|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value显示文摘 | Changsong Zou Aojun Chen Lihong Xiao Heike M Muller Peter Ache Georg Haberer Meiling Zhang Wei Jia Ping Deng Ru Huang Daniel Lang Feng Li Dongliang Zhan Xiangyun Wu Hui Zhang Jennifer Bohm Renyi Liu Sergey Shabala Rainer Hedrich Jian-Kang Zhu Heng Zhang | 2017 | Cell Research2017，27，11： | 22 |
| 2 | 高密度脂蛋白相关生物学标志物是慢性肝衰竭患者短期生存的有效预测因子显示文摘【据《J Hepatol》2020年7月报道】题:高密度脂蛋白相关生物学标志物是慢性肝衰竭患者短期生存的有效预测因子(作者Trieb M等)慢性肝病患者的高密度脂蛋白胆固醇(HDL-C)水平降低,并与疾病严重程度呈负相关。在合并脓毒症等急危重症情况下,HDL-C水平迅速下降,HDL颗粒的组成和功能亦随之发生显著变化。该项研究通过前瞻性队列以及验证队列明确了HDL的构成及水平与终末期肝病患者的疾病进展和短期生存预后相关。 | TRIEB M RAINER F STADLBAUER V 高沿航 | 2020 | 临床肝胆病杂志2020，36，8： | 22 |
| 3 | Intravenous itraconazole emulsions produced by SolEmuls technology显示文摘 | Aslihan Akkar Rainer H. Müller | 2003 | European Journal of Pharmaceutics and Biopharmaceutics2003，，1： | 3 |
| 4 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 5 | Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art显示文摘 | Rainer H. Müller Karsten M?der Sven Gohla | 2000 | European Journal of Pharmaceutics and Biopharmaceutics2000，，1： | 2 |
| 6 | Solubilizing poorly soluble antimy cotic agents by emulsification via a solvenent-free process显示文摘 | Aslihan Akkar Pawel Namsolleck Michael Blaut Rainer H. Müller | 2004 | AAPS PharmSciTech2004，，1： | 2 |
| 7 | Chronic hepatitis C:Treat or wait? Medical decision making in clinical practice显示文摘AIM:To analyzes the decision whether patients with chronic hepatitis C virus (HCV) infection are treated or not.METHODS:This prospective cohort study included 7658 untreated patients and 6341 patients receiving pegylated interferon α2 a/ribavirin,involving 434 physicians/institutions throughout Germany (377 in private practice and 57 in hospital settings).A structured questionnaire had to be answered prior to the treatment decision,which included demographic data,information about the personal life situation of the patients,anamnesis and symptomatology of hepatitis C,virological data,laboratory data and data on concomitant diseases.A second part of the study analyzes patients treated with pegylated interferon α2a.All questionnaires included reasons against treatment mentioned by the physician.RESULTS:Overall treatment uptake was 45%.By multivariate analysis,genotype 1/4/5/6,HCV-RNA ≤ 520 000 IU/mL,normal alanine aminotransferase (ALT),platelets ≤ 142 500/μL,age > 56 years,female gender,infection length > 12.5 years,concomitant diseases,human immunodeficiency virus co-infection,liver biopsy not performed,care in private practice,asymptomatic disease,and unemployment were factors associated with reduced treatment rate.Treatment and sustained viral response rates in migrants (1/3 of cohort) were higher than in German natives although 1/3 of migrants had language problems.Treatment rate and liver biopsy were higher in clinical settings when compared to private practice and were low when ALT and HCV-RNA were low.CONCLUSION:Some reasons against treatment were medically based whereas others were related to fears,socio-economical problems,and information deficits both on the side of physicians and patients. | Claus Niederau Dietrich Hüppe Elmar Zehnter Bernd Mller Renate Heyne Stefan Christensen Rainer Pfaff Arno Theilmeier Ulrich Alshuth Stefan Mauss | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 8 | Topical anesthesia with PH adjusted versus standard indocaine 4% for corneal cataract surgery显示文摘 | Zehetmayer M Rainer G Turnheim K | 1997 | J Cataract Refract Surg1997，23，9： | 1 |
| 9 | Health Consequences o{ Aircraft Noise显示文摘 | Martin K Christian M Rainer K | 2008 | Dtsch Arztebl Int2008，105，3132： | 1 |
| 10 | The differentiation of humane adult mesenchimal stem cells of bone marrow (hMSC) into urothelial cells on bio-engineering support (scaffold):preliminary experience of tissue engineering显示文摘 | Falavolti C Rainer A Centola M | | 0，，03： | 1 |
