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| 1 | Genetically modified mouse models for the study of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is associated with obesity,insulin resistance,and type 2 diabetes.NAFLD represents a large spectrum of diseases ranging from(1) fatty liver(hepatic steatosis);(2) steatosis with inflammation and necrosis;to(3) cirrhosis.The animal models to study NAFLD/nonalcoholic steatohepatitis(NASH) are extremely useful,as there are still many events to be elucidated in the pathology of NASH.The study of the established animal models has provided many clues in the pathogenesis of steatosis and steatohepatitis,but these remain incompletely understood.The different mouse models can be classified in two large groups.The first one includes genetically modified(transgenic or knockout) mice that spontaneously develop liver disease,and the second one includes mice that acquire the disease after dietary or pharmacological manipulation.Although the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex,genetically modified animal models may be a key for the treatment of NAFLD.Ideal animal models for NASH should closely resemble the pathological characteristics observed in humans.To date,no single animal model has encompassed the full spectrum of human disease progression,but they can imitate particular characteristics of human disease.Therefore,it is important that the researchers choose the appropriate animal model.This review discusses various genetically modified animal models developed and used in research on NAFLD. | Perumal Nagarajan M Jerald Mahesh Kuma Ramasamy Venkatesan Subeer S Majundar Ramesh C Juyal M Jerald Mahesh Kuma | 2012 | World Journal of Gastroenterology2012，18，11： | 7 |
| 2 | A microwave assisted synthesis of 2-aryl-1-arylmethyl-1H-1,3-benzimidazoles in the presence of K-10显示文摘 | PERUMAL S MARIAPPAN S SELVARAJ S | | 0，，： | 1 |
| 3 | Discovery of Antimycobacterial Spiro - piperidin - 4 - ones : An Atom Economic, Stereoselective Synthesis, and Biological Intervention 显示文摘 | Kumar R R Perumal S Senthilkumar P | 2008 | J Med Chem2008，51，： | 1 |
| 4 | Proteomic analysis of cytoplasmic and surface proteins from yeast cells, hyphae, and biofilms of Candida albicans 显示文摘 | Montserrat M G Perumal P Mekala S | 2009 | Proteomics2009，9，8： | 1 |
| 5 | A microwave assisted synthesis of 2-aryl-1-arylmethyl-1H-1,3-benzi-midazoles in the presence of K - 10 显示文摘 | Perumal S Mariappan S Selvaraj S | 2004 | Arkivoc2004，8，： | 1 |
| 6 | Randomized clinical study to compare the accuracy of navigated and non-navigated thoracic pedicle screws in deformity correction surgeries显示文摘 | Rajasekaran S Perumal SV Shetty AP | | 0，，： | 1 |
| 7 | Randomized Clinical Study to Compare the Accuracy of Navigated and Non-Navigated Thoracic Pedicle Screws in Deformity Correction Surgeries显示文摘 | S Rajasekaran S Vidyadhara Perumal Ramesh Ajoy P. Shetty | 2007 | Spine2007，，： | 1 |
| 8 | A Facile Four-component Tandem Protocol for the Synthesis of Novel 2,6-Diaryl-2,3-dihydro-lH- pyridin-4 -ones 显示文摘 | Devi N S Perumal S | 2007 | Tetrahedron Lett2007，48，32： | 1 |
| 9 | A QSRR treatment ofsolvent effects on the decarboxylation 6-nitrobenzisoxazole- 3-carboxylates employing molecular descriptors 显示文摘 | Katritzky A R Perumal S Petrukhin R | 2001 | The Journal ofOrganic Chemistry2001，66，11： | 1 |
| 10 | Functional electrical stimulation of ankle plantarflexor and dorsiflexor muscles effects on poststroke gait显示文摘 | Kesar T M Perumal i:< Reisman D S | 2009 | Stroke2009，40，12： | 1 |
| 11 | Preparation of zein nanopart icles by p H controlled nanoprecipitation显示文摘 | PODARALLA S PERUMAL O | 2010 | Journal of Biomedical Nanotechnology2010，6，4： | 1 |
| 12 | Chromium stress in paddy:(i)Nutrient status of paddy under chromium stress;(ii) Phytoremediation of chromium by aquatic and terrestrial weeds 显示文摘 | Perumal S Alagappan C Kaliyaperumal S G | 2010 | Comptes Rendus Biologies2010，333，8： | 1 |
| 13 | Melatonin, immune function and aging显示文摘 | Srinivasan V Maestroni G Cardinali D Esquifino A Perumal SP Miller S | 2005 | Immun Ageing2005，2，： | 1 |
| 14 | Growth, structural, spectral, mechanical and dielectric character- ization of RbCl-doped L-alanine hydrogen chloride mono- hydrate single crystals 显示文摘 | Rose A S J L Selvarajan P Perumal S | 2011 | Physica B: Condensed Mat- ter2011，406，3： | 1 |
| 15 | Preparation and evaluation of mesalamine collagen in situ rectal gel:A novel therapeutic approach for treating ulcerative colitis显示文摘 | Ramadass SK Perumal S Jabaris SL | 2013 | European journal of pharmaceutical sciences2013，48，12： | 1 |
| 16 | Myrtenal, a natural monoterpene, down-regulates TNF-c expression and suppresses car- cinogen-induced hepatocellular carcinoma in rats 显示文摘 | Babu LH Perumal S Balasubramanian MP | 2012 | Mol Cell Biochem2012，369，12： | 1 |
| 17 | Synthesis of nanoscale NbSe2 materials from molecular precursors 显示文摘 | Perumal S Eric C G Jeremy E | 2005 | J Am Chem Sog2005，127，： | 1 |
| 18 | Novel ofloxaein derivatives: Synthesis, antimycobacterial and toxicological evaluation 显示文摘 | Murugesan D Palaniappan S Perumal Y | 2008 | Bioorg Med Chem Lett2008，18，： | 1 |
| 19 | Antioxidant properties of various solvent extracts of total phenolic consitituents from three different agroclimatic origins of drumstick three leaves 显示文摘 | Klaus B | 2003 | Agricultural and Food Chemistry2003，，5： | 1 |
| 20 | L-proline-catalysed novel tandem reactions of 1-substituted piperidin-4-ones with (E)-4-arylbut-3-en-2-ones:N-substituent mediated product selectivity and synthesis of novel nitrogen heterocycles 显示文摘 | Srinivasan M Perumal S | 2007 | Tetrahedron2007，63，： | 1 |
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