|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants. | Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan | 2020 | Molecular Plant2020，13，7： | 51 |
| 2 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 3 | Identification of immunoreactive proteins of Brucella melitensis by immunoproteomics显示文摘Infection with Brucella causes brucellosis, a chronic disease in humans, which induces abortion and sterility in livestock. Among the different Brucella species, Brucella melitensis is considered the most virulent and is the predominant species associated with outbreaks in China. To date, no safe human vaccine is available against Brucella infection. The currently used live vaccines against Brucella in livestock induce antibodies that interfere with the diagnosis of field infection in vaccinated animals, which is harmful to eradication programs. However, there is as yet no complete profile of immunogenic proteins of B. melitensis. Towards the development of a safer, equally efficacious, and field infection-distinguishable vaccine, we used immunoproteomics to identify novel candidate immunogenic proteins from B. melitensis M5. Eighty-eight immunoreactive protein spots from B. melitensis M5 were identified by Western blotting and were assigned to sixty-one proteins by mass spectrometry, including many new immunoreactive proteins such as elongation factor G, F0F1 ATP synthase subunit beta, and OMP1. These provide many candidate immunoreactive proteins for vaccine development. | ZHAO ZhongPeng YAN Fang JI WenHui LUO DeYan LIU Xin XING Li DUAN YueQiang YANG PengHui SHI XiuMin LI Zhong WANG XiLiang | 2011 | Science China(Life Sciences)2011，54，9： | 12 |
| 4 | Tectonic Evolution and Geological Characteristics of Hydrocarbon Reservoirs in Marine Mesozoic-Paleozoic Strata in the South Yellow Sea Basin显示文摘The South Yellow Sea Basin is the main body of the lower Yangtze area in which marine Mesozoic–Paleozoic strata are widely distributed.The latest geophysical data were used to overcome the limitation of previous poor-quality deep data.Meanwhile,the geological characteristics of hydrocarbon reservoirs in the marine Mesozoic–Paleozoic strata in the South Yellow Sea Basin were analyzed by comparing the source rocks and the reservoir and utilizing drilling and outcrop data.It is believed that the South Yellow Sea Basin roughly underwent six evolutionary stages:plate spreading,plate convergence,stable platform development,foreland basin development,faulted basin development,and depression basin development.The South Yellow Sea Basin has characteristics of a composite platform-fault depression geological structure,with a half-graben geological structure and with a ‘sandwich structure' in the vertical direction.Four sets of hydrocarbon source rocks developed – the upper Permian Longtan–Dalong formation,the lower Permian Qixia formation,the lower Silurian Gaojiabian formation,and the lower Cambrian Hetang formation/Mufushan formation,giving the South Yellow Sea Basin relatively good hydrocarbon potential.The carbonate is the main reservoir rock type in the South Yellow Sea area,and there are four carbonate reservoir types:porous dolomitic,reef-bank,weathered crust,and fractured.There are reservoir-forming horizons similar to the typical hydrocarbon reservoirs in the Yangtze land area developed in the South Yellow Sea,and there are three sets of complete source-reservoir-cap rock assemblages developed in the marine strata,with very good hydrocarbon potential. | YUAN Yong CHEN Jianwen ZHANG Yuxi LIANG Jie ZHANG Yinguo ZHANG Penghui | 2018 | Journal of Ocean University of China2018，17，5： | 11 |
