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您的检索式：作者名="P.Habibovic"
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| 1 | Mesoporous bioactive glass composition effects on degradation and bioactivity显示文摘Mesoporous bioactive glasses(MBGs)are promising materials for regenerative medicine,due to their favorable properties including bioactivity and degradability.These key properties,but also their surface area,pore structure and pore volume are strongly dependent on synthesis parameters and glass stoichiometry.However,to date no systematic study on MBG properties covering a broad range of possible compositions exists.Here,24 MBG compositions in the SiO_(2)-CaO-P_(2)O_(5) system were synthesized by varying SiO_(2)(60-90 mol%),CaO and P_(2)O_(5) content(both 0 to 40 mol-%),while other synthesis parameters were kept constant.Mesopore characteristics,degradability and bioactivity were analysed.The results showed that,within the tested range of compositions,mesopore formation required a molar SiO_(2) content above 60%but was independent of CaO and P_(2)O_(5) content.While mesopore size did not depend on glass stoichiometry,mesopore arrangement was influenced by the SiO_(2) content.Specific surface area and pore volume were slightly altered by the SiO_(2) content.All materials were degradable;however,degradation as well as bioactivity,i.e.the ability to form a CaP mineral on the surface,depended on stoichiometry.Major differences were found in early surface reactions in simulated body fluid:where some MBGs induced direct hydroxyapatite crystallization,high release of calcium in others resulted in calcite formation.In summary,degradation and bioactivity,both key parameters of MBGs,can be controlled by glass stoichiometry over a broad range while leaving the unique structural parameters of MBGs relatively unaffected.This allows targeted selection of material compositions for specific regenerative medicine applications. | M.Schumacher P.Habibovic S.van Rijt | 2021 | Bioactive Materials2021，6，7： | 2 |
| 2 | Decoupling the role of chemistry and microstructure in hMSCs response to an osteoinductive calcium phosphate ceramic显示文摘Calcium phosphates(CaP)are widely used synthetic bone graft substitutes,having bioactivity that is regulated by a set of intertwined physico-chemical and structural properties.While some CaPs have shown to be as effective in regenerating large bone defects as autologous bone,there is still the need to understand the role of individual material properties in CaP performance.Here,we aimed to decouple the effects of chemical composition and surface-microstructure of a beta-tricalcium phosphate(TCP)ceramic,with proven osteoinductive potential,on human mesenchymal stromal cells(hMSCs)differentiation.To this end,we replicated the surface structure of the TCP ceramic into polylactic acid without inorganic additives,or containing the chemical constituents of the ceramic,i.e.,a calcium salt,a phosphate salt,or TCP powder.The microstructure of the different materials was characterized by confocal laser profilometry.hMSCs were cultured on the materials,and the expression of a set of osteogenic genes was determined.The cell culture medium was collected and the levels of calcium and phosphate ions were quantified by inductively-coupled plasma mass spectrometry.The results revealed that none of the tested combinations of properties in polymer/composite replicas was as potent in supporting the osteogenic differentiation of hMSCs as the original ceramic.Nevertheless,we observed some effects of the surface structure in the absence of inorganics,as well as combined effects of surface structure and the added salts,in particular calcium,on osteogenic differentiation.The approach presented here can be used to study the role of independent properties in other CaP-based biomaterials. | V.P.Galván-Chacon D.de Melo Pereira S.Vermeulen H.Yuan J.Li P.Habibovic | 2023 | Bioactive Materials2023，，1： | 0 |
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