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| 1 | 制造型企业如何卖服务显示文摘许多制造公司在其产品开始同质化时,常常试图通过提供增值服务来获得竞争优势。这种战略一旦奏效,会给公司带来巨大收益。公司甚至可能会发现,提供服务比产品本身更赚钱。但是,与每个成功故事相伴的是,至少有5个警示性的事例发生,提醒我们制造公司要从服务业务中获取利润,并非易事。 | 维尔纳·赖纳茨(Werner Reinartz) 沃尔夫冈·乌拉加(Wolfgang Ulaga) 张乐(翻译) | 2008 | 商业评论2008，，7： | 6 |
| 2 | Human intestinal acyl-CoA synthetase 5 is sensitive to the inhibitor triacsin C显示文摘AIM:To investigate whether human acyl-CoA synthetase 5(ACSL5) is sensitive to the ACSL inhibitor triacsin C.METHODS:The ACSL isoforms ACSL1 and ACSL5 from rat as well as human ACSL5 were cloned and recombinantly expressed as 6xHis-tagged enzymes.Ni 2+-affinity purified recombinant enzymes were assayed at pH 7.5 or pH 9.5 in the presence or absence of triacsin C.In addition,ACSL5 transfected CaCo2 cells and intestinal human mucosa were monitored.ACSL5 expression in cellular systems was verified using Western blot and immunofluorescence.The ACSL assay mix included TrisHCl(pH 7.4),ATP,CoA,EDTA,DTT,MgCl 2,[9,103 H] palmitic acid,and triton X-100.The 200 μL reaction was initiated with the addition of solubilized,purified recombinant proteins or cellular lysates.Reactions were terminated after 10,30 or 60 min of incubation with Doles medium.RESULTS:Expression of soluble recombinant ACSL proteins was found after incubation with isopropyl betaD-1-thiogalactopyranoside and after ultracentrifugation these were further purified to near homogeneity with Ni 2+-affinity chromatography.Triacsin C selectively and strongly inhibited recombinant human ACSL5 protein at pH 7.5 and pH 9.5,as well as recombinant rat ACSL1(sensitive control),but not recombinant rat ACSL5(insensitive control).The IC50 for human ACSL5 was about 10 μmol/L.The inhibitory triacsin C effect was similar for different incubation times(10,30 and 60 min) and was not modified by the N-or C-terminal location of the 6xHis-tag.In order to evaluate ACSL5 sensitivity to triacsin C in a cellular environment,stable human ACSL5 CaCo2 transfectants and mechanically dissected normal human intestinal mucosa with high physiological expression of ACSL5 were analyzed.In both models,ACSL5 peak activity was found at pH 7.5 and pH 9.5,corresponding to the properties of recombinant human ACSL5 protein.In the presence of triacsin C(25 μmol/L),total ACSL activity was dramatically diminished in human ACSL5 transfectants as well as in ACSL5-rich human intestinal mucosa.CONCLUSION:The data strongly indicate that human ACSL5 is sensitive to triacsin C and does not compensate for other triacsin C-sensitive ACSL isoforms. | Elke Kaemmerer Anne Peuscher Andrea Reinartz Christian Liedtke Ralf Weiskirchen Jürgen Kopitz Nikolaus Gassler | 2011 | World Journal of Gastroenterology2011，17，44： | 3 |
| 3 | Side effects of budesonide in liver cirrhosis due to chronic autoimmune hepatitis: Influence of hepatic metabolism versus portosystemic shunts on a patient complicated with HCC显示文摘AIM: To investigate the systemic availability of budesonide in a patient with Child A drrhosis due to autoimmune hepatitis (AIH) and primary hepatocellular carcinoma, who developed serious side effects.METHODS: Serum levels of budesonide, 6β-OH-budesonide and 16α-OH-prednisolon were measured by HPLC/MS/MS;portosysternic shunt-index (SI) was determined by 99mTc nuclear imaging. All values were compared with a matched control patient without side effects.RESULTS: Serum levels of budesonide were 13-fold increased in the index patient. The ratio between serum levels of the metabolites 6β-OH-budesonide and 16α-OH-prednisolone, respectively, and serum levels of budesonide was diminished (1.0 vs. 4.0 for 6β-OH-budesonide, 4.2 vs.10.7 for 16α-OH-prednisolone). Both patients had portosystemic SI (5.7% and 3.1%) within the range of healthy subjects.CONCLUSION: Serum levels of budesonide vary up to 13-fold in AIH patients with Child A cirrhosis in the absence of relevant portosysternic shunting. Reduced hepatic metabolism, as indicated by reduced metabolite-to-drug ratio, rather than portosystemic shunting may explain systemic side effects of this drug in cirrhosis. | Andreas Geier Carsten Gartung Christoph G.Dietrich Hermann E.Wasmuth Patrick Reinartz Siegfried Matern | 2003 | World Journal of Gastroenterology2003，9，12： | 3 |
