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| 1 | Larvicidal activity of green synthesized silver nanoparticles using bark aqueous extract of Ficus racemosa against Culex quinquefasciatus and Culex gelidus显示文摘Objective:To investigate the larvicidal activity of synthesized silver nanoparticles(Ag NPs) utilizing aqueous bark extract of Ficus racemosa(F.racemosa) was tested against fourth instar larvae of filariasis vector,Culex quinquefasciatus(Cx.quinquefasciatus) and japanese encephalitis vectors,Culex gelidus(Cx.gelidus).Methods:The synthesized Ag NPs was characterized by UV-vis spectrum,X-ray diffraction(XRD),Scanning electron microscopy(SEM) and Fourier transform infrared(FTIR).The larvicidal activities were assessed for 24 h against the larvae of Cx.quinquefasciatus and Cx.gelidus with varying concentrations of aqueous bark extract off.racemosa and synthesized Ag NPs.LC50 and r2 values were calculated.Results:The maximum efficacy was observed in crude aqueous extract of F.racemosa against the larvae of Cx.quinquefasciatus and Cx.gelidus(LC50=67.72 and 63.70 mg/L;r2=0.995 and 0.985) and the synthesized Ag NPs(LC50=12.00 and 11.21 mg/L;r2=0.997 and 0.990).respectively.Synthesized Ag NPs showed the XRD peaks at 2θvalues of 27.61,29.60,35.48,43.48 and 79.68 were identified as (210),(121),(220),(200) and(311) reflections,respectively.The FTIR spectra of Ag NPs exhibited prominent peaks at 3 425,2 878,1 627 and 1 382 in the region 500-3 000 cm-1.The peaks correspond to the presence of a stretching vibration of(NH) C=O group.SEM analysis showed shape in cylindrical,uniform and rod with the average size of 250.60 nm.Conclusions:The biosynthesis of silver nanoparticles using bark aqueous extract of F.racemosa and its larvicidal activity against the larvae of disease spreading vectors.The maximum larvicidal efficacy was observed in the synthesized Ag NPs. | Kanayairam Velayutham Abdul Abdul Rahuman Govindasamy Rajakumar Selvaraj Mohana Roopan Gandhi Elango Chinnaperumal Kamaraj Sampath Marimuthu Thirunavukkarasu Santhoshkumar Moorthy Iyappan Chinnadurai Siva | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，2： | 2 |
| 2 | An efticiem one pot-three component cyclocondensation in the synthe- sis of 2-(2-chlom-quinolin-3-yl)-2,3-dihydroquinazolin-4 (1H) -ones :Potential antitumor agents 显示文摘 | Roopan S M Nawaz Khan F Jin J S | 2012 | Res Chem In- termed2012，37，8： | 1 |
| 3 | Biosynthetic trends and future aspects of bimetallic nanoparticles and its medicinal applications显示文摘 | ROOPAN S M SURENDRA T V ELANGO G | 2014 | Applied Microbiology and Biotechnology2014，98，12： | 1 |
| 4 | Synthesis, Crystal Structure and Antibacterial Activity of 1-((2-Chloroquinolin-3-yl)-methyl)-pyridin-2(1H)-one显示文摘On the basis of the interesting structures and biological activities exhibited by several heterocyclic systems possessing the pyridone nucleus such as mappcine and camptothecin, we have planed to design the synthesis, crystal studies and antibacterial activity of the new 1-((2- chloroquinolin-3yl)-methyl)-pyridine-2(1H)-one building block. An X-ray analysis has provided valuable insight into the effect of steric factors on the three-dimensional shape of this compound which serves as a useful advanced intermediate in the synthesis of these biologically active molecules. A multistep synthesis of camptothecin (5) has been designed by retrosynthetic analysis as part of an ongoing program on lead anticancer drug. | S. Mohana Roopan Venkatesha R. Hathwar F. Nawaz Khan Atul Kumar Kushwaha | 2010 | Chinese Journal of Structural Chemistry2010，29，11： | 1 |
