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| 1 | 澜沧江和怒江流域的气候变化及其对径流的影响显示文摘采用VIP(Vegetation Interface Processes)模型和HIMS(Hydro-Informatic Modeling System)模型,模拟分析了1957—2012年澜沧江和怒江流域(简称两江流域)水资源量的演变。根据CMIP5 RCP2.6,RCP4.5和RCP8.5情景预测,模拟了2030年代和2050年代流域水资源的变化。研究发现,过去50年间,两江流域的气温都呈升高趋势,但海拔较高的上游地区升幅大于下游。年总降水量的变化趋势不明显,但春季降水增加趋势明显。两江流域年总水资源量为650亿~850亿m^3,水资源总量长期变化趋势不明显,其中澜沧江的波动性(1.884,最大与最小之比)大于怒江。空间上水资源量呈现北低-南高的格局。在未来,两江流域气温仍呈增加趋势,降水呈增加趋势,径流呈增加趋势,空间变异性趋小,但较强的季节性变化对水资源安全仍具有较大的挑战性。 | 刘苏峡 丁文浩 莫兴国 王盛 刘昌明 罗贤 何大明 Sagar Ratna Bajracharya Arun Bhakta Shrestha Nand Kishor Agrawal | 2017 | 气候变化研究进展2017，13，4： | 17 |
| 2 | CT平扫预测高血压脑出血早期血肿扩大的价值显示文摘目的探讨CT平扫征象预测高血压脑出血(ICH)患者血肿扩大的价值。方法入组80例发病6 h以内的ICH患者,入院行头颅CT扫描,由两位影像科医师评估血肿内“黑洞征”和“卫星征”。根据24 h CT复查结果,分为血肿扩大组和血肿未扩大组。ROC曲线比较“黑洞征”、“卫星征”及其联合征象对血肿扩大的预测能力。结果“黑洞征”、“卫星征”和联合征象在血肿扩大组与血肿未扩大组之间差异有统计学意义(P均<0.05)。联合征象预测早期血肿扩大的敏感性、特异性、阳性预测值、阴性预测值及准确性分别为84.09%、63.89%、74.00%、76.67%和75.30%,其预测的准确性高于“黑洞征”(66.00%)和“卫星征”(69.70%)。结论头颅CT平扫联合征象较单一征象更能预测早期血肿扩大。 | 傅璠 Shakya Milind Ratna 於帆 张苗 孙胜军 卢洁 | 2020 | 医学影像学杂志2020，30，11： | 11 |
| 3 | Influence of heat treatment on the machinability and corrosion behavior of AZ91 Mg alloy显示文摘In the present study,AZ91 Mg alloy was heat treated at 410℃ for 6,12 and 24 h to investigate the influence of heat treatment on machinability and corrosion behavior.The effect of soaking time on the amount and distribution of Mg 17 Al 12(β-phase)was analyzed under the optical microscope.Microhardness measurements demonstrated the increased hardness with increased heat treatment soaking time,which can be attributed to the solid solution strengthening.The influence of super saturatedα-grains on reducing the cutting force(F z)with respect to increased cutting speed was observed as prominent.The corrosion behavior of the heat treated specimens was studied by conducting electrochemical tests.Surprisingly,corrosion rate of heat treated samples was observed as increased compared with the base material.From the results,it is evident that the machinability of AZ91 Mg alloy can be improved by producing super saturatedα-grains through heat treatment but at the cost of losing corrosion resistance. | Swetha Chowdary V Ravikumar Dumpala Anand Kumar S Kondaiah VV Ratna Sunil B | 2018 | Journal of Magnesium and Alloys2018，6，1： | 7 |
| 4 | MicroRNAs:Role in hepatitis C virus pathogenesis显示文摘Hepatitis C virus(HCV)is a global health burden with an estimated 170e200 million peoples chronically infected worldwide.HCV infection remains as an independent risk factor for chronic hepatitis,liver cirrhosis,hepatocellular carcinoma,and a major reason for liver transplantation.Discovery of direct acting antiviral(DAA)drugs have shown promising results with more than 90%success rate in clearing the HCV RNA in patients,although long-term consequences remain to be evaluated.microRNAs(miRNAs)are important players in establishment of HCV infection and target crucial host cellular factors needed for productive HCV replication and augmented cell growth.Altered expression of miRNAs is involved in the pathogenesis associated with HCV infection by controlling signaling pathways such as immune response,proliferation and apoptosis.miRNA is emerging as a means of communication between various cell types inside the liver.There is likely possibility of developing circulating miRNAs as biomarkers of disease progression and can also serve as diagnostic tool with potential of early therapeutic intervention in HCV associated end stage liver disease.This review focuses on recent studies highlighting the contribution of miRNAs in HCV life cycle and their coordinated regulation in HCV mediated liver disease progression. | Shubham Shrivastava Robert Steele Ranjit Ray Ratna B.Ray | 2015 | Genes & Diseases2015，2，1： | 6 |
