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| 1 | A longitudinal assessment of retinal function and structure in the APP/PS1 transgenic mouse model of Alzheimer’s disease显示文摘Background:A great body of evidence suggests that there are retinal functional and structural changes that occur in Alzheimer’s disease(AD).However,whether such changes are primary or secondary remains to be elucidated.We studied a range of retinal functional and structural parameters in association with AD-specific pathophysiological markers in the double transgenic APP/PS1 and control mice across age.Methods:Electroretinogram(ERG)and optical coherence tomography(OCT)was performed in APP/PS1 and wild type(WT)control mice every 3 months from 3 to 12 months of age.For functional assessment,the a-and b-wave of the ERG,amplitude of oscillatory potentials(OP)and the positive scotopic threshold response(pSTR)were quantified at each time point.For structural assessment,the inner and outer retinal thickness was segmented and measured from OCT scans.Episodic memory was evaluated at 6,9 and 12 months of age using the novel object recognition test.Amyloid beta(Aβ)distribution in the hippocampus and the retina were visualised at 3,6 and 12 months of age.Interand intra-group analysis was performed to study rate of change for each parameter between the two groups.Results:Inter-group analysis revealed a significant difference in b-wave and OPs of APP/PS1 compared to WT controls starting from 3 months(p<0.001).There was also a significant difference in the amplitude of pSTR between the two groups starting from 6 months(p<0.001).Furthermore,a significant difference in the inner retinal thickness,between the two groups,was observed starting from 9 months(p<0.001).Conclusions:We observed an age-related decline in retinal functional and structural parameters in both APP/PS1 and WT controls,however,inter-group analysis revealed that inner retinal functional and structural decline is exacerbated in APP/PS1 mice,and that retinal functional changes precede structural changes in this strain.Further studies are required to confirm whether such phenomenon occurs in humans and if studying retinal functional changes can aid-in early assessment of AD. | Dana Georgevsky Stephanie Retsas Newsha Raoufi Olga Shimoni S.Mojtaba Golzan | 2019 | Translational Neurodegeneration2019，8，1： | 3 |
| 2 | Protective effect of N-acetylcysteine on antituberculosis drug-induced hepatotoxicity显示文摘 | Shadi Baniasadi Parivash Eftekhari Payam Tabarsi Fanak Fahimi Mohammad Reza Raoufy Mohammad Reza Masjedi Ali Akbar Velayati | 2010 | European Journal of Gastroenterology & Hepatology2010，，10： | 2 |
| 3 | Reactive power rescheduling with generator ranking for voltage stability improvement 显示文摘 | RAOUFI H KALANTAR M | 2009 | Energy Conversion and Management2009，50，4： | 1 |
| 4 | CFD analysis of flow field in square cyclones显示文摘 | Raoufi A Shams M Kanani H | 2009 | Powder Technol2009，191，3： | 1 |
| 5 | Surface modification of silica core-shell nanoeapsules: biomedical implications显示文摘 | Hashemi O R Raoufi F Ganjall M R | 2006 | Biomacromolecules2006，7，3： | 1 |
| 6 | Enhanced removal of methylene blue and methyl violet dyes from aqueous solution using a nanocomposite of hydrolyzed polyacrylamide grafted xanthan gum and incorporated nanosilica显示文摘 | Ghorai S Sarkar A Raoufi M | 2014 | ACS Appl Mater Interfaces2014，6，7： | 1 |
| 7 | Reactive power rescheduling with generator ranking for voltage stability improvement显示文摘 | RAOUFI H KALANTAR M | 2009 | Energy Conversion and Management2009，50，4： | 1 |
| 8 | Feasibility and preliminary accuracy of high-resolution imaging of the liver and pancreas using FNA compatible microendoscopy (with video)显示文摘 | Renu Regunathan Jenny Woo Mark C. Pierce Alexandros D. Polydorides Mohammad Raoufi Sasan Roayaie Myron Schwartz Daniel Labow Dongsuk Shin Rei Suzuki Manoop S. Bhutani Lezlee G. Coghlan Rebecca Richards-Kortum Sharmila Anandasabapathy Michelle Kang Kim | 2012 | Gastrointestinal Endoscopy2012，，： | 1 |
| 9 | CFD analysis of flow field in square cyclones显示文摘 | Raoufi A Shams M Kanani H | 2009 | Powder Technology2009，191，3： | 1 |
| 10 | Numerical simu-lation and optimization of fluid flow in cyclone vortex finder显示文摘 | Raoufi A Shams M Farzaneh ct al | 2008 | Chemical Engineering and Processing2008，47，1： | 1 |
| 11 | Surface characterization and microstructure of ITO thin films at different annealing temperatures 显示文摘 | Raoufi D Kiasatpour A Faltah H R | 2007 | Appl Surf Sci2007，253，： | 1 |
| 12 | Nuerical simulation and optimization of fluid flow in cyclone vortex finder显示文摘 | ARMAN Raoufi MEHRZAD Shams MEISAM Farzaneh | 2007 | Chemical Engineering and Processing2007，47，： | 1 |
| 13 | The effect of heat treatment on the physical properties of sol-gel derived ZnO thin films显示文摘 | Davood Raouf Taha Raoufi | 2009 | Applied SurfaceScience2009，255，： | 1 |
| 14 | Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome显示文摘 | Chen Y Segarini P Raoufi F | 2001 | Exp Cell Res2001，271，1： | 1 |
| 15 | Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome显示文摘 | Chen Y Segarini P Raoufi F | 2001 | Exp Cell Res2001，271，1： | 1 |
| 16 | Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome显示文摘 | Chen Y Segarini P Raoufi F | 2001 | Exp Cell Res2001，271，1： | 1 |
| 17 | The effect of heat treatment on the physical properties of sol-gel derived ZnO thin films 显示文摘 | Raoufi D Raoufi T | 2009 | Appl Surf Sei2009，255，7： | 1 |
| 18 | Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome显示文摘 | Chen Y Segarini P Raoufi F | 2001 | Exp Cell Res2001，271，： | 1 |
| 19 | Numerical simulation and optimization of fluid flow in cyclone vortex finder 显示文摘 | Raoufi A Shams M Farzaneh M | 2008 | Chemical Engineering and Processing2008，47，1： | 1 |
| 20 | Restrained shrinkage cracking in concrete elements:Role of substrate bond on crack development显示文摘 | RAOUFI K POUR GHAZ M POURSAEE A | 2010 | Journal of Materials in Civil Engineering2010，22，6： | 1 |
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