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| 1 | Antioxidant activities of Indigofera cassioides Rottl.Ex.DC.using various in vitro assay models显示文摘Objective:To evaluate the antioxidant potential of methanolic leaf extract of Indigofera cassioides(MEIC) using various in vilro antioxidant assay systems.Methods:Antioxidant and free radical scavenging activity of MEIC was assayed by using different in vitro models like ABTS, DPPH,nitric oxide,superoxide,hydrogen peroxide and hydroxyl radical.Reductive ability of the extract was tested by the complex formation with potassium ferricyanide.Further total phenol and flavonoid contents of the crude extract were also determined.Rutin and ascorbic acid were used as standards.Results:MEIC exhibited potent and concentration dependent free radical scavenging activity in all the tested models.Reductive ability was also found to increase with increase in MEIC concentration.Total phenol and flavonoid content determination showed that the extract is rich in phenols and flavonoids.Conclusions:All the results of the in vitro antioxidant assays reveal potent antioxidant and free radical scavenging activity of the leaves of Indigofera cassioides,equivalent to that of standard ascorbic acid and rutin.This potent antioxidant activity may be attributed to its high phenolic and flavonoid contents. | R Senthil Kumar B Rajkapoor P Perumal | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 15 |
| 2 | 不同入路冠状动脉介入治疗术围手术期周围血管并发症发生率的对比显示文摘目的:比较经股动脉和桡动脉入路冠状动脉介入治疗(percutaneous coronary intervention,PCI)术中周围血管并发症的发生率,为其临床诊治提供参考。方法:分析2014年7月至2016年12月在我院心血管介入治疗中心进行冠状动脉造影及介入治疗的780例患者的临床资料,比较周围血管并发症发生情况。结果:经股动脉途径471例,经桡动脉途径309例。经股动脉途径总体并发症发生率13.2%,高于经桡动脉途径的4.5%,差异有统计学意义(P<0.001)。经股动脉途径出血并发症发生率为7.9%,高于经桡动脉途径2.6%,差异有统计学意义(P=0.002)。经股动脉途径患者重大并发症(后腹膜血肿、假性动脉瘤、动静脉瘘、动脉夹层形成)发生率高于经桡动脉途径(2.1%vs 0%),但差异无统计学意义。结论:经股动脉途径冠状动脉介入治疗术围手术期周围血管并发症发生率高于经桡动脉途径,临床入路选择时需综合考虑。 | 张树清 崔磊 祁荣兴 SANJEEV KUMAR P S 黄胜 葛莉 钱澄 | 2017 | 中国临床医学2017，24，5： | 11 |
| 3 | Antihyperglycemic and antioxidant effects of Solanum xanthocarpum leaves(field grown & in vitro raised) extracts on alloxan induced diabetic rats显示文摘Objective:To investigate antidiabetic efficacy of the extract of field grown and in vitro raised leaves of Solanum xanthocarpum(S.xanthocarpum) against alloxan induced diabetic rats. Methods:The antidiabetic activity of the crude methanol extracts of the field grown and in vitro raised leaves of S.xanthocarpum at different concentrations(100-200 mg/kg bw) was tested against alloxan induced diabetic rats.The antidiabetic efficacy was validated through various biochemical parameters and the antioxidant effect was also determined.The phytochemical analyses of field grown S.xanthocarpum and in vitro rasied 5.xanthocarpum leaves were done by estimating their chlorophyll,carotenoids,total sugar,protein,amino acid and minerals contents. Results:The results revealed that the methanol extracts of both the leaves(field grown and in vitro raised) of S.xanthocarpum was efficient anti hyperglycemic agents at a concentration of 200 mg/kg bw and posses potent antioxidant activity.However,the extracts of in vitro rasied S.xanthocarpum raised leaves exhibit higher efficacy than the field grown leaves in all tested concentrations.Proximal composition and mineral analysis of S.xanthocarpum revealed higher concentration of contents in in vitro rasied S.xanthocarpum than field grown S.xanthocarpum. Conclusions:From the results it can be concluded that the leaves extracts of S.xanthocarpum can be a potential candidate in treating the hyperglycemic conditions and suits to be an agent to reduce oxidative stress. | K Poongothai P Ponmurugan K Syed Zameer Ahmed B Senthil Kumar SA Sheriff | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 9 |
