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| 1 | 尿激酶治疗急性心肌梗塞多中心临床试验1406例总结显示文摘为观察尿激酶天普洛欣(UKTP)经静脉溶栓治疗急性心肌梗塞(AMI)的临床有效性及安全性。收集协作组148家医院1994年11月至1996年4月经静脉UKTP溶栓治疗AMI患者1406例,观察临床疗效、副作用及病死率等。其中124例行90分钟冠状动脉造影评价梗塞血管开通情况。结果:梗塞血管临床再灌注率为73.5%,90分钟冠状动脉造影血管开通率为72.6%,5周总病死率为7.8%(109/1406),轻度出血10.2%(143/1406),中重度出血0.43%(6/1406),脑出血0.50%(7/1406)。老年(>65岁)甚至高龄(>75岁)患者溶栓及距发病超过6小时者,其用药仍然安全有效,UKTP合适的用药剂量可能为150万U左右。结果提示UKTP治疗AMI安全有效。 | The collaborative study group for national multicenter clinical trial of urokinase thrombolytic therapy (Correspondence: Hu Dayi, Xu Zhimin. Beijing Red Cross Chao Yao Hospital, Beijing 100020) | 1997 | 中华心血管病杂志1997，25，3： | 139 |
| 2 | 不稳定性心绞痛、急性非Q波心肌梗死不同抗栓疗法的对比研究显示文摘目的 观察不同抗栓方案对急性冠状动脉综合征心脏事件、出血风险和预后的影响。方法 本研究为前瞻性、多中心、随机、开放试验 ,入选患者随机分为静脉滴注普通肝素组和皮下注射低分子量肝素组。入选对象为不稳定性心绞痛或非Q波心肌梗死 ,入选前 4 8小时以内至少有一次心绞痛发作 ,ST段无抬高。肝素 10 0IU/kg静注 ,续 10 0 0IU/h ,维持活化的部分凝血活酶时间 (APTT)或活化的全血凝固时间 (ACT)于正常的 1 5~ 2 0倍 ,连续 7日。低分子量肝素 0 4~ 0 6ml,每日两次皮下注射 ,连续 7日。主要观察终点 :随访治疗 3 0日内发生急性心肌梗死、心脏性或非心脏性死亡和药物治疗无法控制心绞痛 ,需行急性血运重建术。住院至少 7日 ,随访至治疗后 3 0日。结果 本研究共入选符合条件的患者 4 0 2例 ,两组在性别、年龄、心血管危险因素和心绞痛发作方面差异无显著性。治疗后 7日 ,两组用药期间平均胸痛发作次数差异无显著性 ,但肝素组有更多的患者需口服硝酸甘油缓解胸痛 ;病死率在低分子量肝素组较普通肝素组低 ,两组比较P值为 0 0 62 ,复合终点事件 (死亡、心肌梗死和紧急血管重建 )在低分子量肝素组明显下降。低分子量肝素组出血事件明显少于肝素组。治疗开始后 3 0日 ,低分子量肝素组死亡和复合终点事? | Clinical Collaborative Study Group of Low Molecular Weight Heparin (Correspondent: HU Dayi, XU Juntang. Beijing Red Cross Chaoyang Hospital, Beijing University of Medical Sciences, Beijing 100020, China) | 2000 | 中华心血管病杂志2000，28，1： | 172 |
| 3 | LCSH,SKOS和关联数据显示文摘论述将美国国会图书馆MARCXML格式的主题标目转换为SKOS(RDF编码格式)的技术方法。着重阐述SKOS词表的优势、可能的扩展方向以及与其他语义网词表的整合,如都柏林核心集。还介绍一个利用关联数据(LinkedData)技术在网上发布词表的Web应用。 | Ed Summers Antoine Isaac Clay Redding Dan Krech 姚小乐 刘炜(译) 张春景(校) | 2009 | 现代图书情报技术2009，，3： | 41 |
| 4 | Regulation of the G1 phase of the mammalian cell cycle显示文摘In any multi-cellular organism, the balance between cell division and cell death maintains a constant cell number. Both cell division cycle and cell death are highly regulated events. Whether the cell will proceed through the cycle or not, depends upon whether the conditions required at the checkpoints during the cycle are fulfilled. In higher eucaryotic cells, such as mammalian cells, signals that arrest the cycle usually act at a G1 checkpoint. Cells that pass this restriction point are committed to complete the cycle. Regulation of the GI phase of the cell cycle is extremely complex and involves many different families of proteins such as retinoblastoma family cyclin dependent kinases, cyclins, and cyclic kinase inhibitors. | DONJERKOVIC DUBRRAVKA DAVID W SCOTT (Department of Immunology, Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD) | 2000 | Cell Research2000，10，1： | 18 |
| 5 | 天然及合成甜味剂的最新进展显示文摘甜味剂的使用可以追溯到史前时期蜂蜜的发现。科学研究已经表明,人类对甜味的需求是先天的,而不是后天对环境要求的一种客观反应。 甜味剂发展概况 五、六十年代以前的近一个世纪,糖精是人们所能应用的唯一的高甜度甜味剂。五、六十年代之后,甜蜜素、二肽甜味剂以及Acesulfamek等在美国。 | F red F.Shih 周明霞 黄占先 | 1991 | 食品与发酵工业1991，17，5： | 13 |
