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| 1 | MATRIEX imaging:multiarea two-photon real-time in vivo explorer显示文摘Two-photon laser scanning microscopy has been extensively applied to study in vivo neuronal activity at cellular and subcellular resolutions in mammalian brains.However,the extent of such studies is typically confined to a single functional region of the brain.Here,we demonstrate a novel technique,termed the multiarea two-photon real-time in vivo explorer(MATRIEX),that allows the user to target multiple functional brain regions distributed within a zone of up to 12mm in diameter,each with a field of view(FOV)of ~200μm in diameter,thus performing two-photon Ca2+imaging with single-cell resolution in all of the regions simultaneously.For example,we demonstrate real-time functional imaging of single-neuron activities in the primary visual cortex,primary motor cortex and hippocampal CA1 region of mice in both anesthetized and awake states.A unique advantage of the MATRIEX technique is the configuration of multiple microscopic FOVs that are distributed in three-dimensional space over macroscopic distances(>1 mm)both laterally and axially but that are imaged by a single conventional laser scanning device.In particular,the MATRIEX technique can be effectively implemented as an add-on optical module for an existing conventional single-beam-scanning two-photon microscope without requiring any modification to the microscope itself.Thus,the MATRIEX technique can be readily applied to substantially facilitate the exploration of multiarea neuronal activity in vivo for studies of brain-wide neural circuit function with single-cell resolution. | Mengke Yang Zhenqiao Zhou Jianxiong Zhang Shanshan Jia Tong Li Jiangheng Guan Xiang Liao Bing Leng Jing Lyu Kuan Zhang Min Li Yan Gong Zhiming Zhu Junan Yan Yi Zhou Jian K Liu Zsuzsanna Varga Arthur Konnerth Yuguo Tang Jinsong Gao Xiaowei Chen Hongbo Jia | 2019 | Light(Science & Applications)2019，8，1： | 4 |
| 2 | Dye loading with patch pipettes显示文摘 | Jens Eilers Arthur Konnerth | | 0，，04： | 1 |
| 3 | A new type of convergence at the deictic center:Second person and cislocative in Karbi显示文摘 | Konnerth Linda | 2015 | Studies in Language2015，，1： | 1 |
| 4 | Feasibility of Particle Board Production Using Bone Glue显示文摘 | KONNERTH J HAHN G GINDL W | 2009 | European Journal of Wood and Wood Products2009，67，2： | 1 |
| 5 | Imaging calcium in neurons显示文摘 | Grienberger C Konnerth A | | 0，，05： | 1 |
| 6 | Targeted bulk-loading of fluorescent indicators for two-photon brain imaging in vivo显示文摘 | Olga Garaschuk Ruxandra I Milos Arthur Konnerth | | 0，，01： | 1 |
| 7 | In vivo two-photon calcium imaging using multicell bolus loading显示文摘 | Garaschuk O Konnerth A | | 0，，10： | 1 |
| 8 | A study on the frequency of olfactory dysfunction显示文摘 | LANDIS B N KONNERTH C G HUMMEL T | 2004 | Laryngoscope2004，114，： | 1 |
| 9 | Comparison of two opti- cal methods for contactless, full field and highly sensitive in- plane deformation measurements using the example of plywood 显示文摘 | Valla A Konnerth J Keunecke D eta| | 2011 | Wood Sci Technol2011，45，4： | 1 |
| 10 | A Thin Slice Preparation for Patch Clamp Recordings from Neurons of the Mammalian Central Nervous System显示文摘 | EDWARDS FA KONNERTH A SAKMANN B et a1 | 1989 | Pfliigers Arch1989，414，： | 1 |
| 11 | Long-term potentiation and functional synapse induction in developing hippocampus显示文摘 | Durand GM Kovdchuk Y Konnerth A | 1996 | Nature1996，381，： | 1 |
| 12 | Hippocampal slices of kindled rats reveal calcium involvement in epileptogen显示文摘 | WADMAN W J HEINEMAN U KONNERTH A | 1985 | Exp Brain Res1985，57，： | 1 |
| 13 | Neurotrophin - mediated rapid signaling in the central nervous system: mechanisms and functions 显示文摘 | Blum R Konnerth A | 2005 | Physiology( Bethesda)2005，20，： | 1 |
| 14 | Long-term potentiation and functional synapse induction in developing hippocampus显示文摘 | DURAND G M KOVALCHUK Y KONNERTH A | 1996 | Nature1996，381，： | 1 |
| 15 | Mechnical characterizationof wood-adhesive interphase cell walls bynanoindentation显示文摘 | Konnerth J Gindl W | 2006 | Holzforschung2006，60，4： | 1 |
| 16 | Comparison of two opti- cal methods for contactless, full field and highly sensitive in plane deformation measurements using the example of plywood 显示文摘 | Valla A Konnerth J Keunecke D | 2011 | Wood Sci Technol2011，，45： | 1 |
| 17 | Imaging calcium in neurons显示文摘 | Grienberger C Konnerth A | 2012 | Neuron2012，73，5： | 1 |
| 18 | Imaging calciumin neurons显示文摘 | GRIENBERGER C KONNERTH A | 2012 | Neuron2012，73，5： | 1 |
| 19 | A studay on the frequency of olfactory dysfunction显示文摘 | Landis BN Konnerth CG Hummel T | 2004 | Laryngoscope2004，114，10： | 1 |
| 20 | Long-term potentiation as a mechanism of functional synapse induction in the developing hippocampus显示文摘 | DURAND G M KONNERTH A | 1996 | Journal of Physiology Paris1996，90，56： | 1 |
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