| 4 | Antimicrobial potential of Actinomycetes species isolated from marine environment显示文摘Objective:To evaluate the antimicrobial activity of Actinomycetes species isolated from marine environment.Methods:Twenty one strains of Actinomyceteswere isolated from samples of Royapuram, Muttukadu, Mahabalipuram sea shores and Adyar estuary. Preliminary screening was done using cross-streak method against two gram-positive and eight gram-negative bacteria.The most potent strains C11 and C12 were selected from which antibacterial substances were extracted. The antibacterial activities of the extracts were performed using Kirby-Bauer disc diffusion method. Molecular identification of those isolates was done.Results:All those twenty one isolates were active against at least one of the test organisms. Morphological characters were recorded. C11 showed activity againstStaphylococcusspecies(13.0暲0.5 mm),Vibrio harveyi(11.0暲0.2 mm),Pseudomonas species(12.0暲0.3 mm). C12 showed activity against Staphylococcus species(16.0暲0.4 mm),Bacillus subtilis(11.0暲0.2 mm),Vibrio harveyi(9.0暲0.1 mm),Pseudomonas species(10.0暲0.2 mm). 16S rRNA pattern strongly suggested that C11 and C12 strains were Streptomyces species.Conclusions:The results of the present investigation reveal that the marineActinomycetesfrom coastal environment are the potent source of novel antibiotics.Isolation, characterization and study of Actinom ycetescan be useful in discovery of novel species of Actinomy cetes. | Valli S Suvathi Sugasini S Aysha OS Nirmala P Vinoth Kumar P Reena A | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，6： | 8 |
| 5 | A GFP-based bacterial biosensor with chromosomally integrated sensing cassette for quantitative detection of Hg(Ⅱ) in environment显示文摘A mercury biosensor was constructed by integrating biosensor genetic elements into E. coli JM109 chromosome in a single copy number, using the attP/attB recombination mechanism of λ phage. The genetic elements used include a regulatory protein gene (merR) along with operator/promoter (O/P) derived from the mercury resistance operon from pDU1358 plasmid of Serratia marcescens. The expression of reporter gene gfp is also controlled by merR/O/P. Integration of the construct into the chromosome was done to increase the stability and precision of the biosensor. This biosensor could detect Hg(Ⅱ) ions in the concentration range of 100–1700 nmol/L, and manifest the result as the expression of GFP. The GFP expression was significantly different (P 0.05) for each concentration of inducing Hg(Ⅱ) ions in the detection range, which reduces the chances of misinterpretation of results. A model using regression method was also derived for the quantification of the concentration of Hg(Ⅱ) in water samples. | Himanshu Priyadarshi Absar Alam Gireesh-Babu P Rekha Das Pankaj Kishore Shivendra Kumar Aparna Chaudhari | 2012 | Journal of Environmental Sciences2012，24，5： | 6 |
| 6 | Anti-microbial principles of selected remedial plants from Southern India显示文摘Objective:To examine the anti-bacterial activity of leaf extracts of Morus alba L.(Moraceae)and Piper betel L.(Piperaceae),and seed extracts of Bombax ceiba L.(Borabacaceae).Methods:We have partially purified plant extracts by solvent extraction method,and evaluated the effect of individual fractions on bacterial growth using Escherichia coli(E.coli),Pseudomonas aeruginosa(P.aeruginosa) and Staphylococcus aureus(S.aureus) bacterial strains.Results:Compared with Morus and Bombax fractions,Piper fractions showed significant growth inhibition on all the three types of bacteria studied.The EtOAc-hexane fractions of Piper leaves exhibited significant antibacterial activity with minimum inhibitory concentrations(MIC) of 50 μg/mL culture against both gram-positive and gram-negative bacteria.The EtOAc-fractions Ⅰ,Ⅱ,and Ⅳ inhibited bacterial colony formation on soft agar in addition to growth inhibition.A combination treatment of piper fractions with ampicillin resulted in significant growth inhibition in E.coli and P.aeruginosa,and combination with anticancer drug geldanamycin(2 μg/mL) showed selective growth inhibition against P.aeruginosa and S.aureus.Three major compounds,i.e.,eugenol,3-hexene-ol and stigmasterol,were primarily identified from Piper betel leaf extractions.Among the individual compounds,eugenol treatment showed improved growth inhibition compared with stigmasterol and 3-hexene-ol.Conclusions:We are reporting potential anti-bacterial compounds from Piper betel against both gram-positive and gram-negative bacteria either alone or in combination with drug treatment. | Tirupathi Rao G Suresh Babu K J Ujwal Kumar Sujana P A Veerabhadr Raoa Sreedhar AS | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 5 |