| 6 | 90分钟冠状动脉造影评价急性心肌梗塞血管开通及临床再通指标价值显示文摘通过经静脉溶栓开始后90分钟冠状动脉造影(CAG),观察国产尿激酶(天普洛欣,UKTP)静脉溶栓治疗急性心肌梗塞(AMI)血管开通疗效,并评价临床再灌注标准的判断价值如何。方法:从UKTP多中心治疗AMI1406例中,汇集其中所行冠状动脉造影(CAG)共124例资料。结果提示:(1)124例AMI患者,在溶栓开始后90分钟时的梗塞相关血管的血流达TIMIⅢ级者52例(41.9%)、Ⅱ级38例(30.7%),梗塞相关血管再开通率为72.6%;(2)溶栓距起病时间愈早,具有愈高的开通趋势,但差异无统计学意义;(3)以CAG为金标准,临床标准对血管开通判断敏感性为88%,特异性为69%,准确性为83%。结论:UKTP静脉溶栓治疗AMI血管开通疗效肯定,临床标准判断血管再通的敏感性较高,但特异性欠佳,有待提高。 | The multicentre investigating group of thrombolytic therapy on acute myocardial infarction with Urokinase Techpool Correspondence: Hu Dayi, Xu Zhimin. Chaoyang Red Cross Hospital, Capital University of Medical Sciences, Beijing 100020 | 1997 | 中华心血管病杂志1997，25，4： | 11 |
| 7 | Activation-induced cell death in B lymphocytes显示文摘Upon encountering the antigen (Ag), the immune system can either develop a specific immune response or enter a specific state of unresponsiveness, tolerance. The response of B cells to their specific Ag can be activation and proliferation, leading to the immune response, or anergy and activation-induced cell death (AICD), leading to tolerance. AICD in B lymphocytes is a highly regulated event initiated by crosslinking of the B cell receptor (BCR). BCR engagement initiates several signaling events such as activation of PLCr, Ras, and PI3K, which generally speaking, lead to survival. However, in the absence of survival signals (CD40 or IL-4R engagement), BCR crosslinking can also promote apoptotic signal transduction pathways such as activation of effector caspases, expression of pro-apoptotic genes, and inhibition of pro-survival genes. The complex interplay between survival and death signals determines the B cell fate and, consequently, the immune response. | DONJERKOVIC DUBRAVKA, DAVID W SCOTT (Department of Immunology, Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD, 20855. USA) | 2000 | Cell Research2000，10，3： | 6 |
| 8 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 9 | Economic geography and international inequality显示文摘 | Stephen Redding Anthony J. Venables | 2003 | Journal of International Economics2003，，1： | 3 |
| 10 | 深圳水围柠盟人才公寓显示文摘在深圳,城中村一直都是一个热门的话题,多种观点相互碰撞。在过去的一二十年里,城中村的改造就意味着大规模的拆迁,彻底推倒重建,拆迁改善了生活环境,创造了财富,但导致了城市空间匀质化,同时,造成了一些社会问题,更割断了城市的历史。目前深圳市新出台的政策是通过综合整治,让城中村全面进入柔性改造的通道,鼓励在原来的用地上开展城中村的综合整治。然而新政策出台不久之后,却又发生了原住民反对综合整治,要求城市更新的情况。说明政策的转变对城中村的居民和开发企业都产生了很大的影响,“综合整治”和“拆除重建”的投入产出模型完全不同,两种模式的转变,意味着居民的诉求和企业的战略都应当做出相应的调整,在新形势下共同努力,继续探索。为此,我们选登了通过综合整治获得比较成功的水围村项目,该项目保留了城市的肌理、文脉和集体记忆,同时,也提升了消防、市政配套,及改善了生活设施。并增加空中连廊、电梯,创造出了一个符合现代标准的宜居空间立体的社区。该项目改造后,由政府返租补贴,并以低于市场的价格出租,以确保改造后的房源租金在可负担的范围内。水围村项目为城中村的改造提供了一种可能,并引发了社会各界对城中村改造的再思考,这也反映出有关城中村的争论还在继续,城中村的改造还需要不断的探索…… | Chris Lai Jasmine M.Y.Tsoi Kwan Yee Wong Cindy Yan David Wen Demi Han Zachary Bao Jack Ou Nita Lin Red Liu Ann Hu Morning Dong Ananda de Vos Helene Pohl Arnound Stavenuiter Bert Oostdijk 王晓勇 | 2019 | 世界建筑导报2019，34，1： | 2 |
