|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | MHD free and forced convection boundary layer flow along a vertical porous plate显示文摘 | Hossaln M A Alam K C A Rees D A S | 1997 | Appl Mech Engrg1997，2，1： | 1 |
| 3 | Crade 3 ischemia on the admission electrocardiogram is associated with severe microvascular injury on cardiac mannetic resonance imaging after sl elevation myocardial infarction显示文摘 | WEAYER J C REES D PRASAN A M | 2011 | J Electro- cardiol2011，44，1： | 1 |
| 4 | Teriary and quaternary structure in aqueous polysaccharide systems which model cell wall cohesion: reversible change in conformation and association of agarose , carrageenan and galactomannans显示文摘 | DEAI C M MCKINNON A REES D A | 1972 | J Mol Biol1972，68，： | 1 |
| 5 | Critical flow velocities for the growth and dominance of Anabaena circinalis in some turbid freshwater rivers显示文摘 | MITROVIC S M OLIVER R L REES C | 2003 | Freshwater Biology2003，48，： | 1 |
| 6 | The role of crop rotations in determining soil structure and crop growth conditions显示文摘 | BALL B C BINGHAM I REES R M | 2005 | Canadian Journal of Soil Science2005，85，5： | 1 |
| 7 | A review of recent applications of cyclodextrins for drug discovery 显示文摘 | Zhang M Q Rees D C | 1999 | Expert Opinion On Therapeutic Patents1999，9，12： | 1 |
| 8 | An inverse methodology for the rheology of a power-law non-Newtonian fluid显示文摘 | BANDULASENA H C H ZIMMERMAN W B REES J M | 2008 | Journal of Mechanical Engineering Science2008，222，5： | 1 |
| 9 | The influence of dentofacialappearance on the social attractiveness of young adults 显示文摘 | Shaw W C Rees G Dawe M | 1985 | Am JOrthod1985，87，1： | 1 |
| 10 | Hematomas requiring surgical evacuation following face lift surgery显示文摘 | REES T D BARONE C M VALAURI F A | 1994 | Plast Reconstr Surg1994，93，6： | 1 |
| 11 | Comptonization of diffuse ambient radiation by a relativistic jet:The source of gamma rays from blazars?显示文摘 | SIKORA M BEGELMAN M C REES M J | 1994 | The Astrophysical Journal1994，421，1： | 1 |
| 12 | Associations of like and un- like polysacchm'ides mechanisms and specificity in glucomannans, interacting bacterial polysacchardies and related systems 显示文摘 | Dea I C M Morns E R Rees D A | 1977 | Carbo- hydrate research1977，57，1： | 1 |
| 13 | Photovol- taic cogeneration in the built environment显示文摘 | Bazilian M D Leenders F Van der Ree B G C | 2001 | Solar Energy2001，71，1： | 1 |
| 14 | Fragment-based lead discovery显示文摘 | Rees D C Congreve M Murray C W | 2004 | Nat Rev Drug Discovery2004，3，： | 1 |
| 15 | Low-molecular- weight organic acids in rhizosphere soils of durum wheat and their effect on cadmium bioaccumulation 显示文摘 | Cieslinski G Van Rees K C J Szmigielska A M | 1998 | Plant and soil1998，203，1： | 1 |
| 16 | The effect of cigarette smoking on skin-flap survival in the face lift patient 显示文摘 | REES T D LIVERETF D M GUY C L | 1984 | Plast Reconstr Surg1984，73，6： | 1 |
| 17 | Low molecular weight dicarboxylic acids in rhizosphere soil of durum wheat 显示文摘 | Szmigielask A M Van Rees K C J Cieslinski G | 1996 | J Agric Food Chem1996，44，： | 1 |
| 18 | Human mast cell heterogeneity: histamine release from mast cells dispersed from skin, lung, adenoids, tonsils, and colon in response to IgE-dependent and nonimmunologic stimuli显示文摘 | Lowman M A Rees P H Benyon R C | 1988 | J Allergy Clin Immunol1988，81，： | 1 |
| 19 | Genome-Wide SNP detection,validation,and development of an 8K SNP array for apple显示文摘 | Chagne D Crowhurst R N Troggio M Davey M W Gilmore B Lawley C Vanderzande S Hellens R P Kumar S CestaroA Velasco R Main D Rees J D Iezzoni A Mockler T Wilhelm L Van de Weg E Gardiner S E Bassil N Peace C | | 0，，： | 1 |
| 20 | Efficient data distribution in a web server farm显示文摘 | BURNS R C REES R M LONG D D E | 2001 | IEEE Internet Computing2001，5，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员