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		题名	作者	年代	出处	被引量
	1	肠易激综合征中下丘脑-垂体-肠腺轴调节失调:血浆细胞因子是否为潜在的生物标记显示文摘Background & Aims: Irritable bowel syndrome (IBS) is a functional disorder with an etiology that has been linked to both psychological stress and infection. The primary aim of this study was to examine the hypothalamic-pituitary-adrenal axis in patients with IBS and to relate such response to plasma cytokine profiles. Methods: A total of 151 subjects, 76 patients and 75 controls, were recruited. The patients with IBS were diagnosed according to Rome II criteria. Forty-nine patients and 48 matched controls had cytokine levels measured, and a subset of 21 patients and 21 controls also underwent a corticotropin-releasing hormone (CRH) stimulation test with plasma levels of adrenocorticotropic hormone (ACTH) and cortisol measured. The remaining 27 patients and 27 controls underwent a dexamethasone (1 mg) challenge. Results: Cortisol and the proinflammatory cytokines interleukin (IL)- 6 (together with its soluble receptor) and IL-8 were elevated in all IBS subgroups (diarrhea predominant, constipated, and alternators), although the elevation was most marked in the constipated subgroup. There was no alteration in the anti-inflammatory cytokine IL- 10. Following CRH infusion, an exaggerated release of both ACTH and cortisol was observed in patients with IBS. There was a significant correlation between the ACTH response (δ ACTH) and the IL- 6 levels. A similar relationship existed between the δ ACTH/δ cortisol ratio and the IL- 6 levels. Dexamethasone suppression of cortisol was similar in patients and controls. Conclusions: IBS is characterized by an overactivation of the hypothalamic-pituitary-adrenal axis and a proinflammat ory cytokine increase.	Dinan T.G. Quigley E.M.M. Ahmed S.M.M. 赵天智	2006	世界核心医学期刊文摘(胃肠病学分册)2006，2，8：	3
	2	Thin film stress measurement by fiber optic strain gage显示文摘	S.M.M. Quintero W.G. Quirino A.L.C. Triques L.C.G. Valente A.M.B. Braga C.A. Achete M. Cremona	2005	Thin Solid Films2005，，1：	1
	3	Management of bleeding and leakage after pancreatic surgery显示文摘	S.M.M. de Castro O.R.C. Busch D.J. Gouma	2004	Best Practice & Research Clinical Gastroenterology2004，，5：	1
	4	Surgical treatment of pancreatic adenocarcinoma显示文摘	K.F.D. Kuhlmann S.M.M. de Castro J.G. Wesseling F.J.W. ten Kate G.J.A. Offerhaus O.R.C. Busch T.M. van Gulik H. Obertop D.J. Gouma	2003	European Journal of Cancer2003，，4：	1
	5	Effects of time and temperature on the creep forming of 7075 aluminum alloy: Springback and mechanical properties显示文摘	R. Arabi Jeshvaghani M. Emami H.R. Shahverdi S.M.M. Hadavi	2011	Materials Science & Engineering A2011，，29：	1
	6	Reliability Comparison of MPPT Converter in DCM and CCM Operation显示文摘	B. Abdi L. Yazdanparast H. Gholamrezaei S.M.M. Mirtalaei	2011	Journal of Energy and Power Engineering2011，5，10：	0

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