| 4 | Lipid-induced up-regulation of human acyl-CoA synthetase 5 promotes hepatocellular apoptosis显示文摘 | Andrea Reinartz Josef Ehling Andrea Leue Christian Liedtke Ursula Schneider Jürgen Kopitz Thomas Weiss Claus Hellerbrand Ralf Weiskirchen Ruth Knüchel Nikolaus Gassler | 2010 | BBA - Molecular and Cell Biology of Lipids2010，，9： | 2 |
| 5 | 水性汽车漆表面缺陷的消除显示文摘水性汽车修补涂料的开发对于涂料配方设计师而言是一个挑战,因为他们将面对大量的原本在传统溶剂型涂料中并不突显的问题:较差的基材润湿性、涂膜缩孔、过多的泡沫、桔皮表面,针孔和溶剂爆孔。用有代表性的标准底漆、色漆和罩光漆配方进行涂布研究,结果表明:高性能表面活性剂和分子消泡剂可以帮助配方师解决这些问题,而不会对涂料的再涂性、层间附着力或涂膜性能产生不良影响。 | Reinartz Roger Reader Jim 陈进伟 | 2008 | 上海涂料2008，46，3： | 2 |
| 6 | Traffic Monitoring with Serial Images from Airborne Cameras显示文摘 | Peter Reinartz Marie Lachaise | 2006 | ISPRS Journal of Photogrammetry & Remote Sensing2006，，61： | 1 |
| 7 | Vaccination of patients with advanced ovarian carcinoma with the anti-idiotype ACA125:immunological response and aurvival (phase Ib/II)显示文摘 | Reinartz S Kohler S Schlebusch H | | 0，，： | 1 |
| 8 | Hybrid offerings: How manufacturing firms combine goods and services successfully显示文摘 | Ulaga W Reinartz W J | 2011 | Journal of Marketinz2011，75，6： | 1 |
| 9 | Therban(R)-the high performance elastomer for the new millennium显示文摘 | Wrana C Reinartz K Winkelbach H R | 2001 | Macromolecular materials and engineering2001，286，11： | 1 |
| 10 | Vaccination of patients with advanced ovarian carcinoma with the anti-idiotype ACA125: immunological response and survival显示文摘 | Reinartz S Kohler S Schlebusch H | 2004 | Clin Cancer Res2004，10，5： | 1 |
| 11 | Empiri- cal generalizations from brand extension research: how sure are we? 显示文摘 | ECHAMBADI R ARRONIZ I REINARTZ W | 2006 | International Journal of Research in Marketing2006，23，3： | 1 |
| 12 | Distributing through multiple chan- nels in industrial wholesaling:how many and how much? 显示文摘 | Kiiuferle M Reinartz W | 2014 | Journal of the Academy of Marketing Science2014，43，16： | 1 |
| 13 | Radionuelide imaging of the painful hip arthroplasty: positron - emission tomography versus triple- phase bone scanning 显示文摘 | Reinartz P Mumme T Hennanns B | 2005 | J Bone Joint Surg Br2005，87，4： | 1 |
| 14 | Aerodynamic performance analysis of a hypersonic inlet isolator using computation and experiment显示文摘 | Reinartz B Herrmann C D Ballmann J | 2003 | Journal of Propulsion and Power2003，19，5： | 1 |
| 15 | On the Prof- itability of Long-life Customers in a Non-contractual Setting: an Empirical Investigation and Implications for Marketing显示文摘 | Reinartz W J Kumar V | 2000 | Journal of Marketing2000，，10： | 1 |
| 16 | Hybrid Offerings: How Manufacturing Firms Combine Goods and Services Successfully 显示文摘 | ULAGA W REINARTZ W J | 2011 | Journal of Marketing2011，75，6： | 1 |
| 17 | Diagnostic values of positron emission tomography versus triple - phase bone scan in hip arthroplasty loosening 显示文摘 | Mumme T Reinartz P Alfer J | 2005 | Arch Orthop Trauma Surg2005，125，5： | 1 |
| 18 | To PIOPED,or not to PIOPED显示文摘 | Reinartz P | 2008 | J Nucl Med2008，49，11： | 1 |
| 19 | Therban-the High Performance Elastomer for the New Millennium显示文摘 | Wrana C Reinartz K Winkelbach H R | | 0，，11： | 1 |
| 20 | Hybridofferings:how manufacturing firms combine goods and serv- ices successfully显示文摘 | ULAGA WOLFGANG REINARTZ WERNER J | 2011 | Journal of Marketing2011，75，6： | 1 |
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