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| 1 | Computed morphometric analysis and expression of alpha fetoprotein in hepatocellular carcinoma and its related lesion显示文摘INTRODUCTION Hepatocellular carcinoma(HCC)is closely relatedwith hepatitis and cirrhosis.In order to investigatethe pathogenesis and early pathologic diagnosis ofHCC,HCC and related lesions were analyzedqualitively and quantitively by automatic imageanalysor and immunohistochemical assay. | Li Juan Shen Zong Ji Zhang Yang Ming Ou Hua Xian Zhang Run Huang Yun He Min Jie Wang Guo Shu Xu | 2000 | World Journal of Gastroenterology2000，6，3： | 11 |
| 2 | Two gap-free reference genomes and a global view of the centromere architecture in rice显示文摘Rice(Oryza sativa),a major staple throughout the world and a model system for plant genomics and breeding,was the first crop genome sequenced almost two decades ago.However,reference genomes for all higher organisms to date contain gaps and missing sequences.Here,we report the assembly and analysis of gap-free reference genome sequences for two elite O.sativa xian/indica rice varieties,Zhenshan 97 and Minghui 63,which are being used as a model system for studying heterosis and yield.Gap-free reference genomes provide the opportunity for a global view of the structure and function of centromeres.We show that all rice centromeric regions share conserved centromere-specific satellite motifs with different copy numbers and structures.In addition,the similarity of CentO repeats in the same chromosome is higher than across chromosomes,supporting a model of local expansion and homogenization.Both genomes have over 395 non-TE genes located in centromere regions,of which∼41%are actively transcribed.Two large structural variants at the end of chromosome 11 affect the copy number of resistance genes between the two genomes.The availability of the two gap-free genomes lays a solid foundation for further understanding genome structure and function in plants and breeding climate-resilient varieties. | Jia-Ming Song Wen-Zhao Xie Shuo Wang Yi-Xiong Guo Dal-Hoe Koo Dave Kudrna Chenbo Gong Yicheng Huang Jia-Wu Feng Wenhui Zhang Yong Zhou Andrea Zuccolo Evan Long Seunghee Lee Jayson Talag Run Zhou Xi-Tong Zhu Daojun Yuan Joshua Udall Weibo Xie Rod AWing Qifa Zhang Jesse Poland Jianwei Zhang Ling-Ling Chen | 2021 | Molecular Plant2021，14，10： | 9 |
| 3 | Biochemical sensing in graphene-enhanced microfiber resonators with individual molecule sensitivity and selectivity显示文摘Photonic sensors that are able to detect and track biochemical molecules offer powerful tools for information acquisition in applications ranging from environmental analysis to medical diagnosis.The ultimate aim of biochemical sensing is to achieve both quantitative sensitivity and selectivity.As atomically thick films with remarkable optoelectronic tunability,graphene and its derived materials have shown unique potential as a chemically tunable platform for sensing,thus enabling significant performance enhancement,versatile functionalization and flexible device integration.Here,we demonstrate a partially reduced graphene oxide(prGO)inner-coated and fiber-calibrated Fabry-Perot dye resonator for biochemical detection.Versatile functionalization in the prGO film enables the intracavity fluorescent resonance energy transfer(FRET)to be chemically selective in the visible band.Moreover,by measuring the intermode interference via noise canceled beat notes and locked-in heterodyne detection with Hz-level precision,we achieved individual molecule sensitivity for dopamine,nicotine and single-strand DNA detection.This work combines atomic-layer nanoscience and high-resolution optoelectronics,providing a way toward high-performance biochemical sensors and systems. | Zhongxu Cao Baicheng Yao Chenye Qin Run Yang Yanhong Guo Yufeng Zhang Yu Wu Lei Bi Yuanfu Chen Zhenda Xie Gangding Peng Shu-Wei Huang Chee Wei Wong Yunjiang Rao | 2019 | Light(Science & Applications)2019，8，1： | 8 |
| 4 | A new neuroprotective bakkenolide from the rhizome of Petasites tricholobus显示文摘新 bakkenolide 类型混合物, bakkenolide-Va (1 ) ,从 Petasites tricholobus 的根茎被孤立。结构根据各种各样的 NMR 被描绘(1H, 13C, 1H 鈥 ? H 舒适, HMQC, HMBC 和 NOESY ) 并且集体 spectrometry 数据。bakkenolide-Va 的 neuroprotective 活动在组织缺氧葡萄糖剥夺和氧化侮辱的各种各样的类型对待的首先有教养的神经原被调查。 | Na Zhang Mei Li Guo Ge Zhang Run Ping Li | 2008 | Chinese Chemical Letters2008，19，7： | 7 |
