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| 1 | Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors显示文摘 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Lisi Sang Libin Wang Changlong Guo Wanwan Zhu Man Tong Lei Liu Wei Li Zhong-Hua Liu Xiao-Yang Zhao Liu Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，4： | 12 |
| 2 | 一项在欧洲和中国进行的新型胃泌素释放肽前体(ProGRP)免疫检测多中心评估研究显示文摘背景在欧洲和中国进行Elecsys?胃泌素释放肽前体(ProGRP)免疫检测的多中心评估研究。方法在欧洲的3个中心和中国的2个中心,在肺癌中,通过不精密度、稳定性、方法学比较和鉴别诊断能力来评价该检测法。结果 5个分析物浓度的中间不精密度范围为变异系数:2.2%-6.0%。在不同储存条件下,血浆和血清样本均显示出良好的稳定性。在血浆中Elecsys?和ARCHITECT检测(斜率1.02,截距-2.72 pg/m L)之间表现出良好的相关性。同时,Elecsys?检测在血清和血浆样本之间表现出良好的相关性(斜率0.93,截距2.35 pg/m L;相关系数0.97)。ProGRP作为不受种族、年龄、性别或吸烟史相关影响的检测手段,可鉴别小细胞和非小细胞肺癌(NSCLC);截断值为84pg/m L时,曲线下面积为0.90,95%CI:0.87-0.93;敏感性为78.3%,特异性为95%。ProGRP浓度中位数在良性病变(38pg/m L)、其他恶性肿瘤(40 pg/m L)或NSCLC(39 pg/m L)中较低,而在3期以上慢性肾脏疾病中浓度较高(>100pg/m L)。结论 Elecsys?ProGRP检测在血清和血浆中稳定性增加,较现有检测法明显更具优势。ProGRP检测在中国的首次评价在不同种族中显示出相当的鉴别能力。 | Catharina M.KORSE Stefan HOLDENRIEDER Xiuyi ZHI Xiaotong ZAHNG Ling QIU Andrea GEISTANGER Marcus-Rene LISY Birgit WEHNL Daan van den BROEK José M.ESCUDERO Jens STANDOP Mu HU Rafael MOLINA | 2017 | 中国肺癌杂志2017，20，8： | 7 |
| 3 | Endoscopic ultrasonography:Transition towards the futureof gastro-intestinal diseases显示文摘Endoscopic ultrasonography(EUS) is a technique with an established role in the diagnosis and staging of gastro-intestinal tumors. In recent years, the spread of new devices dedicated to tissue sampling has improved the diagnostic accuracy of EUS fine-needle aspiration. The development of EUS-guided drainage of the biliopancreatic region and abdominal fluid collections has allowed EUS to evolve into an interventional tool that can replace more invasive procedures. Emerging techniques applying EUS in pancreatic cancer treatment and in celiac neurolysis have been described. Recently, confocal laser endomicroscopy has been applied to EUS as a promising technique for the in vivo histological diagnosis of gastro-intestinal, bilio-pancreatic and lymph node lesions. In this state-of-the-art review, we report the most recent data from the literature regarding EUS devices, interventional EUS, EUS-guided confocal laser endomicroscopy and EUS pancreatic cancer treatment, and we also provide an overview of their principles, clinical applications and limitations. | Stefania De Lisi Marc Giovannini | 2016 | World Journal of Gastroenterology2016，22，5： | 7 |
| 4 | In situ grown Fe_(3)O_(4)particle on stainless steel:A highly efficient electrocatalyst for nitrate reduction to ammonia显示文摘NH_(3)is an essential feedstock for fertilizer synthesis.Industry-scale NH_(3)synthesis mostly relies on the Haber-Bosch method,however,which suffers from massive CO_(2) emission and high energy consumption.Electrocatalytic NO_(3)-reduction is an attractive substitute to the Haber-Bosch method for synthesizing NH_(3)under mild conditions.As this reaction will produce a variety of products,it highly desires efficient and selective electrocatalyst for NH_(3)generation.Here,we report in situ grown Fe_(3)O_(4)particle on stainless steel(Fe_(3)O_(4)/SS)as a high-efficiency electrocatalyst for NO_(3)^(-)reduction to NH_(3).In 0.1 M NaOH with 0.1 M NaNO_(3),such Fe_(3)O_(4)/SS reaches a remarkable Faradaic efficiency of 91.5%and a high NH_(3)yield of 10,145μg·h^(-1)·cm^(-2)at-0.5 V vs.reversible hydrogen electrode(RHE).Furthermore,it owns robust structural and electrochemical stability.This work provides useful guidelines to expand the scope of metallic oxide electrocatalysts for NH_(3)synthesis.The catalytic mechanism is uncovered and discussed further by theoretical calculations. | Xiaoya Fan Lisi Xie Jie Liang Yuchun Ren Longcheng Zhang Luchao Yue Tingshuai Li Yonglan Luo Na Li Bo Tang Yang Liu Shuyan Gao Abdulmohsen Ali Alshehri Qian Liu Qingquan Kong Xuping Sun | 2022 | Nano Research2022，15，4： | 7 |
