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| 1 | Drug nanoclusters formed in confined nano-cages of CD-MOF: dramatic enhancement of solubility and bioavailability of azilsartan显示文摘Tremendous efforts have been devoted to the enhancement of drug solubility using nanotechnologies, but few of them are capable to produce drug particles with sizes less than a few nanometers. This challenge has been addressed here by using biocompatible versatile γ-cyclodextrin(γ-CD) metal-organic framework(CD-MOF) large molecular cages in which azilsartan(AZL) was successfully confined producing clusters in the nanometer range. This strategy allowed to improve the bioavailability of AZL in Sprague–Dawley rats by 9.7-fold after loading into CD-MOF. The apparent solubility of AZL/CD-MOF was enhanced by 340-fold when compared to the pure drug. Based on molecular modeling, a dual molecular mechanism of nanoclusterization and complexation of AZL inside the CD-MOF cages was proposed, which was confirmed by small angle X-ray scattering(SAXS) and synchrotron radiation-Fourier transform infrared spectroscopy(SR-FTIR) techniques. In a typical cage-like unit of CD-MOF, three molecules of AZL were included by the γ-CD pairs, whilst other three AZL molecules formed a nanocluster inside the 1.7 nm sized cavity surrounded by six γ-CDs. This research demonstrates a dual molecular mechanism of complexation and nanoclusterization in CD-MOF leading to significant improvement in the bioavailability of insoluble drugs. | Yuanzhi He Wei Zhang Tao Guo Guoqing Zhang Wei Qin Liu Zhang Caifen Wang Weifeng Zhu Ming Yang Xiaoxiao Hu Vikramjeet Singh Li Wu Ruxandra Gref Jiwen Zhang | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 13 |
| 2 | Superior mesenteric artery first approach versus standard pancreaticoduodenectomy: a systematic review and meta-analysis显示文摘BACKGROUND: The superior mesenteric artery(SMA) first approach was proposed recently as a new modification of the standard pancreaticoduodenectomy. Increasing evidence showed that a periadventiceal dissection of the SMA with early transection of the inflow during pancreaticoduodenectomy associates better early perioperative results, and setup the scene for long-term oncological benefits. The objectives of the current study are to compare the operative results and long-term oncological outcomes of SMA first approach pancreaticoduodenectomy(SMA-PD) with standard pancreaticoduodenectomy(S-PD).DATA SOURCES: Electronic search of the PubM ed/MEDLINE, EMBASE, Web of Science and Cochrane Library was performed until July 2015. We considered randomized controlled trials(RCTs) and non-randomized comparative studies(NRCSs) comparing SMA-PD with S-PD to be eligible if they included patients with periampullary cancers.RESULTS: A total of one RCT and thirteen NRCSs met the inclusion criteria, involving 640 patients with SMA-PD and 514 patients with S-PD. The SMA-PD was associated with less intraoperative bleeding, less blood transfusions and higher rate of associated venous resections. The pancreatic fistula and delayed gastric emptying had a significantly lower rate in the SMA-PD group. There were no differences between the two approaches regarding overall complications, major complication rates and in-hospital mortality. There was no difference regarding R0 resection rate, and one-, two-or three-year over-all survival. The SMA-PD was associated with a lower local, hepatic and extrahepatic metastatic rate.CONCLUSIONS: The SMA-PD is associated with better perioperative outcomes, such as blood loss, transfusion requirements, pancreatic fistula, and delayed gastric emptying. Although the one-, two-or three-year overall survival rate is not superior, the SMA-PD has a lower local and metastatic recurrence rate. | Ionut Negoi Sorin Hostiuc Alexandru Runcanu Ruxandra Irina Negoi Mircea Beuran | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，2： | 10 |
