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| 1 | Value of a comprehensive geriatric assessment for predicting one-year outcomes in patients undergoing transcatheter aortic valve implantation: results from the CGA-TAVI multicentre registry显示文摘Background In a three-month report from the CGA-TAVI registry, we found the Multidimensional Prognostic Index (MPI) and Short Physical Performance Battery (SPPB) to be of value for predicting short-term outcomes in elderly patients undergoing transcatheter aortic valve implantation (TAVI). In the present analysis, we examined the association of these tools with outcomes up to one year post-TAVI. Methods CGA-TAVI is an international, observational registry of geriatric patients undergoing TAVI. Patients were assessed using the MPI and SPPB. Efficacy of baseline values and any postoperative change for predicting outcome were established using logistic regression. Kaplan- Meier analysis was carried out for each comprehensive geriatric assessment tool, with survival stratified by risk category. Results One year after TAVI, 14.1% of patients deceased, while 17.4% met the combined endpoint of death and/or non-fatal stroke, and 37.7% the combined endpoint of death and/or hospitalisation and/or non-fatal stroke. A high-risk MPI score was associated with an increased risk of all-cause mortality (aOR = 36.13, 95% CI: 2.77–470.78, P = 0.006) and death and/or non-fatal stroke (aOR = 10.10, 95% CI: 1.48–68.75, P = 0.018). No significant associations were found between a high-risk SPPB score and mortality or two main combined endpoints. In contrast to a worsening SPPB, an aggravating MPI score at three months post-TAVI was associated with an increased risk of death and/or non-fatal stoke at one year (aOR = 95.16, 95% CI: 3.41–2657.01). Conclusions The MPI showed value for predicting the likelihood of death and a combination of death and/or non-fatal stroke by one year after TAVI in elderly patients. | Martijn S.van Mourik Nathalie van der Velde Giulio Mannarino Marie-Pierre Thibodeau Jean-Bernard Masson Gennaro Santoro Jan Baan Sofie Jansen Jana Kurucova Martin Thoenes Cornelia Deutsch ANDreas W.Schoenenberger ANDrea Ungar Peter Bramlage M Marije Vis | 2019 | Journal of Geriatric Cardiology2019，16，6： | 3 |
| 2 | Mesoporous bioactive glass composition effects on degradation and bioactivity显示文摘Mesoporous bioactive glasses(MBGs)are promising materials for regenerative medicine,due to their favorable properties including bioactivity and degradability.These key properties,but also their surface area,pore structure and pore volume are strongly dependent on synthesis parameters and glass stoichiometry.However,to date no systematic study on MBG properties covering a broad range of possible compositions exists.Here,24 MBG compositions in the SiO_(2)-CaO-P_(2)O_(5) system were synthesized by varying SiO_(2)(60-90 mol%),CaO and P_(2)O_(5) content(both 0 to 40 mol-%),while other synthesis parameters were kept constant.Mesopore characteristics,degradability and bioactivity were analysed.The results showed that,within the tested range of compositions,mesopore formation required a molar SiO_(2) content above 60%but was independent of CaO and P_(2)O_(5) content.While mesopore size did not depend on glass stoichiometry,mesopore arrangement was influenced by the SiO_(2) content.Specific surface area and pore volume were slightly altered by the SiO_(2) content.All materials were degradable;however,degradation as well as bioactivity,i.e.the ability to form a CaP mineral on the surface,depended on stoichiometry.Major differences were found in early surface reactions in simulated body fluid:where some MBGs induced direct hydroxyapatite crystallization,high release of calcium in others resulted in calcite formation.In summary,degradation and bioactivity,both key parameters of MBGs,can be controlled by glass stoichiometry over a broad range while leaving the unique structural parameters of MBGs relatively unaffected.This allows targeted selection of material compositions for specific regenerative medicine applications. | M.Schumacher P.Habibovic S.van Rijt | 2021 | Bioactive Materials2021，6，7： | 2 |
| 3 | Kinet-ic modelling of reactions in heated disaccharide-casein systems显示文摘 | Carline M J.Brands Martinus A J S.van Boekel | | 0，，： | 1 |
