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| 1 | 声波测井新技术显示文摘自50年前问世以来,声波测井技术已经取得了长足进展。最新的声波测井技术能够提供迄今为止最高质量的数据,根据声波测量数据能够描述井眼周围和距离井眼数十英尺深地层的力学和流体特性。 | J.L.Arroyo Franco M.A.Mercado rtiz Gopa S.De Lasse Renlie Stephen williams | 2007 | 国外测井技术2007，22，2： | 8 |
| 2 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 3 | Importance of intellectual property generated by biomedical research at universities and academic hospitals显示文摘Biomedical research has many different facets.Researchers and clinicians study disease biology and biochemistry to discover novel therapeutic targets,unravel biochemical pathways and identify biomarkers to improve diagnosis,or devise new approaches to clinically manage diseases more effectively.In all instances,the overall goal of biomedical research is to ensure that results thereof(such as a therapy,a device,or a method which may be broadly referred to as“inventions”)are clinically implemented.Most of the researchers’efforts are centered on the advance of technical and scientific aspects of an invention.The development and implementation of an invention can be arduous and very costly.Historically,it has proven to be crucial to protect intellectual property rights(IPR)to an invention(i.e.,a patent)to ensure that companies can obtain a fair return on their investment that is needed to develop an academic invention into a product for the benefit of patients.However,the importance of IPR is not generally acknowledged among researchers at academic institutions active in biomedical research.Therefore this paper aims to(1)raise IP awareness amongst clinical and translational researchers;(2)provide a concise overview of what the patenting trajectory entails;and(3)highlight the importance of patenting for research and the researcher.Importance for patients:Adequate patent protection of inventions generated through biomedical research at academic institutions increases the probability that patients will benefit from these inventions,and indirectly enables the financing of clinical studies,mainly by opening up funding opportunities(e.g.specific grants aimed at start-ups,pre-seed and seed capital)that otherwise would not be accessible.As a consequence,patented inventions are more likely to become clinically tested and reach the market,providing patients with more treatment options. | Joris J.Heus Elmar S.de Pauw Mirjam Leloux Margherita Morpurgo Michael R Hamblin Michal Heger | 2017 | Journal of Clinical & Translational Research2017，3，2： | 3 |
| 4 | Artificial neural network approach for rheological characteristics of coal-water slurry using microwave pre-treatment显示文摘Detailed experimental investigations were carried out for microwave pre-treatment of high ash Indian coal at high power level(900 W) in microwave oven. The microwave exposure times were fixed at60 s and 120 s. A rheology characteristic for microwave pre-treatment of coal-water slurry(CWS) was performed in an online Bohlin viscometer. The non-Newtonian character of the slurry follows the rheological model of Ostwald de Waele. The values of n and k vary from 0.31 to 0.64 and 0.19 to 0.81 Pa·sn,respectively. This paper presents an artificial neural network(ANN) model to predict the effects of operational parameters on apparent viscosity of CWS. A 4-2-1 topology with Levenberg-Marquardt training algorithm(trainlm) was selected as the controlled ANN. Mean squared error(MSE) of 0.002 and coefficient of multiple determinations(R^2) of 0.99 were obtained for the outperforming model. The promising values of correlation coefficient further confirm the robustness and satisfactory performance of the proposed ANN model. | B.K.Sahoo S.De B.C.Meikap | 2017 | International Journal of Mining Science and Technology2017，27，2： | 3 |
| 5 | 巴西、日本、俄罗斯和瑞典的分权改革与公民参与的比较研究显示文摘在过去20年中,分权被作为一项提高公民参与的战略提出来。像世界银行这样的援助组织都激发和推动了若干国家的分权过程,希望籍此提倡对公民赋权、减少腐败、提高效率并改善公共服务的提供。在此假设基础上,本文从比较的角度分析了巴西、日本、俄罗斯和瑞典在地方层次上的分权和公民参与之间的关系。为了测试'普适性模式'和'多元化发展'两个假说,本文运用多层回归分析处理了在'民主和地方治理项目'中获得的数据。数据分析的结果支持了第二个假说:官员所意识到的自治需要对于公民参与的开放程度,在不同国家具有不同的影响。 | Christina W.Andrews Michiel S.de Vries 王洋洋(译) 敬乂嘉(译) | 2008 | 中国行政管理2008，，10： | 2 |
| 6 | PET-modified red mud as catalysts for oxidative desulfurization reactions显示文摘This work describes the synthesis of catalysts based on red mud/polyethylene terephthalate(PET) composites and their subsequent heat treatment under N2 atmosphere.The materials were characterized by scanning electron microscopy(SEM),temperature programmed reduction(TPR),Fourier transform infrared spectroscopy(FT–IR),X-ray diffraction(XRD),thermogravimetric(TG) analysis and N2adsorption/desorption.The catalysts were evaluated in the oxidative desulfurization reaction of dibenzothiophene(DBT) in a biphasic system.The results indicated that the PET impregnation on red mud increased the affinity of the catalyst with the nonpolar phase(fuel),in which the contaminant was dissolved,allowing a higher conversion(up to 80%) and selectivity to the corresponding dibenzothiophene sulfone.The sulfone compound is more polar than DBT and diffused into the polar solvent as indicated by the data obtained via gas chromatography–mass spectrometry(GC–MS). | Nayara T.do Prado Ana P.Heitmann Herman S.Mansur Alexandra A.Mansur Luiz C.A.Oliveira Cinthia S.de Castro | 2017 | Journal of Environmental Sciences2017，29，7： | 2 |
