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| 1 | Clinical outcome in patients with hilar malignant strictures type Ⅱ Bismuth-Corlette treated by minimally invasive unilateral versus bilateral endoscopic biliary drainage显示文摘BACKGROUND:Stenting of malignant hilar strictures remains a standard endoscopic treatment in patients with unresectable tumors.The aim of this two-center prospective study was to compare unilateral versus bilateral drainage in hilar malignant stenosis Bismuth-Corlette type II.METHODS:During a 3-year period,a total of 49 patients with hilar tumors(Bismuth-Corlette type II) were referred for endoscopic treatment,following the criteria of unresectability.Ultrasound,computed tomography scan and magnetic resonance cholangiopancreatography(MRCP) were previously performed in all patients in order to facilitate endoscopic retrograde cholangiopancreatography(ERCP).The stricture was first passed by the hydrophilic guide-wire and then contrast medium was injected.Mechanical bile duct dilation was performed,followed by plastic stent placement only in the liver lobe which was previously opacified.The procedures were performed under conscious sedation.The patients were followed up for the next 12 months with a stent exchange every 3 months.Primary outcome was assessed by patient survival in the first 12 months after the procedure.RESULTS:All 49 patients were treated with ERCP while 39(79.59%) had successful stent placement.Among these,32 had hilar cholangiocarcinoma(82%) and 7(18%) had gallbladder cancer.Two groups of patients had Bismuth II strictures:A,21 patients(54%) with unilateral contrast injection and drainage,and B,18(46%) with bilateral contrast injection and drainage.A total of 57 plastic stents were used(10 Fr,89%;11.5 Fr,11%).Group B showed a lower bilirubin level 7 days after the procedure(P=0.008).Early complications were cholangitis(3 patients,2 in group A and 1 in group B) and acute pancreatitis(2 patients,1 each in A and B) with no statistical difference between the groups.Late complications were stent migration(5 patients,1 in A and 4 in B) and stent clogging(6 patients,2 in A and 4 in B) showing a significant difference between the groups(P<0.01).The first stent replacement after 3 months was successful in 87% of patients(four died due to disease progression and one due to cardiopulmonary insufficiency) showing no statistical difference between the groups.At 6 months follow-up,72% patients survived,with no statistical difference between the groups.A final follow-up(12 months) showed the survival rate of 18%(4 patients from group A and 3 from group B)(P>0.05).CONCLUSIONS:A minimally invasive approach,based on the criterion that every bile duct being opacified needs to be drained,is associated with a lower incidence of early complications.Considering that the clinical outcome measured by bilirubin level was lower in patients with bilateral drainage 7 days after the procedure,we assumed that drainage of 50% or more of the liver volume leads to sufficient drainage effectiveness. | Milutin Bulajic Nikola Panic Miodrag Radunovic Radisav Scepanovic Radoslav Perunovic Predrag Stevanovic Tatjana Ille Maurizio Zilli Mirko Bulajic | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 8 |
| 2 | Micronutrients in women's reproductive health: I Vitamins 显示文摘 | Kontic - Vucinic O Sulovic N Radunovic N | 2006 | Int J Fertil Womens Med2006，51，3： | 1 |
| 3 | Fetal and maternal plasma endothelin levels during the second half pregnancy显示文摘 | Charles J Lockwood Manny Alvarez | 1995 | Am Obstet Gynecol1995，172，1： | 1 |