| 5 | Endoscopic ultrasonography findings in autoimmune pancreatitis显示文摘Endoscopic ultrasonography is an established diagnostic tool for pancreatic masses and chronic pancreatitis.In recent years there has been a growing interest in the worldwide medical community in autoimmune pancreatitis (AIP),a form of chronic pancreatitis caused by an autoimmune process.This paper reviews the current available literature about the endoscopic ultrasonographic findings of AIP and the role of this imaging technique in the management of this protean disease. | Elisabetta Buscarini Stefania De Lisi Paolo Giorgio Arcidiacono Maria Chiara Petrone Arnaldo Fuini Rita Conigliaro Guido Manfredi Raffaele Manta Dario Reggio Claudio De Angelis | 2011 | World Journal of Gastroenterology2011，17，16： | 6 |
| 6 | Preparation and visible photocatalytic dye degradation of Mn-TiO2/sepiolite photocatalysts显示文摘The performance of Mn-TiO2/sepiolite photocatalysts prepared by the solgel method and calcinated at different temperatures was studied in the photocatalytic degradation of direct fast emerald green dye under visible light irradiation,and a series of analytical techniques such as XRD,SEM,FTIR,TG-DSC,XPS,UV-vis-DRS and Raman spectroscopy were used to characterize the morphology,structure and optical properties of the photocatalysts.It is found that the anatase TiO2 was formed in all photocatalysts.Mn4+might incorporate into the lattice structure of TiO2 and partially replace Ti4+,thus causing the defects in the crystal structure and the broadening of the spectral response range of TiO2.At the same time,TiO2 particles were dispersed on the surface of the sepiolite,which immobilized TiO2 particles with sepiolite via the bond of Ti-O-Si.Mn-TiO2/sepiolite calcined at 400°C exhibits the highest photocatalytic activity and the degradation rate of direct fast emerald green is up to 98.13%.Meanwhile,it also shows good stability and universality. | Pengfei Zhu Zhihao Ren Ruoxu Wang Ming Duan Lisi Xie Jing Xu Yujing Tian | 2020 | Frontiers of Materials Science2020，14，1： | 6 |
| 7 | Effects of external stimuli on the pacemaker function of the sinoatrial node in sodium channel gene mutations models显示文摘Loss of function and gain of function mutations of the sodium channel were investigated using an intact two-dimensional rabbit sinoatrial node (SAN) and atrial cell model. The effects of three external stimuli (acetylcholine secretion by the vagal nerve, acid-base concentration, and tissue temperature) on cardiac pacemaker function and conduction were studied. Our results show that these two groups of mutations have different effects on pacemaker function and conduction. Furthermore, we found that the negative effects of these mutations could be altered by external stimuli. The bradycardic effects of mutations were magnified by an increase in acetylcholine level. Changes in acid-base concentration and tissue temperature increased the ability of the SAN to recover its pacemaker function. The results of this study increase our understanding of sodium channel disorders, and help to advance research on the treatment of these conditions. | ZHANG JiQian LI Xiang LIANG LiSi HUANG ShouFang ZHANG HengGui | 2013 | Science China(Life Sciences)2013，56，9： | 6 |