| 7 | Benign intratesticular schwannoma:a rare finding显示文摘神经鞘瘤是一个周围神经瘤,偶尔在生殖泌尿道定位了。我们在一个 79 岁的病人描述了睾丸内神经鞘瘤的一个极其稀罕的盒子。 | Maria Chiara Sighinolfi Alessandro Mofferdin Stefano S.De Stefani Antonio Celia Salvatore Micali Giovanni Saredi Giulio Rossi Riccardo Valli Giampaolo Bianchi | 2006 | Asian Journal of Andrology2006，8，1： | 2 |
| 8 | 查看详情显示文摘 | S.De U.Dammalapati K.Jungmann L.Willmann | | 0，，04： | 1 |
| 9 | A randomized controlled trial of rituximab for the treatment of severe cryoglobulinemic vasculitis显示文摘 | S.De Vita L.Quartuccio M.Isola C.Mazzaro P.Scaini M.Lenzi M.Campanini C.Naclerio A.Tavoni M.Pietrogrande C.Ferri M. T.Mascia P.Masolini A.Zabotti M.Maset D.Roccatello A. L.Zignego P.Pioltelli A.Gabrielli D.Filippini O.Perrella S.Migliaresi M.Galli S.Bomba | 2012 | Arthritis & Rheumatism2012，，3： | 1 |
| 10 | Ventricular Dysphonia: Clinical Aspects and Therapeutic Options显示文摘 | YouriMaryn Marc S.De Bodt PaulVan Cauwenberge | 2009 | The Laryngoscope2009，，5： | 1 |
| 11 | The impact of insulin resistance, serum adipocytokines and visceral obesity on steatosis and fibrosis in patients with chronic hepatitis C显示文摘 | O.LO IACONO G.VENEZIA S.PETTA C.MINEO S.DE LISI V.DI MARCO V.RODOLICO M.AMATO D.FERRARO C.GIORDANO P.L.ALMASIO A.CRAXí | 2007 | Alimentary Pharmacology & Therapeutics2007，，10： | 1 |
| 12 | Photolithography by a tunable electro-optical lithium niobate phase array显示文摘Photolithography experiments are performed by means of an optical phase mask with electrooptically tunable phase step. The phase mask consists of a 2-dimensional hexagonal lattice of inverted ferroelectric domains fabricated on a z-cut lithium niobate substrate. The electro-optically tunable phase step, between inverted domain, is obtained by the application of an external electric field along the z axis of the crystal via transparent electrodes. The collimated beam of an argon laser passes through the phase mask and the near field intensity patterns, at different planes of the Talbot length and for different values of the applied voltage, are used for photolithographic experiments. Preliminary results are shown and further applications are discussed. | M. Paturzo C. Del Core S. Grilli S.De Nicola P. Ferraro P. De Natale G. Coppola M. Iodice M. Gioffré | 2007 | Optoelectronics Letters2007，3，4： | 1 |
| 13 | Increased angiogenesis and permeability in the mesenteric microvasculature of rats with cirrhosis and portal hypertension: an in vivo study显示文摘 | Anja M.Geerts An S.De Vriese ElineVanheule HansVan Vlierberghe SiskaMortier Kin‐JipCheung PieterDemetter NorbertLameire MartineDe Vos IsabelleColle | 2006 | Liver International2006，，7： | 1 |
| 14 | The number of lymph nodes examined and staging accuracy in renal cell carcinoma显示文摘 | C.Terrone S.Guercio S.De Luca M.Poggio E.Castelli C.Scoffone R.Tarabuzzi R.M.Scarpa D.Fontana S.Rocca Rossetti | 2003 | BJU International2003，，： | 1 |
| 15 | Meta analysis: cancer risk in Barrett’s oesophagus显示文摘 | T.THOMAS K. R.ABRAMS J. S.DE CAESTECKER R. J.ROBINSON | 2007 | Alimentary Pharmacology & Therapeutics (鈥?)2007，，11： | 1 |
| 16 | ABCG2 Transporter Identifies a Population of Clonogenic Human Limbal Epithelial Cells显示文摘 | Cintia S.de Paiva ZhuoChen Rosa M.Corrales Stephen C.Pflugfelder De‐QuanLi | 2009 | STEM CELLS2009，，1： | 1 |
| 17 | Design, Synthesis, and Biological Evaluation of Substituted 2-Cyclohexyl-4-phenyl-1H-imidazoles: Potent and Selective Neuropeptide Y Y5-Receptor Antagonists显示文摘 | C.A.Blum X.Zheng S.De Lombaert | | 0，，9： | 1 |
| 18 | Serum transforming growth factor β1 during diabetes development in non‐obese diabetic mice and humans显示文摘 | A.Olivieri S.De Angelis S.Dionisi G.D’Annunzio M.Locatelli M.Marinaro V.Bonato A.Amendola M.Songini F.Velluzzi C.Schirru R.Cotichini M. A.Stazi F.Dotta R.Lorini G. F.Bottazzo M.Boirivant | 2010 | Clinical & Experimental Immunology2010，，3： | 1 |
| 19 | Effects of a single pre‐operative dexmedetomidine dose on isoflurane requirements and peri‐operative haemodynamic stability显示文摘 | C. J.Lawrence S.De Lange | 2004 | Anaesthesia2004，，8： | 1 |
| 20 | Early statin therapy for acute coronary syndromes显示文摘 | S.De Denus S.A.Spinler | | 0，，36： | 1 |
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