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| 1 | Effect of sample size on the fluid flow through a single fractured granitoid显示文摘Most of deep geological engineered structures,such as rock caverns,nuclear waste disposal repositories,metro rail tunnels,multi-layer underground parking,are constructed within hard crystalline rocks because of their high quality and low matrix permeability.In such rocks,fluid flows mainly through fractures.Quantification of fractures along with the behavior of the fluid flow through them,at different scales,becomes quite important.Earlier studies have revealed the influence of sample size on the confining stress-permeability relationship and it has been demonstrated that permeability of the fractured rock mass decreases with an increase in sample size.However,most of the researchers have employed numerical simulations to model fluid flow through the fracture/fracture network,or laboratory investigations on intact rock samples with diameter ranging between 38 mm and 45 cm and the diameter-to-length ratio of 1:2 using different experimental methods.Also,the confining stress,σ_3,has been considered to be less than 30 MPa and the effect of fracture roughness has been ignored.In the present study,an extension of the previous studies on 'laboratory simulation of flow through single fractured granite' was conducted,in which consistent fluid flow experiments were performed on cylindrical samples of granitoids of two different sizes(38 mm and 54 mm in diameters),containing a 'rough walled single fracture'.These experiments were performed under varied confining pressure(σ_3=5-40 MPa),fluid pressure(f_p ≤25 MPa),and fracture roughness.The results indicate that a nonlinear relationship exists between the discharge,Q,and the effective confining pressure,σ_(eff),and Q decreases with an increase in σ_(eff).Also,the effects of sample size and fracture roughness do not persist when σ_(eff)≥ 20 MPa.It is expected that such a study will be quite useful in correlating and extrapolating the laboratory scale investigations to in-situ scale and further improving theoretical/numerical models associated with fluid flow through rock masses. | Kunal Kumar Singh Devendra Narain Singh Ranjith Pathegama Gamage | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，3： | 5 |
| 2 | Biodiesel from microalgae: A critical evaluation from laboratory to large scale production显示文摘 | Rawat I Ranjith Kumar R Mutanda T | 2013 | Appl Energ2013，103，： | 1 |
| 3 | Advances in hydrogel-based vascularized tissues for tissue repair and drug screening显示文摘The construction of biomimetic vasculatures within the artificial tissue models or organs is highly required for conveying nutrients,oxygen,and waste products,for improving the survival of engineered tissues in vitro.In recent times,the remarkable progress in utilizing hydrogels and understanding vascular biology have enabled the creation of three-dimensional(3D)tissues and organs composed of highly complex vascular systems.In this review,we give an emphasis on the utilization of hydrogels and their advantages in the vascularization of tissues.Initially,the significance of vascular elements and the regeneration mechanisms of vascularization,including angiogenesis and vasculogenesis,are briefly introduced.Further,we highlight the importance and advantages of hydrogels as artificial microenvironments in fabricating vascularized tissues or organs,in terms of tunable physical properties,high similarity in physiological environments,and alternative shaping mechanisms,among others.Furthermore,we discuss the utilization of such hydrogels-based vascularized tissues in various applications,including tissue regeneration,drug screening,and organ-on-chips.Finally,we put forward the key challenges,including multifunctionalities of hydrogels,selection of suitable cell phenotype,sophisticated engineering techniques,and clinical translation behind the development of the tissues with complex vasculatures towards their future development. | Ying Wang Ranjith Kumar Kankala Caiwen Ou Aizheng Chen Zhilu Yang | 2022 | Bioactive Materials2022，7，3： | 1 |
| 4 | Overview of the potential of microalgae for CO2 sequestration显示文摘 | Bhola V Swalaha F Ranjith Kumar R | 2014 | International Journal of Environmental Science and Technology2014，11，7： | 1 |