| 3 | Optimization and design of an aircraft's morphing wing-tip demonstrator for drag reduction at low speeds, Part II- Experimental validation using Infra-Red transition measurement from Wind Tunnel tests显示文摘In the present paper, an ‘in-house' genetic algorithm was numerically and experimentally validated. The genetic algorithm was applied to an optimization problem for improving the aerodynamic performances of an aircraft wing tip through upper surface morphing. The optimization was performed for 16 flight cases expressed in terms of various combinations of speeds, angles of attack and aileron deflections. The displacements resulted from the optimization were used during the wind tunnel tests of the wing tip demonstrator for the actuators control to change the upper surface shape of the wing. The results of the optimization of the flow behavior for the airfoil morphing upper-surface problem were validated with wind tunnel experimental transition results obtained with infra-red Thermography on the wing-tip demonstrator. The validation proved that the 2D numerical optimization using the ‘in-house' genetic algorithm was an appropriate tool in improving various aspects of a wing's aerodynamic performances. | Andreea Koreanschi Oliviu Sugar Gabor Joran Acotto Guillaume Brianchon Gregoire Portier Ruxandra Mihaela Botez Mahmoud Mamou Youssef Mebarki | 2017 | Chinese Journal of Aeronautics2017，30，1： | 10 |
| 4 | Optimization and design of an aircraft's morphing wing-tip demonstrator for drag reduction at low speed, Part Ⅰ–Aerodynamic optimization using genetic, bee colony and gradient descent algorithms显示文摘In this paper, an ‘in-house' genetic algorithm is described and applied to an optimization problem for improving the aerodynamic performances of an aircraft wing tip through upper surface morphing. The algorithm's performances were studied from the convergence point of view, in accordance with design conditions. The algorithm was compared to two other optimization methods,namely the artificial bee colony and a gradient method, for two optimization objectives, and the results of the optimizations with each of the three methods were plotted on response surfaces obtained with the Monte Carlo method, to show that they were situated in the global optimum region. The optimization results for 16 wind tunnel test cases and 2 objective functions were presented. The 16 cases used for the optimizations were included in the experimental test plan for the morphing wing-tip demonstrator, and the results obtained using the displacements given by the optimizations were evaluated. | Andreea Koreanschi Oliviu Sugar Gabor Joran Acotto Guillaume Brianchon Gregoire Portier Ruxandra Mihaela Botez Mahmoud Mamou Youssef Mebarki | 2017 | Chinese Journal of Aeronautics2017，30，1： | 8 |
| 5 | PillCam Colon 2 capsule in patients unable or unwilling to undergo colonoscopy显示文摘AIM: To assess the feasibility, accuracy and acceptability of PillCam Colon 2 in detection of significant lesions in colorectal cancer risk patients, unable or unwilling to perform colonoscopy. METHODS: This is a prospective, single center study using the second generation of PillCam Colon capsule. In all patients the readers were instructed to review the entire colon capsule endoscopy(CCE) examination using Rapid 7 software and additionally to note significant extra-colonic findings. Colonic significant findings were described according to European Society of Gastrointestinal Endoscopy guidelines. CCE procedure completion rate, level of bowel preparation and rate of adverse events were assessed. RESULTS: A total of 70 patients at risk of colorectal cancer were enrolled in the study. In three patients the procedure failed because the capsule was not functioning when entered the colon. PillCam Colon 2 showed positive findings in 23(34%, 95%CI: 21.6%-44.1%) of the remaining 67 patients. Six patients were diagnosedwith tumors: 4 with colon cancers, 1 with gastric cancer and 1 with a small bowel cancer. The capsule findings were confirmed after surgery in all these patients. The capsule excretion rate in twelve hours was 77% with 54 patients having a complete examination. The rectum was not explored during CCE procedure, in 16 patients(23%, 95%CI: 13.7%-34.1%). Every patient accepted CCE as an alternative exploration tool and 65/70(93%) agreed to have another future control by CCE. No complications were reported during or after CCE examination. CONCLUSION: PillCam Colon 2 capsule was effective in detecting significant lesions and might be considered an adequate alternative diagnostic tool in patients unable or unwilling to undergo colonoscopy. | Lucian Negreanu Ruxandra Babiuc Andreea Bengus Roxana Sadagurschi | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 7 |
