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| 1 | Larvicidal and repellent activity of medicinal plant extracts from Eastern Ghats of South India against malaria and filariasis vectors显示文摘Objective:To evaluate the larvicidal and repellent activities of ethyl acetate and methanol extracts of Acacia concinna(A.concinna),Cassia siamea(C.siamea).Conundrum sativum(C. sativum),Cuminum cyminum(C.cyminum),Lantana camma(L.camara),Nelumbo nucifera (N.nucifera) Phyllanlhus amarus(P.amarus).Piper nigrum(P.nigrum) and Trachyspermum ammi(T.ammi) against Anopheles stephensi(An.stephensi) and Culex quinquefasciatus(Cx. quinquefasciatus).Methods:The larvicidal activity of medicinal plant extracts were tested against earl) fourth-instar larvae of malaria and filariasis vectors.The mortality was observed 24 h and 48 h after treatment,data were subjected to probit analysis to determine the lethal concentrations(LC50 and LC90) to kill 50 and 90 per cent of the treated larvae of the tested species. The repellent efficacy was determined against two mosquito species at five concentrations(31.25. 62.50.125.00.250.00,and 500.00 ppm) under the laboratory conditions.Results:All plant extracts showed moderate effects after 24 h and 48 h of exposure;however,the highest activity was observed after 24 h in the leaf methanol extract ol N.nucifera.seed ethyl acetate and methanol extract of P.nigrum against the larvae of An.Stephensi(LC50 = 34.76.24.54 and 30.20 ppm) and against Cx.quinquefasciatus(LC50= 37.49.43.94 and 57.39 ppm),respectively.The toxic effect of leaf methanol extract of C.siamea,seed methanol extract of C.cyminum,leaf ethyl acetate extract of N.nucifera.leaf ethyl acetate and methanol extract of P.amarus and seed methanol extract of T.ammi were showed 100%mortality against An.stephensi and Cx.quinquefasciatus alter 48 h exposer.The maximum repellent activity was observed at 500 ppm in methanol extracts of N. nucifera.ethyl acetate and methanol extract of P.nigrum and methanol extract of T.ammi and the mean complete protection time ranged from 30 to 150 min with the different extracts tested. Conclusions:These results suggest that the leaf and seed extracts of C.siamea.N.nucifera.P. amarus.P.nigrum and T.ammi have the potential to be used as an ideal ecofriendly approach for the control of the An.stephensi and Cx.quinquefasciatus. | Chinnaperumal Kamaraj Abdul Abdul Rahuman Asokan Bagavan Gandhi Elango Abdul Abduz Zahir Thirunavukkarasu Santhoshkumar | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，9： | 5 |
| 2 | Larvicidal activity of green synthesized silver nanoparticles using bark aqueous extract of Ficus racemosa against Culex quinquefasciatus and Culex gelidus显示文摘Objective:To investigate the larvicidal activity of synthesized silver nanoparticles(Ag NPs) utilizing aqueous bark extract of Ficus racemosa(F.racemosa) was tested against fourth instar larvae of filariasis vector,Culex quinquefasciatus(Cx.quinquefasciatus) and japanese encephalitis vectors,Culex gelidus(Cx.gelidus).Methods:The synthesized Ag NPs was characterized by UV-vis spectrum,X-ray diffraction(XRD),Scanning electron microscopy(SEM) and Fourier transform infrared(FTIR).The larvicidal activities were assessed for 24 h against the larvae of Cx.quinquefasciatus and Cx.gelidus with varying concentrations of aqueous bark extract off.racemosa and synthesized Ag NPs.LC50 and r2 values were calculated.Results:The maximum efficacy was observed in crude aqueous extract of F.racemosa against the larvae of Cx.quinquefasciatus and Cx.gelidus(LC50=67.72 and 63.70 