| 11 | Sustained effects of once-daily memantine treatment on cognition and functional communication skills in patients with moderate to severe Alzheimer's disease:results of a 16-week open-label trial显示文摘 | Schulz JB Rainer M Klünemann HH | | 0，，03： | 1 |
| 12 | Can the full range of paramedic skills improve survival from out of hospital cardiac arrests? 显示文摘 | Mitchell R G Guly U M Rainer T H | 1997 | J Accid Emerg Med1997，14，5： | 1 |
| 13 | Cardiac fibrosis in human transplanted hearts is mainly driven by cells of intracardiac origin 显示文摘 | Piehler M Rainer P P Schauer S | 2012 | J Am Coil Cardiol2012，59，11： | 1 |
| 14 | Comparison of 4 methods for quantifying posterior capsule opacification显示文摘 | Findl O Buehl W Menapace R Georgopoulos M Rainer G Siegl H | 2003 | JCataract Refract Surg2003，29，1： | 1 |
| 15 | Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice显示文摘Tumor necrosis factor(TNF)and its receptors TNF receptor type 1(TNFR1)and type 2(TNFR2)have a central role in chronic inflammatory diseases.While TNFR1 mainly confers inflammation,activation of TNFR2 elicits not only pro-inflammatory but also anti-inflammatory effects.In this study,we wanted to investigate the anti-inflammatory therapeutic potential of selective activation of TNFR2 in mice with established collageninduced arthritis.Mice with established arthritis induced by immunization with bovine collagen type II were treated with six injections of the TNFR2-specific agonist TNCscTNF80,given every second day.Two days after treatment cessation,the cell compositions of bone marrow,spleen and lymph nodes were analyzed.Mice were visually scored until day 30 after the start of therapy and the degree of joint inflammation was determined by histology.Treatment with TNCscTNF80 increased arthritis-induced myelopoiesis.Little effect was seen on the infiltration rate of inflammatory immature myeloid cells and on the reduction of lymphoid cells in secondary lymphoid organs.Upon treatment,frequency of regulatory T(Treg)cells in the CD4+T-cell population was increased in both spleen and inguinal lymph nodes.In addition,the expression of TNFR2 on Treg cells was enhanced.The clinical score started to improve 1 week after cessation treatment and remained lower 30 days after initiation of therapy.The histological score also revealed amelioration of joint inflammation in TNCscTNF80-treated versus control mice.Activation of TNFR2 might provide a suitable therapeutic strategy in autoimmune arthritis by increasing the numbers of regulatory cell types,in particular Treg cells,and by attenuation of arthritis. | Vanessa Lamontain Tobias Schmid Dorothea Weber-Steffens David Zeller Zsuzsa Jenei-Lanzl Harald Wajant Rainer H Straub Daniela N Männel | 2019 | Cellular & Molecular Immunology2019，16，1： | 1 |
| 16 | Parkin-associated Parkinson's disease显示文摘 | Rainer von Coelln Valina L Dawson Ted M Dawson | 2004 | Cell Tissue Res2004，318，： | 1 |
| 17 | Effectiveness of occu pational therapy at home for older people with dementia and their caregivers显示文摘 | Sebastian VR Graff M Rainer L | 2009 | BMC2009，9，44： | 1 |
| 18 | Value of serum procalcitonin, neopterin, and C-reactive Protein in differentiating bacterial from viral etiolo-gies in patients presenting with Lower respiratory tract infections显示文摘 | IP M Rainer TH Lee N | 2007 | Diagn Microbiol Infect Dis2007，59，2： | 1 |
| 19 | Lipid nanoparticles(SLN,NLC)in cosmetic and pharmaceutical dermal products显示文摘 | Jana P Aiman H Rainer H M | 2008 | International Journal of Pharmaceutics2008，366，1： | 1 |
| 20 | Nanostructured lipid carriers(NLC)in cosmetic dermal products显示文摘 | Rainer H M Aiman H Jana P | 2007 | Advanced Drug Delivery Reviews2007，59，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员