| 5 | Effect of nanoparticle concentration on zeta-potential measurement results and reproducibility显示文摘The effect of nanoparticle concentration on zeta-potential measurement results at dilute concentrations was evaluated. The values of the zeta-potential for four different types of nanoparticles, Ludox (silica), multi-walled carbon nanotubes (bamboo-shaped and hollow nanotubes) and gold, at various concentra- tions, were obtained using a laser Doppler electrophoresis instrument. The size of the nanoparticles on dilution was measured using dynamic light scattering (DLS). The results show that there is a concentration range within which the zeta-potential, and particle size, are not affected by nanoparticle concentration. The lower concentration limit for the system to produce consistent results was dependent on the nature of the sample under study and ranged between 10 -2 and 10 -4 wt%. Below this concentration, there was an apparent shift in zeta-potential values to less negative values, which was accompanied by an increase in the particle size. The shift in zeta-potential was attributed to an increase in contribution of the signal from extraneous particulate matter. The increase in particle size was attributed to the nature of the homodyne optical configuration of the instrument. The aim of this study was to elucidate the range in nanoparticle concentration that allows for accurate and reliable measurement of the zeta-potential and DLS data. | Ratna Tantra Philipp Schulze Paul Quincey | 2010 | Particuology2010，8，3： | 6 |
| 6 | Hepatitis C virus infection,microRNA and liver disease progression显示文摘Hepatitis C virus(HCV) is a global health problem with an estimated 170-200 million peoples(approximately3% of world population) are chronically infected worldwide and new infections are predicted to be on rise in coming years. HCV infection remains categorized as a major risk factor for chronic hepatitis,liver cirrhosis and hepatocellular carcinoma worldwide. There has been considerable improvement in our understanding of virus life cycle since,the discovery of HCV two-decades ago.MicroRNAs(miRNAs) are important players in establishment of HCV infection and their propagation in infected hepatocytes. They target crucial host cellular factors needed for productive HCV replication and augmented cell growth.Very first anti-miRNA oligonucleotides,miravirsen has been tested in clinical trial and shown promising results as therapeutic agent in treatment against chronic HCV infection.Deregulated expression of miRNAs has been linked to the pathogenesis associated with HCV infection by controlling signaling pathways such as,proliferation,apoptosis and migration. Circulating miRNAs emerging as growing field in identification of biomarkers in disease progression and their potential as a means of communication between cells inside the liver is an exciting area of research in future.This review focuses on recent studies enforcing the contribution of miRNAs in HCV life cycle and coordinated regulation in HCV mediated liver disease progression. | Shubham Shrivastava Anupam Mukherjee Ratna B Ray | 2013 | World Journal of Hepatology2013，5，9： | 6 |
