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| 1 | Novel Magnesium Alloys Developed for Biomedical Application:A Review显示文摘There is an increasing interest in the development of magnesium alloys both for industrial and biomedical applications.Industrial interest in magnesium alloys is based on strong demand of weight reduction of transportation vehicles for better fuel efficiency,so higher strength,and better ductility and corrosion resistance are required.Nevertheless,biomedical magnesium alloys require appropriate mechanical properties, suitable degradation rate in physiological environment,and what is most important,biosafety to human body. Rather than simply apply commercial magnesium alloys to biomedical field,new alloys should be designed from the point of view of nutriology and toxicology.This article provides a review of state-of-the-art of magnesium alloy implants and devices for orthopedic,cardiovascular and tissue engineering applications. Advances in new alloy design,novel structure design and surface modification are overviewed.The factors that influence the corrosion behavior of magnesium alloys are discussed and the strategy in the future development of biomedical magnesium alloys is proposed. | Nan Li Yufeng Zheng | 2013 | Journal of Materials Science & Technology2013，29，6： | 58 |
| 2 | Radiofrequency ablation or microwave ablation combined with transcatheter arterial chemoembolization in treatment of hepatocellular carcinoma by comparing with radiofrequency ablation alone显示文摘Objective:To compare radiofrequency ablation(RFA) or microwave ablation(MWA) and transcatheter arterial chemoembolization(TACE) with RFA or MWA monotherapy in hepatocellular carcinoma(HCC).Methods:A prospective,randomized,controlled trial was conducted on 94 patients with HCC ≤7 cm at a single tertiary referral center from June 2008 to June 2010 at the Department of Hepatobiliary Surgery,the Second Affiliated Hospital of Southeast University.The patients were randomly assigned into the TACERFA or TACE-MWA(combined treatment group) and the RFA-alone or MWA-alone groups(control group).The primary end point was overall survival.The secondary end point was recurrence-free survival,and the tertiary end point was adverse effects.Results:Until the time of censor,17 patients in the TACE-RFA or TACE-MWA group had died.The median follow-up time of the patients who were still alive for the TACE-RFA or TACE-MWA group was 47.5±11.3 months(range,29 to 62 months).The 1-,3- and 5-year overall survival for the TACE-RFA or TACE-MWA group was 93.6%,68.1% and 61.7%,respectively.Twenty-five patients in the RFA or MWA group had died.The median follow-up time of the patients who were still alive for the RFA or MWA group was 47.0±12.9 months(range,28 to 62 months).The 1-,3- and 5-year overall survival for the RFA or MWA group was 85.1%,59.6% and 44.7%,respectively.The patients in the TACE-RFA or TACE-MWA group had better overall survival than the RFA or MWA group [hazard ratio(HR),0.526;95% confidence interval(95% CI),0.334-0.823;P=0.002],and showed better recurrence-free survival than the RFA or MWA group(HR,0.582;95% CI,0.368-0.895;P=0.008).Conclusions:RFA or MWA combined with TACE in the treatment of HCC ≤7 cm was superior to RFA or MWA alone in improving survival by reducing arterial and portal blood flow due to TACE with iodized oil before RFA. | Yongxiang Yi Yufeng Zhang Qiang Wei Liang Zhao Jianbo Han Yan Song Ying Ding Guilan Lu Junmao Liu Huaiying Ding Feng Dai Xiaojun Tang | 2014 | Chinese Journal of Cancer Research2014，26，1： | 29 |
| 3 | Cluster analysis for syndromes of real-world coronary heartdisease with angina pectoris显示文摘Syndromes of coronary heart disease with angina pectoris were analyzed to provide guidance forclinical practice and to improve accuracy of traditional Chinese medicine (TCM) diagnoses and efficacy of TCMtreatment. A total of 860 cases with coronary heart disease with angina pectoris were selected from TCM ClinicalResearch Information Sharing System for TCM clinics and research. Syndromes were automatically extractedwith the cluster method and were analyzed to provide objective evidence for clinical studies. Final syndromeclassifications were recognized and confirmed by clinical experts. Popular syndromes included Qi and blooddeficiency, blood stasis and obstruction collaterals, liver depression and spleen deficiency, and Qi stagnation andblood stasis. Syndromes Qi and blood deficiency and blood stasis and obstruction collaterals accounted for 28.61%of total syndromes, whereas liver depression and spleen deficiency and Qi stagnation and blood stasis accountedfor 26.44%. The main syndrome elements comprised Qi deficiency, blood deficiency, blood stasis, and Qistagnation. | Yufeng Zhao Xueyun Yu Xinyu Cao Lin Luo Liyun He Shusong Mao Li Ma Peijing Rong Yuxue Zhao Guozheng Li Baoyan Liu | 2018 | Frontiers of Medicine2018，12，5： | 28 |
