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	题名	作者	年代	出处	被引量
1	Drug nanoclusters formed in confined nano-cages of CD-MOF: dramatic enhancement of solubility and bioavailability of azilsartan显示文摘Tremendous efforts have been devoted to the enhancement of drug solubility using nanotechnologies, but few of them are capable to produce drug particles with sizes less than a few nanometers. This challenge has been addressed here by using biocompatible versatile γ-cyclodextrin(γ-CD) metal-organic framework(CD-MOF) large molecular cages in which azilsartan(AZL) was successfully confined producing clusters in the nanometer range. This strategy allowed to improve the bioavailability of AZL in Sprague–Dawley rats by 9.7-fold after loading into CD-MOF. The apparent solubility of AZL/CD-MOF was enhanced by 340-fold when compared to the pure drug. Based on molecular modeling, a dual molecular mechanism of nanoclusterization and complexation of AZL inside the CD-MOF cages was proposed, which was confirmed by small angle X-ray scattering(SAXS) and synchrotron radiation-Fourier transform infrared spectroscopy(SR-FTIR) techniques. In a typical cage-like unit of CD-MOF, three molecules of AZL were included by the γ-CD pairs, whilst other three AZL molecules formed a nanocluster inside the 1.7 nm sized cavity surrounded by six γ-CDs. This research demonstrates a dual molecular mechanism of complexation and nanoclusterization in CD-MOF leading to significant improvement in the bioavailability of insoluble drugs.	Yuanzhi He Wei Zhang Tao Guo Guoqing Zhang Wei Qin Liu Zhang Caifen Wang Weifeng Zhu Ming Yang Xiaoxiao Hu Vikramjeet Singh Li Wu Ruxandra Gref Jiwen Zhang	2019	Acta Pharmaceutica Sinica B2019，9，1：	13
2	Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery显示文摘A series of host-guest interaction-adjusted polylactide stereocomplex micelles was prepared via the self-assembly of 4-armed poly(ethylene glycol)-block-poly(L-lactide/D-lactide)-cholesterol(4-armed PEG-b-PLLA/PDLA-CHOL) and poly(β-cyclodextrin)(PCD) with the molar ratios of CHOL/β-CD at 1:0.5, 1:1, and 1:2 in an aqueous environment. The hydrodynamic diameters of the micelles ranged from 84.1 nm to 107 nm depending on the molar ratio of CHOL/β-CD. It was shown that the micelle with the largest proportion of PCD possessed excellent abilities in drug release, cell internalization as well as proliferation inhibitory effect toward human A549 lung cancer cells. The results demonstrated that the stereocomplex and host-guest interactions-mediated PLA micelles exhibited great potential in sustained drug delivery.	Xiang-ru Feng 丁建勋 Ruxandra Gref Xue-si Chen	2017	Chinese Journal of Polymer Science2017，35，6：	6
3	Stealth corona-core nanoparticles surface modified by polyethylene glycol: influences of the corona PEG chain length and surface density and of the core composition on phagocytic uptake and plasma protein adsorption显示文摘	Gref R Luck M Quellec P	2000	Colloid SurfB Biointerfaces2000，18，34：	1
4	Study of emulsion stabilization by graft copolymers using the optical analyzer Turbiscan显示文摘	Caroline Lemarchand Patrick Couvreur Christine Vauthier Dominique Costantini Ruxandra Gref	2002	International Journal of Pharmaceutics2002，，1：	1
5	Influence of experimental parameters on the characteristics of poly (lactic acid) nanoparticles prepared by a double emulsion method显示文摘	Zambaux M F Bonneaux F Gref R	1998	J Controlled Release1998，50，：	1
6	Preparation and characterization of protein C-loaded PLA nanoparticles显示文摘	Zambaux M F Bonneaux F Gref R	1999	J Controlled Release1999，60，：	1
7	Pervaporation -esterification coupling ( Ⅰ ) Basic kinetic model; (Ⅱ) Modeling of the influence of the operating parameters显示文摘	Gref R Nguyen T O	1991	Chem Eng Res Des1991，69，：	1
8	Toxic effects of some conifer resin acids and tea tree oil on human epithelial and fibroblast cells显示文摘	SODERBERG T A JOHANSSON A GREF R	1996	Toxicology1996，107，：	1
9	Stealth PLA-PEG nanoparticles as protein carriers for nasal administration 显示文摘	TOBIO M GREF R SANCHEZ A	1998	Pharm Res1998，15，2：	1
10	Squalenoylation: a ge- neric platform for nanoparticular drug delivery显示文摘	Desmaele D Gref R Couvreur P	2012	J Con- trol Release2012，161，2：	1
11	The effect of a PEG versus a chitosan coating on the interaction of drug colloidal carriers with the ocular mucosa显示文摘	De Campos AM Sanchez A Gref R		0，，：	1
12	The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres 显示文摘	Gref R Domb A Quellec P	1995	Adv Drug Deliv Rev1995，16，23：	1
13	Biodegradable longcirculation polymeric nanospheres 显示文摘	Gref R Minamitake Y Peracchia	1994	Science1994，263，1994：	1
14	Biodegradable long-circulating polymeric nanospheres显示文摘	GREF R MINAMITAKE Y PERACCHIA M T	1994	Science1994，263，：	1
15	Toxic effects of some conifer resin acids and tea tree oil on human epithelial and fibroblast cells显示文摘	S derberg T A Johansson A Gref R	1996	Toxicology1996，107，2：	1
16	Influence of polysaccharide coating on the interactions of nanoparticles with biological systems 显示文摘	LEMARCHAND C GREF R PASSIRANI C	2006	Biomaterials2006，27，1：	1
17	Preparation andcharacterization of protein C-loaded PLA nanoparticles 显示文摘	Zambaux MF Bonneaux F Gref R	1999	J Controlled Release1999，60，：	1
18	Influence of experimental parameters on the characteristics of poly ( lactic acid) nanoparticles prepared by a double emulsion method 显示文摘	Zambaux MF Bonneaux F Gref R	1998	J Controlled Release1998，50，13：	1
19	Polysaccha- rides grafted with polyesters:novel amphiphilic copoly- mers for biomedical applications 显示文摘	GREF R RODRIGUES J COUVREUR P	2002	Macromolecules2002，35，27：	1
20	DNA Methylation in the Neuropeptide S Receptor 1 (NPSR1) promoter in relation to asthma and environmental factors 显示文摘	Reinius LE Gref A Saaf A	2013	PloS One2013，8，53：	1

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