| 8 | Efficacy and Safety of Tofacitinib in Chinese Patients with Rheumatoid Arthritis显示文摘Background:Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA).This study assessed the efficacy and safety of tofacitinib in Chinese patients with RA enrolled in Phase 3and long-term extension (LTE)studies. Methods:ORAL Sync was a 1-year,randomized,placebo-controlled,Phase 3trial.Patients received tofacitinib 5 or 10 mg twice daily (BID)or placebo advanced to tofacitinib 5 or 10 mg BID at 3 or 6 months.All patients remained on >1background conventional synthetic disease-modifying antirheumatic drug.ORAL Sequel is an open-label LTE study (data-cut:March 2015;data collection and analyses were ongoing,and study database was not locked at the time of analysis;study was closed in 2017).Efficacy outcomes:American College of Rheumatology (ACR)20/50/70response rates and Disease Activity Score in 28 joints using erythrocyte sedimentation rate (DAS28-4[ESR]).Patient-and physician-reported outcomes:HealthAssessment Questionnaire-Disability Index (HAQ-DI),Patient and Physician Global Assessment of Arthritis,and pain (visual analog scale).Safety was assessed throughout. Results:ORAL Sync included 218 patients;192 were subsequently enrolled into ORAL Sequel.In ORAL Sync,more patients achieved ACR20(tofacitinib 5 mg BID,67.4%;10 mg BID,70.6%;placebo,34.1%)and DAS28-4(ESR)<2.6(tofacitinib 5 mg BID,7.1%; 10mg BID,13.1%;placebo,2,3%)with tofacitinib versus placebo at Month 6.Mean changes from baseline in HAQ-DI were greater with tofacitinib versus placebo at Month 6.In ORAL Sequel,efficacy was consistent to Month 48.Incidence rates for adverse events of special interest in tofacitinib-treated patients were similar to the global population. Conclusions:To.facitinib significantly reduced signs/symptoms and improved physical function and quality of life in Chinese patients with moderate-to-severely active RA up to Month 48.The safety profile was consistent with the global population. | Zhan-Guo Li Yi Liu Hu-Ji Xu Zhi-Wei Chen Chun-De Bao Jie-Ruo Gu Dong-Bao Zhao Yuan An Lie-Ju Hwang Lisy Wang Joel Kremer Qi-Zhe Wu | 2018 | Chinese Medical Journal2018，，22： | 5 |
| 9 | Chromosome-scale genome assembly of sweet cherry(Prunus avium L.)cv.Tieton obtained using long-read and Hi-C sequencing显示文摘Sweet cherry(Prunus avium)is an economically significant fruit species in the genus Prunus.However,in contrast to other important fruit trees in this genus,only one draft genome assembly is available for sweet cherry,which was assembled using only Illumina short-read sequences.The incompleteness and low quality of the current sweet cherry draft genome limit its use in genetic and genomic studies.A high-quality chromosome-scale sweet cherry reference genome assembly is therefore needed.A total of 65.05 Gb of Oxford Nanopore long reads and 46.24 Gb of Illumina short reads were generated,representing~190x and 136x coverage,respectively,of the sweet cherry genome.The final de novo assembly resulted in a phased haplotype assembly of 344.29 Mb with a contig N50 of 3.25 Mb.Hi-C scaffolding of the genome resulted in eight pseudochromosomes containing 99.59%of the bases in the assembled genome.Genome annotation revealed that more than half of the genome(59.40%)was composed of repetitive sequences,and 40,338 protein-coding genes were predicted,75.40%of which were functionally annotated.With the chromosomescale assembly,we revealed that gene duplication events contributed to the expansion of gene families for salicylic acid/jasmonic acid carboxyl methyltransferase and ankyrin repeat-containing proteins in the genome of sweet cherry.Four auxin-responsive genes(two GH3s and two SAURs)were induced in the late stage of fruit development,indicating that auxin is crucial for the sweet cherry ripening process.In addition,772 resistance genes were identified and functionally predicted in the sweet cherry genome.The high-quality genome assembly of sweet cherry obtained in this study will provide valuable genomic resources for sweet cherry improvement and molecular breeding. | Jiawei Wang Weizhen Liu Dongzi Zhu Po Hong Shizhong Zhang Shijun Xiao Yue Tan Xin Chen Li Xu Xiaojuan Zong Lisi Zhang Hairong Wei Xiaohui Yuan Qingzhong Liu | 2020 | Horticulture Research2020，7，1： | 4 |
