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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | The HTR3A Polymorphism c. -42C>T Is Associated With Amygdala Responsiveness in Patients With Irritable Bowel Syndrome显示文摘 | Lisa A. Kilpatrick Jennifer S. Labus Kristen Coveleskie Christian Hammer Gudrun Rappold Kirsten Tillisch Joshua A. Bueller Brandall Suyenobu Johana M. Jarcho Jim A. McRoberts Beate Niesler Emeran A. Mayer | 2011 | Gastroenterology2011，，7： | 2 |
| 3 | Functional and Phenotypic Characterization of Cord Blood and Bone Marrow Subsets Expressing FLT3 (CD135) Receptor Tyrosine Kinase显示文摘 | Rappold I Ziegler BL Kohler I | 1997 | Blood1997，90，1： | 1 |
| 4 | Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system 显示文摘 | Bacon C Endris V Rappold G | 2009 | J Comp Neurel2009，513，2： | 1 |
| 5 | Critical role of aquaporin-4(AQP4)in astrocytic Ca2+signaling events elicited by cerebral edema显示文摘 | Thrane AS Rappold PM Fujita T | 2011 | Proce Natio Aca Sci2011，108，2： | 1 |
| 6 | Implant Breakage of the Proximal Femoral Nail (PFN):Reasons and Case Reports显示文摘 | Rappold G Hertz H Spitaler R | 2001 | Eur J Trauma2001，27，6： | 1 |
| 7 | A comparative study between paranomic hysteroscopy with direct biopsies and curettage显示文摘 | Gimpelson RJ Rappold HO | 1988 | AM J Obstet Gynecol1988，158，： | 1 |
| 8 | Deletions of the homeobox gene SHOX (short stature homeobox) are an important cause of growth failure in children with short stature 显示文摘 | Rappold G Fukami M Niesler B | 2002 | J Clin Endocrinol Metab2002，87，： | 1 |
| 9 | Genotypes and phe- notypes in children with short stature: clinieal indicators of SHOX haploinsuffieiency 显示文摘 | Rappold G Blum WF Shavfikova EP | 2007 | Med Genet2007，44，5： | 1 |
| 10 | Growth hormone and gonadotropin - releasing hormone analog therapy in haploin- sufficiency of SHOX显示文摘 | Ogata T Onigata K Hotsubo T Matsuo N Rappold G | 2001 | Endocr J2001，48，： | 1 |
| 11 | 5-HT(3)receptors:role in diseaseand target of drugs显示文摘 | Walstab J Rappold G Niesler B | 2010 | Pharmacol Ther2010，128，1： | 1 |
| 12 | MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation显示文摘 | Ying Yang Marco Marcello Volker Endris Rainer Saffrich Roger Fischer Michael F. Trendelenburg Rolf Sprengel Gudrun Rappold | 2006 | Experimental Cell Research2006，，12： | 1 |
| 13 | Plating of fresh claviclefrac-tures:results of 122 operations显示文摘 | Rappold G Fischer W | 1992 | Injury1992，23，2： | 1 |
| 14 | Critical role of aquaporin-4 (AQP4) in astrocytic Ca~(2-) signaling events elicited by cerebral edema显示文摘 | Thrane AS Rappold PM Fujita T | 2011 | Proc Natl Acad Sci U S A2011，108，2： | 1 |
| 15 | Plating of fresh calvicular fractures: Results of 122 operations 显示文摘 | Poigenfurst J Rappold G Fischer W | 1992 | Injury1992，23，2： | 1 |
| 16 | Cardiovascular effects caused by increasing concentrations of diesel exhaust in middle-aged healthy GSTM1 null human volunteers显示文摘 | Haiyan Tong Ana G. Rappold Melissa Caughey Alan L. Hinderliter Donald W. Graff Jon H. Berntsen Wayne E. Cascio Robert B. Devlin James M. Samet | 2014 | Inhalation Toxicology2014，，6： | 1 |
| 17 | Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system显示文摘 | Bacon C Endris V Rappold G | 2009 | J Comp Neurol2009，513，2： | 1 |
| 18 | Imp lant breakage of the proximalfemo ral nail (PFN) 显示文摘 | Rappold G Hertz H Sp italar R | 2001 | Eur J Trauma2001，27，： | 1 |
| 19 | Tumor suppressor p53binding protein 1 (53BP1) is involved in DNA damage-signalingpathways显示文摘 | Rappold I Iwabuchi K Date T | 2001 | J Cell Biol2001，153，3： | 1 |
| 20 | Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporte' 3显示文摘 | Rappold PM Cui M Chesser AS | 2011 | Proc Natl Acad Sci U S A2011，108，20： | 1 |
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