| 5 | Impact of CuO nanoleaves on MWCNTs/GCE nanocomposite film modi lied electrode for the electrochemical oxidation of folic acid显示文摘 | Manoj D Ranjith Kumar D Santhanalakshmi J | 2012 | Appl Nanosci2012，2，： | 1 |
| 6 | Biodiesel from mi-croalgae :A critical evaluation from laboratory to large scale produc-tion 显示文摘 | Rawat I Ranjith Kumar R Mutanda T | 2013 | Applied Energy2013，103，3： | 1 |
| 7 | Screening for probiotic properties of strains isolated from feces of various human groups显示文摘 | Sathyaseelan Sathyabama Rajendran Vijayabharathi Palanisamy Bruntha devi Manohar Ranjith kumar Venkatesan Brindha Priyadarisini | 2012 | Journal of Microbiology2012，，4： | 1 |
| 8 | 3D bioprinting of conductive hydrogel for enhanced myogenic differentiation显示文摘Recently,hydrogels have gained enormous interest in three-dimensional(3D)bioprinting toward developing functional substitutes for tissue remolding.However,it is highly challenging to transmit electrical signals to cells due to the limited electrical conductivity of the bioprinted hydrogels.Herein,we demonstrate the 3D bioprinting-assisted fabrication of a conductive hydrogel scaffold based on poly-3,4-ethylene dioxythiophene(PEDOT)nanoparticles(NPs)deposited in gelatin methacryloyl(GelMA)for enhanced myogenic differentiation of mouse myoblasts(C2C12 cells).Initially,PEDOT NPs are dispersed in the hydrogel uniformly to enhance the conductive property of the hydrogel scaffold.Notably,the incorporated PEDOT NPs showed minimal influence on the printing ability of GelMA.Then,C2C12 cells are successfully encapsulated within GelMA/PEDOT conductive hydrogels using 3D extrusion bioprinting.Furthermore,the proliferation,migration and differentiation efficacies of C2C12 cells in the highly conductive GelMA/PEDOT composite scaffolds are demonstrated using various in vitro investigations of live/dead staining,F-actin staining,desmin and myogenin immunofluorescence staining.Finally,the effects of electrical signals on the stimulation of the scaffolds are investigated toward the myogenic differentiation of C2C12 cells and the formation of myotubes in vitro.Collectively,our findings demonstrate that the fabrication of the conductive hydrogels provides a feasible approach for the encapsulation of cells and the regeneration of the muscle tissue. | Ying Wang Qingshuai Wang Shengchang Luo Zhoujiang Chen Xiang Zheng Ranjith Kumar Kankala Aizheng Chen Shibin Wang | 2021 | Regenerative Biomaterials2021，8，5： | 1 |
| 9 | Biodiesel from microalgae: A critical evaluation from laboratory to large scale production显示文摘 | I. Rawat R. Ranjith Kumar T. Mutanda F. Bux | 2013 | Applied Energy2013，，： | 1 |
| 10 | Supercritical fluid-assisted controllable fabrication of open and highly interconnected porous scaffolds for bone tissue engineering显示文摘Recently tremendous progress has been evidenced by the advancements in developing innovative three-dimensional(3 D)scaffolds using various techniques for addressing the autogenous grafting of bone. In this work, we demonstrated the fabrication of porous polycaprolactone(PCL) scaffolds for osteogenic differentiation based on supercritical fluid-assisted hybrid processes of phase inversion and foaming. This eco-friendly process resulted in the highly porous biomimetic scaffolds with open and interconnected architectures. Initially, a 2^3 factorial experiment was designed for investigating the relative significance of various processing parameters and achieving better control over the porosity as well as the compressive mechanical properties of the scaffold. Then, single factor experiment was carried out to understand the effects of various processing parameters on the morphology of scaffolds. On the other hand, we encapsulated a growth factor, i.e., bone morphogenic protein-2(BMP-2), as a model protein in these porous scaffolds for evaluating their osteogenic differentiation. In vitro investigations of growth factor loaded PCL scaffolds using bone marrow stromal cells(BMSCs) have shown that these growth factor-encumbered scaffolds were capable of differentiating the cells over the control experiments. Furthermore, the osteogenic differentiation was confirmed by measuring the cell proliferation, and alkaline phosphatase(ALP) activity, which were significantly higher demonstrating the active bone growth. Together, these results have suggested that the fabrication of growth factor-loaded porous scaffolds prepared by the eco-friendly hybrid processing efficiently promoted the osteogenic differentiation and may have a significant potential in bone tissue engineering. | Hanxiao Tang Ranjith Kumar Kankala Shibin Wang Aizheng Chen | 2019 | Science China(Life Sciences)2019，62，12： | 1 |
