|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 2 | A life support-based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis: a multiple center study显示文摘Fulminant myocarditis(FM) has unacceptable high mortality. This study aimed to evaluate the therapeutic efficacy of a life support-based comprehensive treatment regimen(LSBCTR), a completely novel treatment regimen, for FM. A total of 169 FM patients recruited from January 2008 to December 2018 were divided into two groups: patients receiving LSBCTR(81 cases),which includes(i) mechanical life support(positive pressure respiration, intra-aortic balloon pump with or without extracorporeal membrane oxygenation),(ii) immunomodulation therapy using sufficient doses of glucocorticoids and immunoglobulins, and(iii) application of neuraminidase inhibitors, and those receiving conventional treatment(88 cases). The endpoints were in-hospital death and heart-transplantation. Of all the population, 44 patients(26.0%) died in hospitals. Inhospital mortality was 3.7%(3/81) for LSBCTR group and 46.6%(41/88) for traditional treatment(P<0.001). Early application of LSBCTR, mechanical life support, neuraminidase inhibitors, and immunomodulation therapy significantly contributed to reduction in in-hospital mortality. This study describes a novel treatment regimen for FM patients that dramatically reduces inhospital mortality. Its generalization and clinical application will efficiently save lives although further optimization is needed.This study offers an insight that virus infection induced inflammatory waterfall results in cardiac injury and cardiogenic shock and is the therapeutic target. | Sheng Li Shengyong Xu Chenze Li Xiao Ran Guanglin Cui Mengying He Kun Miao Chunxia Zhao Jiangtao Yan Rutai Hui Ning Zhou Yan Wang Jiangang Jiang Jing Zhang Daowen Wang | 2019 | Science China(Life Sciences)2019，62，3： | 43 |
| 3 | A journey to understand wheat Fusarium head blight resistance in the Chinese wheat landrace Wangshuibai显示文摘Fusarium head blight(FHB) or scab caused by Fusarium graminearum is a major threat to wheat production in China as well as in the world. To combat this disease, multiple efforts have been carried out internationally. In this article, we review our long-time effort in identifying the resistance genes and dissecting the resistance mechanisms by both forward and reverse genetics approaches in the last two decades. We present recent progress in resistance QTL identification, candidate functional gene discovery, marker-assisted improvement of FHB resistant varieties, and findings in investigating association of signal molecules, such as Ca^(++),SA, JA, and ET, with FHB response, with the assistance from rapidly growing genomics platforms. The information will be helpful for designing novel and efficient approaches to curb FHB. | Haiyan Jia Jiyang Zhou Shulin Xue Guoqiang Li Haisheng Yan Congfu Ran Yiduo Zhang Jinxing Shi Li Jia Xin Wang Jing Luo Zhengqiang Ma | 2018 | The Crop Journal2018，6，1： | 24 |
| 4 | TD-AltBOC:A new COMPASS B2 modulation显示文摘AltBOC(15,10) is the baseline of COMPASS B2 signal modulation.It is a BOC-like signal having different PN codes in the lower and the upper main split lobes,which allow one signal service per lobe.The two lobes can be received and processed separately like two BPSK(10) signals,or coherently processed to achieve better performance.Interoperability among COMPASS B2,Galileo E5 and GPS L5 is also achievable using AltBOC modulation.However,Galileo's 4-code AltBOC has drawbacks such as low efficiency and great receiver complexity.This paper presents a new modulation type named TD-AltBOC (Time Division AltBOC).The signal generation scheme and receiving method are presented,and are compared with AltBOC in the areas of power spectrum,ranging accuracy,anti-multipath performance,anti-interference performance,processing flexibility and complexity.Analysis results show TD-AltBOC has similar spectrum characteristics,interoperability,flexibility and anti-interference performance with AltBOC.When the frontend bandwidth is more than 50 MHz,TD-AltBOC can achieve better ranging accuracy and anti-multipath performance.It also has such advantages as high efficiency and low receiver complexity.TD-AltBOC could be a good solution to COMPASS B2 navigation signal. | TANG ZuPing ZHOU HongWei WEI JiaoLong YAN Tao LIU YuQi RAN YiHang ZHOU YanLing | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 20 |