| 10 | Dissimilar titanium/aluminum friction stir welding lap joints by experiments and numerical simulation显示文摘 | G. Buffa M. De Lisi E. Sciortino L. Fratini | 2016 | Advances in Manufacturing2016，4，4： | 4 |
| 11 | Electrochemistry of samarium in lithium-beryllium fluoride salt mixture显示文摘The electrochemical behaviour of samarium was investigated in LiF-BeF2 system on an inert (Mo) electrode by cyclic voltammetry and chronopotentiometry at 804, 833, 847 and 872 K. Redox process Sm3++e-→Sm2+ was recognized and analysed. Cyclic voltammetry data suggested that at potential sweep rates lower than 0.25 V/s, the reduction was limited by the diffusion of Sm3+ ions. It was not possible to observe reduction process of Sm2++2e-→Sm0 due to insufficient electrochemical stability of LiF-BeF2. Diffusion coefficients of Sm3+ ions in LiF-BeF2 were calculated from voltammetric and chronopotentiometric data in the temperature range 804-872 K. Diffusion coefficient values obeyed Arrhenius law. Activation energy was calculated to be 102.5 kJ/mol. | Martin Straka Michal Korenko Frantisek Lisy Lórant Szatmáry | 2011 | Journal of Rare Earths2011，29，8： | 3 |
| 12 | Miniature EMP Generator Based on Marx Circuit显示文摘A monopole and a dual-polar ten-stage miniature Marx generators with avalanche transistors are designed and developed for experiments of electromagnetic pulses.These avalanche transistors,which exceed traditional gas-gap switches in stability,size and repetition rate,are used as the high-speed switches in the Marx circuit.The influences of charging resistors,capacitances and load impedances on pulse width,repetition rate of output pulses are analyzed.The monopole Marx circuit has a size of 74 mm×32 mm,and its output voltage is1.8 kV when the charging voltage is 280 V.The dual-polar Marx circuit,which is 98 mm×32 mm,can generate either positive or negative polarity pulses synchronously with an output voltage of±1.6 kV,and a repetition rate of 10 kHz.The feasibility of the presented dual-polar Marx generator is proved by further tests. | ZHOU Xing ZHAO Min FAN Lisi WANG Qingguo YANG Qingxi | 2013 | 高电压技术2013，39，10： | 3 |
| 13 | ITO@TiO_(2)nanoarray:An efficient and robust nitrite reduction reaction electrocatalyst toward NH_(3)production under ambient conditions显示文摘Ambient electrochemical nitrite(NO_(2)^(-))reduction is viewed as an effective and sustainable approach for simul-taneously removing NO_(2)^(-)and producing ammonia(NH_(3)).However,the complex multi-electron transfer steps involved in the NO_(2)^(-)reduction reaction(NO_(2)^(-)RR)lead to sluggish kinetics and low product selectivity toward NH_(3),underscoring the need for NH_(3)synthesis electrocatalysts with high activity and durability.Herein,we report amorphous indium-tin oxide sputtered on a TiO_(2)nanobelt array on a Ti plate(ITO@TiO_(2)/TP)as a 3D NH_(3)-producing catalyst for the NO_(2)^(-).In 0.5 M LiClO_(4)with 0.1 M NO_(2)^(-),it shows greatly boosted NO_(2)^(-)RR activity toward NH_(3)production,with excellent selectivity,achieving a large NH_(3)yield of 411.3μmol h^(-1)cm^(-2)and a high Faradaic efficiency of 82.6%.It also shows high durability for continuous electrolysis.A Zn-NO_(2)^(-)battery with ITO@TiO_(2)/TP cathode offers an NH_(3)yield of 23.1μmol h^(-1)cm^(-2)and a peak power density of 1.22 m. | Shaoxiong Li Jie Liang Peipei Wei Qian Liu Lisi Xie Yonglan Luo Xuping Sun | 2022 | eScience2022，2，4： | 3 |
