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| 1 | 单针吗啡诱导小鼠行为敏化新的神经生物学机制显示文摘受他刊启发,本期开辟了[研究报道]栏目,其目的是为广大读者,特别是工作在戒毒一线的医务人员,提供一个了解国内研究人员在国外高水平刊物发表的研究成果的平台。本期共组织了三篇文章,一篇是一个课题组近年在国外期刊发表的研究成果总结报道:单针吗啡诱导小鼠行为敏化新的神经生物学机制;一篇是已采用英文语言在国外杂志发表过的中药治疗海洛因急性戒断症状的汇萃分析;一篇是相关数据库收录的药物滥用文献检索分析。希望大家喜欢,同时也希望大家支持,将自己在国外刊物已发表的重要研究成果,用中文总结,在本栏目展示。 | 梁建辉 景丽 罗娟 Andrew J.Lawrence 张敏 覃旺军 刘青 李语玲 王燕婷 文睿婷 | 2011 | 中国药物依赖性杂志2011，20，4： | 2 |
| 2 | G-Quadruplex(G4) Motifs in the Maize(Zea mays L.) Genome Are Enriched at Specific Locations in Thousands of Genes Coupled to Energy Status,Hypoxia,Low Sugar,and Nutrient Deprivation显示文摘The G-quadruplex(G4) elements comprise a class of nucleic acid structures formed by stacking of guanine base quartets in a quadruple helix.This G4 DNA can form within or across single-stranded DNA molecules and is mutually exclusive with duplex B-form DNA.The reversibility and structural diversity of G4 s make them highly versatile genetic structures,as demonstrated by their roles in various functions including telomere metabolism,genome maintenance,immunoglobulin gene diversification,transcription,and translation.Sequence motifs capable of forming G4 DNA are typically located in telomere repeat DNA and other non-telomeric genomic loci.To investigate their potential roles in a large-genome model plant species,we computationally identified 149,988 non-telomeric G4 motifs in maize(Zea mays L.,B73 AGPv2),29%of which were in non-repetitive genomic regions.G4 motif hotspots exhibited non-random enrichment in genes at two locations on the antisense strand,one in the 5'UTR and the other at the 5'end of the first intron.Several genic G4 motifs were shown to adopt sequence-specific and potassium-dependent G4 DNA structures in vitro.The G4 motifs were prevalent in key regulatory genes associated with hypoxia(group VII ERFs),oxidative stress(DJ-1/GATase1),and energy status(AMPK/SnRK) pathways.They also showed statistical enrichment for genes in metabolic pathways that function in glycolysis,sugar degradation,inositol metabolism,and base excision repair.Collectively,the maize G4 motifs may represent conditional regulatory elements that can aid in energy status gene responses.Such a network of elements could provide a mechanistic basis for linking energy status signals to gene regulation in maize,a model genetic system and major world crop species for feed,food,and fuel. | Carson M.Andorf Mykhailo Kopylov Drena Dobbs Karen E.Koch M.Elizabeth Stroupe Carolyn J.Lawrence Hank W.Bass | 2014 | Journal of Genetics and Genomics2014，41，12： | 2 |
| 3 | 区域经济可持续发展的路径优化研究显示文摘区域经济可持续发展是以'代内公平'和'代际公平'为前提、以区域总体经济效益最大化为目标的路径优化问题。通过对一个地区经济发展路径的优化可发现:在该地区经济发展的前期和后期,宜分别采用较低和较高的经济可持续性发展标准;而通过对一个区域内经济发展路径的优化发现:在区域经济发展的初期和中期,应集中资金分别投向经济发展水平较高和较低的地区。 | 孙卫东 William J.Lawrence | 2011 | 经济纵横2011，，7： | 2 |
| 4 | Investigating the climate impacts of global land cover change in the community climate system model显示文摘 | Peter J.Lawrence Thomas N.Chase | 2010 | Int J Climatol2010，，13： | 2 |
| 5 | 博弈论视角下的可持续发展问题研究显示文摘可持续发展是属于外部不经济的'公共地'问题。从历史上看,造成目前一系列全球环境问题的主要责任在发达国家,所以,在可持续发展问题上,国际社会形成了'共同但有区别'的责任分摊原则。通过博弈模型分析发现,目前发达国家与发展中国家之所以谈判一再陷入僵局,是因为双方合作还缺乏适当的条件和机制,可持续发展问题的妥善解决,至少需要三个先决条件,但目前还没有一个条件已经满足。 | 孙卫东 William J.Lawrence | 2010 | 科技管理研究2010，30，23： | 2 |
