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4篇 您的检索式：作者名="Benjamin Cravatt"

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		题名	作者	年代	出处	被引量
	1	Evaluation of fatty acid amides in the carrageenan-induced paw edema model显示文摘	Laura E Wise Roberta Cannavacciulo Benjamin F Cravatt		0，，01：	1
	2	Cancer Cell:利用脑瘤对胆固醇的需求或可开发出癌症治疗的新方法显示文摘最近路德维希癌症研究所的研究人员发表了一项研究进展,他们发现了成胶质细胞瘤的一个代谢弱点,并在研究中揭示了如何利用这个弱点开发潜在治疗方法。成胶质细胞瘤是一种侵袭性强并且不可治愈的脑癌类型。研究人员发现成胶质细胞瘤细胞向细胞内转入大量胆固醇以维持细胞存活。可以利用处于临床开发阶段的药物分子特异且有效地削弱这一维持癌细胞存活的机制。相关研究结果发表在国际学术期刊Cancer Cell上。	Genaro R. Villa Jonathan J. Hulce Ciro Zanca Junfeng Bi Shiro Ikegami Gabrielle L. Cahill Yuchao Gu Kenneth M. Lum Kenta Masui Huijun Yang Xin Rong Cynthia Hong Kristen M. Turner Feng Liu Gary C. Hon David Jenkins Michael Martini Aaron M. Armando Oswald Quehenberger Timothy F. Cloughesy Frank B. Furnari Webster K. Cavenee Peter Tontonoz Timothy C. Gahman Andrew K. Shiau Benjamin F. Cravatt Paul S. Mischel	2016	现代生物医学进展2016，16，35：	1
	3	NNMTpromotes epigenetic remodeling in cancer by creating a metabolicmethylation sink 显示文摘	Oleasya A Ulanovskaya AndreaMZuhl Benjamin F Cravatt	2013	Nature Chemical Biology2013，9，5：	1
	4	A novel monoacylglycerol lipase-targeted^(18)F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network显示文摘Monoacylglycerol lipase(MAGL)constitutes a serine hydrolase that orchestrates endocannabinoid homeostasis and exerts its function by catalyzing the degradation of 2-arachidonoylglycerol(2-AG)to arachidonic acid(AA).As such,selective inhibition of MAGL represents a potential therapeutic and diagnostic approach to various pathologies including neurodegenerative disorders,metabolic diseases and cancers.Based on a unique 4-piperidinyl azetidine diamide scaffold,we developed a reversible and peripheral-specific radiofluorinated MAGL PET ligand[^(18)F]FEPAD.Pharmacokinetics and binding studies on[^(18)F]FEPAD revealed its outstanding specificity and selectivity towards MAGL in brown adipose tissue(BAT)–a tissue that is known to be metabolically active.We employed[^(18)F]FEPAD in PET studies to assess the abundancy of MAGL in BAT deposits of mice and found a remarkable degree of specific tracer binding in the BAT,which was confirmed by post-mortem tissue analysis.Given the negative regulation of endocannabinoids on the metabolic BAT activity,our study supports the concept that dysregulation of MAGL is likely linked to metabolic disorders.Further,we now provide a suitable imaging tool that allows non-invasive assessment of MAGL in BAT deposits,thereby paving the way for detailed mechanistic studies on the role of BAT in endocannabinoid system(ECS)-related pathologies.	Ran Cheng Masayuki Fujinaga Jing Yang Jian Rong Ahmed Haider Daisuke Ogasawara Richard S.Van Tuo Shao Zhen Chen Xiaofei Zhang Erick R.Calderon Leon Yiding Zhang Wakana Mori Katsushi Kumata Tomoteru Yamasaki Lin Xie Shaofa Sun Lu Wang Chongzhao Ran Yihan Shao Benjamin Cravatt Lee Josephson Ming-Rong Zhang Steven H.Liang	2022	Acta Pharmacologica Sinica2022，43，11：	0

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