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| 1 | Histopathological studies and oxidative stress of synthesized silver nanoparticles in Mozambique tilapia (Oreochromis mossambicus)显示文摘To evaluate the potential environmental effects of engineered nano metals,it is important to determine the adverse effects of various nanomaterials on aquatic species.Adult tilapia (Oreochromis mossambicus) were maintained in 10 L glass aquaria,and exposed to a graded series of synthesized silver nanoparticles (Ag-NPs) at 25,50 and 75 mg/L for eight days.The LC 50 value was 12.6 mg/L.Reduced activities of antioxidant enzymes and the contents of antioxidants were lowered in the gills and liver of fishes treated with AgNPs,which resulted in heavy accumulation of free radicals.Histopathological results imply that the balance between the oxidative and antioxidant system in the fish was broken down during Ag-NPs exposure.The principal concern related with the release of nanomaterials and their smaller particle may change the materials transport and potential toxicity to aquatic organisms compared to larger particles. | Rajakumar Govindasamy Abdul Abdul Rahuman | 2012 | Journal of Environmental Sciences2012，24，6： | 14 |
| 2 | 2002~2005年期间萨斯喀彻温省儿科三级医疗中心因呼吸道合胞病毒感染住院的儿童病例分析(英文)显示文摘中文概呼吸道合胞病毒(RSV)是2岁以下儿童呼吸道感染最常见的病原体,也是引起婴儿病毒感染所致死亡的主要原因。到目前为止,尚未见加拿大萨斯喀彻温省RSV流行病学的研究报道。本研究的目的是描述2002年7月至2005年6月期间在萨斯喀彻温省的两个儿科三级医疗中心,即皇家大学医院(RUH)和萨斯卡通和里贾纳总医院(RGH),因RSV感染住院的儿童的流行病学特点及疾病严重程度,其中部分患儿有帕利珠单抗(palivizumab)预防史。 在上述2个医疗中心住院时间≥24h的儿童(年龄:从出生到16岁11个月)经实验室病毒鉴定确诊为RSV感染的儿童纳入本研究。在RUH中心,患儿鼻咽部分泌物经直接荧光抗体(DFA)检测阳性者确诊为RSV感染。如果DFA为阴性,则对该标本进行病毒培养。在RGH中心,所有患儿鼻咽部分泌物标本均进行DFA检测和病毒培养。确诊后对患儿的健康记录进行回顾性分析,内容包括患儿的人口统计信息、转诊模式、帕利珠单抗预防史、感染严重程度及转归。目前尚无统一的感染严重程度的判断标准,本研究根据住院时间、是否需要小儿重症监护及持续时间、是否机械通气等进行评估。在研究期间,萨斯喀彻温省的帕利珠单抗预防的标准与加拿大儿科学会(CPS)的建议一致。 2002年7月至2005年6月3年期间,总共有590名RSV儿童(包括324名男童)住院治疗,共602次住院记录,其中12名儿童住院1次以上。入院时患儿中位实足年龄为5.3个月,平均住院时间为4.0d(范围:〈1d至121.2个月)。82.4%的患儿出生时胎龄≥36周,7.5%为33-35周,9.5%≤32周。RSV感染住院情况呈现季节性模式,其中大部分发生在三月和六月。患儿最常见的临床表现为细支气管炎(70.2%),38.1%表现为肺炎,17.3%为上呼吸道感染,0.5%表现为哮吼(患儿可能同时有1个以上的临床表现)。478例(81.0%)为RSV轻度至中度感染,110例(18.6%)为重度感染。25.1%的患儿有继发性细菌感染。共有39例(6.7%)需要入住儿科重症监护病房(PICU),中位入住时间为5.0d。其中,22例重症患儿(56%)需要机械通气(通气时间中位数6.0d),14例重症患儿(36%)有继发性细菌感染。与入住普通病房的患儿比较,PICU患儿大多有如下情况:入院时年龄较小(P〈0.01),有潜在的肺部疾病(P〈0.01)或先天性心脏疾病(P=0.01),有两个或更多潜在的疾病(P〈0.01),与其他儿童共同居住(P=0.02)。在本研究过程中,2例儿童死亡,但均与RSV感染无关。 本研究有22例患儿在入院前接受过帕利珠单抗预防RSV感染,其中18例已完成至少2个月的剂量,17例(77%)有1个或以上的慢性疾病,14例(64%)出生时胎龄不超过32周。入院时中位实足年龄为5.6个月(范围0-27.5个月),中位住院时间为9.5d(范围2-271d)。大多数儿童(17/22)为轻度至中度RSV感染。 小结:RSV在萨斯喀彻温省保持较高的发病率,男性、实足年龄小于1岁的足月儿或晚期早产儿发病率较高。细支气管炎是最常见的临床表现。大多数患儿呈轻度至中度感染,但约7%的患儿需要重症监护。较小的实足年龄、潜在的肺部或心脏疾病或多个潜在疾病等因素均有可能导致患儿需要重症监护。此外,与其他孩子同住也有可能是导致患儿需要重症监护的一个因素。需要重症监护的患儿往往胎龄大于35周。虽然部分接受过帕利珠单抗预防的患儿也感染了RSV,但是其大部分患儿的病情为轻度至中度。这些曾接受过帕利珠单抗预防的患儿更可能有潜在疾病,并且出生时胎龄往往小于32周。在本研究中,无一例因RSV感染而引起的死亡病例。本研究尚浅,需要开展更深入的研究,以进一步确定RSV患儿,特别是PICU患儿以及曾接受过帕利珠单抗预防却仍然受到RSV感染的患儿的特征。 | Ayisha Kurji Ben Tan Jaya Bodani Bonnie Janzen Athena McConnell Rachana Bodani Derek Rajakumar Anil Sharma Koravangattu Sankaran | 2014 | 中国当代儿科杂志2014，16，10： | 3 |