| 5 | Ribosome profiling analysis identified a KRAS-interacting microprotein that represses oncogenic signaling in hepatocellular carcinoma cells显示文摘The roles of concealed microproteins encoded by long noncoding RNAs(lncRNAs)are gradually being exposed,but their functions in tumorigenesis are still largely unclear.Here,we identify and characterize a conserved 99-amino acid microprotein named KRASIM that is encoded by the putative lncRNA NCBP2-AS2.KRASIM is differentially expressed in normal hepatocytes and hepatocellular carcinoma(HCC)cells and can suppress HCC cell growth and proliferation.Mechanistically,KRASIM interacts and colocalizes with the KRAS protein in the cytoplasm of human HuH-7 hepatoma cells.More importantly,the overexpression of KRASIM decreases the KRAS protein level,leading to the inhibition of ERK signaling activity in HCC cells.These results demonstrate a novel microprotein repressor of the KRAS pathway for the first time and provide new insights into the regulatory mechanisms of oncogenic signaling and HCC therapy. | Wenli Xu Bing Deng Penghui Lin Chang Liu Bin Li Qiaojuan Huang Hui Zhou Jianhua Yang Lianghu Qu | 2020 | Science China(Life Sciences)2020，63，4： | 11 |
| 6 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 7 | The Late Carboniferous–Early Permian Ocean-Continent Transition in the West Junggar,Central Asian Orogenic Belt: Constraints from Columnar Jointed Rhyolite显示文摘The West Junggar of the western Central Asian Orogenic Belt is one of the typical regions in the term of ocean subduction, contraction and continental growth in the Late Paleozoic. However, it is still controversial on the exact time of ocean-continent transition so far. This study investigates rhyolites with columnar joint in the West Junggar for the first time.Based on zircon U-Pb dating, we determined that the ages of the newly-discovered rhyolites are between 303.6 and 294.5 Ma, belonging to Late Carboniferous–Early Permian, which is the oldest rhyolite with columnar joint preserved in the world at present. Geochemical results show that the characteristics of the major element compositions include a high content of SiO_2(75.78–79.20 wt%) and a moderate content of Al_2O_3(12.21–13.19 wt%). The total alkali content(K_2O +Na_2O) is 6.14–8.05 wt%, among which K_2O is 2.09–4.72 wt% and the rate of K_2O/Na_2O is 0.38–3.05. Over-based minerals such as Ne, Lc, and Ac do not appear. The contents of TiO_2(0.09–0.24 wt%), CaO(0.15–0.99 wt%) and MgO(0.06–0.18 wt%) are low. A/CNK=0.91–1.68, A/NK=1.06–1.76, and as such, these are associated with the quasi-aluminum-weak peraluminous high potassium calc-alkaline and some calc-alkaline magma series. These rhyolites show a significant negative Eu anomaly with relative enrichment of LREE and LILE(Rb, Ba, Th, U, K) and depletion of Sr, HREE and HFSE(Nb, Ta, Ti, P). These rhyolites also have the characteristics of an A2-type granite, similar to the Miaoergou batholith,which indicates they both were affected by post-orogenic extension. Combining petrological, zircon U-Pb dating and geochemical characteristics of the rhyolites, we conclude that the specific time of ocean-continent transition of the West Junggar is the Late Carboniferous–Early Permian. | XU Shenglin CHEN Xuanhua LI Tingdong SHI Jianjie DING Weicui LI Bing HUANG Penghui ZHANG Yiping ZHANG Yaoyao MA Feizhou | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 9 |
| 8 | COVID-19: a new challenge for human beings显示文摘Since December 2019,just a month before the Chinese Spring Festival,multiple cases of pneumonia of unknown etiology appeared in Wuhan,Hubei Province,China.Later,a novel coronavirus was identified in a bronchoalveolar lavage fluid sample from the Wuhan Seafood Market using metagenomic next-generation sequencing technology.1 On February 11,2020,the virus was named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)by the International Committee on Taxonomy of Viruses(ICTV).SARS-CoV-2 is the seventh member of the coronavirus family that can infect humans after the emergence of severe acute respiratory syndrome coronavirus(SARS-CoV)and Middle East respiratory syndrome coronavirus(MERS-CoV). | Penghui Yang Xiliang Wang | 2020 | Cellular & Molecular Immunology2020，17，5： | 9 |
