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| 1 | 围生期新生儿B族链球菌感染显示文摘曹云教授受《中国循证儿科杂志》编辑部委托,在"第三届上海国际新生儿医学论坛"会议期间,很荣幸邀请到美国哈佛大学波士顿儿童医院Michael Wessels教授和上海市(复旦大学附属)公共卫生临床中心妇产科蒋佩茹教授就围生期新生儿B族链球菌(GBS)感染进行讨论。 | Michael Wessels 蒋佩茹 曹云 | 2011 | 中国循证儿科杂志2011，6，4： | 37 |
| 2 | IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treat- ment of Cancer Brain Tumor Group显示文摘 | van den Bent M J Dubbink HJ Marie Y Brandes AA Taphoorn MJ Wesseling P Frenay M Tijssen CC Lacombe D ldbaih A van Marion R Kros JM Dinjens WN Gorlia T. Sanson M. | 2010 | 中国神经肿瘤杂志2010，8，1： | 22 |
| 3 | MicroRNAs, immune cells and pregnancy显示文摘在他们调整互补 RNA 的表示的地方, MicroRNAs (miRNAs ) 是在许多房间类型被表示的非编码的 RNA 的一个最近发现的班,这样 modulating mRNAs 的稳定性和翻译。miRNAs 被预言调整 ~ 的表示 50 %在哺乳动物编码基因的所有蛋白质。因此,他们几乎参予到目前为止调查的所有细胞的过程。改变的 miRNAs 表达式与两个被联系生理(怀孕) 并且病理学的进程(癌症) 。当动态母亲胎儿的接口在成功的怀孕的维护起一个关键作用,对繁殖纸巾唯一的 miRNAs 富有地被表示,这不令人吃惊。这个领域里的研究表明了联系怀孕的 miRNAs 的一个不同集合的存在和 dysregulation;然而,大多数研究在在与正常或复杂的怀孕联系的繁殖 microdomains 本地化各种各样的 miRNAs 上集中了。尽管规章的机制与子宫内膜的感受性,有免疫力的房间, angiogenesis 和胎盘的开发联系了的几独立 miRNA 被学习了,怀孕的调停 miRNA 的规定仍然保持糟糕理解。这评论象在子宫被发现的 miRNAs 的功能的侧面一样在 miRNA 规定上提供当前的数据的一篇摘要,在与到涉及 angiogenesis 和胎盘的开发的胎儿,和那些的母亲的忍耐联系的有免疫力的房间。 | Mallikarjun Bidarimath | 2014 | Cellular & Molecular Immunology2014，11，6： | 11 |
| 4 | 国际视野下的数字人文教育--基础设施视角的社区驱动型数字人文课程登记中心显示文摘数字人文以其新实践、新途径和新方法丰富了传统的人文学科领域。进入21世纪以来,暑期学校、研讨会和其他类似形式的教育活动普及了一系列与之相关的必备技能,以保证学生、学者们能够把握数字时代的新机会,同时世界各地推出了越来越多相关的学士和硕士项目。本文论述的焦点--数字人文课程登记中心(Digital Humanities Course Registry,DHCR)的创建就是为了展现全球日益兴盛的数字人文教育状况,其使命是广泛收集同类课程的资料,提供数字人文领域教学和培训的最新动态。文章探讨了数字人文这一新兴领域,并对CLARIN和DARIAH这两个欧洲基础设施进行介绍--它们是DHCR的共同运营者。文中还具体描述了DHCR的数据模型和数据管护流程,简要介绍其历史。利用DHCR实时数据,以定量方式描绘了数字人文教学的国际格局。 | Tanja Wissik Jennifer Edmond Frank Fischer Franciska de Jong Stefania Scagliola Andrea Scharnhorst Hendrik Schmeer Walter Scholger Leon Wessels 郑炜楠(译) 肖鹏(译) 林佩倩(校) | 2020 | 图书馆论坛2020，40，6： | 6 |
| 5 | MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models显示文摘激活 mitogen 的蛋白质 kinase (MAPK ) 的激活小径在癌症是经常的。药发展努力在这条小径集中于 kinases,最尤其是在皇家空军和 MEK 上。我们这里证明 MEK 抑制激活通过 DUSP4 的抑制发信号的 JNK6 月,导致她的受体酷氨酸 Kinases 的激活。这面对药刺激 MAPK 小径,从而弄钝 MEK 抑制的效果。失去了 MAP3K1 或 MAP2K4 的癌症没能因而激活 JNK-JUN. ,在 MAP3K1 或 MAP2K4 的 loss-of-function 变化由在 MEK 抑制之上停用 JNK-JUN-mediated 反馈循环授与敏感到 MEK 抑制。在 168 个耐心的导出的异种皮移植(PDX ) 肿瘤的一块面板, MAP3K1 和 MAP2K4 变化地位是对 MEK 抑制的反应的一个强壮的预言者。我们的调查结果建议在 MAP3K1 或 MAP2K4 有变化的癌症,在胸,前列腺和冒号的肿瘤经常,可以对 MEK 禁止者作出回应。我们的调查结果也建议 MAP3K1 和 MAP2K4 是在有 MEK 禁止者的联合的潜在的药目标,尽管有他们被肿瘤 suppressor 基因编码的事实。 | Zheng Xue Daniel J. Vis Alejandra Bruna Tonci Sustic Sake van Wageningen Ankita Sati Batra Oscar M. Rueda Evert Bosdriesz Carlos Caldas Lodewyk F. A. Wessels Rene Bernardt | 2018 | Cell Research2018，28，7： | 5 |
| 6 | SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer显示文摘 | Andreas I Papadakis Chong Sun Theo A Knijnenburg Yibo Xue Wipawadee Gremrum Michael Holzel Wouter Nijkamp Lodewyk FA Wessels Roderick L Beijersbergen Rene Bernards Sidong Huang | 2015 | Cell Research2015，25，4： | 4 |
| 7 | 污水深度处理臭氧技术应用显示文摘本文介绍了ITT WEDECO臭氧系统在江苏省昆山水厂深度处理中的应用情况,并以昆山泾河水厂为例,介绍了臭氧系统的组成与工作原理。 | Marc Wesseler 王健 马乐宁 | 2008 | 建设科技2008，，21： | 3 |
| 8 | The fit of Industry 4.0 applications in manufacturing logistics: a multiple case study显示文摘 | Jo Wessel Strandhagen Erlend Alfnes Jan Ola Strandhagen Logan Reed Vallandingham | 2017 | Advances in Manufacturing2017，5，4： | 3 |
