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| 1 | Novel concepts in radiation-induced cardiovascular disease显示文摘Radiation-induced cardiovascular disease(RICVD) is the most common nonmalignant cause of morbidity and mortality among cancer survivors who have undergone mediastinal radiation therapy(RT).Cardiovascular complications include effusive or constrictive pericarditis,cardiomyopathy,valvular heart disease,and coronary/vascular disease.These are pathophysiologically distinct disease entities whose prevalence varies depending on the timing and extent of radiation exposure to the heart and great vessels.Although refinements in RT dosimetry and shielding will inevitably limit future cases of RICVD,the increasing number of long-term cancer survivors,including those treated with older higher-dose RT regimens,will ensure a steady flow of afflicted patients for the foreseeable future.Thus,there is a pressing need for enhanced understanding of the disease mechanisms,and improved detection methods and treatment strategies.Newly characterized mechanisms responsible for the establishment of chronic fibrosis,such as oxidative stress,inflammation and epigenetic modifications,are discussed and linked to potential treatments currently under study.Novel imaging modalities may serve as powerful screening tools in RICVD,and recent research and expert opinion advocating their use is introduced.Data arguing for the aggressive use of percutaneous interventions,such as transcutaneous valve replacement and drug-eluting stents,are examined and considered in the context of prior therapeutic approaches.RICVD and its treatment options are the subject of a rich and dynamic body of research,and patients who are at risk or suffering from this disease will benefit from the care of physicians with specialty expertise in the emerging field of cardiooncology. | Jason R Cuomo Gyanendra K Sharma Preston D Conger Neal L Weintraub | 2016 | World Journal of Cardiology2016，8，9： | 17 |
| 2 | 围绝经期与绝经早期妇女心脏左室功能的组织追踪成像及应变率成像特点显示文摘目的探讨围绝经期与绝经早期妇女心脏左室功能的组织追踪成像(TTI)、应变率成像(SRI)特点。方法选择绝经期女性137例,其中围绝经期组69例,绝经早期组68例;均行常规超声心动图检测,测量E、A峰血流速度,计算E/A;采用TTI、SRI测量后间隔与侧壁、下壁与前壁、后壁与前间隔的二尖瓣环处收缩期峰值位移(D)、平均位移(mean D)及心室收缩期、心室舒张早期、心房收缩期心肌的峰值应变率(SRs、SRe、SRa)、SRe/SRa。结果与围绝经期组比较,绝经早期组女性E值、E/A降低(P均<0.01),左室各壁二尖瓣环处SRs、SRe/SRa降低(P均<0.05),左室多数室壁二尖瓣环处D值和mean D值降低(P<0.05或<0.01)。结论绝经早期妇女左室舒缩功能较围绝经期妇女受损严重,且其心肌局部收缩和舒张功能变化早于心脏整体功能变化。 | 董瑾莹 李青 葛菲 | 2015 | 山东医药2015，55，41： | 3 |
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