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| 1 | Strain-induced band gap engineering in layered TiS3显示文摘 | Robert Biele Eduardo Flores Jose Ramon Ares Carlos Sanchez Isabel J. Ferrer Gabino Rubio-Bollinger Andres Castellanos-Gomezs Roberto D'Agosta | 2018 | Nano Research2018，11，1： | 3 |
| 2 | 膜型巨噬细胞集落刺激因子对人脑胶质细胞瘤的免疫治疗作用显示文摘摘要 目的 探讨基因转染膜型巨噬细胞集落刺激因子(mM-CSF)对U251MG人脑胶质瘤细胞的免疫治疗作用。方法 用逆转录病毒载体将mM-CSF基因转入U251MG细胞,采用流式细胞术检测mM-CSF的表达;通过细胞毒性实验、兔疫组化方法以及观察转染细胞在免疫缺陷小鼠体内的生长情况研究mM-CSF对U251MG细胞的作用。结果①获得了表达mM-CSF的MG-2F11细胞;②大鼠巨噬细胞、人外周血淋巴细胞(PBL)和人单核细胞均可杀伤MG-2F11细胞,但不能杀伤U251MG母细胞;③接种瘤细胞到裸小鼠皮下18 h后,侵入MG-2F11肿瘤的巨噬细胞明显多于侵入MG-VV(仅转染病毒载体的U251MG细胞)肿瘤的巨噬细胞;④接种MG-2F11细胞的8只裸小鼠均无肿瘤生长,而接种MG-VV细胞的8只裸小鼠中的7只有肿瘤生长(P<0.01);另一免疫缺陷更严重的NIH-bg-nu-xidBR 小鼠,接种MG-2F11细胞后8只中的1只有肿瘤生长,而接种MG-VV细胞后8只中的7只有肿瘤生长(P<0.01)。结论mM-CSF转染的人脑胶质瘤细胞致瘤性降低,有进一步对其进行临床研究的必要。 | 陈义军 Cheri Lloyd Ramon Sanchez Martin R Jadus H Terry Wepsic | 2002 | 中华神经外科疾病研究杂志2002，1，3： | 2 |
| 3 | Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial显示文摘 | Rafael Rosell Enric Carcereny Radj Gervais Alain Vergnenegre Bartomeu Massuti Enriqueta Felip Ramon Palmero Ramon Garcia-Gomez Cinta Pallares Jose Miguel Sanchez Rut Porta Manuel Cobo Pilar Garrido Flavia Longo Teresa Moran Amelia Insa Filippo De Marinis | 2012 | Lancet Oncology2012，，3： | 1 |
| 4 | Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial显示文摘 | Rafael Rosell Enric Carcereny Radj Gervais Alain Vergnenegre Bartomeu Massuti Enriqueta Felip Ramon Palmero Ramon Garcia-Gomez Cinta Pallares Jose Miguel Sanchez Rut Porta Manuel Cobo Pilar Garrido Flavia Longo Teresa Moran Amelia Insa Filippo De Marinis | 2012 | Lancet Oncology2012，，3： | 1 |
| 5 | Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial显示文摘 | Rafael Rosell Enric Carcereny Radj Gervais Alain Vergnenegre Bartomeu Massuti Enriqueta Felip Ramon Palmero Ramon Garcia-Gomez Cinta Pallares Jose Miguel Sanchez Rut Porta Manuel Cobo Pilar Garrido Flavia Longo Teresa Moran Amelia Insa Filippo De Marinis | 2012 | Lancet Oncology2012，，3： | 1 |
| 6 | Comparison of different denaturing gradient gel electrophoresis primer sets for the study of marine bacterioplankton communities显示文摘 | Sanchez Olga (Jasol Josep M Massana Ramon | 2007 | Applied and Environmental Microbiology2007，73，18： | 1 |
| 7 | Human resource management and business strategy links: an empirical study显示文摘 | SANZ -VALLE RAQUEL SABATER -SANCHEZ RAMON ARAGON-SANCH EZ ANTONIO | 1999 | International Journal of Human Resource Management1999，10，： | 1 |
| 8 | Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial显示文摘 | Rafael Rosell Enric Carcereny Radj Gervais Alain Vergnenegre Bartomeu Massuti Enriqueta Felip Ramon Palmero Ramon Garcia-Gomez Cinta Pallares Jose Miguel Sanchez Rut Porta Manuel Cobo Pilar Garrido Flavia Longo Teresa Moran Amelia Insa Filippo De Marinis | 2012 | Lancet Oncology2012，，3： | 1 |
| 9 | Problems in supercritical water oxidation process and proposed solutions 显示文摘 | VADILLO V SANCHEZ O J RAMON P J | 2013 | Industrial & Engineering Chemistry Research2013，52，23： | 1 |
| 10 | Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial显示文摘 | Rafael Rosell Enric Carcereny Radj Gervais Alain Vergnenegre Bartomeu Massuti Enriqueta Felip Ramon Palmero Ramon Garcia-Gomez Cinta Pallares Jose Miguel Sanchez Rut Porta Manuel Cobo Pilar Garrido Flavia Longo Teresa Moran Amelia Insa Filippo De Marinis | 2012 | Lancet Oncology2012，，3： | 1 |
