorylated and activated by different kinases, such as protein kinase A and MAPK, and then it recruits the histone acetyltransferase co-activator CREB-binding protein (CBP) and its homologue p300. The recruitment of CBP/p300 and changes in the level of histone acetylation are required for transcription activation. Transcriptional repression is also a dynamic and essential mechanism of down-regulation of genes for resolution of inflammation, which seems to be mediated mainly by protein phosphatases (PP1, PP2A and MKP1) and histone deacetylases(HDACs) .Class HDACs are key transcriptional regulators whose activities are controlled via phosphorylationdependent nucleo/cytoplasmic shuttling. PP2A is responsible for dephosphorylation of class HDACs, triggeringnuclear localization and repression of target genes, whereas phosphorylation triggers cytoplasmic localization leading to activation of target genes. The potential benefit from treatment with phosphodiesterase inhibitors and histone deacetylase inhibitors is discussed. | Javier Escobar Javier Pereda Alessandro Arduini Juan Sastre Juan Sandoval Luis Aparisi Gerardo López-Rodas Luis Sabater | 2010 | World Journal of Gastrointestinal Pharmacology and Therapeutics2010，1，3： | 2 |
| 11 | Sorafenib for non-selected patient population with advanced hepatocellular carcinoma: efficacy and safety data according to liver function显示文摘 | Jon Zugazagoitia Aránzazu Manzano Javier Sastre Jose María Ladero Javier Puente Eduardo Díaz-Rubio | 2013 | Clinical and Translational Oncology2013，，2： | 2 |
| 12 | Persistence and growth of faecal culturable bacterial indicators in water column and sediments of Vidy Bay,Lake Geneva,Switzerland显示文摘The aims of this study was to investigate the persistence and the growth of culturable bacterial indicators(CBI) including total coliforms(TC) and faecal coliforms represented by Escherichia coli,enterococcus(ENT) ,and aerobic mesophilic bacteria(AMB) in the surface sediments and the water column of Vidy Bay(Lake Geneva,City of Lausanne,Switzerland) . The study was carried out for 60 d using microcosms containing Sewage Treatment Plant(STP) effuent and nonsterile water without CBI,as well as contaminated and non-contaminated sediments. The effects of water temperature and of organic matter associated with sediments on the survival of CBI in the sediments and the water column were observed. The number of CBI colonies in the contaminated sediments of Vidy Bay and in the STP effuent was almost identical in the order of 105-107,104-106,103-105,and 104-107 CFU/100 g sediment or /100 mL water for TC,E. coli,ENT,and AMB respectively. A degradation of CBI was observed in the sediments where organic mater content was low and in the water column at a temperature of 10°C after 5 d of experimentation. In addition,a growth of CBI was observed in the sediment which is rich in organic matter at 20°C. The results of this study indicate:(1) the higher concentrations of the CBI observed in dierent points in the water column of Vidy Bay may not be explained only by the recent contribution of the three potential sources of the Bay contamination including STP and the Chamberonne and Flon Rivers,but also by the persistence,removal from sediment and multiplication of CBI in the sediment and water column;(2) the sediment of Vidy Bay constitute a reservoir of CBI and can even support their growth;and(3) the CBI not only survive in sediments,but also can be remobilized and increased in the water column,therefore,it become a permanent microbiological pollution in Vidy Bay. | POTE John HALLER Laurence KOTTELAT Régis SASTRE Vincent ARPAGAUS Philippe WILDI Walter | 2009 | Journal of Environmental Sciences2009，21，1： | 2 |
| 13 | Current evidence and future research needs for FeNO measurement in respiratory diseases显示文摘 | Leif Bjermer Kjell Alving Zuzana Diamant Helgo Magnussen Ian Pavord Giorgio Piacentini David Price Nicolas Roche Joaquin Sastre Mike Thomas Omar Usmani | 2014 | Respiratory Medicine2014，，： | 2 |
| 14 | Shapley inequality decomposition by factor components: Some methodological issues显示文摘 | Mercedes Sastre Alain Trannoy | 2002 | Journal of Economics2002，，1： | 2 |
| 15 | Nonsteroidal anti-inflammatory drugs repress-β secretase gene promoter activity by the activation of PPAR显示文摘 | Sastre M Dewachter I Rossners S | 2006 | Neuro Sci2006，103，4： | 1 |
| 16 | Validation of ARIA (allergic rhinitis and its impact on asthma) classification in a pediatric popu- lation: the PEDRIAL study显示文摘 | J6uregui I D6vila I Sastre J | 2011 | Pediatr Allergy Immuno12011，22，4： | 1 |
| 17 | The role of mitochondrial oxidative stress in aging显示文摘 | SASTRE J PALLARDO FV VINA J | 2003 | Free Radical Bio Med2003，35，1： | 1 |
| 18 | Selective synthesis of glycerol monolaurate with zeolitic molecular sieves显示文摘 | M da S Machado J P6rez - Pariente E Sastre | 2000 | Applied Catalysis A : General2000，203，2： | 1 |
| 19 | MDM2 and CDK4 immu- nostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: A comparative analysis of 559 soft tissue neoplasms with genetic data 显示文摘 | Binh MB Sastre Garau X Guillou L | 2005 | Am J Surgical Pathology2005，29，10： | 1 |
| 20 | Selective Synthesis of Glycerol Monolaurate with Zeolitie Molecular Sieves显示文摘 | MACHADO M S PEREZ-PARIENTE J SASTRE E | 2000 | Applied Catalysis A:Gen- eral2000，203，2： | 1 |
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