| 4 | Toward prac- tical opportunistic routing with inlra-session network coding for mesh networks显示文摘 | Radunovic B Gkantsidis C Key P Rodriguez P | 2010 | IEEE/ACM Transactions on Network- ing2010，18，2： | 1 |
| 5 | Rate performance objectives of multi-hop wireless networks 显示文摘 | RADUNOVIC B BOUDEC J Y | 2004 | IEEE Transactions on Mobile Computing2004，3，4： | 1 |
| 6 | Practical application of fiber-optic current sensor in power system har- monic measurement显示文摘 | SLOBODAN J Petricevic ZLATAN Stojkovic JOVAN B Radunovic | 2006 | IEEE Transactions on Instrumentation and Measure- ment2006，55，3： | 1 |
| 7 | The role of antioxi- dant vitamins in hypertensive disorders of pregnancy 显示文摘 | Kontic - Vucinic O Terzic M Radunovic N | 2008 | J Perinat Med2008，36，4： | 1 |
| 8 | NK1 ,NK2,NK3 and CGRP1 receptors identified in rat oral soft tissues, and in bone and dental hard tissue cells 显示文摘 | Fristad I Vandevska - Radunovic V Fjeld K | 2003 | Cell Tissue Res2003，311，3： | 1 |
| 9 | Colorectal cancer screening in a low-incidence area: general invitation versus family risk targeting: a comparative study from Montenegro显示文摘 | Nikola Panic Thomas R?sch Brigita Smolovic Miodrag Radunovic Mirko Bulajic Aleksandra Pavlovic-Markovic Zoran Krivokapic Srdjan Djuranovic Tatjana Ille Milutin Bulajic | 2015 | European Journal of Gastroenterology & Hepatology2015，，10： | 1 |
| 10 | Cu/Zn superoxide dismutase gene mutations in amyotrophic lateral sclerosis: correlation between genotype and clinical features显示文摘 | Radunovic A | 1996 | J Neurol Neurosurg Psychiatry1996，61，6： | 1 |
| 11 | Optimal power control, scheduling, and routing in UWBnetworks 显示文摘 | Radunovic B Boudec J Y L | 2004 | IEEE Journal on Selected Areas in Communications2004，22，7： | 1 |
| 12 | Optimal power control,scheduling,and routing in UWB networks显示文摘 | RADUNOVIC B BOUDEC J Y L | 2004 | IEEE Journal on Selected Areas in Communcations2004，22，7： | 1 |
| 13 | Optimal power control, scheduling, and routing in UWB networks显示文摘 | Le Boudec Jean-Yves Radunovic Bozidar | 2004 | IEEE Journal on Selected Areas in Communications2004，22，7： | 1 |
| 14 | NK1 ,NK2, NK3 and CGRP1 receptors identified in rat oral soft tissues,and in bone and dental hard tissue cells显示文摘 | Fristad I Vandevska - Radunovic V Field K | 2003 | Cell Tissue Res2003，311，3： | 1 |
| 15 | Mechanical ventilation foramyotrophic lateral sclerosis/motor neuron disease 显示文摘 | Radunovic A Annane D Rafiq MK | 2013 | Cochrane Database Syst Rev2013，3，00： | 1 |
| 16 | Preterm and premature rupture of membranes in pregnancies after in vitro fertilization显示文摘 | Tabs Dunja Vejnovic'Tihomir Radunovic'Neboja | 2010 | Medicinski Pregled2010，58，78： | 1 |
| 17 | NK1, NK2,NK3 and CGRP1 receptors identified in rat oral soft tissues, and in bone and dental hard tissue cells显示文摘 | Fristad I Vandevska - Radunovic V Field K | 2003 | Cell Tissue Res2003，311，3： | 1 |
| 18 | CGRP1 and NK1 receptors in postnatal, developing rat dental tissues显示文摘 | Vandevska Radunovic V Fristad I Wimalawansa SJ | 2003 | Eur K Oral Sci2003，111，： | 1 |
| 19 | CGRP1 and NK1 receptors in postnatal, developing rat dental tissues显示文摘 | Vandevska Radunovic V Fristad I Wimalawansa S J | 2003 | Eur J Oral Sci2003，111，6： | 1 |
| 20 | Practical Application of Fiber-Optic Current Sensor in Power System Harmonic Measurement显示文摘 | Petricevic S J Stojkovic Z Radunovic J B | 2006 | IEEE Trans on Istrumentation and Measurement2006，3，： | 1 |
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