| 7 | Cancer therapy using natural ligands that target estrogen receptor beta显示文摘Estrogen receptor beta(ERβ) is one of the two key receptors(ERα, ERβ) that facilitate biological actions of 17β-estradiol(E2). ERβ is widely expressed in many tissues, and its expression is reduced or lost during progression of many tumors. ERβ facilitates estrogen signaling by both genomic(classical and non-classical) and extra-nuclear signaling. Emerging evidence suggests that ERβ functions as a tissue-specific tumor suppressor with anti-proliferative actions. Recent studies have identified a number of naturally available selective ERβ agonists. Targeting ERβ using its naturally available ligands is an attractive approach for treating and preventing cancers. This review presents the beneficial actions of ERβ signaling and clinical utility of several natural ERβ ligands as potential cancer therapy. | Gangadhara R Sareddy Ratna K.Vadlamudi | 2015 | Chinese Journal of Natural Medicines2015，13，11： | 5 |
| 8 | Targeting LIF/LIFR signaling in cancer显示文摘Leukemia inhibitory factor (LIF), and its receptor (LIFR), are commonly over-expressed in many solid cancers and recent studies have implicated LIF/LIFR axis as a promising clinical target for cancer therapy. LIF/LIFR activate oncogenic signaling pathways including JAK/STAT3 as immediate effectors and MAPK, AKT, mTOR further downstream. LIF/LIFR signaling plays a key role in tumor growth, progression, metastasis, stemness and therapy resistance. Many solid cancers show overexpression of LIF and autocrine stimulation of the LIF/LIFR axis;these are associated with a poorer relapse-free survival. LIF/LIFR signaling also plays a role in modulating multiple immune cell types present in tumor micro environment (TME). Recently, two targeted agents that target LIF (humanized anti-LIF antibody, MSC-1) and LIFR inhibitor (EC359) were under development. Both agents showed effectivity in preclinical models and clinical trials using MSC-1 antibody are in progress. This article reviews the significance of LIF/LIFR pathways and inhibitors that disrupt this process for the treatment of cancer. | Suryavathi Viswanadhapalli Kalarickal V.Dileep Kam Y.J.Zhang Hareesh B.Nair Ratna K.Vadlamudi | 2022 | Genes & Diseases2022，9，4： | 4 |
| 9 | Does investor protection affect the choice of earnings management methods through real activity manipulation and accrual manipulation? Asian comparison显示文摘 | Ratna Candra Sari Sony Warsono Sri Suryaningsum | 2010 | Journal of Modern Accounting and Auditing2010，6，6： | 4 |
| 10 | IL-15 temporally reorients IL-10 biased B-la cells toward I L- 12 expression显示文摘 | Amlan Kanti Ghosh Debolina Sinha Subhadeep Mukherjee Ratna Biswas Tapas Biswas | 2016 | Cellular & Molecular Immunology2016，13，2： | 3 |
| 11 | 反思金融深化:新兴市场的稳定与发展显示文摘有深度和流动性良好的金融系统,加上有丰富的金融工具可抵御金融冲击,还可以增加一国金融的稳定性。但是金融发展或许存在一个边界,越过此边界进一步发展其收益或将下降。本文通过研究新兴市场发现:一、大部分新兴市场金融进一步发展仍然对经济的增长和稳定有利。二、金融发展对经济增长的促进作用是倒U型的,在越过高点之后金融深化对要素生产率的促进作用将下降。三、如果金融发展过快,快速深化的金融产业可能引发经济和金融动荡。四、提升金融稳定与金融发展之间没有太大冲突,更好的金融监管有助于提升金融稳定,促进金融发展。五、发展金融机构或金融市场不存在通用的顺序,尽管前者对经济的作用在下降而后者在上升。 | IMF课题组 Ratna Sahay Martin Cihak Papa N’Diaye Adolfo Barajas Ran Bi Diana Ayala Yuan Gao Annette Kyobe Lam Nguyen Christian Saborowski Katsiaryna Svirydzenka Seyed Reza Yousefi 胡妍斌 王辰 | 2015 | 新金融2015，0，10： | 2 |