| 5 | regionalclimate Characteristics of regional climate change and pattern analysis on Ordos Plateau显示文摘The characteristics of precipitation, temperature and their combination determine the special ecological environment pattern of Ordos Plateau. Analyzing its evolutionary trend attributes to understanding the succession process of the ecological environment of Ordos Plateau and has crucial instructional significance on the ecological restoration research being conducted in this region. Four time scales, arranging from ten days, one month, one season(growing season contrasting to non growing season)to one year were adopted to analyze the climate data which included nearly 30 years and were collected by eight weather stations on Ordos Plateau. The results indicated that the mean annual temperature and the mean monthly temperature of February, September and December, had increased significantly during the late 30 years. The annual precipitation did not show significant changes but its distribution pattern had changed obviously. The ratio of precipitation of major growing season (May October)to annual precipitation had increased distinctively,and five counties’ precipitation reached statistically significant level. And the ratio of precipitation of latter growing season (September)to one year decreased significantly while the ratio of non growing season(November next April)to one year changed insignificantly. The results showed that maybe the interaction of increased mean temperature and insignificant change of precipitation in non growing season was one of the reasons why the desertification of the region was deteriorating in recent years. Using some factors closely relating to vegetation succession such as mean annual temperature, mean annual precipitation, distributive pattern of precipitation, mean temperature of the coldest month, mean temperature of the warmest month, precipitation of the warmest month, mean temperature of growing season, precipitation of growing season, potential evapotranspiration(PET)and radiative dryness index(RDI), to synthetically analyze the climate characteristics of Ordos Plateau. The regionalized Ordos Plateau to three synthetical climate types were recognized as follows: Type I, semi humid and low evaporation(including Jungar Banner, Dongsheng City and Ejin Horo Banner), Type II, semi arid, semi humid and moderate evaporation(including Uxin Banner and Dalad Banner), Type III,arid and high evaporation(including Hanggin Banner, Otog Banner and Otog Qian Banner). | LI Guo qing, ZHENG Yuan run * (Laboratory of Quantitative Vegetation Ecology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China.) | 2002 | Journal of Environmental Sciences2002，14，4： | 5 |
| 6 | Transformation and migration of phosphorus in excess sludge reduction pretreatment by alkaline ferrate oxidation combined with anaerobic digestion显示文摘Recently,more and more attention has been paid to the strong oxidation ability of newly prepared potassium ferrate(NAPF) in sludge reduction process,but less attention has been paid to the change of phosphorus in this process.The feasibility of phosphorus migration and transformation during excess sludge reduction pretre atment using NAPF pre-oxidation combined with anaerobic digestion was investigated.After 70 mg/g suspended solids NAPF pretreatment and 16 days anaerobic digestion,the solid-phase volatile suspended solids decreased by 44.2%,and much organic matter had been released into the liquid-phase and then degraded during digestion by indigenous microorganisms.As the sludge pre-oxidation process was performed,solid-phase organic phosphorus and chemically combined phosphorus also released into the liquid-phase as PO4^3-,peaking at 100 mg/L.During anaerobic digestion,the Fe3+in the liquid-phase was gradually reduced to Fe2+,and then formed Fe^2+-PO4^3- compound crystals and re-migrated to the solid-phase.The concentration of PO4^3- decreased to 17.08± 1.1 mg/L in the liquid-phase after anaerobic digestion.Finally,the phosphorus in the Fe^2+-PO4^3- compound accounts for 80% of the total phosphorus in the solid-phase.A large number of vivianite crystals in sludge were observed.Therefore,this technology not only effectively reduces sludge,but also increases the proportion of PO43-in the sludge in the form of Vivianite. | Xiang Li Yan Yuan Yong Huang Chao-ran Guo Run Jin Ting-ting Liu Jun Ma | 2020 | Journal of Environmental Sciences2020，32，6： | 4 |