| 9 | Occurrence, polarity and bioavailability of dissolved organic matter in the Huangpu River,China显示文摘Dissolved organic matter(DOM)plays an important role in biogeochemical cycles in aquatic ecosystem.To investigate the characteristics of DOM in Huangpu River(the last tributary of the Yangtze River),surface water samples were collected along the river from December2011 to June,2013.The concentrations of dissolved organic carbon(DOC),the absorbance and fluorescence spectrum of DOM in water samples were measured.Fluorescent DOM in the Huangpu River was decomposed into four components by the parallel factor analysis(PARAFAC),including one humic-like substance and three protein-like substances.It showed that high spatial variability of DOC concentration was observed in the upstream water compared to the downstream water,and so did the absorbance coefficients of chromophoric dissolved organic matter and the total fluorescence intensities of different PARAFAC components of DOM.Furthermore,there was a large difference between the polarity and bioavailability of DOM in the Huangpu River.Polar compounds dominated tyrosine-like component of fluorescent DOM in all seasons.Tryptophan-like and humic-like substances had more polar fraction in summer and autumn than those in winter,while aromatic protein-like materials had the highest polar fraction in winter.Almost all of fluorescent DOM components were refractory in spring,while less than 20%of fluorescent DOM in average were biodegradable within 4 weeks in other seasons.We concluded that the spatial variation in the abundance of DOM in the Huangpu River is mainly affected by the water discharges from the Hangjiahu Plain and the seasonal difference in polarity and bioavailability of DOM is largely determined by its origins. | Qianqian Dong Penghui Li Qinghui Huang Ahmed A.Abdelhafez Ling Chen | 2014 | Journal of Environmental Sciences2014，26，9： | 7 |
| 10 | Preparation of phosphorus-modified PITQ-13 catalysts and their performance in 1-butene catalytic cracking显示文摘A series of phosphorus-modified PITQ-13 catalysts was prepared by wet impregnation of NH4H2PO4solution into an HITQ-13 parent. The catalysts were characterized using XRD, N2adsorption, MAS NMR and NH3-TPD. Their catalytic performance in 1-butene catalytic cracking was evaluated in a fixed fluidized bed reactor. The results showed that the crystallinity, surface area and pore volume of P-modified PITQ-13catalysts decreased with the increasing amounts of P. The number of weak acid sites increased, whereas that of strong acidity decreased. The selectivity to propylene in 1-butene cracking reactions increased because of the decrease in strong acidity. The yield of propylene achieved41.6% over PITQ-13-2 catalyst with a P content of 1.0 wt%, which was 5.1% greater than that achieved over HITQ-13 catalyst. | Penghui Zeng Yun Liang Shengfu Ji Baojian Shen Honghai Liu Baojie Wang Hongjuan Zhao Mingfu Li | 2014 | Journal of Energy Chemistry2014，23，2： | 6 |
| 11 | Non-affine parameter dependent LPV model and LMI based adaptive control for turbofan engines显示文摘The precise control of turbofan engines thrust is an important guarantee for an aircraft to obtain good flight performance and a challenge due to complex nonlinear dynamics of engines and time-varying parameters. The main difficulties lie in the following two aspects. Firstly, it is hard to obtain an accurate kinetic model for the turbofan engine. Secondly, some model parameters often change in different flight conditions and states and even fluctuate sharply in some cases. These variable parameters bring huge challenge for the turbofan engine control. To solve the turbofan engine control problem, this paper presents a non-affine parameter-dependent Linear Parameter Varying(LPV) model-based adaptive control approach. In this approach, polynomial-based LPV modeling method is firstly employed to obtain the basis matrices, and then the Radial Basis Function Neural Networks(RBFNN) is introduced for the online estimation of the non-affine model parameters to improve the simulation performance. LPV model-based Linear Matrix Inequality(LMI) control method is applied to derive the control law. A robust control term is introduced to fix the estimation error of the nonlinear time-varying model parameters for better control performance. Finally, the Lyapunov stability analysis is performed to ensure the asymptotical convergence of the closed loop system. The simulation results show that the states of the engine can change smoothly and the thrust of the engine can accurately follow the desired trajectory, indicating that the proposed control approach is effective. The contribution of this work lies in the combination of linear system control and nonlinear system control methods to design an effective controller for the turbofan engine and to provide a new way for turbofan engine control research. | Bei YANG Xi WANG Penghui SUN | 2019 | Chinese Journal of Aeronautics2019，32，3： | 5 |