| 6 | 缓解中美贸易摩擦的战略分析——基于中国产业集群的视角显示文摘近年来,中国凭借产业集群获得了巨大的国际竞争力。中国产业集群的特点是产量大、劳动密集和生产成本低,其明显缺点是生产效率低、污染严重、附加值低。这些缺点为国外愈演愈烈的对中国反倾销及其它指责提供了口实。中美有各自的优势,两者的合作,将不仅能够促进中国产业集群的转型升级,而且将大大缓解中美间的贸易摩擦。 | 孙卫东 William J.Lawrence | 2010 | 科技进步与对策2010，27，2： | 1 |
| 7 | 'Jiangnan Sizhu Music Clubs in Shanghai:Context,Concept and Identity'显示文摘 | J.Lawrence Witzleben | | 0，，： | 1 |
| 8 | Colorectal stenting for malignant obstruction: an 8‐year clinical experience显示文摘 | HanumantChouhan Christopher X.Wong PreeyaMaharaj Mathew J.Lawrence AndrewHunter James W.Moore | 2012 | ANZ Journal of Surgery2012，，6： | 1 |
| 9 | The effects of climate change on the reproduction of coastal invertebrates显示文摘 | Andrew J.Lawrence Jane M.Soame | 2004 | Ibis2004，，： | 1 |
| 10 | Effects of a single pre‐operative dexmedetomidine dose on isoflurane requirements and peri‐operative haemodynamic stability显示文摘 | C. J.Lawrence S.De Lange | 2004 | Anaesthesia2004，，8： | 1 |
| 11 | 中美服务贸易领域拓展及其途径选择显示文摘多年来,美国对华巨大贸易逆差使其对中国愈来愈不满,而并不刻意追求贸易顺差的中国也在试图转变经济增长方式,试图摆脱过于依赖出口和外资的不利局面。本文分析了中美两国在新的经济切合点—服务贸易上的共同利益,阐述了两国可以率先扩大服务贸易领域及其操作方法。 | 孙卫东 宋砚清 WILLIAM J.LAWRENCE | 2010 | 商业时代2010，，26： | 1 |
| 12 | S2B-2 Comorbidity of Anxiety and Depression Induced by Liang’s Contextual-Stress Box in Mice显示文摘Rationale:Comorbidity of depression and anxiety is one of the most common mental disorders in practice.Few experimental procedures,however,have focused on identifying mixed depression-and anxiety-like behaviors in animal models.Objectives:To develop a novel testing paradigm,the so-called Liang’s contextual-stress Box(briefly,Liang’s Box),for evaluating depression-and/or anxiety-like behaviors in mice.Methods:Liang’s Box consisted of a central area(CA)with three peripheral arms(PA).Mice were placed individually in the end of a peripheral arm facing to the central area and were allowed to travel around Liang’s Box.During a test period,behavioral parameters were recorded and collected by a video-tracking system named SMART 3.0(Panlab,Spain),including①Latency to CA,②Time spent in CA(CA-time),③Distance traveled in CA(CA-distance),④Distance traveled in PA(PA-distance),⑤Transition number between CA and PA,⑥Global activity,⑦CA-time/cm2,⑧PA-time/cm2,⑨CAdistance/cm2,and⑩PA-distance/cm2.In order to assess the reliability and validity of Liang’s Box and get baseline information,we undertook a series of experiment,including verifying consistency and stability in the various strains of mice(KM,ICR,and C57 BL/6 J mice),imposing high illumination,restraint and tail suspension stress,pre-treating with an anxiolytic(diazepam,buspirone)or antidepressant(desipramine,mianserin).Results:①There were not remarkable differences in all the parameters among KM,ICR,and C57 BL/6 J mice;②High illumination,restraint and tail suspension significantly increased the latency to CA and decreased the CA-time,CA-distance and transition number.However,these three types of stresses evoked different effect on global activity.High illumination increased activity,but restraint stress had no significant influence.In contrast with high illumination,tail suspension stress markedly reduced activity in mice;③The anxiolytics diazepam(0.25 