mg/L;r2=0.995 and 0.985) and the synthesized Ag NPs(LC50=12.00 and 11.21 mg/L;r2=0.997 and 0.990).respectively.Synthesized Ag NPs showed the XRD peaks at 2θvalues of 27.61,29.60,35.48,43.48 and 79.68 were identified as (210),(121),(220),(200) and(311) reflections,respectively.The FTIR spectra of Ag NPs exhibited prominent peaks at 3 425,2 878,1 627 and 1 382 in the region 500-3 000 cm-1.The peaks correspond to the presence of a stretching vibration of(NH) C=O group.SEM analysis showed shape in cylindrical,uniform and rod with the average size of 250.60 nm.Conclusions:The biosynthesis of silver nanoparticles using bark aqueous extract of F.racemosa and its larvicidal activity against the larvae of disease spreading vectors.The maximum larvicidal efficacy was observed in the synthesized Ag NPs. | Kanayairam Velayutham Abdul Abdul Rahuman Govindasamy Rajakumar Selvaraj Mohana Roopan Gandhi Elango Chinnaperumal Kamaraj Sampath Marimuthu Thirunavukkarasu Santhoshkumar Moorthy Iyappan Chinnadurai Siva | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，2： | 2 |
| 3 | Acaricidal activity of synthesized titanium dioxide nanoparticles using Calotropis gigantea against Rhipicephalus microplus and Haemaphysalis bispinosa显示文摘Objective:To assess the acaricidal activity of titanium dioxide nanoparticles(TiO_2 NPs)synthesized from flower aqueous extract of Calotropis gigantea(C.gigantea)against the larvae of Rhipicephalus(Boophilus)microplus[R.(B.)microplus]and the adult of Haemaphrysalis bispinosa(H.bispinosa).Methods:The lyophilized C.gigantea flower aqueous extract of 50 mg was added with 100 mL of TiO(OH_2)(10 mM)and magnetically stirred for 6 h.Synthesized TiO_2 NPs were characterized by X-ray diffraction(XRD).Fourier transform infrared spectroscopy(FTIR),Scanning electron microscopy(SEM),and Energy dispersive X-ray spectroscopy(EDX).The synthesised TiO_2 NPs were tested against the larvae of R(B.)microplus and adult of H.bispinosa were exposed to filter paper impregnated method.Results:XRD confirmed the crystalline nature of the nanoparticles with the mean size of 10.52 nm.The functional groups for synthesized TiO_2NPs were 1405.19,and 1053.45 cm^(-1)for-NH_2 bending,primary amines and amides and 1053.84and 1078.45 cm^(-1)for C-O.SEM micrographs of the synthesized TiO_2 NPs showed the aggregated and spherical in shape.The maximum efficacy was observed in the aqueous flower extract of C.gigantea and synthesized TiO_2 NPs against R.(B.)microplus(LC_(50)=24.63 and 5.43 mg/L and r^2=0.960 and 0.988)and against H.bispinosa(LC_(50)=35.22 and 9.15 mg/L and r^2=0.969 and 0.969).respectively.Conclusions:The synthesized TiO_2 NPs were highly stable and had significant acaricidal activity against the larvae of R.(B.)microplus and adult of H.bispinosa.This study provides the first report of synthesized TiO_2 NPs and possessed excellent anti-parasitic activity. | Sampath Marimuthu Abdul Abdul Rahuman Chidambaram Jayaseelan Arivarasan Vishnu Kirthi Thirunavukkarasu Santhoshkumar Kanayairam Velayutham Asokan Bagavan Chinnaperumal Kamaraj Gandhi Elango Moorthy Iyappan Chinnadurai Siva Loganathan Karthik Kokati Venkata Bhaskara Rao | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，9： | 2 |
| 4 | Biosynthesis of titanium dioxide nanoparticles using bacterium Bacillus subtilis显示文摘 | A.Vishnu Kirthi A. Abdul Rahuman G. Rajakumar S. Marimuthu T. Santhoshkumar C. Jayaseelan G. Elango A. Abduz Zahir C. Kamaraj A. Bagavan | 2011 | Materials Letters2011，，17： | 2 |
| 5 | Cataract-causing aAG98R mutant shows substrate-dependent chaperone activity显示文摘 | Murugesan R Santhoshkumar P Sharma KK | | 0，，： | 1 |