| 12 | Effect of laminate thickness on moisture diffusion of polymer matrix composites in artificial seawater ageing显示文摘影响在海水沉浸,以及结果在潮湿散开上把聚合物矩阵 composites 的厚度压成薄片为 glass/isopolyester (G/IPE ) 的 composites 的机械性质降级, carbon/isopolyester (C/IPE ) , glass/vinylester (G/VE ) 和 carbon/vinylester (C/VE ) ,在这份报纸被调查。把 3 压成薄片并且在厚度的 10mm,使用湿手上篮技术制作,被描绘因为在人工的海水媒介的潮湿吸收,和他们的曲折力量和 interlaminar 砍力量(ILSS ) 降级被学习。潮湿散开被观察是到 Ficks 的 anamolous 为 3 的法律和 10mm 在散开的以后的阶段的厚样品。10mmthick 样品的潮湿渗透是比 3mm 的大的二~三份订单厚的,当潮湿浸透的时间仍然保持未改变时。随增加把厚度压成薄片, 1.4% 为 C/VE 增加的潮湿浸透并且 7% 为 G/IPE。剩余曲折力量和 ILSS 在 10mm 的情况下是更大的在 200 天暴露以后的厚标本。折断的标本的 SEM 检查在 10mm 显示出纤维 / 矩阵 debonding 的更大的层次厚标本。 | Ratna PAL H.N.NARASIMHA MURTHY M.SREEJlTHz,K.R.VISHNU MAHESH M.KRISHNA IS.C.SHARMA | 2012 | Frontiers of Materials Science2012，6，3： | 2 |
| 13 | Functions of autophagy in normal and diseased liver显示文摘 | Mark J. Czaja Wen-Xing Ding Terrence M. Donohue Scott L. Friedman Jae-Sung Kim Masaaki Komatsu John J. Lemasters Antoinette Lemoine Jiandie D. Lin Jing-hsiung James Ou David H. Perlmutter Glenn Randall Ratna B. Ray Allan Tsung Xiao-Ming Yin | 2013 | Autophagy2013，，8： | 2 |
| 14 | A FEniCS implementation of the phase field method for quasi-static brittle fracture显示文摘In the recent years, the phase field method for simulating fracture problems has received considerable attention. This is due to the salient features of the method: 1) it can be incorporated into any conventional finite element software;2) has a scalar damage variable is used to represent the discontinuous surface implicitly and 3) the crack initiation and subsequent propagation and branching are treated with less complexity. Within this framework, the linear momentum equations are coupled with the diffusion type equation, which describes the evolution of the damage variable. The coupled nonlinear system of partial differential equations are solved in a 'staggered? approach. The present work discusses the implementation of the phase field method for brittle fracture within the open-source finite element software, FEniCS. The FEniCS provides a framework for the automated solutions of the partial differential equations. The details of the implementation which forms the core of the analysis are presented. The implementation is validated by solving a few benchmark problems and comparing the results with the open literature. | HIRSHIKESH Sundararajan NATARAJAN Ratna Kumar ANNABATTULA | 2019 | Frontiers of Structural and Civil Engineering2019，13，2： | 2 |
| 15 | Themomechanical properties and morphology of blends of a hydroxyl-functionalized hyperbranched polymer and epoxy resin显示文摘 | RATNA D SIMON G P | 2001 | Polymer2001，42，21： | 1 |
| 16 | Self-assembling phospholipid filaments显示文摘 | Ratna B R Kan B | 1991 | Nature1991，352，： | 1 |
| 17 | Toughening of epoxy resin using acrylate-based liquid rubbers 显示文摘 | Ratna D Banthia A K Deb P C | 2000 | Jounal of Applied Polymer Science2000，78，4： | 1 |
| 18 | Introduction to the Special Issue on New Perspectives on Youth Development and Social Identity in the 21st Century显示文摘 | Jean Anyon Ratna Ghosh Roslyn Arlin | 2007 | The Teachers College Record2007，109，2： | 1 |
| 19 | Remanufacturing for the Automotive Aftermarket-strategic Factors: Literature Review and Future Research Needs 显示文摘 | Ramesh Subramoniam Donald Huisingh Ratna Babu Chinnam | 2009 | Journal of Cleaner Production2009，17，： | 1 |
| 20 | Novel Pyridinium compound from marine actinomycete, Amycolatopsis alba var. nov. DVR D4 showing antimicrobial and cytotoxic activities in vitro显示文摘 | Venkata Ratna Ravi Kumar Dasari Murali Krishna Kumar Muthyala Murali Yugandhar Nikku Sri Rami Reddy Donthireddy | 2012 | Microbiological Research2012，，6： | 1 |
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