| 4 | Contamination of food products with Mycobacterium avium paratuberculosis: a systematic review显示文摘 | M.M.Eltholth V.R.Marsh S.Van Winden F.J.Guitian | 2009 | Journal of Applied Microbiology2009，，4： | 1 |
| 5 | B淋巴细胞克隆性免疫扩增与多发性硬化症显示文摘 | 秦幼棻 S.Van den Noort 张一平 | 2000 | 上海免疫学杂志2000，20，2： | 1 |
| 6 | Ovarian cancer prediction in adnexal masses using ultrasound‐based logistic regression models: a temporal and external validation study by the IOTA group显示文摘 | D.Timmerman B.Van Calster A. C.Testa S.Guerriero D.Fischerova A. A.Lissoni C.Van Holsbeke R.Fruscio A.Czekierdowski D.Jurkovic L.Savelli I.Vergote T.Bourne S.Van Huffel L.Valentin | 2010 | Ultrasound Obstet Gynecol2010，，： | 1 |
| 7 | Iron and inflammatory bowel disease显示文摘 | B.Oldenburg J. C.Koningsberger G. P.Van Berge Henegouwen B. S.Van Asbeck J. J. M.Marx | 2003 | Alimentary Pharmacology & Therapeutics2003，，4： | 1 |
| 8 | Ecological impact of land reclamation on Jiangsu coast(China):A novel ecotope assessment for Tongzhou Bay显示文摘China’s continuous and rapid economic growth has led to the reclamation of large sections of the intertidal mud coast in combination with port construction,such as that of the proposed Tongzhou Bay port on the Jiangsu coast.These reclamations threaten the local ecosystem services.An ecotope distribution map was created and a hydrodynamic numerical model of Tongzhou Bay was set up to quantify the impacts of reclamation on the ecosystem.Based on the field data and model results,several abiotic features were classified into 11 ecotopes and visualized in an ecotope map of the Tongzhou Bay ecosystem.Validation with spatial distributions of two threatened shorebird species(bar-tailed godwit and great knot) showed confirmation with the mid-range and low-range littoral zones(inundated from 40% to 100% of a tidal cycle),indicating the importance of the areas with these conditions to these populations.Overlaying the ecotope map with recent and proposed land reclamation schemes revealed a loss of ecotopes,composed of the high-range(42%),mid-range(48%),and low-range(38%) littoral habitats,corresponding to a 44%-45% loss of the most important ecotopes for bar-tailed godwit and great knot(mid-range and low-range littoral zones).These results confirm the applicability of the novel ecotope assessment approach in practice. | Jos R.M.Muller Yong-ping Chen Stefan G.J.Aarninkhof Ying-Chi Chan Theunis Piersma Dirk S.van Maren Jian-feng Tao Zheng Bing Wang Zheng Gong | 2020 | Water Science and Engineering2020，13，1： | 1 |
| 9 | Der p 1 and Der p 2 induce less severe late asthmatic responses than native Dermatophagoides pteronyssinus extract after a similar early asthmatic response显示文摘 | M. J.Van Der Veen H. M.Jansen R. C.Aalberse J. S.Van Der Zee | 2002 | Clinical & Experimental Allergy2002，，5： | 1 |
| 10 | CONTROLLING THE 3D NANOSCALE ORGANIZATION OF BULK HETEROJUNCTION POLYMER SOLAR CELLS显示文摘In this study,the three dimensional nanoscale organization in the photoactive layers of poly(3-hexylthiophene) (P3HT) and a methanofullerene derivative (PCBM) is revealed by transmission electron tomography.After annealing treatment,either at elevated temperature or during slow solvent evaporation,nanoscale interpenetrating networks are formed with high crystalline order and favorable concentration gradients of both components through the thickness of the photoactive layer.Such a tailored morphology acco... | Svetlana S.van Bavel Erwan Sourty Gijsbertus de With Joachim Loos | 2009 | Chinese Journal of Polymer Science2009，27，1： | 1 |
| 11 | Enhanced resolution based on minimum variance estimation and exponential data modeling显示文摘 | S.Van Huffel | | 0，，03： | 1 |
| 12 | Accelerated atherosclerosis: An extraarticular feature of rheumatoid arthritis?显示文摘 | S.Van Doornum G.McColl I. P.Wicks | 2002 | Arthritis & Rheumatism2002，，4： | 1 |
| 13 | Numerical simulation of precipitation kinetics in multicomponent alloys显示文摘A universal numerical model based on the particle size distribution(PSD)approach has been developed for the simulation of precipitation kinetics in multicomponent alloys during isothermal ageing.Nucleation was implemented utilizing the classical nucleation theory(CNT).Growth and coarsening were modeled by a single growth kinetics equation,which is constructed based on the interfacial diffusion flux balance and the capillarity effect.Only partial off-diagonal terms in the diffusion matrix(diffusion of individual components in the matrix)were taken into account in the calculations to minimize the