| 12 | Diagenesis and Diagenetic Evolution of Deltaic and Neritic Gas-Bearing Sandstones in the Lower Mingyuefeng Formation of Paleogene, Lishui Sag, East China Sea Shelf Basin: Implications for Depositional Environments and Sequence Stratigraphy Controls显示文摘Gas-bearing deposits in the Lower Mingyuefeng Formation of Paleogene, Lishui Sag, East China Sea Shelf Basin consist of shoreface sandstones of the highstand systems tract(HST) and transgressive systems tract(TST), and deltaic sandstones of the lowstand systems tract(LST) and falling stage systems tract(FSST).Detailed petrographic observations suggest that the diagenetic features and related evolution of these deposits cannot be simply characterized and demonstrated in the depth domain.However, the occurrence of diagenetic minerals systematically depends on the studied interval within the HST, TST, LST, and FSST; therefore, diagenesis in this region can be better constrained when studied in the context of the depositional environments and sequence stratigraphic framework.The eogenetic processes in such settings include:(1) microcrystalline siderite precipitated as concretions in almost all environments and systems tracts, which inhibited further mechanical compaction;(2) grain dissolution and kaolinitization occurred in shoreface HST sandstones and deltaic LST and FSST sandstones;(3) glaucony was locally observed, which did not clearly reflect the controls of facies or sequence stratigraphy; and(4) cementation by pyrite aggregates occurred in the shoreface HST sandstones and deltaic LST sandstones.The mesogenetic diagenesis includes:(1) partial conversion of kaolinite into dickite in deltaic LST sandstones, and minor chlorite cementation in deltaic FSST sandstones;(2) transformation of kaolinite into illite and quartz cementation in deltaic LST and FSST sandstones;(3) frequent precipitation of ankerite and ferroan calcite in shoreface TST sandstones and early HST sandstones, forming baffles and barriers for fluid flow, with common calcite in shoreface HST sandstones as a late diagenetic cement; and(4) formation of dawsonite in the deltaic LST and FSST sandstones, which is interpreted to be a product of the invasion of a CO2-rich fluid, and acts as a good indicator of CO2-bearing reservoirs.This study has thus constructed a reliable conceptual model to describe the spatial and temporal distribution of diagenetic alterations.The results may provide an entirely new conceptual framework and methodology for successful gas exploration in the continental margins of offshore China, thus allowing us to predict and unravel the distribution and quality evolution of clastic reservoirs at a more detailed and reliable scale. | XU Fa ZHANG Penghui ZHANG Jinliang LIU Jinshui HOU Guowei ZHANG Ming LI Jingzhe LIU Shasha GUO Jiaqi MENG Ningning | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 5 |
| 13 | Comparative study on virus shedding patterns in nasopharyngeal and fecal specimens of COVID-19 patients显示文摘Dear Editor,An acute viral pneumonia(COVID-19),caused by the novel coronavirus known as SARS-CoV-2,was first identified during December 2019 in China(Zhu et al.,2020).SARSCoV-2 was found to be highly transmissible in humans(Wang et al.,2020)and is now a pandemic spreading to over 140 countries and causing over 150,000 infections and 6,000 deaths as of March 15,2020.Diagnosis is critical for confirmation and treatment of COVID-19.Currently the primary criterion for diagnosis of COVID-19 is viral RNA detection for respiratory samples.Recently,two studies on virus loads in clinical samples reported that viral loads in nasal and throat swabs and sputum specimens peaked at 3–7 days after illness onset(d.a.o.)and virtually disappeared before 15 d.a.o.