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| 1 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 2 | The effect of local attachment of cationized antioxidant enzymes on experimental colitis in the rat 显示文摘 | Sigal B Ron K Paul B | 2000 | Pharm Res2000，17，9： | 1 |
| 3 | Soil zoology:an indispensable component of integrated ecosystem studies显示文摘 | RON G G L IJBERT B | 2002 | European Journal of Soil Biology2002，38，： | 1 |
| 4 | Chop deletion reduces oxidative stress,improvesβcell function,and promotes cell survival in multiple mouse models of diabetes显示文摘 | Song B Scheuner D Ron D | 2008 | J Clin Invest2008，118，： | 1 |
| 5 | Antibiotics against Pseudomonas aeruginosa for COPD exacerbation in ICU:a 10-year retrospective study显示文摘 | Planquette B Péron J Dubuisson E | 2015 | Int J Chron Obstruct Pulmon Dis2015，10，： | 1 |
| 6 | From safety verification to safety testing 显示文摘 | Rusu V MARCHAND H TSCHAEN V JE'RON T JEANNET B | 2004 | Lecture Notes in Computer Science LNCS2004，2978，： | 1 |
| 7 | Clustering gene expression patterns显示文摘 | Ron S Zohar Y | 1999 | Joumal of Computational Biology1999，6，34： | 1 |
| 8 | New criteria of performance management A transition from enterprise to collaborative Supply Chain显示文摘 | Ron B | 2001 | Measureing Bussiness Excellence 52001，，4： | 1 |
| 9 | Framelets: MRA-based Constructions of Wavelet Frames 显示文摘 | Daubechies I Han B Ron A | 2003 | Applied Computational Harmonic Analysis2003，14，1： | 1 |
| 10 | Stroke units versus general medical wards, I: Twelve- and eighteen-month survival: a randomised,controlled trial显示文摘 | Ronning OM Guldvog B | 1998 | Stroke1998，29，： | 1 |
| 11 | Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in mul- tiple mouse models of diabetes显示文摘 | Song B Scheuner D Ron D | 2008 | J Clin Invest2008，118，10： | 1 |
| 12 | Identification of genes potentially involved in rupture of human atherosclerotic plaques显示文摘 | Birgit C G F Kitty B J M C Ron L J N | 2001 | Circ Res2001，89，6： | 1 |
| 13 | The benefit of an acute stroke unit in patients with intracranial haemorrhage: a controlled trial 显示文摘 | RONNING 0 M GULDVOG B STAVEM K | 2001 | J Neurol Neurosurg Psychiatry2001，70，5： | 1 |
| 14 | A fractal-based algorithm for detecting first arrivals on seismic traces显示文摘 | Mike D D Ron D L | 1993 | Geophysics1993，61，4： | 1 |
| 15 | Progression from paroxysmal to persistent atrial fibrillation 显示文摘 | CEES B DE VOS RON PISTERS ROBBY NIEUWLAAT | 2010 | J Am Coil Cardiol2010，55，8： | 1 |
| 16 | The chemistry of five canary pleurocarpous mosses : chemosystematic relationship 显示文摘 | Alfatate MG Estebanez B Ron E | 1997 | Biochem System Ecol1997，25，1： | 1 |
| 17 | Tamoxifen inhibits topoisomerases,depletes mitochondrial DNA and triggers steatosis in mouse liver显示文摘 | Larosche I Lettéron P Fromenty B | | 0，，02： | 1 |
| 18 | Volatile constituents of Asian pear(Pyrus serotina)显示文摘 | Gary R T Ron G B Robert A F | 1992 | Food Chemistry1992，4，： | 1 |
| 19 | Stroke units versus general medical wards,Ⅰ:twelve and eighteen months survival:a randomized,controlled trial显示文摘 | Ronning OM Gullrog B | 1998 | Stroke1998，29，1： | 1 |
| 20 | Epitaxial BiFeO3 multiferroic thin film heterostructure 显示文摘 | WANG J NEA'rON J B ZHENG H | 2003 | Sci- ence2003，299，： | 1 |
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