computational cost while coupling with CALPHAD to extract thermodynamics equilibrium around the interface.A new feature of the model is the incorporation of a more realistic spatial site distribution via a Voronoi construction in the characteristic cell,for the purpose of modifying the diffusion distance.Computational predictions of the precipitate dimensions and the precipitation kinetics were compared with the atom probe tomography(APT)measurements on ternary Ni-Al-Cr alloys isothermally aged at 873 K.It is found that the temporal evolution of the dimensions and composition of the precipitates is well captured,as is the dependence on changes in the alloy composition.The new modification with Voronoi construction demonstrates that the overall precipitation kinetics depends on the density and the spatial site distribution of precipitates.The ability to handle sophisticated alloy chemistries by quantitative equations,the compositional sensitivity of microstructural characteristics emerging from the simulation results,and the ability to visualize the spatial distribution of precipitates make the work very promising for multicomponent alloy design and optimization. | K.Xu J.D.Liu S.van der Zwaag W.Xu J.G.Li | 2022 | Journal of Materials Science & Technology2022，，33： | 1 |
| 14 | Predicting the survival of patients with peritoneal carcinomatosis of colorectal origin treated by aggressive cytoreduction and hyperthermic intraperitoneal chemotherapy显示文摘 | V. J.Verwaal H.van Tinteren S.van Ruth F. A. N.Zoetmulder | 2004 | Br J Surg2004，，6： | 1 |
| 15 | Accuracy of contrast-enhanced breast ultrasound for preoperative tumor size assessment in patients diagnosed with invasive ductal carcinoma of the breast显示文摘 | S.van Esser W.B.Veldhuis R.van Hillegersberg | | 0，，07： | 1 |
| 16 | The Atlanta Classification of acute pancreatitis revisited显示文摘 | T. L.Bollen H. C.van Santvoort M. G.Besselink M. S.van Leeuwen K. D.Horvath P. C.Freeny H. G.Gooszen | 2007 | Br J Surg2007，，1： | 1 |
| 17 | Mud-induced wave damping and wave-induced liquefaction显示文摘 | Johan C.Winterwerp Gerben J.de Boer Gert Greeuw Dirk S.van Maren | | 0，，64： | 1 |
| 18 | Explicit trust delegation:Security for dynamic grids显示文摘 | D.F.Snelling S.van den Berghe V.-Q.Li | | 0，，： | 1 |
| 19 | A novel monoacylglycerol lipase-targeted^(18)F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network显示文摘Monoacylglycerol lipase(MAGL)constitutes a serine hydrolase that orchestrates endocannabinoid homeostasis and exerts its function by catalyzing the degradation of 2-arachidonoylglycerol(2-AG)to arachidonic acid(AA).As such,selective inhibition of MAGL represents a potential therapeutic and diagnostic approach to various pathologies including neurodegenerative disorders,metabolic diseases and cancers.Based on a unique 4-piperidinyl azetidine diamide scaffold,we developed a reversible and peripheral-specific radiofluorinated MAGL PET ligand[^(18)F]FEPAD.Pharmacokinetics and binding studies on[^(18)F]FEPAD revealed its outstanding specificity and selectivity towards MAGL in brown adipose tissue(BAT)–a tissue that is known to be metabolically active.We employed[^(18)F]FEPAD in PET studies to assess the abundancy of MAGL in BAT deposits of mice and found a remarkable degree of specific tracer binding in the BAT,which was confirmed by post-mortem tissue analysis.Given the negative regulation of endocannabinoids on the metabolic BAT activity,our study supports the concept that dysregulation of MAGL is likely linked to metabolic disorders.Further,we now provide a suitable imaging tool that allows non-invasive assessment of MAGL in BAT deposits,thereby paving the way for detailed mechanistic studies on the role of BAT in endocannabinoid system(ECS)-related pathologies. | Ran Cheng Masayuki Fujinaga Jing Yang Jian Rong Ahmed Haider Daisuke Ogasawara Richard S.Van Tuo Shao Zhen Chen Xiaofei Zhang Erick R.Calderon Leon Yiding Zhang Wakana Mori Katsushi Kumata Tomoteru Yamasaki Lin Xie Shaofa Sun Lu Wang Chongzhao Ran Yihan Shao Benjamin Cravatt Lee Josephson Ming-Rong Zhang Steven H.Liang | 2022 | Acta Pharmacologica Sinica2022，43，11： | 0 |
| 20 | 企业在渠道多元化后……显示文摘曾几何时,企业只需要一个渠道就可以向客户提供所有产品和服务。但如今,为了满足客户对更多渠道的需求,企业已纷纷开拓多种与客户接触途径。通常,客户使用多种渠道会比只用一种渠道平均多消费20%~30%,而且像互联网和海外电话中心这样的渠道还可以节约大量成本。 | Joseph B.Myers Andrew D.Pickersgill Evan S.Van Metre | 2005 | 中外管理2005，，10： | 0 |
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