| 6 | Laparoscopic vs open complete mesocolic excision with central vascular ligation for colon cancer: A systematic review and meta-analysis显示文摘AIM To compare the effectiveness of laparoscopic complete mesocolic excision(CME) with central vascular ligation(L-CME) with its open(O-CME) counterpart. METHODS We conducted an electronic search of the Pub Med/MEDLINE, Excerpta Medica Database, Web of Science Core Collection, Cochrane Center Register of Controlled Trails, Cochrane Database of Systematic Reviews, Sci ELO, and Korean Journal databases from their inception until May 2017. We considered randomized controlled trials(RCTs) and controlled clinical trials(CCTs) that included patients with colonic cancer comparing L-CME and O-CME. Primary outcomes included the quality of the resected specimen(lymph nodes retrieved, complete mesocolic plane excision, tumor to arterial high tie, resected mesocolon surface). Secondary outcomes included the three-year and five-year overall and disease-free survival rates, recurrence of the disease, surgical data, and postoperative morbidity and mortality. Two authors of the review screened the methodological quality of the eligible trials and independently extracted data from individualstudies.RESULTS A total of one RCT and eleven CCTs(four from Europe and seven from Asia) met the inclusion criteria for the current meta-analysis. These studies involved 1619 patients in L-CME and 1477 patients in O-CME. The L-CME was associated with the same quality of the resected specimen, with no differences regarding the retrieved lymphnodes(MD =-1.06, 95%CI:-3.65 to 1.53, P = 0.42), and tumor to high tie distance(MD = 14.26 cm, 95%CI:-4.30 to 32.82, P = 0.13); the surface of the resected mesocolon was higher in the L-CME group(MD = 11.75 cm2, 95%CI: 9.50 to 13.99, P < 0.001). The L-CME was associated with a lower rate of blood transfusions(OR = 0.45, 95%CI: 0.27 to 0.75, P = 0.002), faster recovery of gastrointestinal function, and less postoperative overall complication rate. The L-CME approach was associated with a statistical significant better three-year overall(OR = 2.02, 95%CI: 1.31 to 3.12, P = 0.001, I2 = 28%) and disease-free(OR = 1.45, 95% CI: 1.00 to 2.10, P = 0.05, I2 = 0%) survival. CONCLUSION The laparoscopic approach offers the same quality of the resected specimen as the open approach in complete mesocolic excision with central vascular ligation for colon cancer. The laparoscopic complete mesocolic excision with central vascular ligation is superior in all perioperative results and at least non-inferior in long-term oncological outcomes. | Ionut Negoi Sorin Hostiuc Ruxandra Irina Negoi Mircea Beuran | 2017 | World Journal of Gastrointestinal Oncology2017，9，12： | 7 |
| 7 | A new non-linear vortex lattice method:Applications to wing aerodynamic optimizations显示文摘This paper presents a new non-linear formulation of the classical Vortex Lattice Method(VLM) approach for calculating the aerodynamic properties of lifting surfaces. The method accounts for the effects of viscosity, and due to its low computational cost, it represents a very good tool to perform rapid and accurate wing design and optimization procedures. The mathematical model is constructed by using two-dimensional viscous analyses of the wing span-wise sections,according to strip theory, and then coupling the strip viscous forces with the forces generated by the vortex rings distributed on the wing camber surface, calculated with a fully three-dimensional vortex lifting law. The numerical results obtained with the proposed method are validated with experimental data and show good agreement in predicting both the lift and pitching moment, as well as in predicting the wing drag. The method is applied to modifying the wing of an Unmanned Aerial System to increase its aerodynamic efficiency and to calculate the drag reductions obtained by an upper surface morphing technique for an adaptable regional aircraft wing. | Oliviu Sugar Gabor Andreea Koreanschi Ruxandra Mihaela Botez | 2016 | Chinese Journal of Aeronautics2016，29，5： | 6 |