| 11 | MRI angiography is superior to helical CT for detection of HCC prior to liver transplantation: An explant correlation显示文摘 | Marta Burrel Josep M. Llovet Carmen Ayuso Carmela Iglesias Margarita Sala Rosa Miquel Teresa Caralt Juan Ramon Ayuso Manel Solé Marcelo Sanchez Concepció Brú Jordi Bruix | 2003 | Hepatology2003，，4： | 1 |
| 12 | Reevaluating the Sonographic Criteria for Acute Appendicitis in Children显示文摘 | Andrew T. Trout Ramon Sanchez Maria F. Ladino-Torres | 2012 | Academic Radiology2012，，： | 1 |
| 13 | Circulating dendritic cells subsets and regulatory T - cells at multiple sclerosis relapse: differential short - term changes on corticosteroids therapy显示文摘 | Navarro J Aristimuno C Sanchez - Ramon S | 2006 | J Neuroimmunol2006，79，9： | 1 |
| 14 | Interleukins network in rheumatoid arthritis path physiology beyond proinflammatory cytokines 显示文摘 | Sanchez Ramon S Lopez Lonqo F J Carreno L | 2011 | Remittal Clan2011，6，3： | 1 |
| 15 | Hybrid Security Assessment Methodology for Web Applications显示文摘This study presents a methodology to evaluate and prevent security vulnerabilities issues for web applications.The analysis process is based on the use of techniques and tools that allow to perform security assessments of white box and black box,to carry out the security validation of a web application in an agile and precise way.The objective of the methodology is to take advantage of the synergies of semi-automatic static and dynamic security analysis tools and manual checks.Each one of the phases contemplated in the methodology is supported by security analysis tools of different degrees of coverage,so that the results generated in one phase are used as feed for the following phases in order to get an optimized global security analysis result.The methodology can be used as part of other more general methodologies that do not cover how to use static and dynamic analysis tools in the implementation and testing phases of a Secure Software Development Life Cycle(SSDLC).A practical application of the methodology to analyze the security of a real web application demonstrates its effectiveness by obtaining a better optimized vulnerability detection result against the true and false positive metrics.Dynamic analysis with manual checking is used to audit the results,24.6 per cent of security vulnerabilities reported by the static analysis has been checked and it allows to study which vulnerabilities can be directly exploited externally.This phase is very important because it permits that each reported vulnerability can be checked by a dynamic second tool to confirm whether a vulnerability is true or false positive and it allows to study which vulnerabilities can be directly exploited externally.Dynamic analysis finds six(6)additional critical vulnerabilities.Access control analysis finds other five(5)important vulnerabilities such as Insufficient Protected Passwords or Weak Password Policy and Excessive Authentication Attacks,two vulnerabilities that permit brute force attacks. | Roddy A.Correa Juan Ramon Bermejo Higuera Javier Bermejo Higuera Juan Antonio SiciliaMontalvo Manuel Sanchez Rubio A.Alberto Magrenan | 2021 | Computer Modeling in Engineering & Sciences2021，，1： | 0 |