| 7 | Establishment of a Sandwich ELISA Method for Detection of Vascular Endothelial Growth Factor in Serum Samples of Hepatocellular Carcinoma Patients显示文摘Objective To establish a sandwich ELISA method for detecting vascular endothelial growth factor (VEGF) in sera of population and the patients with hepatocellular carcinoma (HCC). Methods Full length and two truncated human VEGF cDNA sequences were amplified from a commercial plasmid pBLAST49-hVEGF by PCR and inserted into the prokaryotic-expression plasmid pET-32a or pGEX-2T. Various VEGF proteins were expressed and purified from E. coli in His-Trx or GST fusion forms. The specific VEGF antibodies were elicited in experimental rabbits and mice by immunization of the full length VEGF fusion protein His-Trx-VEGF1-165. After purification of antibodies with chromatograph of Protein G, a sandwich ELISA technique was established. Serum VEGF levels were evaluated in 229 adults and 291 HCC patients. Results SDS-PAGE displayed that the molecular weights of the expressed full length (His-Trx-VEGF1-165), N-terminal (His-Trx-VEGF1-100) and C-terminal (GST-VEGF100-165) human VEGF fusion proteins were about 38KD, 31KD, and 33KD, respectively. Western blots confirmed that the prepared antisera were able to recognize both prokaryoticly and eukaryoticly expressed recombinant VEGF proteins. Assays of serially diluted His-Trx-VEGF1-100 by the established sandwich ELISA method showed that the linear range of the standard curve was 0.625-320 ng/mL, with the squared correlation coefficient R2=0.991. Screening of a serum panel containing 291 serum samples of HCC patients and 229 health adults revealed that the average VEGF level in HCC patients was higher than that in healthy controls, with a statically significant difference. Conclusion The established sandwich ELISA reflects the level of serum VEGF and provide scientific basis for screening metastasis and recurrence of HCC using serum VEGF as an index. | BING SHAN CHEN GAO JIAN-MING CHEN XIN-Yu BI BAO-YUN ZHANG YAN GUO CHEN-FANG DONG RUN AN QI SHI JING-QUN HU PING ZHAO JUN HAN XIAO-PING DONG | 2008 | Biomedical and Environmental Sciences2008，21，1： | 4 |
| 8 | The research progress of acupuncture and moxibustion in the treatment of peripheral facial paralysis显示文摘As a common and frequently-occurring disease in clinic,peripheral facial paralysis is worth paying attention to.In fact,as one of the methods for the treatment of peripheral facial paralysis,acupuncture has been widely promoted and applied in clinic,and has been recognized by doctors at home and abroad.However,there are many other factors that affect the curative effect in clinic due to their different operating methods.Therefore,there are still many disputes in the treatment of peripheral facial paralysis.The relevant literatures in recent years were searched and consulted in order to understand the current situation and provide routine treatment methods for clinical acupuncturists to treat this disease.And we intended to analyze and introduce from acupuncture manipulation,warm acupuncture,electroacupuncture,giant acupuncture,fire acupuncture,acupuncture combined with massage,acupuncture timing and other treatments,and different classification of acupuncture points and methods. | Ming-Zhu Jiang Xin-Yue Guo Run Li | 2021 | Medical Data Mining2021，4，1： | 3 |
| 9 | Pterostilbene Ameliorates Glycemic Control,Dyslipidemia and Liver Injury in Type 2 Diabetes Rats显示文摘Type 2 diabetes mellitus(T2DM)is typified by the increment of chronic blood glucose levels that is caused by an absolute and/or a relative deficiency of insulin,accounts for 90%of diabetes and causes a range of complications[1]. | ZHANG Yu Jing SUN Hua Lei WANG Teng LIU Xin Xin LIU Chang SHEN Fang WANG Bing Ya DING Run Rong LIU Yi Ming HUANG Guo Yu LI Wen Jie LI Xing | 2020 | Biomedical and Environmental Sciences2020，33，5： | 3 |
| 10 | Splenic littoral cell hemangioendothelioma: Report of a case with hepatic metastases and review of the literature显示文摘 | Ping He Xi‐De Yan Jin‐Rui Wang Run‐Cai Guo Hua‐Bin Zhang | 2014 | Ultrasound2014，，5： | 2 |
| 11 | Effects of exogenous putrescine on gas-exchange characteristics and chlorophyll fluorescence of NaCl-stressed cucumber seedlings显示文摘 | Run Hua Zhang Jun Li Shi Rong Guo Takafumi Tezuka | 2009 | Photosynthesis Research2009，，3： | 1 |
| 12 | A No- vel Kernel-based Fuzzy C-Means Algorithm with Spatial Information for Image Segmentation显示文摘 | Yang Yue Guo Shuxu Tian Run/an | 2011 | En- ergy Procedia2011，13，： | 1 |
