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| 1 | Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound显示文摘AIM:To evaluate whether contrast enhanced ultrasound(CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer.METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal cancer underwent CEUS before treatment(CEUS date 1) and before the second(CEUS date 2) and fourth(CEUS date 3) cycle of bevacizumab based chemotherapy.Three parameters [PEAK,Time to peak(TTP) and RISE RATE]were correlated with radiological response.RESULTS:For neoadjuvant purpose a reduction of tumour mass was required to assume clinical response.Based on these response criteria there was a significant(P < 0.001) correlation in TTP between metastases of responders(9.08 s) and non-responders(14.76 s) archived on CEUS date 1.By calculating a standardized quotient(metastases divided by normal liver tissue) we were able to define a cut off,predicting response with a sensitivity of 92.3 % and a specificity of 100 %.To reflect a palliative intention only those patients with progressive disease were classified as non-responders.In this stetting TTP was also significantly(P < 0.01) different between responders and non-responders.In contrast,Peak and Rise rate did not show any significant difference between responder and non-responder.CONCLUSION:CEUS might serve as a surrogate marker to predict treatment response in patients with metastasized colorectal cancer who receive antiangiogenic therapy. | Ramin Schirin-Sokhan Ron Winograd Christoph Roderburg Jhenee Bubenzer Nicole Cabral do ó Dorothee Guggenberger Hartmut Hecker Christian Trautwein Jens J W Tischendorf | 2012 | World Journal of Gastroenterology2012，18，6： | 16 |
| 2 | m TOR signaling in liver regeneration: Rapamycin combined with growth factor treatment显示文摘AIM: To investigate the effects of mammalian target of rapamycin(mT OR) inhibition on liver regeneration and autophagy in a surgical resection model.METHODS: C57BL/6 mice were subjected to a 70% partial hepatectomy(PH) and treated intraperitoneally every 24 h with a combination of the m TOR inhibitor rapamycin(2.5 mg/kg per day) and the steroid dexamethasone(2.0 mg/kg per day) in phosphate bufferedsaline(PBS) or with PBS alone as vehicle control. In the immunosuppressant group, part of the group was treated subcutaneously 4 h prior to and 24 h after PH with a combination of human recombinant interleukin 6(IL-6; 500 μg/kg per day) and hepatocyte growth factor(HGF; 100 μg/kg per day) in PBS. Animals were sacrificed 2, 3 or 5 d after PH and liver tissue and blood were collected for further analysis. Immunohistochemical staining for 5-Bromo-2'-deoxyuridine(Brd U) was used to quantify hepatocyte proliferation. Western blotting was used to detect hepatic microtubule-associated protein 1 light chain 3(LC3)-Ⅱ protein expression as a marker for autophagy. Hepatic gene expression levels of proliferation-, inflammation- and angiogenesisrelated genes were examined by real-time reverse transcription-polymerase chain reaction and serum bilirubin and transaminase levels were analyzed at the clinical chemical core facility of the Erasmus MC-University Medical Center.RESULTS: m TOR inhibition significantly suppressed regeneration, shown by decreased hepatocyte proliferation(2% vs 12% Brd U positive hepatocyte nuclei at day 2, P < 0.01; 0.8% vs 1.4% at day 5, P = 0.02) and liver weight reconstitution(63% vs 76% of initial total liver weight at day 3, P = 0.04), and furthermore increased serum transaminase levels(aspartate aminotransferase 641 U/L vs 185 U/L at day 2, P = 0.02). Expression of the autophagy marker LC3-Ⅱ, which was reduced during normal liver regeneration, increased after mT OR inhibition(46% increase at day 2, P = 0.04). Hepatic gene expression showed an increased inflammation-related response [tumor necrosis factor(TNF)-α 3.2-fold upregulation at day 2, P = 0.03; IL-1Ra 6.0-fold upregulation at day 2 and 42.3-fold upregulation at day 5, P < 0.01] and a reduced expression of cell cycle progression and angiogenesis-related factors(HGF 40% reduction at day 2; vascular endothelial growth factor receptor 2 50% reduction at days 2 and 5; angiopoietin 1 60% reduction at