| 3 | Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner显示文摘遇到 hypoxic 应力的房间由 downregulating 保存资源和精力蛋白质合成。这里我们 demonstratethat 在这回答的一机制是最高的 mRNAs 的翻译压抑编码 translationalapparatus 的部件。规定的这个模式包含 TSC 和 Rheb,当 Rheb 的 TSC1 或 TSC2 或 overexpression 的大美人在剥夺氧的房间救了最高的 mRNA 翻译。导致压力的翻译 repressionof 这些 mRNAs 密切与 4E-BP 的 hypophosphorylated 状态相关,一个翻译抑压者。然而, seriesof 4E-BP loss-of-function 和 gain-of-function 实验在氧或生长因素剥夺下面反驳在 phosphorylation statusof 4E-BP 和最高的 mRNAs 的翻译压抑之间的一种 cause-and-effect 关系。而且,血缺氧的 repressiveeffect 类似于由 Torin 1,而是更多 pronouncedthan 猛禽或 rictor 大美人由 mTOR 活动的有效抑制到达了那。同样,猛禽或 rictor 的缺乏它温和地 downregulated TOPmRNAs 的基础翻译效率,没能压制最高的 mRNAs 的调停氧的翻译激活。最后, TIA-1 和 TIAR co 击倒,二 RNA 有约束力的蛋白质以前在氨基的酸饥饿的房间在最高的 mRNAs 的翻译压抑含有, failedto 在另外的压力条件下面减轻最高的 mRNA 翻译。因此,近似翻译管理者 ofTOP mRNAs 的性质留下逃犯。 | Rachel Miloslavski Elad Cohen Adam Avraham Yifat I luz Zvi Hayouka Judith Kasir Rajini Mudhasani Stephen N. Jones Nadine Cybulski Markus A. Ruegg Ola Larsson Valentina Gandin Arjuna Rajakumar Ivan Topisirovic Oded Meyuhas | 2014 | Journal of Molecular Cell Biology2014，8，3： | 3 |
| 4 | Larvicidal activity of green synthesized silver nanoparticles using bark aqueous extract of Ficus racemosa against Culex quinquefasciatus and Culex gelidus显示文摘Objective:To investigate the larvicidal activity of synthesized silver nanoparticles(Ag NPs) utilizing aqueous bark extract of Ficus racemosa(F.racemosa) was tested against fourth instar larvae of filariasis vector,Culex quinquefasciatus(Cx.quinquefasciatus) and japanese encephalitis vectors,Culex gelidus(Cx.gelidus).Methods:The synthesized Ag NPs was characterized by UV-vis spectrum,X-ray diffraction(XRD),Scanning electron microscopy(SEM) and Fourier transform infrared(FTIR).The larvicidal activities were assessed for 24 h against the larvae of Cx.quinquefasciatus and Cx.gelidus with varying concentrations of aqueous bark extract off.racemosa and synthesized Ag NPs.LC50 and r2 values were calculated.Results:The maximum efficacy was observed in crude aqueous extract of F.racemosa against the larvae of Cx.quinquefasciatus and Cx.gelidus(LC50=67.72 and 63.70 mg/L;r2=0.995 and 0.985) and the synthesized Ag NPs(LC50=12.00 and 11.21 mg/L;r2=0.997 and 0.990).respectively.Synthesized Ag NPs showed the XRD peaks at 2θvalues of 27.61,29.60,35.48,43.48 and 79.68 were identified as (210),(121),(220),(200) and(311) reflections,respectively.The FTIR spectra of Ag NPs exhibited prominent peaks at 3 425,2 878,1 627 and 1 382 in the region 500-3 000 cm-1.The peaks correspond to the presence of a stretching vibration of(NH) C=O group.SEM analysis showed shape in cylindrical,uniform and rod with the average size of 250.60 nm.Conclusions:The biosynthesis of silver nanoparticles using bark aqueous extract of F.racemosa and its larvicidal activity against the larvae of disease spreading vectors.The maximum larvicidal efficacy was observed in the synthesized Ag NPs. | Kanayairam Velayutham Abdul Abdul Rahuman Govindasamy Rajakumar Selvaraj Mohana Roopan Gandhi Elango Chinnaperumal Kamaraj Sampath Marimuthu Thirunavukkarasu Santhoshkumar Moorthy Iyappan Chinnadurai Siva | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，2： | 2 |
| 5 | 2219-T87铝合金的中心表面裂纹拉伸试样的断裂强度(英文)显示文摘将2219-T87铝合金板材进行低温拉伸试验,用改进的固有缺陷模型分析铝合金基材和焊接接头金属表面裂纹试样的断裂强度数据,通过构成的失效评估图来确定材料的断裂参数。通过考虑材料的极限拉伸强度、铝基材及焊接接头金属的断裂强度数据,对具有不同厚度的中心表面裂纹拉伸试样进行断裂分析。由拉伸断裂板材所得到的失效评估图能够应用到由相同材料构成的任何开裂组件的失效压力估计。 | S. RAJAKUMAR T. CHRISTOPHER | 2011 | Transactions of Nonferrous Metals Society of China2011，21，12： | 2 |