| 7 | 脓毒性休克早产儿血流动力学变化:前瞻性观察性研究显示文摘目的 采用功能性超声心动图评估脓毒性休克早产儿血流动力学变化并研究血管活性药对血流动力学参数的影响。 | Saini SS Kumar P Kumar RM 方伯梁(译) 钱素云(校) | 2014 | 中国小儿急救医学2014，21，6： | 5 |
| 8 | Laparoscopic liver resection:Wedge resections to living donor hepatectomy, are we heading in the right direction?显示文摘Despite inception over 15 years ago and over 3000 completed procedures, laparoscopic liver resection has remained mainly in the domain of selected centers and enthusiasts. Requirement of extensive open liver resection(OLR) experience, in-depth understanding of anatomy and considerable laparoscopic technical expertise may have delayed wide application. However healthy scepticism of its actual benefits and presence of a potential publication bias; concern about its safety and technical learning curve, are probably equally responsible. Given that a large proportion of our work, at least in transplantation is still OLR, we have attempted to provide an entirely unbiased, mature opinion of its pros and cons in the current invited review. We have dividedthis review into two sections as we believe they merit separate attention on technical and ethical grounds. The first part deals with laparoscopic liver resection(LLR) in patients who present with benign or malignant liver pathology, wherein we have discussed its overall outcomes; its feasibility based on type of pathology and type of resection and included a small section on application of LLR in special scenarios like cirrhosis. The second part deals with the laparoscopic living donor hepatectomy(LDH) experience to date, including its potential impact on transplantation in general. Donor safety, graft outcomes after LDH and criterion to select ideal donors for LLR are discussed. Within each section we have provided practical points to improve safety in LLR and attempted to reach reasonable recommendations on the utilization of LLR for units that wish to develop such a service. | P Thomas Cherian Ashish Kumar Mishra Palaniappen Kumar Vijayant Kumar Sachan Anand Bharathan Gadiyaram Srikanth Baiju Senadhipan Mohamad S Rela | 2014 | World Journal of Gastroenterology2014，20，37： | 4 |
| 9 | Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic显示文摘Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues.The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/kg.Mangiferin and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral analysis.Results:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 h.Conclusions:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines. | Shashi Kant Singh Saurabh K Sinha SK Prasad R Kumar Bhawani S Bithu S Sadish Kumar P Singh | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 4 |
| 10 | Genetic determinant s of diabetic nephropathy显示文摘 | Chowdhury T A Dyer P H Kumar S | | 0，，： | 2 |
| 11 | Ordered Intermetallics显示文摘 | E P George M Yamaguchi K S Kumar C T Liu | 1994 | Annual Review of Materials Science1994，，： | 2 |
| 12 | 混凝土的耐久性——未来混凝土的关键问题 | P Kumar Mehfa 赵宇虹 | 1998 | 吉林建筑大学学报1998，29，3X： | 2 |
| 13 | Phytoextraction:the use of plants to remove heavy metals from soils显示文摘 | NADAN KUMAR P B A DUSHENKOV V MOTTO H | 1995 | Environ Sci Technol1995，29，5： | 2 |
| 14 | A lupane derivative and the 13C-NMR chemical shifts lupanone from Pleurostylia opposita 显示文摘 | Dantanarayana A P Kumar N S | 1982 | Phytochemistry1982，21，8： | 2 |
| 15 | Nanocrystalline TiO2 studied by optical, FTIR and X-ray photoelectron spectroscopy: correlation to presence of surface states 显示文摘 | Madhu Kumar P Badrinarayanan S Sastry M | 2000 | Thin Solid Films2000，358，12： | 2 |