| 11 | The α_Mβ_2 integrin and its role in neutrophil function显示文摘Neutrophils are the first cell type to arrive at the in-jury sites and play a critical role in host defense, by virtueof its ability to adhere and transmigrate through endothe-lium, to phagocytose foreign pathogens, and to producefree oxygen radicals and proteolytic enzymes. Yet, inap-propriate neutrophil activation causes tissue damage andvarious inflammatory diseases. These physiological andpathological functions of neutrophils depend on the en-gagement of certain surface receptors, especially αMβ2,the ma jor β2 integrin receptor present on neutrophil sur-face. Understanding of the molecular mechanisms under-lying ligand binding by αMβ2, as well as the roles of αMβ2-ligand interactions in neutrophil functions will enable usto regulate more precisely neutrophil activities: that is,to promote their host defense functions, and at the sametime to minimize their deleterious effects on normal cells. | ZHANG LI (Department of Vascular Biology, American Red Cross,Holland La6oratory, 15601 Crabbs Branch Way, Rockville,MD 20855 USA)Tel: 301-738-0657 Fax: 301-738-0465e-mail: zhangl@u8a.redcross. org | 1999 | Cell Research1999，9，3： | 2 |
| 12 | 生物乙醇生产及木质纤维素稀酸预处理的研究进展(英文)显示文摘作为一种汽油替代品,液体燃料因其可持续及环境友好的特点引起了人们的广泛兴趣.文中介绍了几种能够替代汽油的液体燃料:生物甲醇、生物乙醇和生物丁醇,指出生物乙醇最具潜力.对生产生物乙醇的原料进行了概述,指出由于政策性限制,使用淀粉或糖来生产乙醇受到制约,因此人们转向利用木质纤维原料来生产乙醇.在分析了各种木质纤维原料不同的预处理方法后,指出稀酸或稀酸与蒸汽爆破相结合的方法具有经济可行性,但稀酸预处理木质纤维易产生糠醛、羟甲基糠醛、木素小分子等发酵抑制物,因此在未来设计生物质转化液体燃料时要考虑减少这类物质的生成,降低其后续影响. | Arthur Redding 陈元彩 付时雨 詹怀宇 Jay J.Cheng | 2012 | 华南理工大学学报(自然科学版)2012，40，3： | 2 |
| 13 | Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance显示文摘 | Justin I. Odegaard Roberto R. Ricardo-Gonzalez Alex Red Eagle Divya Vats Christine R. Morel Matthew H. Goforth Vidya Subramanian Lata Mukundan Anthony W. Ferrante Ajay Chawla | 2008 | Cell Metabolism2008，，6： | 2 |
| 14 | Optimal Low-Thrust Transfers to Synchronous Orbit 显示文摘 | Redding D C Breakwell J V | 1984 | Journal of Guidance Control and Dynamics1984，7，2： | 1 |
| 15 | Organoclay sorption of benzene as a function of total organic carbon content 显示文摘 | Redding A Z Bums S E Upson R T | 2002 | J Colloid interface Sci2002，250，： | 1 |
| 16 | Epidemiology of oropharyngeal Candida clonization and infection in patients receiving radiation for head and neck cancer 显示文摘 | Redding SW Zellars RC Kirkpatrick WR | 1999 | Clin Microbiol1999，37，： | 1 |
| 17 | Tool selection for five-axis curvature matched machining显示文摘 | JENSEN C RED W PI J | 2002 | Computer-Aided Design2002，34，： | 1 |
| 18 | Economic geography and international inequality显示文摘 | Redding S Venables A | 2004 | Journal of International E- conomics2004，62，1： | 1 |
| 19 | Urbanization and structural transformation显示文摘 | Michaels G Rauch F Redding S J | 2012 | The Quarterly Journal of Economics2012，127，2： | 1 |
| 20 | Path dependence, endogenous innovation, and growth 显示文摘 | REDDING S | 2002 | International Economic Review2002，43，4： | 1 |
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