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| 1 | Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial显示文摘 | Ian M Gralnek Peter D Siersema Zamir Halpern Ori Segol Alaa Melhem Alain Suissa Erwin Santo Alan Sloyer Jay Fenster Leon M G Moons Vincent K Dik Ralph B D’Agostino Douglas K Rex | 2014 | Lancet Oncology2014，，3： | 6 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | Melanoma of the gallbladder misdiagnosed as gallbladder cancer显示文摘To the Editor:Metastatic melanoma of the gallbladder is extremely rare,and despite appropriate therapy its prognosis is poor withfew patients surviving more than 2 years. We present acase of gallbladder involvement by malignant melanomain | Renata Potonyacz Colaneri Bárbara dos Santos Nunes Paulo Herman | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 3 |
| 4 | rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study显示文摘AIM To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS Polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. Prophylactic measures of hemorrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recommended by the American Society for Gastrointestinal Endoscopy. Patients were followed for 48 h, one week and 1 mo after theprocedure. RESULTS308 patients were included and a single polypectomy was performed in 205. Only 36(11.7%) were on prior anticoagulant therapy. Mean polyp size was 15 ± 8.9 mm(5-60) and in 294 cases(95.4%) were located in the stomach. Hemorrhage prophylaxis was performed in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatment were performed). Other 24 hemorrhagic episodes could be managed without any change in the outcome of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of bleeding.CONCLUSION Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location. | Henry Córdova Lidia Argüello Carme Loras Antonio Naranjo Rodríguez Faust Riu Pons Joan B Gornals David Nicolás-Pérez Xavier Andújar Murcia Luis Hernández Santos Santolaria Carles Leal Carles Pons Enrique Pérez-Cuadrado-Robles Orlando García-Bosch Michel Papo Berger José Luis Ulla Rocha Cristina Sánchez-Montes Gloria Fernández-Esparrach | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 5 | Prognosis and follow-up of 135 patients with ischemic colitis over a five-year period显示文摘AIM:To study the prognosis(recurrence and mortality)of patients with ischemic colitis(IC).METHODS:This study was conducted in four Spanish hospitals,participants in the Ischemic Colitis in Spain study We analyzed prospectively 135 consecutive patients who met criteria for definitive or probable IC according to Brandt criteria,and follow up these patients during the next five years,retrospectively.Long-term results(recurrence and mortality)were evaluated retrospectively after a median interval of 62 mo(range54-75 mo).RESULTS:Estimated IC recurrence rates were 2.9%,5.1%,8.1%and 9.7%at years 1,2,3 and 5 years,respectively.Five-year survival was 69%(93 of 135)and 24%(10 of 42 patients)died for causes related to the IC.Among these 10 patients,8 died in their first episode at hospital(4 had gangrenous colitis and 4 fulminant colitis)and 2 due to recurrence.CONCLUSION:The five-year recurrence rate of IC was low.On the other hand,mortality during follow-up was high and was not associated with ischemic colitis. | Angel Cosme Miguel Montoro Santos Santolaria Ana B Sanchez-Puertolas Marta Ponce Margarita Durán Jose Luis Cabriada Nerea Borda Cristina Sarasqueta Luis Bujanda | 2013 | World Journal of Gastroenterology2013，19，44： | 2 |
| 6 | Geog raphic differences in the allele frequencies of the human Y-linked tetranucleotide polymorphism DYS19 显示文摘 | Grelsaikhan T Munkhtuja B | 1996 | Hum Genet1996，97，3： | 1 |
| 7 | Thermal models for bobbin tool friction stir welding 显示文摘 | HILGERT J SCHMIDT H N B dos SANTOS J F HUBER N | 2011 | Journal of Materials Processing Technology2011，211，2： | 1 |
| 8 | Efficacy of chlorhexidine- and calcium hydroxide-containing medicaments against Enterococcus faecalis in vitro显示文摘 | Basrani B Santos J M Pascon E | 2003 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2003，96，5： | 1 |
| 9 | DNA microarray anal-ysis of gene expression in alveolar epithelial cells in response toTNFalpha, LPS, and cyclic stretch显示文摘 | dos Santos CC Han B Andrade CF | 2004 | Physiol Genomics2004，19，3： | 1 |
| 10 | Mechanical behavior and microstructure of high carbon Si- Mn- Cr steel with TRIP effect 显示文摘 | SANTOS D B BARBOSA R De OLIVEIRA P P | 2009 | ISH International2009，49，10： | 1 |
| 11 | Mechanical properties of HSLA bainitic steel subjected to controlled rolling with accelerated cooling显示文摘 | RODRIGUES P C M PERELOMA E V SANTOS D B | 2000 | Materials Science and Engineering: A2000，283，： | 1 |
| 12 | Comparison of root-system efficiency and arsenic up- take of two fern Species 显示文摘 | SILVA GONZAGA M I SANTOS J A G COMERFORD N B | 2007 | Communications in Soil Science and Plant Analysis2007，38，： | 1 |
| 13 | Automatic defects classification-A contribution 显示文摘 | Santos J B Perdigao F | 2001 | NDT and E International2001，34，5： | 1 |
| 14 | A review of theplants of the genus phyllanthus:Their chemistry,pharmacology and thera-peutic potential显示文摘 | CALIXO J B SANTOS A R S CECHINEL FILHO | 1998 | Med Res Rev1998，18，： | 1 |
| 15 | Dynamic reprogramming of DNA methylation in the early mouse embryo 显示文摘 | SANTOS F HENDRICH B REIK W | 2002 | Dev Biol2002，241，1： | 1 |
| 16 | Catechols from abietic acid-synthesis and evaluation as bioactive compounds显示文摘 | GIGANTE B SANTOS C SILVA A M | 2003 | Bioorganic and Medicinal Chemistry2003，11，8： | 1 |
| 17 | Influence of common lambsquarters (Chenopodium album) densities and phosphorus fertilization on lettuce显示文摘 | SANTOS B M DUSKY J A STALL W M | 2004 | Crop Protection2004，23，： | 1 |
| 18 | Vascular en- dothelia~ growth factor expression in the urethral epithelium of castrated adult female rats treated with tamoxifen显示文摘 | Dos Santos A R Lopes-Costa P V da Silva B B | 2009 | Gynecol Endocrinol2009，25，5： | 1 |
| 19 | Influence of knee position on the postural stability index regis- tered by the Biodex Stability System 显示文摘 | PEREIRA H M DE CAMPOS T F SANTOS M B | 2008 | Gait Posture2008，28，4： | 1 |
| 20 | Sequential determination of fat- and water-soluble vitamins in green leafy vegetables during storage显示文摘 | Santos J Mendiola J A Oliveira M B P P | 2012 | Chromatogr A2012，1261，： | 1 |
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