| 11 | Preparation of alumina-carbon composites with phloroglucinol-formaldehyde resin and their application in asymmetric hydrogenation显示文摘To overcome the shortcomings of single component carrier supported platinum(Pt)-based catalysts,herein,we demonstrate the fabrication of alumina combined mesoporous carbon to prepare a series of alumina-carbon composites and their corresponding Pt-based catalysts.The alumina-carbon composites Al@PhFC are synthesized by using phloroglucinol-formaldehyde resin as carbon source and aluminum acetylacetone as the aluminum source.Further,the effect of alumina content on the properties of the composites is investigated.The composites and catalysts are characterized by using XRD,XPS,N2 sorption,and TEM.The Pt/Al@PhFC-1.8 composite with appropriate amounts of alumina,pore diameter,and moderate Pt nanoparticle size,resulted in 99.5%of conversion efficiency and 77.4%of optical selectivity in the asymmetric hydrogenation of ethyl 2-oxo-4-phenylbutanoate(EOPB).Intere stingly,this composite can be used more than 20 times without a significant decrease in its performance. | Wenrui Cai Renjie Xiong Cong Mao Meitian Xiao Yongjun Liu Ranjith Kumar Kankala Xueqin Zhang | 2020 | Chinese Chemical Letters2020，31，5： | 1 |
| 12 | Fatty acids, tocols, and carotenoids in pulp oil of three sea buckthorn species (Hippophae rhamnoides, H. salicifolia, and H. tibetana) grown in the Indian Himalayas显示文摘 | A. Ranjith K. Sarin Kumar V. V. Venugopalan C. Arumughan R. C. Sawhney Virendra Singh | 2006 | Journal of the American Oil Chemists’ Society2006，，4： | 1 |
| 13 | 显示文摘 | RANJITH KUMAR R PERUMAL S SENTHILKUMAR P | 2009 | Eur J Med Chem2009，44，： | 1 |
| 14 | Biodiesel from microalgae:A critical evaluation from laboratory to large scale production显示文摘 | Rawat I Ranjith Kumar R Mutanda T | 2013 | Applied Energy2013，103，： | 1 |
| 15 | Dithienylcyclopentadienone derivative-co benzothiadiazole: An alternating copolymer for organic photovoltaics显示文摘 | K Ranjith S Swathi P Kumar etal | 2012 | Solar energy materials and solar cells2012，98，： | 1 |
| 16 | Metal Concentra-tions and Metal Mobility in Unsaturated Mine Wastes in Mining Ar-eas of Goa, India 显示文摘 | YELLISHETTY M RANJITH P G KUMAR D L | 2009 | Resources Conservation and Recycling2009，53，7： | 1 |
| 17 | Synergistic chemo-/photothermal therapy based on supercritical technology-assisted chitosan–indocyanine green/luteolin nanocomposites for wound healing显示文摘Despite the success,it is highly challenging to battle against pathogenic biofilms-based chronic bacterial infections by conventional antibiotic therapy.Herein,we report a near-infrared(NIR)/acid-induced nanoplatform based on chitosan(CS)-coated indocyanine green(ICG,photosensitizer)/luteolin(LUT,a natural quorum sensing inhibitor)nanocomposites(ICG/LUT-CS)as antibacterial and antibiofilm agents for skin wound healing.Initially,the ICG/LUT nanoplatforms are prepared by the supercritical antisolvent technology and coated with the CS layer.The obtained ICG/LUT-CS with ultra-high encapsulation efficiency exhibited more favorable photothermal conversion effects and improved NIR laser/acid dual-induced drug release behavior than individual modalities,achieving exceptional bacteria-killing and biofilm elimination effects.Moreover,the ICG/LUT-CS realized the synergetic effects of chemotherapy and photothermal therapy outcomes for wound healing.Together,our findings provided an appealing strategy for the rapid preparation and future translational application of ICG/LUT-CS as an ideal agent for fighting against biofilm infections. | Pei-Yao Xu Ranjith Kumar Kankala Yue-Wei Li Shi-Bin Wang Ai-Zheng Chen | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 18 | Preparation of aripiprazole-poly(methyl vinyl ether-co-maleic anhydride)nanocomposites via supercritical antisolvent process for improved antidepression therapy显示文摘Aripiprazole(ARI),a second-generation atypical antipsychotic drug approved for schizophrenia treatment,shows