| 14 | Interpretation of the west segment of the coastal fault zone in the coastal region of South China based on the gravity data显示文摘By systemic processing, comprehensive analysis, and interpretation of gravity data, we confirmed the existence of the west segment of the coastal fault zone(west of Yangjiang to Beibu Bay) in the coastal region of South China. This showed an apparent high gravity gradient in the NEE direction, and worse linearity and less compactness than that in the Pearl River month. This also revealed a relatively large curvature and a complicated gravity structure. In the finding images processed by the gravity data system, each fault was well reflected and primarily characterized by isolines or thick black stripes with a cutting depth greater than 30 km. Though mutually cut by NW-trending and NE-trending faults, the apparent NEE stripe-shaped structure of the west segment of the coastal fault zone remained unchanged,with good continuity and an activity strength higher than that of NW and NE-trending faults. Moreover,we determined that the west segment of the coastal fault zone is the major seismogenic structure responsible for strong earthquakes in the coastal region in the border area of Guangdong, Guangxi, and Hainan. | Lisi Bi Zhenhuan Ren Xiuwei Ye Tianyou Liu Jihua Qiao | 2018 | Geodesy and Geodynamics2018，9，2： | 2 |
| 15 | Study of the Seismogenic Structure of the October 12^(th),2019 MS5.2 Beiliu Earthquake,Guangxi,China显示文摘On October 12th,2019,a MS5.2 earthquake occurred in Beiliu City,Guangxi Zhuang Autonomous Region,China,with a focal depth of 10 km. The epicenter is located in the junction of Guangxi and Guangdong where the moderate-strong earthquakes are relatively active. The highest intensity of this earthquake is estimated up to Ⅵ besides the isoseismic line showed an ellipse shape with a long axis trend in the NW direction.The aftershocks are not evenly distributed. The parameters of the focal mechanism solutions are: strike 346°,dip 85°,rake 19° for the nodal planeⅠ,and strike 254°,dip 71°,rake 175° for the nodal planeⅡ. The type of the coseismic fault is strikeslip. After analyzing these results above and the active faults near the epicenter,we get that the nodal planeⅠ is interpreted as the coseismic rupture plane and the BamaBobai Fault is a seismogenic structure of MS5.2 Beiliu earthquake. | BI Lisi LU Banghua YANG Xuan WU Bin | 2020 | Earthquake Research in China2020，34，2： | 2 |
| 16 | Evidence for charge and spin density waves in single crystals of La_(3)Ni_(2)O_(7) and La_(3)Ni_(2)O_(6)显示文摘Charge and spin orders are intimately related to superconductivity in copper oxide superconductors.Elucidation of the competing orders in various nickel oxide compounds is crucial,given the fact that superconductivity has been discovered in Nd_(0.8)Sr_(0.2)NiO_(2)films.Herein,we report structural,electronic transport,magnetic,and thermodynamic characterizations of single crystals of La_(3)Ni_(2)O_(7)and La_(3)Ni_(2)O_(6).La_(3)Ni_(2)O_(7)is metallic with mixed Ni^(2+)and Ni^(3+)valent states.Resistivity measurements yield two transition-like kinks at~110 and 153 K.The kink at 153 K is further revealed from magnetization and specific heat measurements,indicative of the formation of charge and spin density waves.La_(3)Ni_(2)O_(6)single crystals obtained from the topochemical reduction of La_(3)Ni_(2)O_(7)are insulating and show an anomaly at~176 K on magnetic susceptibility.The transition-like behaviors of La_(3)Ni_(2)O_(7)and La_(3)Ni_(2)O_(6)are analogous to those observed in La_(4)Ni_(3)O_(10) and La_(4)Ni_(3)O_(8),suggesting that charge and spin density waves are a common feature in the ternary La-Ni-O system with mixed-valent states of nickel. | Zengjia Liu Hualei Sun Mengwu Huo Xiaoyan Ma Yi Ji Enkui Yi Lisi Li Hui Liu Jia Yu Ziyou Zhang Zhiqiang Chen Feixiang Liang Hongliang Dong Hanjie Guo Dingyong Zhong Bing Shen Shiliang Li Meng Wang | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，1： | 2 |