day 2, all P ≤ 0.01). Treatmentwith the regeneration stimulating cytokine IL-6 and growth factor HGF could overcome the inhibitory effect on liver weight(75% of initial total liver weight at day 3, P = 0.02 vs immunosuppression alone and P = 0.90 vs controls) and partially reversed gene expression changes caused by rapamycin(TNF-α and IL-1Ra levels at day 2 were restored to control levels). However, no significant changes in hepatocyte proliferation, serum injury markers or autophagy were found.CONCLUSION: mT OR inhibition severely impairs liver regeneration and increases autophagy after PH. These effects are partly reversed by stimulation of the IL-6 and HGF pathways. | Suomi MG Fouraschen Petra E de Ruiter Jaap Kwekkeboom Ron WF de Bruin Geert Kazemier Herold J Metselaar Hugo W Tilanus Luc JW van der Laan Jeroen de Jonge | 2013 | World Journal of Transplantation2013，3，3： | 6 |
| 3 | Organizational decision support system for effective R&D project selection 显示文摘 | TIAN Q MA J LIANG J RON C W K OU L | 2005 | Decision Support Systems2005，39，3： | 1 |
| 4 | Drug interaction between St John's wort and nevirapine显示文摘 | de Maat Monique MR Hoetelmans Richard M W Mathot Ron A A | 2001 | AIDS2001，15，3： | 1 |
| 5 | Aspects of intracerebral hematomas-an update显示文摘 | Ronning P Sorteberg W Nakstad P | 2008 | 118(6):347-3612008，118，6： | 1 |
| 6 | Application of quantitative analytical electron microscopy to the rnineral content of insect cuticle显示文摘 | Ron Rasch Bronwen W Cribb John Barry | 2003 | Microscopy and Microanalysis2003，，： | 1 |
| 7 | Simulink model for economic analysis and envi- ronmental impacts of a PV with diesel-battery system for remote village 显示文摘 | Wies Richard W Johnson Ron A Agrawal Ashisb N | 2005 | IEEE Transactions on Power Sys- tems2005，20，2： | 1 |
| 8 | Continuous Path Verification in Multi-axis NC-machining显示文摘 | Ron W Gershon E | | 0，，04： | 1 |
| 9 | The prevalence of treatable left ventricular systolic dysfunction in patients who present with noncardiac vascular episodes:a case-control study显示文摘 | Anthony S Ron M W | 2002 | J Am Coll Cardiol2002，39，： | 1 |
| 10 | Aspects of iutracerebral hematonms-an update 显示文摘 | Ronning P Sorteberg W Nakstad P | 2008 | Acta Neurol Seand2008，118，6： | 1 |
| 11 | Goede on the relationships between nematodes,mycorrhizal fungi and plants:functional composition of species and plant performance显示文摘 | Brussaard L Thomas W K Ron G M | 2001 | Plant and Soil2001，232，12： | 1 |
| 12 | Organizational Decision Support System for Effective R&D Project Selection 显示文摘 | Tian Q Ma J Liang J Ron C W K Ou L | 2005 | Decision Support Systems2005，39，3： | 1 |
| 13 | The Visibility-voronoi complex and its appli- cations 显示文摘 | RON W | 2007 | Computational Geometry2007，36，26： | 1 |
| 14 | KNN-kemel density- based clustering for high dimensional multivariate data显示文摘 | Thanh N T Ron W Kutgarde M C | 2006 | Computational Statistics and Data Analysis2006，51，2： | 1 |
| 15 | A genome scan for QTL influencing milk production and health traits in dairy cattle 显示文摘 | Heyen D W Weller JI Ron R | 1999 | Physiol Genomics1999，1，： | 1 |
| 16 | Purification, immu- nolocalization, cryoproteetive, and antifreeze activity of PCA 60: A dehydrin from peach(Prunus persica ) 显示文摘 | Michael W Robert W Ron B | 1999 | Physiologia Plantarum1999，105，4： | 1 |
| 17 | Affine systems in L2 (Rd):the analysis of the analysis operator显示文摘 | Ron A Shen Z W | | 0，，02： | 1 |
| 18 | Lower Risk of Cancer in Patients on Metformin in Comparison With Those on Sulfonylurea Derivatives: Results from a large population-based follow-up study显示文摘 | Ruiter Rikje Visser Loes E van Herk-Sukel Myrthe P P Coebergh Jan-Willem W Haak Harm R Geelhoed-Duijvestijn Petronella H Straus Sabine M J M Herings Ron M C Stricker Bruno H CH | 2012 | Diabetes Care2012，，1： | 1 |
| 19 | Macadamia nutconsumption lowers plasma total and LDL cholesterol levels inhypercholesterolemic men显示文摘 | Manohar L G Robert J B Ron B H W | 2003 | The Journal of Nutrition2003，133，4： | 1 |
| 20 | A genome scan for QTL influencing milk production and health traits in dairy cattle显示文摘 | Heyen D W Weller J I Ron M | 1999 | Physiol Genomics1999，1，3： | 1 |
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