(Pan et al.,2020;Zou et al.,2020).Another study showed that the median duration of virus shedding in throat swabs was 20 d.a.o.in survivors and was detectable until death in non-survivors(Zhou et al.,2020).Additionally,live viruses have been isolated in the feces and urine samples of COVID-19 patients.However,the viral dynamics in these types of specimens has not yet been clearly elucidated,as well as comparative studies on virus shedding in the upper respiratory,intestinal,and urinary tracts. | Ning Zhang Yuhuan Gong Fanping Meng Yi Shi Jun Wang Panyong Mao Xia Chuai Yuhai Bi Penghui Yang Fusheng Wang | 2021 | Science China(Life Sciences)2021，64，3： | 5 |
| 14 | Bistratal Au@Bi2S3 nanobones for excellent NIR-triggered/multimodal imaging-guided synergistic therapy for liver cancer显示文摘To fabricate a highly biocompatible nanoplatform enabling synergistic therapy and real-time imaging,novel Au@Bi2S3 core shell nanobones(NBs)(Au@Bi2S3 NBs)with Au nanorods as cores were synthesized.The combination of Au nanorods with Bi2S3 film made the Au@Bi2S3 NBs exhibit ultrahigh photothermal(PT)conversion efficiency,remarkable photoacoustic(PA)imaging and high computed tomography(CT)performance;these Au@Bi2S3 NBs thus are a promising nanotheranostic agent for PT/PA/CT imaging.Subsequently,poly(N-vinylpyrrolidone)-modified Au@Bi2S3 NBs(Au@Bi2S3-PVP NBs)were successfully loaded with the anticancer drug doxorubicin(DOX),and a satisfactory pH sensitive release profile was achieved,thus revealing the great potential of Au@Bi2S3-PVP NBs in chemotherapy as a drug carrier to deliver DOX into cancer cells.Both in vitro and in vivo investigations demonstrated that the Au@Bi2S3-PVP NBs possessed multiple desired features for cancer therapy,including extremely low toxicity,good biocompatibility,high drug loading ability,precise tumor targeting and effective accumulation.Highly efficient ablation of the human liver cancer cell HepG2 was achieved through Au@Bi2S3-PVP NB-mediated photothermal therapy(PTT).As both a contrast enhancement probe and therapeutic agent,Au@Bi2S3-PVP NBs provided outstanding NIR-triggered multi-modal PT/PA/CT imaging-guided PTT and effectively inhibited the growth of HepG2 liver cancer cells via synergistic chemo/PT therapy. | Ruizhuo Ouyang Penghui Cao Pengpeng Jia Hui Wang Tianyu Zong Chenyu Dai Jie Yuan Yuhao Li Dong Sun Ning Guo Yuqing Miao Shuang Zhou | 2021 | Bioactive Materials2021，6，2： | 5 |
| 15 | A novel selective autophagy receptor,CCDC50,delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection显示文摘Autophagy is a con served process that delivers cytosolic substa nces to the lysosome for degradatio n,but its direct role in the regulation of antiviral inn ate immu nity remains poorly un derstood.Here,through high-throughput screeni ng,we discovered that CCDC50 functions as a previously unknown autophagy receptor that negatively regulates the type I interferon(IFN)signaling pathway initiated by RIG-I-like receptors(RLRs),the sensors for RNA viruses.The expression of CCDC50 is enhanced by viral infection,and CCDC50 specifically recognizes K63-polyubiquitinated RLRs,thus delivering the activated RIG-I/MDA5 for autophagic degradation.The associatio n of CCDC50 with phagophore membrane protei n LC3 is con firmed by crystal structure analysis.In contrast to other known autophagic cargo receptors that associate with either the LIR-docking site(LDS)or the UIMdocking site(UDS)of LC3,CCDC50 can bind to both LDS and UDS,representing a new type of cargo receptor.In mouse models with RNA virus infection,CCDC50 deficiency reduces the autophagic degradation of RIG-I/MDA5 and promotes type I IFN responses,resulting in enhaneed viral resistance and improved survival rates.These results reveal a new link between autophagy and antiviral innate immune resp on ses and provide additional in sights into the regulatory mecha nisms of RLR-mediated antiviral signaling. | Panpan Hou Kongxiang Yang Penghui Jia Lan Liu Yuxin Lin Zibo Li Jun Li Shuliang Chen Shuting Guo Ji'An Pan Junyu Wu Hong Peng Weijie Zeng Chunmei Li Yingfang Liu Deyin Guo | 2021 | Cell Research2021，31，1： | 5 |