| 6 | Translational Genomics to Develop a Salmonella enterica Serovar Paratyphi A Multiplex Polymerase Chain Reaction Assay显示文摘 | Hong-Yu Ou Cindy Teh Shuan Ju Kwai-Lin Thong Norazah Ahmad Zixin Deng Michael R. Barer Kumar Rajakumar | 2007 | The Journal of Molecular Diagnostics2007，，5： | 2 |
| 7 | Eclipta prostrata leaf aqueous extract mediated synthesis of titanium dioxide nanoparticles显示文摘 | G. Rajakumar A. Abdul Rahuman B. Priyamvada V. Gopiesh Khanna D. Kishore Kumar P.J. Sujin | 2011 | Materials Letters2011，，： | 2 |
| 8 | Biosynthesis of titanium dioxide nanoparticles using bacterium Bacillus subtilis显示文摘 | A.Vishnu Kirthi A. Abdul Rahuman G. Rajakumar S. Marimuthu T. Santhoshkumar C. Jayaseelan G. Elango A. Abduz Zahir C. Kamaraj A. Bagavan | 2011 | Materials Letters2011，，17： | 2 |
| 9 | The influence of weathering on the reduction of llmenite with carbon显示文摘 | Suresh K. Gupta V. Rajakumar Paul Grieveson | 1989 | Metallurgical Transactions B1989，，： | 1 |
| 10 | Time to frequency domain conversion of step response data显示文摘 | Rajakumar A Krishnaswamy P R | 1975 | Industrial & Engineering Chemical Research (S0888-5885)1975，14，： | 1 |
| 11 | Influence of friction stir welding process and tool parameters on strength proper- ties of AA7075-T6 aluminum alloys joints 显示文摘 | Rajakumar S Muralidharan C Balasubramanian V | 2011 | Materials and De- sign2011，32，： | 1 |
| 12 | Cardiac enzyme levels in myocardial dysfunction in newborns with perinatal asphyxia 显示文摘 | Rajakumar PS Bhat BV Sridhar MG | 2008 | Indian J Pediatr2008，75，12： | 1 |
| 13 | Use of slide latex agglutination test for rapid diagnosis of vaginal candidosis显示文摘 | Rajakumar R Lacey CJ Evans EG | 1987 | Genitourin Med1987，63，3： | 1 |
| 14 | Effects of gender and estradiol treatment on focal brain ischemia显示文摘 | Zhang YQ Shi J Rajakumar G | 1998 | Brain Res1998，784，12： | 1 |
| 15 | Solar ultraviolet radiation and vitamin D;a historical perspective 显示文摘 | Rajakumar K Greenspan SL Thomas SB | 2007 | Am J Pub Health2007，97，10： | 1 |
| 16 | Testosterone increases and estradiol decreases middle cerebral artery occlusion lesion size in male rats显示文摘 | Hawk T Zhang YQ Rajakumar G | 1998 | Brain Res1998，796，12： | 1 |
| 17 | Synthesis,stud-y on anti-arthritic, anti-inflammatory activity and toxicityof some novel bis-oxy cyclophane diamides 显示文摘 | Rajakumar P Padmanabhan R Rajesh N | 2012 | BioorgMed Chem tef2012，22，11： | 1 |
| 18 | Leptin affects system A amino acid transport activity in the human placenta: evidence for STAT3 dependent mechanisms显示文摘 | von Versen-H ynck F Rajakumar A Parrott M | 2009 | Placenta2009，30，： | 1 |
| 19 | Trans-activators regulating neuronal glucose transporter isoform-3 gene expression in mammalian neurons显示文摘 | Rajakumar A Thamotharan S Devaskar SU | | 0，，25： | 1 |
| 20 | Selective overexpression of the hypoxia-inducible transcription factor,HIF-2α,in placentas from women with preeclampsia显示文摘 | Rajakumar A Whitrlock A Weissfeld R | 2001 | Biology of Reproduction2001，64，： | 1 |
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