| 4 | Oxidative stress in granulosa cells contributes to poor oocytequality and IVF-ET outcomes in women with polycystic ovarysyndrome显示文摘The increased levels of intraceHular reactive oxygen species (ROS) in granulosa cells (GCs) may allectthe pregnancy results in women with polycystic ovary syndrome (PCOS). In this study, we compared the in vitrofertilization and embryo transfer (IVF-ET) results of 22 patients with PCOS and 25 patients with tubal factorinfertility and detected the ROS levels in the GCs of these two groups. Results showed that the PCOS group hadsignificantly larger follicles on the administration day for human chorionic gonadotropin than the tubal factorgroup (P 〈 0.05); however, the number of retrieved oocytes was not significantly different between the two groups(P 〉 0.05). PCOS group had slightly lower fertilization, cleavage, grade IflI embryo, clinical pregnancy, andimplantation rates and higher miscarriage rate than the tubal factor group (P 〉 0.05). We further found asignificantly higher ROS level of GCs in the PCOS group than in the tubal factor group (P 〈 0.05). The increasedROS levels in GCs caused GC apoptosis, whereas NADPH oxidase 2 (NOX2) specific inhibitors (diphenyleneio-donium and apocynin) significantly reduced the ROS production in the PCOS group. In conclusion, the increasedROS expression levels in PCOS GCs greatly induced cell apoptosis, which further affected the oocyte quality andreduced the positive IVF-ET pregnancy results of women with PCOS. NADPH oxidase pathway may be involvedin the mechanism of ROS production in GCs of women with PCOS. | Qiaohong Lai Wenpei Xiang Qing Li Hanwang Zhang Yufeng Li Guijin Zhu Chengliang Xiong Lei Jin | 2018 | Frontiers of Medicine2018，12，5： | 26 |
| 5 | The Property of Solution of a Nonstationary Forest Evolution System | WANG Dingjiang Department of Mathematics, Pingdingshan Teacher’s College, He’nan 467000ZHANG Yufeng Department of Mathematics, Yanbian Teacher’s College, Jilin 133000 | 1993 | Systems Science and Systems Engineering1993，3，3： | 23 |
| 6 | Research on heart sound identification technology显示文摘In this article,both the basic principles and the experimental methods of identity recognition technology based on heart sounds are addressed.First,the characteristics of heart sounds and the feasibility of heart sounds as a biometric were analyzed.A synthetic model of heart sounds was then developed based on a family of wavelets;Finally,the characteristic parameters of heart sounds were extracted by using the heart sounds linear band frequency cepstra(HS-LBFC)with a specified configuration,and the similarity distance was adopted for heart sound identification.To highlight the difference in two heart sound signals between the time and frequency domains,a construction method of the heart sound wavelet,a calculation method of the parameters of a synthetic model,selection of the characteristic parameters of heart sounds and the corresponding data processing technology were examined.The experimental results showed that the proposed method exhibited excellent performance and practicability. | CHENG XieFeng MA Yong LIU Chen ZHANG XueJun GUO YuFeng | 2012 | Science China(Information Sciences)2012，55，2： | 20 |
| 7 | Scattering of SH waves induced by a symmetrical V-shaped canyon: a unified analytical solution显示文摘This paper reports a series solution of wave functions for two-dimensional scattering and diffraction of plane SH waves induced by a symmetrical V-shaped canyon with different shape ratios. A half-space with a symmetrical V-shaped canyon is divided into two sub-regions by using a circular-arc auxiliary boundary. The two sub-regions are represented by global and local cylindrical coordinate systems, respectively. In each coordinate system, the wave field satisfying the Helmholtz equation is represented by the separation of variables method, in terms of the series of both Bessel functions and Hankel functions with unknown complex coefficients. Then, the two wave fields are described in the local coordinate system using the Graf addition theorem. Finally, the unknown coefficients are sought by satisfying the continuity conditions of the auxiliary boundary. To consider the phase characteristics of the wave scattering, a parametric analysis is carried out in the time domain by assuming an incident signal of the Ricker type. Surface and subsurface transient responses demonstrate the characteristics and mechanisms of wave propagating and scattering. | Zhang Ning Gao Yufeng Li Dayong Wu Yongxin Zhang Fei | 2012 | Earthquake Engineering and Engineering Vibration2012，11，4： | 19 |
