5篇
您的检索式：作者名="Javier Escobar"
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| 1 | Protein phosphatases and chromatin modifying complexes in the inflammatory cascade in acute pancreatitis显示文摘Acute pancreatitis is an inflammation of the pancreas that may lead to systemic inflammatory response syndrome and death due to multiple organ failure. Acinar cells, together with leukocytes, trigger the inflammatory cascade in response to local damage of the pancreas. Amplification of the inflammatory cascade requires up-regulation of proinflammatory cytokines and this process is mediated not only by nuclear factor κB but also by chromatinmodifying complexes and chromatin remodeling. Among the different families of histone acetyltransferases, the p300/CBP family seems to be particularly associated with the inflammatory process. cAMP activates gene expression via the cAMP-responsive element (CRE) and the transcription factor CRE-binding protein (CREB). CREB can be phosphorylated and activated by different kinases, such as protein kinase A and MAPK, and then it recruits the histone acetyltransferase co-activator CREB-binding protein (CBP) and its homologue p300. The recruitment of CBP/p300 and changes in the level of histone acetylation are required for transcription activation. Transcriptional repression is also a dynamic and essential mechanism of down-regulation of genes for resolution of inflammation, which seems to be mediated mainly by protein phosphatases (PP1, PP2A and MKP1) and histone deacetylases(HDACs) .Class HDACs are key transcriptional regulators whose activities are controlled via phosphorylationdependent nucleo/cytoplasmic shuttling. PP2A is responsible for dephosphorylation of class HDACs, triggeringnuclear localization and repression of target genes, whereas phosphorylation triggers cytoplasmic localization leading to activation of target genes. The potential benefit from treatment with phosphodiesterase inhibitors and histone deacetylase inhibitors is discussed. | Javier Escobar Javier Pereda Alessandro Arduini Juan Sastre Juan Sandoval Luis Aparisi Gerardo López-Rodas Luis Sabater | 2010 | World Journal of Gastrointestinal Pharmacology and Therapeutics2010，1，3： | 2 |
| 2 | Chronotopographical distribution patterns of cell death and of lectin‐positive macrophages/microglial cells during the visual system ontogeny of the small‐spotted catshark S cyliorhinus canicula显示文摘 | Ruth Bejarano‐Escobar Manuel Blasco Ana Carmen Durán Gervasio Martín‐Partido Javier Francisco‐Morcillo | 2013 | Anat2013，，2： | 1 |
| 3 | Chiral discrimination of ibuprofen isomers in β-cyclodextrin inclusion complexes: experimental and theoretical studies显示文摘 | Nunez Ag ero Carlos Javier Escobar Llanos Carolina-Marta Diaz David | 2006 | Tetrahedrom2006，62，17： | 1 |
| 4 | Stroke Volume Response to Liver Graft Reperfusion Stress in Cirrhotic Patients显示文摘 | Bibiana Escobar Pilar Taurá Graciela Martínez-Palli Constatino Fondevila Jaume Balust Joan Beltrán Javier Fernández Juan Carlos García-Pagán Juan Carlos García-Valdecasas | 2014 | World Journal of Surgery2014，，4： | 1 |
| 5 | How Learning from Trauma Benefits the Obstetric Population?Damage Control Surgery显示文摘The recent implementation of trauma-validated damage control strategies in severe postpartum hemorrhage proves the importance of interdisciplinary management in the obstetric patient.Massive hemorrhage control techniques and damage control surgery are clear examples of how learning from trauma can benefit the obstetric population.Currently,most obstetric programs do not include training in this type of interventions.Nevertheless,it has been shown that these interventions are useful in the management of severe postpartum hemorrhage.The aim of this article is to introduce the application of damage control surgery principles in the management of massive obstetric hemorrhage.We propose to include appropriate training and the implementation of damage control surgery in obstetric management protocols.The prompt application of damage control principles can be considered in patients with persistent hemodynamic instability despite control of the source of bleeding. | María Fernanda Escobar Vidarte Daniela Nasner Albaro José Nieto-Calvache María Paula Echavarría Javier Andrés Carvajal | 2023 | Maternal-Fetal Medicine2023，5，4： | 0 |
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