| 5 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 6 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 7 | Novel modified pectin for heavy metal adsorption显示文摘Modified pectin cross-linked with adipic acid, was synthesized and used for heavy metal removal from wastewater. SEM and FTIR were used to investigate its structure and morphology. The modified pectin had a rough, porous phase covered with carboxy groups, resulting a high adsorption capacity. And at the room temperature, the saturated loading capacity for Pb2+, Cu2+ and Zn2+ reached 1.82 mmol/g, 1.794 mmol/g and 0.964 mmol/g, respectively. The results proved its potential application to remove of theheavy metal. | Feng Ting Li Hong Yang Yan Zhao Ran Xu | 2007 | Chinese Chemical Letters2007，18，3： | 16 |
| 8 | Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota显示文摘The phenylalanine-tyrosine-dopa-dopamine pathway provides dopamine to the brain.Iin this process,tyrosine hydroxylase(TH)isthe rate-limiting enzyme that hydroxylates tyrosine and generates levodopa(L-dopa)with tetranydrobiopterin(BH_(4))as a coenzyme.Here,we show that oral berberine(BBR)might supply H^(·) through dihydroberberine(reduced BBR produced by bacterial nitroreductase)and promote the production of BHl from dihydrobiopterin;the increased BH,enhances TH activity,which accelerates the production of L-dopa by the gut bacteria.Oral BBR acts in a way similar to vitamins.The L-dopa produced by theintestinal bacteria enters the brain through the circulation and is transformed to dopamine.To verify the gut-brain dialog activatedby BBR's effect,Enterococcus foecalis or Enterococcus faecium was transplanted into Parkinson's disease(PD)mice.The bacteriasignificantly increased brain dopamine and ameliorated PD manifestation in mice;additionally,combination of BBR with bacteriashowed better therapeutic effect than that with bacteria alone.Moreover,2,4,6-trimethy-pyranylium tetrafluoroborate(TMP-TFB)-derivatized matrix-assisted laser desorption mass spectrometry(MALDI-MS)imaging of dopamine identihed elevated striataldopamine levels in mouse brains with oral Enterococcus,and BBR strengthened the imaging intensity of brain dopamine.Theseresults demonstrated that BBR was an agonist of TH in Enterococcus and could lead to the production of L-dopa in the gut.Furthermore,a study of 28 patients with hyperlipidemia conhrmed that oral BBR increased bloodfecal L-dopa by the intestinalbacteria.Hence,BBR might improve the brain function by upregulating the biosynthesis of-dopa in the gut microbiota through avitamin-like effect. | Yan Wang Qian Tong Shu-Rong Ma Zhen-Xiong Zhao Li-Bin Pan Lin Cong Pei Han Ran Peng Hang Yu Yuan Lin Tian-Le Gao Jia-Wen Shou Xiao-Yang Li Xian-Feng Zhang Zheng-Wei Zhang Jie Fu Bao-Ying Wen Jin-Bo Yu Xuetao Cao Jian-Dong Jiang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 16 |