| 16 | Effectiveness and safety of first-generation protease inhibitors in clinical practice:Hepatitis C virus patients with advanced fibrosis显示文摘AIM:To evaluates the effectiveness and safety of the first generation,NS3/4A protease inhibitors(PIs) in clinical practice against chronic C virus,especially in patients with advanced fibrosis. METHODS:Prospective study and non-experimental analysis of a multicentre cohort of 38 Spanish hospitals that includes patients with chronic hepatitis C genotype 1,treatment-na?ve(TN) or treatment-experienced(TE),who underwent triple therapy with the first generation NS3/4A protease inhibitors,boceprevir(BOC) and telaprevir(TVR),in combination with pegylated interferon and ribavirin. The patients were treatment in routine practice settings. Data on the study population and on adverse clinical and virologic effects were compiled during the treatment period and during follow up.RESULTS:One thousand and fifty seven patients were included,405(38%) were treated with BOC and 652(62%) with TVR. Of this total,30%(n = 319) were TN and the remaining were TE:28%(n = 298) relapsers,12%(n = 123) partial responders(PR),25%(n = 260) null-responders(NR) and for 5%(n = 57) with prior response unknown. The rate of sustained virologic response(SVR) by intention-to-treatment(ITT) was greater in those treated with TVR(65%) than in those treated with BOC(52%)(P < 0.0001),whereas by modified intention-to-treatment(m ITT) no were found significant differences. By degree of fibrosis,56% of patients were F4 and the highest SVR rates were recorded in the non-F4 patients,both TN and TE. In the analysis by groups,the TN patients treated with TVR by ITT showed a higher SVR(P = 0.005). However,by m ITT there were no significant differences between BOC and TVR. In the multivariate analysis by m ITT,the significant SVR factors were relapsers,IL28 B CC and non-F4; the type of treatment(BOC or TVR) was not significant. The lowest SVR values were presented by the F4-NR patients,treated with BOC(46%) or with TVR(45%). 28% of the patients interrupted the treatment,mainly by non-viral response(51%):this outcome was more frequent in the TE than in the TN patients(57% vs 40%,P = 0.01). With respect to severe haematological disorders,neutropaenia was more likely to affect the patients treated with BOC(33% vs 20%,P ≤ 0.0001),and thrombocytopaenia and anaemia,the F4 patients(P = 0.000,P = 0.025,respectively). CONCLUSION:In a real clinical practice setting with a high proportion of patients with advanced fibrosis,effectiveness of first-generation PIs was high except for NR patients,with similar SVR rates being achieved by BOC and TVR. | Javier Salmeron Carmen Vinaixa Ruben Berenguer Juan Manuel Pascasio Juan Jose Sanchez Ruano Miguel angel Serra Ana Gila Moises Diago Manuel Romero-Gomez Jose Maria Navarro Milagros Testillano Conrado Fernandez Dolores Espinosa Isabel Carmona Jose Antonio Pons Francisco Jorquera Francisco Javier Rodriguez Ramon Perez Jose Luis Montero Rafael Granados Miguel Fernandez Ana Belen Martin Paloma Munoz de Rueda Rosa Quiles | 2015 | World Journal of Gastroenterology2015，21，30： | 0 |
| 17 | Hydrogen Storage by Titanium Based Sulfides: Nanoribbons (TiS3) and Nanoplates (TiS2)显示文摘 | Mariam Barawi Eduardo Flores Marine Pomhieu Jose Ramon Ares Fermin Cuevas Fabrice Leardini Isabel Jimenez Ferrer Carlos Sanchez | 2015 | Journal of Electrical Engineering2015，3，1： | 0 |
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