| 8 | Synergistic effect of fluorination on both donor and acceptor materials for high performance non-fullerene polymer solar cells with 13.5% efficiency显示文摘A high performance polymer solar cells(PSCs) based on polymer donor PM6 containing fluorinated thienyl benzodithiophene unit and n-type organic semiconductor acceptor IT-4 F containing fluorinated end-groups were developed. In addition to complementary absorption spectra(300–830 nm) with IT-4 F, the PM6 also has a deep HOMO(the highest occupied molecular) level(-5.50 e V), which will lower the open-circuit voltage(V_(oc)) sacrifice and reduce the E_(loss) of the IT-4 F-based PSCs. Moreover, the strong crystallinity of PM6 is beneficial to form favorable blend morphology and hence to suppress recombination. As a result, in comparison with the PSCs based on a non-fluorinated D/A pair of PBDB-T:ITIC with a medium PCE of 11.2%, the PM6:IT-4 Fbased PSCs yielded an impressive PCE of 13.5% due to the synergistic effect of fluorination on both donor and acceptor, which is among the highest values recorded in the literatures for PSCs to date. Furthermore, a PCE of 12.2% was remained with the active layer thickness of up to 285 nm and a high PCE of 11.4% was also obtained with a large device area of 1 cm^2. In addition, the devices also showed good storage, thermal and illumination stabilities with respect to the efficiency. These results indicate that fluorination is an effective strategy to improve the photovoltaic performance of materials, as well as the both fluorinated donor and acceptor pair-PM6:IT-4 F is an ideal candidate for the large scale roll-to-roll production of efficient PSCs in the future. | Qunping Fan Wenyan Su Yan Wang Bing Guo Yufeng Jiang Xia Guo Feng Liu Thomas P.Russell Maojie Zhang Yongfang Li | 2018 | Science China Chemistry2018，61，5： | 18 |
| 9 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 10 | Pm21 from Haynaldia villosa Encodes a CC-NBS- LRR Protein Conferring Powdery Mildew Resistance in Wheat显示文摘 | Liping Xing Ping Hu Jiaqian Liu Kamil Witek Shuang Zhou Jiefei Xu Weihao Zhou Li Gao Zhenpu Huang Ruiqi Zhang Xiue Wang Peidu Chen Haiyan Wang Jonathan D.G. Jones Miroslava Karafiatova Jan Vrana Jan Baros Jaroslav Dolezel Yuanchun Tian Yufeng Wu Aizhong Cao | 2018 | Molecular Plant2018，11，6： | 16 |
| 11 | Sesquiterpene glycosides from the roots of Codonopsis pilosula显示文摘Three new sesquiterpene glycosides,named codonopsesquilosides A C(1 3),were isolated from an aqueous extract of the dried roots of Codonopsis pilosula.Their structures including absolute configurations were determined by spectroscopic and chemical methods.These glycosides are categorized as C_(15) carotenoid(1),gymnomitrane(2),and eudesmane(3)types of sesquiterpenoids,respectively.Compound 1 is the first diglycoside of C_(15) carotenoids to be reported.Compound 2 represents the second reported example of gymnomitrane-type sesquiterpenoids from higher plants.The absolute configurations were supported by comparison of the experimental circular dichroism(CD)spectra with the calculated electronic CD(ECD)spectra of 13,their aglycones,and model compounds based on quantummechanical time-dependent density functional theory.The influences of the glycosyls on the calculated ECD spectra of the glycosidic sesquiterpenoids,as well as some nomenclature and descriptive problems with gymnomitrane-type sesquiterpenoids are discussed. | Yueping Jiang Yufeng Liu Qinglan Guo Chengbo Xu Chenggen Zhu Jiangong Shi | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 16 |