| 9 | Impact of Long-Term Atrazine Use on Groundwater Safety in Jilin Province, China显示文摘The long-lasting application of representative herbicide atrazine (ATR) has given rise to the accumulation of its residues in the groundwater. To investigate the impact of long-term ATR use on groundwater safety, the residues of ATR and its metabolites, desethylatrazine (DEA), deisopropylatrazine (DIA) and hydroxyatrazine (HA) were monitored in groundwater and top soil at the major corn growing region of Qian'an and Gongzhuling in Jilin Province, China. The residues of the target compounds were analyzed by UPLC-MS/MS. The limits of detection (LODs) of ATR, DEA, DIA, and HA were 0.5, 0.5, 5, and 0.5 ng L-1 in groundwater and 0.33, 0.33, 3.3, and 0.33 μg kg-1 in soil. The target compounds were found in 94% of groundwater samples and 100% of soil samples. The compounds detected most frequently in groundwater were ATR (89%), DEA (64%) and HA (17%), whereas in soil were ATR (97%), DEA (36%) and HA (97%). DIA was not detected in any determined groundwater and soil sample. Average residues were 106.8 ng L-1 for ATR, 0.9 ng L-1 for DEA and 0.3 ng L-1 for HA in groundwater, whereas 11.1 μg kg-1 for ATR, 0.4 μg kg-1 for DEA and 7.8 μg kg-1 for HA in soil. ATR residues detected in groundwater samples were below standards for drinking water quality (GB5749-2006, 2 μg L-1), while the total residues of ATR and its chloro-s-triazine metabolites (DEA and DIA) were below current WHO (World Health Organization) guideline value (GV, 0.1 mg L-1). In addition, concentrations of HA in groundwater were determined below current WHO GV (0.2 mg L-1). The results indicated that ATR is safe to be used in Jilin Province under the current application scheme. However, total residues of ATR and DEA were detected in nearly all wells, thus, it is necessary to pay attention on groundwater monitoring for ATR and its metabolites. | GENG Yue MA Jing JIA Ran XUE Li-qin TAO Chuan-jiang LI Chong-jiu MA Xiao-dong LIN Yan | 2013 | Journal of Integrative Agriculture2013，12，2： | 13 |
| 10 | Dendrobium sonia polysaccharide regulates immunity and restores the dysbiosis of the gut microbiota of the cyclophosphamide-induced immunosuppressed mice显示文摘To recognize the potential medicinal value of the Dendrobium sonia, polysaccharide(DSP) was extracted, purified, and investigated for its immunomodulatory activity. In vitro, DSP was shown to enhance the viability(MTT assay) and phagocytosis of macrophages. In cyclophosphamide-induced immunosuppressed mice, DSP increased serum levels of TNF-α, IL-6 and IFN-γ(enzyme-linked immunosorbent assay, ELISA), and ameliorated the imbalance of the community of gut microbiota as detected by 16 S ribosomal RNA gene sequencing. These results suggest that DSP might be beneficial for patients under immunosuppressed conditions. | LIU Wei YAN Ran ZHANG Liang | 2019 | Chinese Journal of Natural Medicines2019，17，8： | 13 |
| 11 | A study on arsenic trioxide inducing in vitro apoptosis of gastric cancer cell lines显示文摘INTRODUCTION Cell apoptosis,which involves the biologic regulation of the numbers and vital activity of cells,is an important metaboloc process in both normal cells and tumor cells. | Qin Long Gu Ning Li Li Zheng Gang Zhu Hao Ran Yin Yan Zhen Lin | 2000 | World Journal of Gastroenterology2000，6，3： | 12 |
| 12 | Efficacy and significance of various scores for pneumonia severity in the management of patients with community-acquired pneumonia in China显示文摘背景获得社区的肺病(帽子)在 world.Most 附近从传染疾病仍然是领先的原因 ot 死亡之一严重帽子病人进入特别护理单位( ICU ),并且收到学习试图评估肺病严厉索引(希腊语的第二十三个字母)的角色的在场的强烈 treatment.The , CURB-65 ,并且败血在就医的帽子病人的管理得分并且在 675 个帽子病人的一个总数就医了在的严重 cases.Methods 的预后上探索 ICU | Yang Yan Xu Feng Shi Li-yun Diao Ran Cheng Yu-sheng Chen Xi-yuan Jing Ji-yong Wang Xuan-ding Shen Hua-hao | 2012 | Chinese Medical Journal2012，，4： | 12 |
| 13 | Sorafenib extends the survival time of patients with multiple recurrences of hepatocellular carcinoma after liver transplantation显示文摘 | Wei-feng TAN Zhi-quan QIU Yong YU Rong-zheng RAN Bing YI Wan-yee LAU Chen LIU Ying-he QIU Fei-ling FENG Jing-han WANG Pei-ning YAN Bai-he ZHANG Meng-chao WU Xiang-ji LUO Xiao-qing JIANG | 2010 | Acta Pharmacologica Sinica2010，31，12： | 11 |