| 13 | A Preliminary Urinary Metabolomics Study of Sprague-Dawley Rats after Short‑term Ketamine Administration by Proton Nuclear Magnetic Resonance Spectroscopy显示文摘Drug abuse has become a global problem.The mass spectrometry‑based metabolic consequences of ketamine administration in anesthesia and therapy have been well studied,but to the best of our knowledge,metabolomic studies of ketamine abuse based on nuclear magnetic resonance(NMR)spectroscopy are still lacking.In this study,twenty Sprague–Dawley rats were randomly assigned into two groups:a control group(n=10)and a ketamine group(n=10).The animals in the ketamine group received intraperitoneal injections of ketamine twice daily at 12‑h intervals at progressively increasing doses over a period of 9 days,while the control group received an equal volume of saline.The urine samples were collected for 24 h at days 0,1,3,5,7,and 9 for the metabolomics study.The metabolic changes in urine after short‑term ketamine administration were analyzed by proton NMR coupled with multivariate statistical analysis.The results indicated that short‑term ketamine exposure led to significant alterations of the metabolites in the urine of the rats.Specifically,1,3,7‑trimethyluric acid,1,3‑dimethyluric acid,acetoacetic acid,acetylglycine,creatine,sarcosine,dimethylglycine,glycine,and theobromine were significantly increased in the urine.Significant changes were also found in metabolites related to antioxidant and energy metabolism,including acetoacetic acid,succinate,1,3,7‑trimethyluric acid,1,3‑dimethyluric acid,creatine,and taurine.Our findings indicated that short‑term ketamine administration leads to disorder of energy metabolism and oxidative stress.In addition,the modified metabolites identified could serve as the new biological markers and potential biological indices reflecting the underlying mechanism of ketamine abuse. | Xiang Lu Qunxing Tang Yi Ye Run Guo Fan Chen Xinhua Dai Youyi Yan Linchuan Liao | 2016 | Journal of Forensic Science and Medicine2016，2，2： | 1 |
| 14 | Andesite Geochemistry Features of Late Triassic Tumugou Formation, in Zhongdian, Yunnan Province显示文摘 | Huang Jian Guo Han Run Sheng Tao Ren Li Zhi Qiang | 2012 | 2012 (524)2012，，524： | 1 |
| 15 | An Efficient Synthesis of Heterocyclic Substituted Ureidoalkylphosphonates显示文摘A convenient synthesis of various heterocyclic substituted ureidoalkylphosphonic aciddiphenyl esters 3 is reported in this paper. a-Am in oalkylphosphonic acid diphenyl esters 1 reactedwith triphosgene, and then treated with heterocyclic ammes gave 3. Small amount of symmetricurylenediphosphonate 4 are isolated as side products. | Zai Guo LI Run Qui HUANG and Hui Ying LI(Institute of Elemento-Organic Chemistry, State Key Laboratory ofElemento-Organic Chemistry, Nankai University, Tianjin, 300071) | 1998 | Chinese Chemical Letters1998，9，3： | 1 |
| 16 | Clinical application and research progress of extracellular slow wave recording in the gastrointestinal tract显示文摘The physiological function of the gastrointestinal(GI)tract is based on the slow wave generated and transmitted by the interstitial cells of Cajal.Extracellular myoelectric recording techniques are often used to record the characteristics and propagation of slow wave and analyze the models of slow wave transmission under physiological and pathological conditions to further explore the mechanism of GI dysfunction.This article reviews the application and research progress of electromyography,bioelectromagnetic technology,and high-resolution mapping in animal and clinical experiments,summarizes the clinical application of GI electrical stimulation therapy,and reviews the electrophysiological research in the biliary system. | Fan Ding Run Guo Zheng-Yu Cui Hai Hu Gang Zhao | 2022 | World Journal of Gastrointestinal Surgery2022，14，6： | 1 |
| 17 | A review of manufacturing technologies for silicon carbide superjunction devices显示文摘Superjunction technology is believed to reach the optimal specific on-resistance and breakdown voltage trade-off.It has become a mainstream technology in silicon high-voltage metal oxide semiconductor field effect transistor devices.Numerous efforts have been conducted to employ the same concept in silicon carbide devices.These works are summarized here. | Run Tian Chao Ma Jingmin Wu Zhiyu Guo Xiang Yang Zhongchao Fan | 2021 | Journal of Semiconductors2021，42，6： | 1 |
| 18 | Expression of FOXJ1 in hepatocellular carcinoma: Correlation with patients’ prognosis and tumor cell proliferation显示文摘 | Hong‐Wei Chen Xiao‐Dong Huang Hong‐Chen Li Song He Run‐Zhou Ni Cui‐Hua Chen Chen Peng Gang Wu Gui‐Hua Wang Ying‐Ying Wang Yun‐Hong Zhao Yi‐Xin Zhang Ai‐Guo Shen Hui‐Min Wang | 2013 | Mol. Carcinog2013，，8： | 1 |
| 19 | Effects of various degrees of oxidative stress induced by intermittent hypoxia in rat myocardial tissues显示文摘 | WEI ZHOU SHUO LI NANSHENG WAN ZHEN ZHANG RUN GUO BAOYUAN CHEN | 2012 | Respirology2012，，5： | 1 |
| 20 | Variations in the isotopic composition of particulate organic carbon and their relation with carbon dy- namics in the western Arctic Ocean显示文摘 | Zhang Run Chen Min Guo Laodong | 2012 | Deep-Sea Research Part I]: Topical Studies in Oceanography2012，8184，： | 1 |
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