| 12 | A simple and efficient method for CRISPR/Cas9-induced mutant screening显示文摘The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9) system provides a technological breakthrough in mutant generation. Several methods such as the polymerase chain reaction(PCR)/restriction enzyme(RE) assay, T7 endonuclease I(T7EI) assay, Surveyor nuclease assay, PAGE-based genotyping assay, and high-resolution melting(HRM) analysis-based assay have been developed for screening CRISPR/Cas9-induced mutants. However, these methods are timeand labour-intensive and may also be sequence-limited or require very expensive equipment. Here, we described a cost-effective and sensitive screening technique based on conventional PCR, annealing at critical temperature PCR(ACT-PCR), for identifying mutants. ACT-PCR requires only a single PCR step followed by agarose gel electrophoresis. We demonstrated that ACT-PCR accurately distinguished CRISPR/Cas9-induced mutants from wild type in both rice and zebrafish. Moreover, the method can be adapted for accurately determining mutation frequency in cultured cells. The simplicity of ACT-PCR makes it particularly suitable for rapid, large-scale screening of CRISPR/Cas9-induced mutants in both plants and animals. | Yufeng Hua Chun Wang Jian Huang Kejian Wang | 2017 | Journal of Genetics and Genomics2017，44，4： | 16 |
| 13 | A general central limit theorem under sublinear expectations显示文摘Under some weaker conditions,we give a central limit theorem under sublinear expectations,which extends Peng's central limit theorem. | LI Min & SHI YuFeng School of Mathematics,Shandong University,Jinan 250100,China | 2010 | Science China Mathematics2010，53，8： | 15 |
| 14 | Friction of low-dimensional nanomaterial systems显示文摘When material dimensions are reduced to the nanoscale,exceptional physical mechanics properties can be obtained that differ significantly from the corresponding bulk materials.Here we review the physical mechanics of the friction of low‐dimensional nanomaterials,including zero‐dimensional nanoparticles,one‐dimensional multiwalled nanotubes and nanowires,and two‐dimensional nanomaterials-such as graphene,hexagonal boron nitride(h‐BN),and transition‐metal dichalcogenides-as well as topological insulators.Nanoparticles between solid surfaces can serve as rolling and sliding lubrication,while the interlayer friction of multiwalled nanotubes can be ultralow or significantly high and sensitive to interwall spacing and chirality matching,as well as the tube materials.The interwall friction can be several orders of magnitude higher in binary polarized h‐BN tubes than in carbon nanotubes mainly because of wall buckling.Furthermore,current extensive studies on two‐dimensional nanomaterials are comprehensively reviewed herein.In contrast to their bulk materials that serve as traditional dry lubricants(e.g.,graphite,bulk h‐BN,and MoS_(2)),large‐area high‐quality monolayered two‐dimensional nanomaterials can serve as single‐atom‐thick coatings that minimize friction and wear.In addition,by appropriately tuning the surface properties,these materials have shown great promise for creating energy‐efficient self‐powered electro‐opto‐magneto‐mechanical nanosystems.State‐of‐the‐art experimental and theoretical methods to characterize friction in nanomaterials are also introduced. | Wanlin GUO Jun YIN Hu QIU Yufeng GUO Hongrong WU Minmin XUE | 2014 | Friction2014，2，3： | 15 |
| 15 | Acetylenes and fatty acids from Codonopsis pilosula显示文摘Four new acetylenes(1–4) and one new unsaturated ω-hydroxy fatty acid(5),together with 5known analogues,were isolated from an aqueous extract of Codonopsis pilosula roots.Their structures were determined by spectroscopic and chemical methods.The new acetylenes are categorized as an unusual cyclotetradecatrienynone(1),tetradecenynetriol(2),and rare octenynoic acids(3 and 4),respectively,and 3 and 4 are possibly derived from oxidative metabolic degradation of 1 and/or 2.The absolute configuration of 1 was assigned by comparison of the experimental circular dichroism(CD)spectrum with the calculated electronic circular dichroism(ECD) spectra of stereoisomers based on the quantum-mechanical time-dependent density functional theory,while the configuration of 2 was assigned by using modified Mosher's method based on the MPA determination rule of ΔδRSvalues for diols. | Yueping Jiang Yufeng Liu Qinglan Guo Zhibo Jiang Chengbo Xu Chenggen Zhu Yongchun Yang Sheng Lin Jiangong Shi | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 15 |