good efficacy against depression.However,the poorly aqueous solubility of ARI leads to low bioavailability and increased dose-related side effects,seriously limiting its application in pharmaceutics.Herein,we demonstrated the fabrication of ARI and poly(methyl vinyl etherco-maleic anhydride)(PVMMA)composite nanoparticles(PA NPs)using the supercritical antisolvent(SAS)process for enhancing its water-solubility and curative anti-depressant effects.Initially,the optimal experimental conditions(ARI/PVMMA mass ratio of 1:6,pressure of 10MPa,and solution flow rate of 0.75ml min^(-1))were determined by a 23 factorial experimental design,resulting in the PA NPs with an excellent particle morphology.In vitro cell experiments showed that PA NPs significantly inhibited the inflammatory response caused by the microglia activation induced by lipopolysaccharide(LPS).Similarly,mice behavioral tests demonstrated that PA NPs significantly improved LPS-induced depression-like behavior.Importantly,compared with free ARI,the LPS-induced activation of microglia in the mouse brain and the expression of inflammatory factors in serum were significantly reduced after treatment with PA NPs.Together,the innovative PA NPs designed by SAS processmight provide a candidate for developing new ARI-based nano-formulations. | Lin-Fei Chen Ying Chen You-Yu Duan Man-Man Zhang Pei-Yao Xu Ranjith Kumar Kankala Shi-Bin Wang Ai-Zheng Chen | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 19 | Immune-regulating camouflaged nanoplatforms:A promising strategy to improve cancer nano-immunotherapy显示文摘Although nano-immunotherapy has advanced dramatically in recent times,there remain two significant hurdles related to immune systems in cancer treatment,such as(namely)inevitable immune elimination of nanoplat-forms and severely immunosuppressive microenvironment with low immunogenicity,hampering the perfor-mance of nanomedicines.To address these issues,several immune-regulating camouflaged nanocomposites have emerged as prevailing strategies due to their unique characteristics and specific functionalities.In this review,we emphasize the composition,performances,and mechanisms of various immune-regulating camouflaged nano-platforms,including polymer-coated,cell membrane-camouflaged,and exosome-based nanoplatforms to evade the immune clearance of nanoplatforms or upregulate the immune function against the tumor.Further,we discuss the applications of these immune-regulating camouflaged nanoplatforms in directly boosting cancer immunotherapy and some immunogenic cell death-inducing immunotherapeutic modalities,such as chemo-therapy,photothermal therapy,and reactive oxygen species-mediated immunotherapies,highlighting the cur-rent progress and recent advancements.Finally,we conclude the article with interesting perspectives,suggesting future tendencies of these innovative camouflaged constructs towards their translation pipeline. | Biao-Qi Chen Yi Zhao Yang Zhang Yu-Jing Pan Hong-Ying Xia Ranjith Kumar Kankala Shi-Bin Wang Gang Liu Ai-Zheng Chen | 2023 | Bioactive Materials2023，，3： | 0 |
| 20 | Photocatalytic degradation of endocrine disruptor Bisphenol-A in the presence of prepared Ce_xZn_(1-x)O nanocomposites under irradiation of sunlight显示文摘Photocatalytic degradation of Bisphenol A(BPA), a representative endocrine disruptor chemical, was carried out under irradiation of sunlight in the presence of Ce x Zn1-x O nanophotocatalyst. Cerium(Ce) ions were successfully incorporated into the bulk lattice of Zn O by simple co-precipitation process. The Ce x Zn1-x O composite nanostructures exhibited higher photocatalytic efficiency than pure Zn O in the degradation of BPA under sunlight irradiation and nearly complete mineralization of BPA was achieved. The degradation rate was strongly dependent on factors such as the size and structure of catalyst, doping material concentration, BPA concentration, catalyst load, irradiation time and p H levels. This work suggested that the Ce x Zn1-x O assisted photocatalytic degradation is a versatile, economic, environmentally benign and efficient method for BPA removal in the aqueous environment. | Kamaraj M. Ranjith K.S. Rajeshwari Sivaraj Rajendra Kumar R.T. Hasna Abdul Salam | 2014 | Journal of Environmental Sciences2014，26，11： | 0 |
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