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| 1 | Operative link for gastritis assessment vs operative link on intestinal metaplasia assessment显示文摘AIM:To compare the reliability of gastritis staging sys-tems in ranking gastritis-associated cancer risk in a large series of consecutive patients.METHODS:Gastric mucosal atrophy is the precancer-ous condition in which intestinal-type gastric cancer(GC)most frequently develops.The operative link for gas-tritis assessment(OLGA)staging system ranks the GC risk according to both the topography and the severity of gastric atrophy(as assessed histologically on the ba-sis of the Sydney protocol for gastric mucosal biopsy).Both cross-sectional and long-term follow-up trials have consistently associated OLGA stages Ⅲ-Ⅳ with a higher risk of GC.A recently-proposed modification of the OLGA staging system(OLGIM)basically incorporates the OLGA frame,but replaces the atrophy score with an assessment of intestinal metaplasia(IM)alone.A series of 4552 consecutive biopsy sets(2007-2009)was re-trieved and reassessed according to both the OLGA and the OLGIM staging systems.A set of at least 5 biopsy samples was available for all the cases considered.RESULTS:In 4460 of 4552 cases(98.0%),both the high-risk stages(Ⅲ + Ⅳ)and the low-risk stages(0 +Ⅰ + Ⅱ)were assessed applying the OLGA and OL-GIM criteria.Among the 243 OLGA high-risk stages,14(5.8%)were down-staged to a low risk using OLGIM.The 67(1.5%)incidentally-found neoplastic lesions(intraepithelial or invasive)were consistently associated with high-risk stages,as assessed by both OLGA and OLGIM(P < 0.001 for both).Two of 34 intestinal-type GCs coexisting with a high-risk OLGA stage(stage Ⅲ)were associated with a low-risk OLGIM stage(stage Ⅱ).CONCLUSION:Gastritis staging systems(both OLGA and OLGIM)convey prognostically important informa-tion on the gastritis-associated cancer risk.Because of its clinical impact,the stage of gastritis should be included as a conclusive message in the gastritis histol-ogy report.Since it focuses on IM alone,OLGIM staging is less sensitive than OLGA staging in the identif ication of patients at high risk of gastric cancer. | Massimo Rugge Matteo Fassan Marco Pizzi Fabio Farinati Giacomo Carlo Sturniolo Mario Plebani David Y Graham | 2011 | World Journal of Gastroenterology2011，17，41： | 19 |
| 2 | Autoimmune gastritis:Pathologist's viewpoint显示文摘Western countries are seeing a constant decline in the incidence of Helicobacter pylori-associated gastritis, coupled with a rising epidemiological and clinical impact of autoimmune gastritis. This latter gastropathy is due to autoimmune aggression targeting parietal cells through a complex interaction of auto-antibodies against the parietal cell proton pump and intrinsic factor, and sensitized T cells. Given the specific target of this aggression, autoimmune gastritis is typically restricted to the gastric corpus-fundus mucosa. In advanced cases, the oxyntic epithelia are replaced by atrophic(and metaplastic) mucosa, creating the phenotypic background in which both gastric neuroendocrine tumors and(intestinal-type) adenocarcinomas may develop. Despite improvements in our understanding of the phenotypic changes or cascades occurring in this autoimmune setting, no reliable biomarkers are available for identifying patients at higher risk of developing a gastric neoplasm. The standardization of autoimmune gastritis histology reports and classifications in diagnostic practice is a prerequisite for implementing definitive secondary prevention strategies based on multidisciplinary diagnostic approaches integratingendoscopy, serology, histology and molecular profiling. | Irene Coati Matteo Fassan Fabio Farinati David Y Graham Robert M Genta Massimo Rugge | 2015 | World Journal of Gastroenterology2015，21，42： | 8 |
| 3 | 钛合金保载疲劳失效特征及敏感性判定方法显示文摘钛合金在航空发动机上使用时存在保载疲劳失效现象。钛合金保载疲劳寿命显著低于普通疲劳寿命且其断裂特征有别于普通疲劳。本文通过系统的实验研究,从疲劳断口、二次裂纹以及应变积累等方面总结了保载疲劳的失效特征。研究对象涵盖了保载敏感性强、弱以及无的钛合金类型。利用上述总结的特征,给出了判定钛合金保载疲劳失效及敏感性强弱的方法。 | 邱建科 席国强 马英杰 吉海宾 雷家峰 黄爱军 Rugg David 杨锐 | 2017 | 稀有金属材料与工程2017，46，S1： | 4 |
| 4 | Topographic patterns of intestinal metaplasia and gastric cancer显示文摘 | Mauro Cassaro Massimo Rugge Oscar Gutierrez Gioacchino Leandro David Y Graham Robert M Genta | 2000 | The American Journal of Gastroenterology2000，，： | 2 |
| 5 | Management of Gastric Polyps: An Endoscopy-Based Approach显示文摘 | Yasser H. Shaib Massimo Rugge David Y. Graham Robert M. Genta | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 6 | Waist-to-Hip Ratio, but Not Body Mass Index, is Associated with an Increased Risk of Barrett’s Esophagus in White Men显示文摘 | Jennifer R. Kramer Lori A. Fischbach Peter Richardson Abeer Alsarraj Stephanie Fitzgerald Yasser Shaib Neena S. Abraham Maria Velez Rhonda Cole Bhupinderjit Anand Gordana Verstovsek Massimo Rugge Paola Parente David Y. Graham Hashem B. El-Serag | 2012 | Clinical Gastroenterology and Hepatology2012，，： | 1 |
| 7 | Waist-to-Hip Ratio, but Not Body Mass Index, is Associated with an Increased Risk of Barrett’s Esophagus in White Men显示文摘 | Jennifer R. Kramer Lori A. Fischbach Peter Richardson Abeer Alsarraj Stephanie Fitzgerald Yasser Shaib Neena S. Abraham Maria Velez Rhonda Cole Bhupinderjit Anand Gordana Verstovsek Massimo Rugge Paola Parente David Y. Graham Hashem B. El-Serag | 2012 | Clinical Gastroenterology and Hepatology2012，，： | 1 |
| 8 | Different hemodynamic patterns of alcoholic and viral endstage cirrhosis: Analysis of explanted liver weight, degree of fibrosis and splanchnic Doppler parameters显示文摘 | Massimo Bolognesi David Sacerdoti Claudia Mescoli Giancarlo Bombonato Umberto Cillo Roberto Merenda Luciano Giacomelli Carlo Merkel Massimo Rugge Angelo Gatta | 2007 | Scandinavian Journal of Gastroenterology2007，，2： | 1 |
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