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	题名	作者	年代	出处	被引量
1	Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option.	Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres	2012	World Journal of Gastroenterology2012，18，25：	5
2	Improved clinical outcome using polytetrafluoroethylene-coated stents for tips: Results of a randomized study显示文摘	Christophe Bureau Juan carlos Garcia-Pagan Philippe Otal Gilles Pomier-Layrargues Valérie Chabbert Carlos Cortez Pierre Perreault Jean marie Péron Juan G. Abraldes Louis Bouchard José Ignacio Bilbao Jaume Bosch Hervé Rousseau Jean pierre Vinel	2004	Gastroenterology2004，，2：	3
3	Aspects of intracerebral hematomas-an update显示文摘	Ronning P Sorteberg W Nakstad P	2008	118(6):347-3612008，118，6：	1
4	Antibiotics against Pseudomonas aeruginosa for COPD exacerbation in ICU:a 10-year retrospective study显示文摘	Planquette B Péron J Dubuisson E	2015	Int J Chron Obstruct Pulmon Dis2015，10，：	1
5	Carbon membraneds from precursors containing low-carbon residual polymers显示文摘	Linkov Vhdimir M Sanderson Ron D Jacobs Ed P	1994	Polymer International1994，35，3：	1
6	Signal integration in the endoplasmic retieulum unfolded protein response 显示文摘	Ron D Walter P	2007	Nat Rev Mol Cell Biol2007，8，7：	1
7	Switching characteristics of a gas trigatron operated in single and double trigger mode显示文摘	NANU K RON P H IYENGAR S T	1990	IEEE Transactions on Electrical Insulation1990，25，2：	1
8	Signal integration in the endoplasmic reticulum unfolded protein response显示文摘	Ron D Walter P	2007	Nat Rev Mol Cell Biol2007，8，7：	1
9	Thyroid cancer and multiple primary tumors in the SEER cancer registries显示文摘	Ronckers CM Mccarron P Ron E	2005	Int J Cancer2005，117，2：	1
10	Signal interaction in the endoplasmic retieulum un-folded protein response 显示文摘	Ron D Walter P	2007	Nat Rev Mol Cell Biol2007，8，7：	1
11	Signal integration in the endoplasmic reticulum unfolded protein response显示文摘	Ron D Walter P	2007	Nat Rev Mol Cell Biol2007，8，7：	1
12	The unfolded protein response: from stress pathway to homeostatic regulation 显示文摘	Walter P Ron D	2011	Science2011，334，6059：	1
13	Proteomic analysis of dendritic cell-derived exosomes:a secreted subcellular compartment distinct from apoptotic vesicles显示文摘	Théry C Boussac M Véron P	2001	J Immunol2001，166，12：	1
14	Flow in the engine com-partment:analysis and optimization显示文摘	D’Hondt M Gilliéron P Devinant P	2011	International Journal ofAerodynamics2011，134，：	1
15	The unfolded protein response: from stress pathway to homeostatic regulation显示文摘	Walter P Ron D	2011	Science2011，334，6059：	1
16	Stroke unit care benifits patients with intracerebral hemorrhage: systematic review and meta-analysis 显示文摘	LANGHORNE P FEARON P RONNING O M	2013	Stroke2013，44，11：	1
17	Signal integration in the endoplasmic reticulum unfolded protein response显示文摘	Ron D Walter P		0，，07：	1
18	Signal integration in the endoplasmic reticulum unfolded protein response显示文摘	Ron D Walter P	2007	Nat Rev Mol Cell Biol2007，8，7：	1
19	Accurate visible speech synthesis based on concatenating variable length显示文摘	Ma J Cole Ron Bryan P	2006	IEEE Transactions on Visualization and Computer Graphics2006，12，2：	1
20	A core collection of common bean from the Iberian peninsula 显示文摘	Rodino A P Santalla M Ron A M D	2003	Euphytica2003，131，：	1

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