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| 1 | 肝硬化大鼠门静脉高压症不同手术方式对其肝脏的影响显示文摘目的:评价门奇断流术(PAD)、肠腔分流术(MCS)、远端脾腔分流术(DSCS)对门体分流率(PSS)、肝脏功能、线粒体功能和抗氧化能力的影响,为合理选择手术方式提供理论依据. 方法:用CCl4/乙醇诱导大鼠肝硬化门脉高压症模型,观察了不同术式(MCS、DSCS、PAD)的死亡率及手术前后肝功能、门体分流率(PSS)、肝细胞线粒体功能和超微结构及肝组织SOD活性、巯基水平、LPO含量的变化,并探讨了线粒体功能与抗氧化能力的内在关系. 结果:肝硬化门脉高压时,PSS远高于正常,肝细胞线粒体功能、抗氧化能力均下降;肠腔分流(MCS)组术后肝细胞线粒体功能、抗氧化能力进一步下降且恢复慢;选择性远端脾腔分流术(DSCS)组和门奇断流术(PAD)组的上述指际变化小且恢复较快,其中DSCS组恢复更快且死亡率低. 结论:选择性分流术(DSCS) | 徐新保 蔡景修 董家鸿 何振平 韩本立 冷希圣 | 2004 | 世界华人消化杂志2004，12，3： | 5 |
| 2 | Non-classical phenotypes of autoimmune hepatitis and advances in diagnosis and treatment显示文摘Non-classical manifestations of autoimmune hepatitis can delay diagnosis and treatment.Our aims were to describe the clinical phenotypes that can confound the diagnosis,detail scoring systems that can ensure their recognition,and outline advances in treatment that can improve their outcome.Prime source and review articles in English were selected through Medline from 1970-2008 and assimilated into personal libraries spanning 32 years.Acute severe or asymptomatic presentations and atypical histological findings,including centrilobular zone 3 necrosis and concurrent bile duct changes,are compatible with the diagnosis.Cholangiographic abnormalities may be present in children and adults with the disease,and autoimmune hepatitis must be considered in patients without autoantibodies or with antimitochondrial antibodies and no other cholestatic features.Asymptomatic patients frequently become symptomatic;mild disease can progress;and there are no conf ident indices that justify withholding treatment.Two diagnostic scoring systems with complementary virtues have been developed to evaluate patients with confusing features.Normal liver tests and tissue constitute the optimal end point of treatment,and the f irst relapse is an indication for long-term azathioprine therapy.Cyclosporine,tacrolimus and mycophenolate mofetil are promising salvage therapies,and budesonide with azathioprine may be a superior frontline treatment.We conclude that the non-classical phenotypes of autoimmune hepatitis can be recognized promptly,diagnosed accurately,and treated effectively. | Albert J Czaja Yusuf Bayraktar | 2009 | World Journal of Gastroenterology2009，15，19： | 4 |
| 3 | 自身免疫性肝炎的二线药物治疗现状显示文摘自身免疫性肝炎(AIH)是一种由免疫反应介导的、以肝细胞为靶细胞的肝实质炎症,对于AIH标准治疗方案应答不佳或者不耐受的患者,可以使用二线治疗药物替代治疗。综述了AIH的二线药物治疗研究进展。 | 胡智超 凡小丽 沈怡 杨丽 | 2018 | 临床肝胆病杂志2018，34，5： | 4 |
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