| 16 | Spinosad and neem seed kernel extract as bio-controlling agents for malarial vector,Anopheles stephensi and non-biting midge,Chironomus circumdatus显示文摘Objective:Midge egg masses are reported to support non-pathogenic strains of the cholera pathogen.Vibrio cholera(V.cholera).Mosquito born diseases have been reported to cause millions of death worldwide.The present research reveals the toxicity effect of spinosad and neem seed kernel extract(NSKE) against different larval stages of Anopheles stephensi(An.stephensi) and Chironomus circumdatus(Ch.circumdatus).Methods:The neem seeds were collected from Marudamalai hills,Bharathiar University,Coimbatore,India.Neem seed kernels were powdered,extracted and diluted for different concentrations(2 ppm to 10 ppm).Spinosad was purchased from Kalpatharu pesticide Limited,Coimbatore,Tamil Nadu,India and thoroughly mixed with distilled water to prepare various concentrations(0.01 to 0.08 ppm) and used for bioassay.Results:The results depict that spinosad is more toxic in lower concentrations when compared to NSKE and mosquitoes are more susceptible than chironomids.Lethal concentrations were evaluated using the observed mortality.The lowest LC50 value obtained from spinosad against An.stephensi and Ch.circumdalus were 0.002 05 ppm and 0.008 91 ppm.This study investigated on effect of Spinosad and NSKE on the biology of mosquito.The immature stages of both species were susceptible to Spinosad and NSKE.Spinosad and NSKE in individual as well as combined treatment provided additional days in development for mosquitoes.Conclusions:The results conclude that Spinosad and NSKE are potential larvicides against An.stephensi and Ch. circumdatus. | Kumar AN Murugan K Madhiyazhagan P Prabhu K | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，8： | 2 |
| 17 | Objectively determined 10-day African rainfall estimates created for famine early warning systems显示文摘 | Herman A V B Kumar P A Arkin | 1997 | Int J Remote Sens1997，18，： | 2 |
| 18 | Effect of K2O addition on crystallization and microstructural behaviour of the strontium titanate-borosilicate glass-ceramic system显示文摘 | THAKUR O P KUMAR Devendra PARKASH Om etal | 1995 | Mater Lett1995，23，： | 2 |
| 19 | Effect of morin, a flavonoid against DOCA-salt hypertensive rats:a dose dependent study显示文摘Objective:To determine the protective effect of morin, a flavonoid against deoxycorticosterone acetate(DOCA)-salt induced hypertension in male Wistar rats.Methods:Hypertension was induced in uninephrectomized rats by weekly twice subcutaneous injection of DOCA(25 mg/kg bw) and 1% NaCl in the drinking water for six consecutive weeks. Effect of morin against DOCA-salt induced hypertension was evaluated by measuring blood pressure and performing biochemical estimations and histopathological examination of renal tissues.Results:DOCA-salt hypertensive rats showed considerably increased systolic and diastolic blood pressure,serum hepatic marker enzyme activities such as aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatase(ALP) and gamma-glutamyl transpeptidase(GGT)and renal function markers(urea, uric acid and creatinine) in plasma. Oral administration of morin(25, 50 and 75 mg/kg bw) brought back all the above parameters to near normal level.Histopathology of kidney also confirmed the biochemical findings of this study. The effect at a dose of 50 mg/kg bw of morin was more pronounced than that of the other two doses(25 and 75 mg/kg bw).Conclusions:These findings indicate that morin exhibits strong antihypertensive effect against DOCA-salt induced hypertension. | Prahalathan P Kumar S Raja B | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，6： | 2 |
| 20 | On the True Minimum Distarce of Hermitian codes显示文摘 | Kyeongcheol Yang Vijay Kumar P | 1991 | Coding Theory and Algebraic Gometry Proceeding Luminy1991，1518，： | 2 |
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