| 9 | Fetal Growth Restriction: Mechanisms, Epidemiology, and Management显示文摘Fetal growth restriction(FGR)is the condition in which a fetus does not reach its intrinsic growth potential and in which the shortterm and long-term risks of severe complications are increased.FGR is a frequent complication of pregnancy with a complex etiology and limited management options,other than timely delivery.The most common pathophysiological mechanism is placental insufficiency,due to many underlying causes such as maternal vascular malperfusion,fetal vascular malperfusion and villitis.Identifying truly growth restricted fetuses remains challenging.To date,FGR is often defined by a cut-off of the estimated fetal weight below a certain percentile on a population-based standard.However,small fetal size as a single marker does not discriminate adequately between fetuses or newborns that are constitutionally small but healthy and fetuses or newborns that are growth restricted and thus at risk for adverse outcomes.In 2016,the consensus definition of FGR was internationally accepted to better pinpoint the FGR population.In this review we will discuss the contemporary diagnosis and management issues.Different diagnostic markers are considered,like Doppler measurements,estimated fetal growth,interval growth,fetal movements,biomarkers,and placental markers. | Hester D.Kamphof Selina Posthuma Sanne J.Gordijn Wessel Ganzevoort | 2022 | Maternal-Fetal Medicine2022，4，3： | 2 |
| 10 | Degradation of intestinal mRNA:A matter of treatment显示文摘AIM: To characterize the influence of location, species and treatment upon RNA degradation in tissue samples from the gastrointestinal tract. METHODS: The intestinal samples were stored in different medium for different times under varyingconditions: different species(human and rat), varying temperature(storage on crushed ice or room temperature), time point of dissection of the submucous-mucous layer from the smooth muscle(before or after storage), different rinsing methods(rinsing with Medium, PBS, RNALater or without rinsing at all) and different regions of the gut(proximal and distal small intestine, caecum, colon and rectum). The total RNA from different parts of the gut(rat: proximal and distal small intestine, caecum, colon and rectum, human: colon and rectum) and individual gut layers(muscle and submucosal/mucosal) was extracted. The quality of the RNA was assessed by micro capillary electrophoresis. The RNA quality was expressed by the RNA integrity number which is calculated from the relative height and area of the 18 S and 28 S RNA peaks. From rat distal small intestine q PCR was performed for neuronal and glial markers.RESULTS: RNA obtained from smooth muscle tissue is much longer stable than those from submucosal/mucosal tissue. At RT muscle RNA degrades after one day, on ice it is stable at least three days. Cleaning and separation of gut layers before storage and use of RNALater, maintains the stability of muscle RNA at RT for much longer periods. Different parts of the gut show varying degradation periods. RNA obtained from the submucosal/mucosal layer always showed a much worse amplification rate than RNA from muscle tissue. In general RNA harvested from rat tissue, either smooth muscle layer or submucosal/mucosal layer is much longer stable than RNA from human gut tissue, and RNA obtained from smooth muscle tissue shows an increased stability compared to RNA from submucosal/mucosal tissue. At RT muscle RNA degrades after one day, while