| 6 | Efficacy of plant-mediated synthesized silver nanoparticles against hematophagous parasites显示文摘 | Chidambaram Jayaseelan Abdul Rahuman Govindasamy Rajakumar Thirunavukkarasu Santhoshkumar Arivarasan Kirthi Sampath Marimuthu Asokan Bagavan Chinnaperumal Kamaraj Abdul Zahir Gandhi Elango Kanayairam Velayutham Kokati Rao Loganathan Karthik Sankariah Rave | 2012 | Parasitology Research2012，，2： | 1 |
| 7 | J Chromatogr B显示文摘 | Deutsch J C SanthoshKumar C R | 1996 | 677(1) : 1471996，677，1： | 1 |
| 8 | Phe71 is essential for chaperone-like function in alpha A-crystallin显示文摘 | Santhoshkumar P Sharma KK | 2001 | J Biol Chem2001，276，47： | 1 |
| 9 | Drug-induced senescence generates chemoresistant stemlike cells with low reactive oxygen species显示文摘 | Achuthan S Santhoshkumar TR Prabhakar J Nair SA Pillai MR | 2011 | J Biol Chem2011，286，37： | 1 |
| 10 | Highly Oriented(100)ZnO Thin Films by Spray Pyrolysis显示文摘 | Prasada R T Santhoshkumar M C | 2009 | Applied Surface Science2009，255，16： | 1 |
| 11 | Spectrally selective CrMoN/CrON tandem absorber for mid-temperature solar thermal applications显示文摘 | Selvakumar N Santhoshkumar S Basu S et a1 | 2013 | Solar Energy Mater Solar Cells2013，97，： | 1 |
| 12 | Drug-induced senescence generates chemoresistant stemlike cells with low reactive oxygen species显示文摘 | Achuthan S Santhoshkumar TR Prabhakar J | 2011 | J Biol Chem2011，286，37： | 1 |
| 13 | Effect of a single AGE modification on the structure and chaperone activity of human aB-crystallin显示文摘 | BHATTACHARYYA J SHIPOVA E V SANTHOSHKUMAR P | 2007 | Biochemistry2007，46，14： | 1 |
| 14 | Significance of interactions of low molecular weight crystallin fragments in lens aging and cataract formation显示文摘 | Santhoshkumar P Udupa P Murugesan R | 2008 | J Biol Chem2008，283，13： | 1 |
| 15 | A Pre-run-time scheduling algorithm for object-based distributed real-time systems显示文摘 | Manimaran G Siva Ram Murthy C | 1999 | Journal of Systems Architecture1999，45，14： | 1 |
| 16 | Effect of a single AGE modification on the structure and chaperone activity of human alphaB-crystallin显示文摘 | Bhattacharyya J Shipova EV Santhoshkumar P | 2007 | Biochemistry2007，46，14： | 1 |
| 17 | Lens aging: effects of crystallins显示文摘 | Sbanna KK Santhoshkumar P | 2009 | Bioehim Biophys Acta2009，1790，10： | 1 |
| 18 | Lousicidal activity of synthesized silver nanoparticles using Lawsonia inermis leaf aqueous extract against Pediculus humanus capitis and Bovicola ovis显示文摘 | Sampath Marimuthu Abdul Abdul Rahuman Thirunavukkarasu Santhoshkumar Chidambaram Jayaseelan Arivarasan Vishnu Kirthi Asokan Bagavan Chinnaperumal Kamaraj Gandhi Elango Abdul Abduz Zahir Govindasamy Rajakumar Kanayairam Velayutham | 2012 | Parasitology Research2012，，5： | 1 |
| 19 | Antimalarial activities of medicinal plants traditionally used in the villages of Dharmapuri regions of South India显示文摘 | Chinnaperumal Kamaraj Naveen Kumar Kaushik Abdul Abdul Rahuman Dinesh Mohanakrishnan Asokan Bagavan Gandhi Elango Abdul Abduz Zahir Thirunavukkarasu Santhoshkumar Sampath Marimuthu Chidambaram Jayaseelan Arivarasan Vishnu Kirthi Govindasamy Rajakumar Kana | 2012 | Journal of Ethnopharmacology2012，，3： | 1 |
| 20 | Efficacy of botanical extracts against Japanese encephalitis vector, Culex tritaeniorhynchus显示文摘 | Gandhi Elango Abdul Abdul Rahuman Asokan Bagavan Chinnaperumal Kamaraj Abdul Abduz Zahir Govindasamy Rajakumar Sampath Marimuthu Thirunavukkarasu Santhoshkumar | 2010 | Parasitology Research2010，，2： | 1 |
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