| 16 | Serine metabolism orchestrates macrophage polarization by regulating the IGF1–p38 axis显示文摘Serine metabolism is reportedly involved in immune cell functions, but whether and how serine metabolism regulates macrophage polarization remain largely unknown. Here, we show that suppressing serine metabolism, either by inhibiting the activity of the key enzyme phosphoglycerate dehydrogenase in the serine biosynthesis pathway or by exogenous serine and glycine restriction, robustly enhances the polarization of interferon-γ-activated macrophages (M(IFN-γ)) but suppresses that of interleukin-4-activated macrophages (M(IL-4)) both in vitro and in vivo. Mechanistically, serine metabolism deficiency increases the expression of IGF1 by reducing the promoter abundance of S-adenosyl methionine-dependent histone H3 lysine 27 trimethylation. IGF1 then activates the p38-dependent JAK–STAT1 axis to promote M(IFN-γ) polarization and suppress STAT6-mediated M(IL-4) activation. This study reveals a new mechanism by which serine metabolism orchestrates macrophage polarization and suggests the manipulation of serine metabolism as a therapeutic strategy for macrophage-mediated immune diseases. | Xiao Shan Penghui Hu Lina Ni Long Shen Yanan Zhang Zemin Ji Yan Cui Meihua Guo Haoan Wang Liyuan Ran Kun Yang Ting Wang Lei Wang Bin Chen Zhi Yao Vingjie Wu Qiujing Yu | 2022 | Cellular & Molecular Immunology2022，19，11： | 5 |
| 17 | Application of Digital Image Monitoring System to Detecting a High Voltage Icing Conductor显示文摘数字图象操作技术的一个即时系统被采用检查设计结构的动态排水量。首先, CCD 光导摄象管瞄准固定的点。结构上的固定的点的图象被收集卡片的一幅图画聚集。由用一个自我规划的软件处理图画,刻度设备的即时空间坐标能被获得。最后,数据被处理得到运动曲线,并且动态排水量被执行。系统被用于高电压糖衣导体的测试。结果显示流售票员的冰的动态数据包括跳的振幅,排水量时间曲线和变细过程。 | LI Penghui ZHAO Wenguang WEN Yinping CHEN Yong HU Wei | 2009 | Geo-Spatial Information Science2009，12，1： | 4 |
| 18 | A Real-Time System for Monitoring Distant Dynamic Displacement of Structures显示文摘把技术基于数字图象处理,一个即时系统被开发监视并且检测设计结构的动态排水量。由用一个自我规划的软件处理图画,在某个坐标系统的一个目标的即时坐标能也被获得,并且推进动态排水量数据和目标罐头的曲线被完成。数据的也就是说自动的聚会并且即时处理能被这个系统同时执行。首先,为这个系统,一种未触动过的监视技术被采用,罐头它监视或检测目标几到几百米分开;第二,它有灵活安装状况和亚毫米度的好监视精确;第三,它是合适的为动态、伪动态、静态大工程结构监视。通过大桥的几测试和应用程序,系统的好可靠性和优势被证明。 | CHEN Junfeng ZHAO Wenguang LUO Hongbin LI Penghui WEN Yinping | 2008 | Geo-Spatial Information Science2008，11，1： | 4 |
| 19 | Identification of landslide spatial distribution and susceptibility assessment in relation to topography in the Xi'an Region, Shaanxi Province, China显示文摘 | Jianqi ZHUANG Jianbing PENG Javed IQBAL Tieming LIU Na LIU Yazhe LI Penghui MA | 2015 | Frontiers of Earth Science2015，9，3： | 4 |
| 20 | The DFF-PSP Iterative Separation and Theoretical Bound for PCMA with Long Memory显示文摘This paper proposes the Decision feedbackfeedforward per-survivor processing(DFF-PSP) iterative separation algorithm and the Monte Carlo integrationbased method to compute the theoretical bound for Paired carrier multiple access(PCMA) Single channel blind separation(SCBS) which is highly complex with long memory. The truncated PSP is employed while the pre- and post- cursors are disregarded to control the complexity.The delayed decisions feedforward and local decisions feedback filters are designed to process the pre- and postcursors. The Bit-interleaved code modulation iterative decoder(BICM-ID) is combined with the second soft decision of the truncated PSP to obtain a better performance.The mixture signal model is regarded as a Multiple-access channel(MAC) with memory, and the theoretical performance bound is obtained via entropy inequality, Monte Carlo integration and Fano inequality. Simulation results show that the DFF-PSP iterative separation provides the good tradeoff between complexity and performance. | CUI Penghui JIANG Hua CAO Kai LI Taozhu | 2016 | Chinese Journal of Electronics2016，25，5： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员