| 16 | Comparsion analysis of data mining models applied to clinical research in Traditional Chinese Medicine显示文摘OBJECTIVE: To help researchers selecting appropriate data mining models to provide better evidence for the clinical practice of Traditional Chinese Medicine(TCM) diagnosis and therapy.METHODS: Clinical issues based on data mining models were comprehensively summarized from four significant elements of the clinical studies:symptoms, symptom patterns, herbs, and efficacy.Existing problems were further generalized to determine the relevant factors of the performance of data mining models, e.g. data type, samples, parameters, variable labels. Combining these relevant factors, the TCM clinical data features were compared with regards to statistical characters and informatics properties. Data models were compared simultaneously from the view of applied conditions and suitable scopes.RESULTS: The main application problems were the inconsistent data type and the small samples for the used data mining models, which caused the inappropriate results, even the mistake results. These features, i.e. advantages, disadvantages, satisfied data types, tasks of data mining, and the TCM issues, were summarized and compared.CONCLUSION: By aiming at the special features of different data mining models, the clinical doctors could select the suitable data mining models to resolve the TCM problem. | Yufeng Zhao Qi Xie Liyun He Baoyan Liu Kun Li Xiang Zhang Wenjing Bai Lin Luo Xianghong Jing Ruili Huo | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 14 |
| 17 | Impact of anthropogenic activities on the sediment microbial communities of Baiyangdian shallow lake显示文摘Microorganisms are recognized as sensors of external disturbance in freshwater ecosystems.In this study,sediment samples from regions with strong human activity interference(four sites),moderate human activity interference(five sites)and minor human activity interference(five sites)in Baiyangdian Lake were collected;and their physiological and chemical properties and heavy metals contents were analyzed.The structures of bacterial and fungal communities were tested using 16S ribosomal Ribonucleic Acid(rRNA)and Internal Transcribed Spacer 2(ITS2)high-throughput sequencing technologies.The results indicated that Proteobacteria was the most abundant bacterial phylum.Ascomycota,Basidiomycota and Ciliophora were the dominant phyla of fungi.Obvious differences of microbial genera among the three regions were observed,especially fungal genera.With intensified disturbance by human activities,the Simpson and Shannon indices of bacteria significantly decreased.The fungal communities were clustered into three groups in accordance with the different human disturbance levels.The bacterial communities of sediment samples under moderate and minor human disturbance appeared similar,but different from those under strong human disturbance.Redundancy analysis indicated that zinc,total phosphorus,copper,and lead were the dominant factors that influenced the bacterial community.Nitrifiers and sulfate-reducing bacteria were influenced by pH,nitrate(NO3 ),and total nitrogen.The fungal community was significantly affected by total phosphorus.This study reveals that sediment microbial community structures among different regions of a shallow lake are mainly impacted by human activities. | Wenjun Wang Yujun Yi Yufeng Yang Yang Zhou Shanghong Zhang Xuan Wang Zhifeng Yang | 2020 | International Journal of Sediment Research2020，35，2： | 14 |
| 18 | Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity显示文摘Six new indole alkaloid sulfonic acids(1–6), together with two analogues(7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra. In the preliminary assay, compounds 2 and 4 showed antiviral activity against Coxsackie virus B3 and influenza virus A/Hanfang/359/95(H3N2), respectively. | Lingjie Meng Qinglan Guo Yufeng Liu Minghua Chen Yuhuan Li Jiandong Jiang Jiangong Shi | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 14 |
| 19 | Nat Microbiol:已结首次构建出小鼠肠道微生物组数据库显示文摘小鼠模型通常被广泛用于药理学和医学研究。我们都知道小鼠肠道中的微生物群落通常会对研究结果产生明显的影响,然而目前研究者们并没有获取到关于小鼠肠道中栖息细菌群落的详细信息。近日刊登在国际杂志Nature Microbiology上的一篇研究报告中。德国慕尼黑理工大学的研究者通过研究首次收集到了小鼠肠道中的多种细菌群落。同时研究者还对其进行了分裂、特性分析。最后得到了100种细菌,其中还包括15种迄今为止未知的细菌群落。 | Lu, Qiulun Yao, Yufeng Hu, Zhenkun Hu, Changqing Song, Qixue Ye, Jian Xu, Chengqi Wang, Annabel Z. Chen, Qiuyun Wang, Qing Kenneth | 2016 | 现代生物医学进展2016，16，32： | 13 |
| 20 | 8,4′-Oxyneolignane glucosides from an aqueous extract of“ban lan gen”(Isatis indigotica root)and their absolute configurations显示文摘Three pairs of glycosidic 8,4′-oxyneolignane diastereoisomers, named isatioxyneolignosides A-F(1–6), were isolated from an aqueous extract of Isatis indigotica roots. Their structures and absolute configurations were elucidated by comprehensive spectroscopic data analysis and enzyme hydrolysis. The validity of Δδ_(C8-C7) values to distinguish threo and erythro aryl glycerol units and Cotton effects at 235±5 nm to determine absolute configurations at C-8 in 1–6 and their aglycones(1a–6a) are discussed. | Lingjie Meng Qinglan Guo Yufeng Liu Jiangong Shi | 2017 | Acta Pharmaceutica Sinica B2017，7，6： | 13 |
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