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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | 环戊烷在Silicalite-1上吸附的热力学研究显示文摘 用智能重量分析仪测定了环戊烷在Silicalite-1上的吸附等温线,根据吸附等温线数据计算了热力学参数(吸附热Qst、熵变ΔS、Gibbs自由能变ΔG)。423K时,吸附等温线符合Langmuir方程。254,274K时,吸附等温线出现了滞后环。与分子构型相近的苯与环己烷相比,环戊烷的饱和吸附量超乎寻常,Qst、ΔG、ΔS随吸附量的变化较大,表明环戊烷在Silicalite-1上的吸附机理相当复杂。在吸附过程中,吸附质分子之间、吸附质和Silicalite-1之间的相互作用较强,环戊烷分子发生了重排。当吸附量达到1.5mmol/g时,吸附相开始凝聚,吸附热逐渐达到了凝聚热值。 | 段林海 蒋施 孙兆林 张晓彤 宋丽娟 Rees L V C | 2003 | 石油化工高等学校学报2003，16，3： | 4 |
| 3 | 正己烷在ZnNi/HZSM-5上微波芳构化显示文摘 研究了常规加热和微波辐射两种加热方法对正己烷在ZnNi/HZSM-5催化剂上的芳构化反应的影响。考察了温度、空速对反应性能的影响,并利用XRD对ZnNi/HZSM-5催化剂作了表征。结果表明,金属锌和镍高度分散于HZSM-5沸石中,微波辐射对分子筛结构的影响很小。与常规加热反应相比,要达到相同的芳烃收率,在微波加热条件下能使反应温度降低约100℃左右。在一定程度上提高反应温度可以获得较高的总芳烃收率和BTX收率,亦能明显地改变BTX中各组分的相对选择性。改变空速能显著影响总芳烃收率和BTX收率,在常规加热和微波加热条件下的最佳空速分别为1.5h-1和1.0h-1。讨论了正己烷在微波辐射下ZnNi/HZSM-5上的芳构化反应机理。正己烷首先裂解为C03+C=3,一部分烯烃齐聚、环化生成芳烃,另一部分烯烃则经氢转移或加氢生成烷烃,C03和C04在锌和镍活性中心上直接脱氢二聚环化生成芳烃。 | 许健 张晓彤 桂建舟 罗有训 孙兆林 Rees L V C | 2003 | 石油化工高等学校学报2003，16，2： | 3 |
| 4 | A tran sient two-dimensional finite volume model for the simulation of vertical U-tube ground heat exchanges 显示文摘 | YAVUZTURK C SPLITLER J D REES S J | 1999 | ASHRAE Transactions1999，105，2： | 1 |
| 5 | Development of gfp yectors for expression in Listeria monocytogenes and other low G + C gram positive bacteria 显示文摘 | QAXI S N A REES C E D MELLITS K H | 2001 | Microbiology Ecology2001，41，4： | 1 |
| 6 | Animal models of diabetes mellitus 显示文摘 | Rees D A Alcolado J C | 2005 | Diabet Med2005，22，4： | 1 |
| 7 | New route to 2-cyanobenzimidazoles 显示文摘 | Konstantinova L S Rakitin O A Rees C W | 1998 | Tetrahedron1998，54，： | 1 |
| 8 | MHD free and forced convection boundary layer flow along a vertical porous plate显示文摘 | Hossaln M A Alam K C A Rees D A S | 1997 | Appl Mech Engrg1997，2，1： | 1 |
| 9 | The relationship between medical students: attitudes towards communication skills lear- ning and their demographic and education-related charac- teristies显示文摘 | Rees C Sheard C | 2002 | Med Educ2002，36，11： | 1 |
| 10 | Frequency response method for the characterisation of microporous solids显示文摘 | Rees L V C Song L | 2000 | Membrane Scienceand Technology?2000，6，： | 1 |
| 11 | Temporal variability of denitrification in estuarine sediments显示文摘 | LAW C S REES A P OWENS N J P | 1991 | Estuarine Coastal and Shelf Science1991，33，1： | 1 |
| 12 | Size-fractionated nitrogen uptake and carbon fixation during a developing coccolithophore bloom in the North Sea during June 1999显示文摘 | Malcolm E Woodward S Robinson C Cummings D G Tarran G A Joint Ⅰ | 2002 | Deep-Sea Research Ⅱ2002，49，15： | 1 |
| 13 | Frequency response characterization of acid sites in zeolite catalgsts using NH3 as the probe molecule显示文摘 | Lovat V C Rees Gyorgy Onyestyak | 1999 | Microporous and Mesoporous Materials1999，28，： | 1 |
| 14 | One-pot synthesis of tetrasubstituted pyrazoles-proof of regiochemistry 显示文摘 | HANEFELD U REES C W WHITE A J P | 1996 | J Chem Soc Perkin Trans 11996，13，： | 1 |
| 15 | Formation of zeolite from the system Na2O-Al2O3-H2O in alkaline medium (pH>10) 显示文摘 | Lovat V C Ree s Sathy Chandrasekhar | 1993 | Zeolites1993，13，： | 1 |
| 16 | Crade 3 ischemia on the admission electrocardiogram is associated with severe microvascular injury on cardiac mannetic resonance imaging after sl elevation myocardial infarction显示文摘 | WEAYER J C REES D PRASAN A M | 2011 | J Electro- cardiol2011，44，1： | 1 |
| 17 | Nonlinear gas turbine modeling using NARMAX Structures显示文摘 | N Chiras C Evans D Rees | 2001 | IEEE Transactions On Instrumentation And Measurement2001，，： | 1 |
| 18 | Nitrous oxide: Estuarine sources and atmospheric flux 显示文摘 | LAW C S REES A P OWENS N J P | 1992 | Estuarine Coastal and Shelf Science1992，35，3： | 1 |
| 19 | A survey of standing column well installations in North America 显示文摘 | ORIO C D JOHNSON C N REES S J | 2005 | ASHRAE Transactions2005，111，2： | 1 |
| 20 | Crystallographic structure and functional implications of the nitrogenase molybdenum-iron protein from Azotobacter vinelandii 显示文摘 | Kin J Rees D C | 1992 | Nature1992，360，： | 1 |
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