| 8 | Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery显示文摘A series of host-guest interaction-adjusted polylactide stereocomplex micelles was prepared via the self-assembly of 4-armed poly(ethylene glycol)-block-poly(L-lactide/D-lactide)-cholesterol(4-armed PEG-b-PLLA/PDLA-CHOL) and poly(β-cyclodextrin)(PCD) with the molar ratios of CHOL/β-CD at 1:0.5, 1:1, and 1:2 in an aqueous environment. The hydrodynamic diameters of the micelles ranged from 84.1 nm to 107 nm depending on the molar ratio of CHOL/β-CD. It was shown that the micelle with the largest proportion of PCD possessed excellent abilities in drug release, cell internalization as well as proliferation inhibitory effect toward human A549 lung cancer cells. The results demonstrated that the stereocomplex and host-guest interactions-mediated PLA micelles exhibited great potential in sustained drug delivery. | Xiang-ru Feng 丁建勋 Ruxandra Gref Xue-si Chen | 2017 | Chinese Journal of Polymer Science2017，35，6： | 6 |
| 9 | Proportional fuzzy feed-forward architecture control validation by wind tunnel tests of a morphing wing显示文摘In aircraft wing design,engineers aim to provide the best possible aerodynamic performance under cruise flight conditions in terms of lift-to-drag ratio.Conventional control surfaces such as flaps,ailerons,variable wing sweep and spoilers are used to trim the aircraft for other flight conditions.The appearance of the morphing wing concept launched a new challenge in the area of overall wing and aircraft performance improvement during different flight segments by locally altering the flow over the aircraft's wings.This paper describes the development and application of a control system for an actuation mechanism integrated in a new morphing wing structure.The controlled actuation system includes four similar miniature electromechanical actuators disposed in two parallel actuation lines.The experimental model of the morphing wing is based on a full-scale portion of an aircraft wing,which is equipped with an aileron.The upper surface of the wing is a flexible one,being closed to the wing tip;the flexible skin is made of light composite materials.The four actuators are controlled in unison to change the flexible upper surface to improve the flow quality on the upper surface by delaying or advancing the transition point from laminar to turbulent regime.The actuators transform the torque into vertical forces.Their bases are fixed on the wing ribs and their top link arms are attached to supporting plates fixed onto the flexible skin with screws.The actuators push or pull the flexible skin using the necessary torque until the desired vertical displacement of each actuator is achieved.The four vertical displacements of the actuators,correlated with the new shape of the wing,are provided by a database obtained through a preliminary aerodynamic optimization for specific flight conditions.The control system is designed to control the positions of the actuators in real time in order to obtain and to maintain the desired shape of the wing for a specified flight condition.The feasibility and effectiveness of the developed control system by use of a proportional fuzzy feed-forward methodology are demonstrated experimentally through bench and wind tunnel tests of the morphing wing model. | Michel Joёl Tchatchueng Kammegne Ruxandra Mihaela Botez Lucian Teodor Grigorie Mahmoud Mamou Youssef Mebarki | 2017 | Chinese Journal of Aeronautics2017，30，2： | 6 |
| 10 | Modeling novel methodologies for unmanned aerial systems–Applications to the UAS-S4 Ehecatl and the UAS-S45 Bálaam显示文摘The rising demand for Unmanned Aerial Systems(UASs) to perform tasks in hostile environments has emphasized the need for their simulation models for the preliminary evaluations of their missions. The efficiency of the UAS model is directly related to its capacity to estimate its flight dynamics with minimum computational resources. The literature describes several techniques to estimate accurate aircraft flight dynamics. Most of them are based on system identification. This paper presents an alternative methodology to obtain complete model of the S4 and S45 unmanned aerial systems. The UAS-S4 and the UAS-S45 models were divided into four sub-models, each corresponding to