| 14 | Laboratory-based flight performance of the fall armyworm,Spodoptera frugiperda显示文摘In late 2018,the fall armyworm(FAW)Spodoptera frugiperda Smith(Lepidoptera:Noctuidae)made its arrival in China and its populations have since proliferated across most of eastern Asia.While S.frugiperda exhibits a considerable dispersal capacity and engages in long-distance migration,there’s only scant information on the species’flight capability.Here,we empirically assessed S.frugiperda flight activity under varying climatic conditions using a flight mill.More specifically,under laboratory conditions,FAW exhibited superior flight performance at 20-25℃ and 60-90%relative humidity(RH).When quantifying flight performance over five consecutive nights(i.e.,10 h/night),all flight parameters initially increased and then gradually dropped and FAW adults attained a total flight distance,duration and velocity equal to 63.73 km(48.42-94.12 km)(median,quartile range),24.12 h(20.87-27.73 h)and 2.73 km h^(-1)(2.13-3.33 km h^(-1)),respectively.Our work constitutes a first comprehensive assessment of S.frugiperda flight performance and provides baseline information for future efforts to forecast spatiotemporal changes in its geographical distribution,movement patterns and invasion trajectories.Such can ultimately permit a timely and targeted deployment of area-wide pest management measures against this newly-invasive pest in China and across eastern Asia. | GE Shi-shuai HE Li-mei HE Wei YAN Ran Kris AGWYCKHUYS WU Kong-ming | 2021 | Journal of Integrative Agriculture2021，20，3： | 10 |
| 15 | Geochemistry and Sr-Nd isotope characteristics of tonalites in Zêtang,Tibet:New evidence for intra-Tethyan subduction显示文摘Tonalites from the island arc rock assemblage in the Zêtang segment of the Yarlung Zangbo suture zone were analyzed for major,trace elements (including REE) and Sr-Nd isotope. The experimental data demonstrate that the tonalites have the adakite-like characteristics,including high SiO2 (58%―63%),Al2O3 (18.4%―22.4%),Sr (810×10 6―940×10 6),Sr/Y (77―106),low HREE (Y=9×10 6―11×10 6,Yb= 1×10 6―1.3×10 6),with LREE enrichment and faint Eu positive anomaly. ISr (0.70421―0.70487) is rela-tively low whereas 143Nd/144Nd (0.512896―0.512929) and εNd(t) values (+6.7―+7.3) are high. These fea-tures suggest that Zêtang tonalites were formed by the partial melting of subducted oceanic crust,with involvement of a small amount of oceanic sediments. The identification of Zêtang adakites,derived from slab melting,presents new evidence for the intra-Tethyan subduction and the previous sugges-tion about the existence of intra-oceanic island arc within Tethys. | WEI DongLiang XIA Bin ZHOU GuoQing YAN Jun WANG Ran ZHONG LiFeng | 2007 | Science China Earth Sciences2007，50，6： | 9 |
| 16 | Mycoplasma pneumoniae Macrolide Resistance and MLVA Typing in Children in Beijing,China,in 2016:Is It Relevant?显示文摘Objective The aim of this study is to investigate the macrolide resistance rate and molecular type with multiple-locus variable-number tandem-repeat analysis(MLVA)of Mycoplasma pneumoniae of Beijing in 2016 in pediatric patients.Methods Real-time quantitative polymerase chain reaction(PCR)was used to identify M.pneumoniae,and MLVA was performed.The domain V of the 23 S rRNA was sequenced to detect macrolide-resistant point mutations.We also investigated the activities of antibiotics against M.pneumoniae isolates in vitro.Results The PCR detection rate of M.pneumoniae in children in Beijing was 40%,and the macrolide resistance rate was 66%.The A2063 G mutation in the 23 S rRNA V region is the dominant mutation(137/146,93.84%),whereas the A2064 G mutation is rare(9/146,6.16%).Seventy-three samples were typed successfully by MLVA typing,including 86.3%(63/73)were MLVA type 4-5-7-2,and 13.7%(10/73)were MLVA type 3-5-6-2.No other types were found.No strains were resistant to levofloxacin or tetracycline.Conclusion In 2016,a specific decrease in the macrolide resistance rate occurred in Beijing.The detection rate and macrolide resistance rate of outpatients are lower than those of inpatients.The A2063 G mutants M.pneumoniae have high levels of resistance to erythromycin and azithromycin.The primary MLVA type is 4-5-7-2,followed by 3-5-6-2.No other MLVA types were detected.No strains resistant to tetracycline or levofloxacin were found in vitro. | DOU Hai Wei TIAN Xiu Jun XIN De Li WEI Ran ZHOU Wei WANG Hong QIN Xuan Guang SHAO Jun Yan XU Bao Ping GE Li Xia SHI Da Wei | 2020 | Biomedical and Environmental Sciences2020，33，12： | 9 |