| 5 | Catalytic activity of TiO_2 nanoparticles in the synthesis of some2,3-disubstituted dihydroquinazolin-4(1H)-ones显示文摘Green chemistry is playing an important role for synthesizing organic compounds,due to its eco-friendly nature and low cost.In green chemistry,metal nanoparticles exhibited some useful physical and chemical properties(catalytic activity).Due to its diverse properties,nanoparticles can be utilized as a catalyst in various organic reactions.Recent research has been directed towards the utilization of ecofriendly and bio-friendly plant materials in nanoparticles synthesis.In our present work,TiO_2nanoparticles(TiO_2 NPs) were synthesized using Annona squamosa peel extract and their catalytic applications were studied on the 2,3-disubstituted dihydroquinazolin-4(1H)-one synthesis.Synthesized compounds were confirmed using FT-IR,~1H NMR,^(13)C NMR and GC-MS analyses. | A.Bharathi Selvaraj Mohana Roopan Amir Kajbafvala R.D.Padmaja M.S.Darsana G.Nandhini Kumari | 2014 | Chinese Chemical Letters2014，25，2： | 1 |
| 6 | Efficient phyto-synthesis and structural characterization of rutile TiO 2 nanoparticles using Annona squamosa peel extract显示文摘 | Selvaraj Mohana Roopan A. Bharathi A. Prabhakarn A. Abdul Rahuman K. Velayutham G. Rajakumar R.D. Padmaja Mohan Lekshmi G. Madhumitha | 2012 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2012，，： | 1 |
| 7 | Fungus-mediated biosynthesis and characterization of TiO 2 nanoparticles and their activity against pathogenic bacteria显示文摘 | G. Rajakumar A. Abdul Rahuman S. Mohana Roopan V. Gopiesh Khanna G. Elango C. Kamaraj A. Abduz Zahir K. Velayutham | 2012 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2012，，： | 1 |
| 8 | An efficient one pot-three component cyclocondensation in the synthesis of 2-(2-chloro-quinolin-3-yl)-2,3-dihydroquinazolin-4 (1 H)-ones:Potential antitumor agents显示文摘 | Roopan S M Nawaz Khan F Jin J S | 2012 | Res Chem Intermed2012，37，8： | 1 |
| 9 | Acaricidal, insecticidal, and larvicidal efficacy of fruit peel aqueous extract of Annona squamosa and its compounds against blood-feeding parasites显示文摘 | Gunabalan Madhumitha Govindasamy Rajakumar Selvaraj Mohana Roopan Abdul Abdul Rahuman Kanagaraj Mohana Priya Antoneyraj Mary Saral Fazlur Rahman Nawaz Khan Venkatesh Gopiesh Khanna Kannaiyaram Velayutham Chidambaram Jayaseelan Chinnaperumal Kamaraj Gandhi | 2012 | Parasitology Research2012，，5： | 1 |
| 10 | In vivo antiplasmodial potential of three herbal methanolic extracts in mice infected with Plasmodium berghei NK65显示文摘Objective: The present study deals with the investigation of antiplasmodial potential of leaf methanolic extract of Aegle marmelos, Aristolochia indica and Cassia auriculata against Plasmodium berghei(NK65)infected mice.Methods: The chloroquine-sensitive parasites P. berghei(1 × 106) were inoculated into Swiss albino mice intraperitoneally. The methanol extracts of three herbal plants were orally administered in P. berghei infected mice which were further assessed using the four-day suppressive test at different doses of 150, 300 and 600 mg/kg per day. Chloroquine(CQ) was used as the standard drug with of 1.25, 2.5 and 5 mg/kg concentrations and was orally administered.Results: The leaves of A. marmelos, A. indica, and C. auriculata were found to suppress P. berghei parasitaemia in Swiss albino mice by(67.0 ± 4.02)%,(72.0 ± 8.44)% and(52.7 ± 2.06)% at 600 mg/kg/d with ED50 values of 284.73, 233.77 and 562.48 mg/kg, respectively. These herbal plants increased the mean survival time of infected mice and prevented body weight loss. GC-MS analysis revealed the presence of hentriacontan-16-one(C31 H62 O) in A. indica extract. The histopathology study showed non-toxic to kidney and liver at 600 mg/kg/body weight.Conclusions: Overall results revealed that herbal plants may be active in the development of novel and cheap antimalarial compounds. | Pachiyappan Rajiv Gandhi Chinnaperumal Kamaraj Elangovan Vimalkumar Selvaraj Mohana Roopan | 2019 | Chinese Herbal Medicines2019，11，3： | 0 |
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