a specific discipline: aerodynamics, propulsion, mass and inertia, and actuator. The‘‘aerodynamic' sub-model was built using the Fderivatives in-house code, which is an improvement of the classical DATCOM procedure. The ‘‘propulsion' sub-model was obtained by coupling a two-stroke engine model based on the ideal Otto cycle and a Blade Element Theory(BET) analysis of the propeller. The ‘‘mass and the inertia' sub-model was designed utilizing the Raymer and DATCOM methodologies. A sub-model of an actuator using servomotor characteristics was employed to complete the model. The total model was then checked by validation of each submodel with numerical and experimental data. The results indicate that the obtained model was accurate and could be used to design a flight simulator. | Maxime Alex Junior KUITCHE Ruxandra Mihaela BOTEZ | 2019 | Chinese Journal of Aeronautics2019，32，1： | 5 |
| 11 | New reference trajectory optimization algorithm for a flight management system inspired in beam search显示文摘With the objective of reducing the flight cost and the amount of polluting emissions released in the atmosphere, a new optimization algorithm considering the climb, cruise and descent phases is presented for the reference vertical flight trajectory. The selection of the reference vertical navigation speeds and altitudes was solved as a discrete combinatory problem by means of a graphtree passing through nodes using the beam search optimization technique. To achieve a compromise between the execution time and the algorithm's ability to find the global optimal solution, a heuristic methodology introducing a parameter called ‘‘optimism coefficient was used in order to estimate the trajectory's flight cost at every node. The optimal trajectory cost obtained with the developed algorithm was compared with the cost of the optimal trajectory provided by a commercial flight management system(FMS). The global optimal solution was validated against an exhaustive search algorithm(ESA), other than the proposed algorithm. The developed algorithm takes into account weather effects, step climbs during cruise and air traffic management constraints such as constant altitude segments, constant cruise Mach, and a pre-defined reference lateral navigation route. The aircraft fuel burn was computed using a numerical performance model which was created and validated using flight test experimental data. | Alejandro MURRIETA-MENDOZA Bruce BEUZE Laurane TERNISIEN Ruxandra Mihaela BOTEZ | 2017 | Chinese Journal of Aeronautics2017，30，4： | 4 |
| 12 | Quality of Life in GERD Patients: Medical Treatment Versus Antireflux Surgery显示文摘 | Ruxandra Ciovica Michael Gadenst?tter Anton Klingler Wolfgang Lechner Otto Riedl Gerhard P. Schwab | 2006 | Journal of Gastrointestinal Surgery2006，，7： | 2 |
| 13 | Acute Radiation Effects on Cardiac Function Detected by Strain Rate Imaging in Breast Cancer Patients显示文摘 | Katrien Erven Ruxandra Jurcut Caroline Weltens Sorin Giusca Joris Ector Hans Wildiers Walter Van den Bogaert Jens-Uwe Voigt | 2011 | International Journal of Radiation Oncology, Biology, Physics2011，，5： | 2 |
| 14 | 显示文摘 | Ruxandra F R Robert A | 1997 | polymer international1997，42，： | 1 |
| 15 | Innovation in concentrated solar power 显示文摘 | David B Ruxandra V Pieter S | 2011 | Solar Energy Material and Solar Cells2011，95，10： | 1 |
| 16 | Innovation in con- centrated solar power 显示文摘 | David Barlev Ruxandra Pieter Stroeve | 2011 | Solar Energy Materials & Solar Cells2011，95，10： | 1 |
| 17 | Polysaccharide-decorated nanoparticles显示文摘 | Caroline Lemarehand Ruxandra Oref Patrick Couvreur | 2004 | Eur J Pharm Biopharm2004，58，： | 1 |
| 18 | Critically ill pa- tients with 2009 influenza A(H1N1) infection in Canada显示文摘 | ANAND K RYAN Z RUXANDRA P et at | 2009 | JA- MA2009，302，17： | 1 |
| 19 | Study of emulsion stabilization by graft copolymers using the optical analyzer Turbiscan显示文摘 | Caroline Lemarchand Patrick Couvreur Christine Vauthier Dominique Costantini Ruxandra Gref | 2002 | International Journal of Pharmaceutics2002，，1： | 1 |
| 20 | Targeted bulk-loading of fluorescent indicators for two-photon brain imaging in vivo显示文摘 | Olga Garaschuk Ruxandra I Milos Arthur Konnerth | | 0，，01： | 1 |
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