| 17 | Generation of Tripotent Neural Progenitor Cells from Rat Embryonic Stem Cells显示文摘老鼠是为药理学和生理的研究的一个珍贵模型。胚胎的茎(物件) 房间衬里的 Germline 能干的老鼠成功地被建立了,维持物件细胞的自我更新的、无差别的状态的分子的网络也好揭开。然而,很少对区别策略和这些真老鼠 pluripotent 干细胞怎么产生特定的房间类型的内在的机制被知道。这研究的目的是调查物件房间的神经区别能力。借助于一个修改过程基于 激活mitogen 的蛋白质 kinase ( MAPK )和肝糖 synthase kinase 的以前的出版物联合 3 ( GSK3 )禁止者(二个禁止者, 2i )与喂调节中等,我们成功地从物件房间获得了高质量的老鼠胚胎植物或动物身体(美国南北战争时南军士兵)然后区分了他们到 tripotent 神经祖先。这些物件导出房间的神经祖先房间(rNPCs ) 能够自我更新并且产生所有三个神经的系,包括的星形细胞, oligodendrocytes,和神经原。而且,这些导出房间的神经原染色了的物件为 -aminobutyric 酸(伽马氨基丁酸) 和酷氨酸 hydroxylase (TH ) 积极。在摘要,我们为区分物件房间到 tripotent 开发一个试验性的系统神经祖先,它可以为学习象 Parkinson 的疾病和老鼠神经系统的开发那样的许多 neurodegenerative 混乱的致病为药理学测试和一个珍贵平台提供一个强大的工具。 | Zhenkun Wang Chao Sheng Tianda Li Fei Teng Lisi Sang Fenglin Cao Ziwei Wang Wanwan Zhu Wei Li Xiaoyang Zhao Zhonghua Liu Liu Wang Qi Zhou | 2012 | Journal of Genetics and Genomics2012，39，12： | 2 |
| 18 | Vanadyl phosphate dihydrate supported on oxides for the catalytic conversion of ethane to ethylene显示文摘 | L Lisi P Patrono G Ruoppolo | 2003 | J Mol Catal A:Chemical2003，204，： | 2 |
| 19 | An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy显示文摘 | D. Scott Kreiner Steven W. Hwang John E. Easa Daniel K. Resnick Jamie L. Baisden Shay Bess Charles H. Cho Michael J. DePalma Paul Dougherty Robert Fernand Gary Ghiselli Amgad S. Hanna Tim Lamer Anthony J. Lisi Daniel J. Mazanec Richard J. Meagher Robert C | 2014 | The Spine Journal2014，，： | 2 |
| 20 | Systematic screening for potential therapeutic targets in osteosarcoma through a kinome-wide CRISPR-Cas9 library显示文摘Objective:Osteosarcoma is the most common primary malignant bone tumor.However,the survival of patients with osteosarcoma has remained unchanged during the past 30 years,owing to a lack of efficient therapeutic targets.Methods:We constructed a kinome-targeting CRISPR-Cas9 library containing 507 kinases and 100 nontargeting controls and screened the potential kinase targets in osteosarcoma.The CRISPR screening sequencing data were analyzed with the Model-based Analysis of Genome-wide CRISPR/Cas9 Knockout(MAGeCK)Python package.The functional data were applied in the 143B cell line through lenti-CRISPR-mediated gene knockout.The clinical significance of kinases in the survival of patients with osteosarcoma was analyzed in the R2:Genomics Analysis and Visualization Platform.Results:We identified 53 potential kinase targets in osteosarcoma.Among these targets,we analyzed 3 kinases,TRRAP,PKMYT1,and TP53RK,to validate their oncogenic functions in osteosarcoma.PKMYT1 and TP53RK showed higher expression in osteosarcoma than in normal bone tissue,whereas TRRAP showed no significant difference.High expression of all 3 kinases was associated with relatively poor prognosis in patients with osteosarcoma.Conclusions:Our results not only offer potential therapeutic kinase targets in osteosarcoma but also provide a paradigm for functional genetic screening by using a CRISPR-Cas9 library,including target design,library construction,screening workflow,data analysis,and functional validation.This method may also be useful in potentially accelerating drug discovery for other cancer types. | Yuanzhong Wu Liwen Zhou Zifeng Wang Xin Wang Ruhua Zhang Lisi Zheng Tiebang Kang | 2020 | Cancer Biology & Medicine2020，17，3： | 2 |
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