| 17 | Functional Characterization of the Promoter and Second Intron of CUM1 During Flower Development in Cucumber(Cucumis sativus L.)显示文摘The characterization of flower specific promoter is critical during flower development by cucumber transformation technology.AGAMOUS(AG)is an organ identity gene that is required for carpel and stamen development in Arabidopsis.The promoter and second intron of AG contain multiple regulatory elements that confer proper spatial and temporal expression.Cucumber is an important vegetable with unisexual flowers.Cucumber MADS-box 1(CUM1)is the AG homolog in cucumber,belonging to the eu AG lineage along with AG.In situ hybridization showed that CUM1 was specifically expressed in the stamens and carpels of cucumber.GUS staining indicated that the second intron of CUM1 confers stamen-specific expression,while the promoter of CUM1 drives both stamen-and carpel-specific expression during the early stages of flower development,but is restricted to carpel-and connectivum-specific expression during the late stages of flower development.Furthermore,a yeast one-hybrid assay demonstrated that two auxin response factors(Cs ARF13 and Cs ARF17)had bound directly to the second intron of CUM1.Our data suggest that different regulatory circuits operate in AG homologs in plant species with distinct sex types. | GU Ran LIU Xiaofeng ZHAO Wensheng YAN Shuangshuang SUN Linhan WU Binning ZHANG Xiaolan | 2018 | Horticultural Plant Journal2018，4，3： | 9 |
| 18 | Psychological impact of the COVID-19 pandemic on healthcare workers:a cross-sectional study in China显示文摘Background Healthcare workers fighting against the coronavirus disease 2019(COVID-19)pandemic are under tremendous pressure,which puts them at an increased risk of developing psychological problems.Aims This study aimed to investigate the prevalence of psychological problems in different healthcare workers(ie,physicians,medical residents,nurses,technicians and public health professionals)during the COVID-19 pandemic in China and explore factors that are associated with the onset of psychological problems in this population during this public health crisis.Methods A cross-sectional,web-based survey was conducted in February 2020 among healthcare workers during the COVID-19 pandemic.Psychological problems were assessed using the Generalized Anxiety Disorder Scale,Patient Health Questionnaire and Insomnia Severity Index.Logistic regression analyses were used to explore the factors that were associated with psychological problems.Results The prevalence of symptoms of anxiety,depression,insomnia and the overall psychological problems in healthcare workers during the COVID-19 pandemic in China was 46.04%,44.37%,28.75%and 56.59%,respectively.The prevalence of the overall psychological problems in physicians,medical residents,nurses,technicians and public health professionals was 60.35%,50.82%,62.02%,57.54%and 62.40%,respectively.Compared with healthcare workers who did not participate in front-line work,front-line healthcare workers had a higher risk of anxiety,insomnia and overall psychological problems.In addition,attention to negative or neutral information about the pandemic,receiving negative feedback from families and friends who joined front-line work,and unwillingness to join front-line work if given a free choice were three major factors for these psychological problems.Conclusions Psychological problems are pervasive among healthcare workers during the COVID-19 pandemic.Receiving negative information and participating in front-line work appear to be.important risk factors for psychological problems.The psychological health of different healthcare workers should be protected during the COVID-19 pandemic with timely interventions and proper information feedback. | Jianyu Que Le Shi Jiahui Deng Jiajia Liu Li Zhang Suying Wu Yimiao Gong Weizhen Huang Kai Yuan Wei Yan Yankun Sun Maosheng Ran Yanping Bao Lin Lu | 2020 | General Psychiatry2020，33，3： | 8 |