the stability on ice lasts at least three days. Cleaning and separation of gut layers before storage and use of RNALater, maintains the stability of muscle RNA at RT for much longer periods. Different parts of the gut show varying degradation periods. The RNA from muscle and submucosal/mucosal tissue of the proximal small intestine degrades much faster than the RNA of distal small intestine, caecum or colonwith rectum. RNA obtained from the submucosal/mucosal layer always showed a much more reduced amplification rate than RNA from muscle tissue [β-Tubulin Ⅲ for muscle quantification cycle(Cp): 22.07 ± 0.25, for β-Tubulin Ⅲ submucosal/mucosal Cp: 27.42 ± 0.19].CONCLUSION: Degradation of intestinal m RNA depends on preparation and storage conditions of the tissue. Cooling, rinsing and separating of intestinal tissue reduce the degradation of m RNA. | Sabine Heumüller-Klug Carsten Sticht Karin Kaiser Elvira Wink Cornelia Hagl Lucas Wessel Karl-Herbert Schafer | 2015 | World Journal of Gastroenterology2015，21，12： | 2 |
| 11 | ITT臭氧技术在昆山水厂深度处理中的应用显示文摘ITT公司(www.itt.com)是一家多元化高科技工程及制造公司,致力于为人们创造更适宜居住的环境、保障通讯以及提供保护和安全防御。公司在水与流体管理、全球防卫与安全、运动与流动控制等关键领域发挥着重要的作用。ITT有员工约4万名,在全球135个国家设有生产厂家和研发机构。公司总部位于纽约州白滩市(White Plains)。ITT公司一贯坚持为中国的流体技术和环保产业提供产品、技术和工程的全面系统解决方案。重点工程项目包括:黄河小浪底水利枢纽工程防洪排水系统,三峡永久船闸工程,北京高碑店污水处理一二期工程,北小河污水处理厂,扬子石化项目,浙江饮用水处理工程以及宝钢集团不锈钢工程等。 | Marc Wesseler 王健 | 2009 | 通用机械2009，，2： | 2 |
| 12 | Comparison between three-dimensional speckle-tracking echocardiography and cardiac magnetic resonance imaging for quantification of left ventricular volumes and function显示文摘 | Sebastiaan A. Kleijn Wessel P. Brouwer Mohamed F.A. Aly Iris K. Rüssel Gerben J. de Roest Aernout M. Beek Albert C. van Rossum Otto Kamp | 2012 | European Heart Journal – Cardiovascular Imaging2012，，10： | 2 |
| 13 | Electrochemical characterization of LiCoO 2 as rechargeable electrode in aqueous LiNO 3 electrolyte显示文摘 | Riccardo Ruffo Fabio La Mantia Colin Wessells Robert A. Huggins Yi Cui | 2010 | Solid State Ionics2010，，1： | 2 |
| 14 | Surgical treatment of pancreatic adenocarcinoma: actual survival and prognostic factors in 343 patients显示文摘 | Kuhlmann KF DE Castro SM Wesseling JG | 2004 | Eur J Cancer2004，40，4： | 1 |
| 15 | Prediction of maternal complications and adverse infant outcome at admission for temporizing management of early-onset severe hypertensive disorders of pregnancy显示文摘 | Wessel G Annelies R Johanna IP | 2006 | Am J Obstet Gynecol2006，195，4： | 1 |
| 16 | Slow saccades and other eye movement disorders in spinocerebellar atrophy type 1显示文摘 | Klostermann W Heide W | 1997 | J Neurol1997，244，： | 1 |
| 17 | Urologic complications of diabetes显示文摘 | Brown JS Wessells H Chancellor MB | 2005 | Diabetes Care2005，28，1： | 1 |
| 18 | Localization of AA-NAT-mRNA in the rat retina by fluorescence in sire hybridization and laser capture rnicrodissection 显示文摘 | Liu C Fukuhara C Wessel J H 3rd | 2004 | Cell Tissue Res2004，315，2： | 1 |
| 19 | Thrombosis of the right vein of Labbe: radiological and clinical findings 显示文摘 | Dorndorf D Wessel K Kessler C | 1993 | Neuroradiology1993，35，3： | 1 |
| 20 | Tyrosine hydroxylase,the rate-limiting enzyme in catecholamine biosynthesis - discovery of common human genetic variants governing transcription,autonomic activity,and blood pressure in vivo显示文摘 | Rao F Zhang L Wessel J | 2007 | Circulation2007，116，9： | 1 |
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