mg·kg-1 and 0.5 mg·kg-1,i.p.)and buspirone(0.5 mg·kg-1 and 1.0 mg·kg-1,i.p.)significantly decreased latency to CA and transition number,and dosedependently increased the CA-time.However,they did not affect CA-or PA-distance,or global activity;④The antidepressants desipramine(10.0 mg·kg-1 and 30.0 mg·kg-1,i.p.)and mianserin(0.25 mg·kg-1 and 0.5 mg·kg-1,i.p.)significantly decreased latency to CA,and dose-dependently enhanced CA-time,CA-distance and transition number,while neither affected PA-distance or global activity.Conclusion:Our data suggest that Liang’s Box is a useful experimental instrument and method for screening and assessing potential antidepressants and/or anxiolytics.Moreover,depression-and anxiety-like behaviors induced by Liang’s Box in mice may be a new hybrid animal model to investigate the pathogenic mechanisms underlying the comorbidity of anxiety and depression. | LIANG Jian-hui LIANG hui CHENG tao LIU Xiao-yan Simon M.Y.Lee TANG Ben-qin WANG Xiufen CHEN Feng Andrew J.Lawrence | 2018 | 神经药理学报2018，8，4： | 0 |
| 13 | Influence of supraphysiological cortisol manipulation on predator avoidance behaviors and physiological responses to a predation threat in a wild marine teleost fish显示文摘The stress axis in teleost fish attempts to maintain internal homeostasis in the face of allostatic loading.However,stress axis induction has been associated with a higher predation rate in fish.To date,the physiological and behavioral factors associated with this outcome are poorly understood.The purpose of the present study was to investigate the impact of experimental cortisol elevation on anti-predator behavior and physiological responses to predator presence.We hypothesized that semi-chronic cortisol elevation would increase susceptibility to predation by increasing stress-induced risk-taking behaviors.To test this hypothesis,schoolmaster snapper were given cocoa butter implants without cortisol(sham)or with cortisol(50 mg/kg body weight)and tethered to cover.Fish were exposed to either a lemon shark or control conditions for 15-min.Space use and activity were recorded throughout and fish were terminally sampled for blood.Cortisol implantation,relative to shams,resulted in higher blood glucose and plasma cortisol concentrations with a lower plasma lactate concentration.Shark exposure,relative to controls,elicited higher blood glucose and lactate concentrations but had no effect on plasma cortisol concentration.No interactions were detected between shark exposure and cortisol treatment for any physiological trait.Behavioral metrics,including shelter use and activity,were unaffected by either cortisol implantation or shark exposure.Physiological responses to cortisol implantation likely resulted from enhanced gluconeogenic activity,whereas alterations under predator exposure may have been the product of catecholamine mobilization.Further work should address context-specific influences of stress in mediating behavioral responses to predation. | Michael J.LAWRENCE Erika J.ELIASON Jacob W.BROWNSCOMBE Kathleen M.GILMOUR John W.MANDELMAN Lee F.G.GUTOWSKY Steven J.COOKE | 2018 | Integrative Zoology2018，13，2： | 0 |
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