| 19 | Risks faced by donors of right lobe for living donor liver transplantation显示文摘BACKGROUND:Because of the shortage of deceased donors with livers fit for transplantation,living donor liver transplantation(LDLT)is becoming an attractive alternative.Attention should be paid to the donors,especially to those of the right lobe.In this study,we evaluated the risks faced by donors of the right lobe for adult-to-adult LDLT.METHODS:The perioperative data from 105 consecutive living donors of the right lobe performed in West China Hospital from January 2002 to December 2007 were retrospectively studied.Preoperative evaluation included CT,MRCP,and intraoperative cholangiography,showing liver volume,hepatic vasculature and the biliary system.The standard liver volume(SLV)and the ratio of left lobe volume to SLV were calculated.The right lobe grafts were obtained by transecting the liver on the right side of the middle hepatic vein without inflow vascular occlusion,using an ultrasonic dissector.After operation the donors were monitored in the Intensive Care Unit for about three days.Each donor was followed up for at least 6 months.RESULTS:There was no donor mortality.Major complications occurred in 14 donors(13.3%),of whom 3 received conservative treatment,8 required invasive paracentesis,and 3 required further surgery.All donors were recovered well and resumed their previous occupations.CONCLUSIONS:Donors of the right lobe face low risks.The preoperative evaluation,especially evaluation of the volume of the remnant liver,should be exact.During the operation,the patency of the remnant hepatic vasculature and bile duct must be preserved,and the extent of injury to the remnant liver should be limited as much as possible.The detection and treatment of postoperative complications should be diligently performed. | Ran, Shun Wen, Tian-Fu Yan, Lu-Nan Li, Bo Zeng, Yong Chen, Zhe-Yu Zhang, Yu Liao, Zhi-Xue Liang, Guan-Lin Li, Guo Zhang, Xian-Hua | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 8 |
| 20 | TNF-αTNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms显示文摘Increasing evidence suggests that cytokines and chemokines play crucial roles in chronic itch. In the present study, we evaluated the roles of tumor necrosis factor-alpha(TNF-a) and its receptors TNF receptor subtype-1(TNFR1) and TNFR2 in acute and chronic itch in mice.Compared to wild-type(WT) mice, TNFR1-knockout(TNFR1-KO) and TNFR1/R2 double-KO(DKO), but not TNFR2-KO mice, exhibited reduced acute itch induced by compound 48/80 and chloroquine(CQ). Application of the TNF-synthesis inhibitor thalidomide and the TNF-αantagonist etanercept dose-dependently suppressed acute itch. Intradermal injection of TNF-α was not sufficient to evoke scratching, but potentiated itch induced by compound 48/80, but not CQ. In addition, compound 48/80 induced TNF-α mRNA expression in the skin, while CQ induced its expression in the dorsal root ganglia(DRG) and spinal cord. Furthermore, chronic itch induced by dry skin was reduced by administration of thalidomide and etanercept and in TNFR1/R2 DKO mice. Dry skin induced TNF-α expression in the skin, DRG, and spinal cord and TNFR1 expression only in the spinal cord. Thus, our findings suggest that TNF-α/TNFR1 signaling is required for the full expression of acute and chronic itch via peripheral and central mechanisms, and targeting TNFR1 may be beneficial for chronic itch treatment. | Xiuhua Miao Ya Huang Teng-Teng Liu Ran Guo Bing Wang Xue-Long Wang Li-Hua Chen Yan Zhou Ru-Rong Ji Tong Liu | 2018 | Neuroscience Bulletin2018，34，1： | 8 |
您所在的机构暂未开通此部分的功能，请联系管理员