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| 1 | Aberrant Th2 inflammation drives dysfunction of alveolar macrophages and susceptibility to bacterial pneumonia显示文摘The ubiquitin ligase,Itch,is required to prevent autoinflammatory disease in mice and humans.Itch-deficient mice develop lethal pulmonary inflammation characterized by the production of Th2 cytokines(for example,interleukin-4(IL-4));however,the contribution of Itch to immune defense against respiratory pathogens has not been determined.We found that Itch-deficient mice were highly susceptible to intranasal infection with the respiratory pathogen Klebsiella pneumoniae.Infected Itch-deficient mice exhibited increased immune cell infiltration,cytokine levels and bacterial burden in the respiratory tract compared with control mice.However,numbers of resident alveolar macrophages were reduced in the lungs from Itch-deficient mice both before and after infection.High levels of Th2 cytokines in the respiratory tract correlated with deceased alveolar macrophages,and genetic ablation of IL-4 restored alveolar macrophages and host defense to K.pneumoniae in Itch-deficient mice,suggesting that loss of alveolar macrophages occurred as a consequence of Th2 inflammation.Adoptive transfer of Itch−/−CD4+T cells into Rag−/−mice was sufficient to drive reduction in numbers of Itch-replete alveolar macrophages.Finally,we found that Stat6 signaling downstream of the IL-4 receptor directly reduced fitness of alveolar macrophages when these cells were exposed to the Itch−/−inflamed respiratory tract.These data suggest that Th2 inflammation directly impairs alveolar macrophage fitness in Itch−/−mice,and elucidate a previously unappreciated link between Th2 cells,alveolar macrophages and susceptibility to bacterial infection. | Emily K Moser Natania S Field Paula M Oliver | 2018 | Cellular & Molecular Immunology2018，15，5： | 2 |
| 2 | New small2mo lecule synthetic antimyeibacterials 显示文摘 | Ballell L Field RA Duncan K | 2005 | Antimicrob Agents Chemother2005，49，6： | 1 |
| 3 | Eletronic Energy Level in The Trivalent Lanthanide Aquo Ions显示文摘 | Chrnall W T Fields P R Rajna K | 1968 | Journal of Chemical Physics1968，49，： | 1 |
| 4 | The Interaction among Multiple Governance Mechanisms in Young Newly Public Irms 显示文摘 | Tammy K Berry Fields L Paige Wilkins Michael S | 2006 | Journal of Corporate Finance2006，12，3： | 1 |
| 5 | Tensile and Fatigue Strength of Free-standing CVD Diamond显示文摘 | Daviesa A R Field J E Takahashi K | 2005 | Diamond and Related Materials2005，14，： | 1 |
| 6 | Correlates of specific childhood feeding problems 显示文摘 | Field D Garland M Williams K | 2003 | J Paediatr Child Health2003，39，： | 1 |
| 7 | Quantitative determi-nation of 1,4-dioxane and tetrahydrofuran in groundwater bysolid phase extraction GC/MS/MS显示文摘 | ISAACSON C MOHR T K FIELD J A | 2006 | Environmental Scienceand Technology2006，40，23： | 1 |
| 8 | Evaluation of clinical management of gonorrhoea using enhanced surveillance in South East Queensland 显示文摘 | Field E Heel K Palmer C | 2010 | Sex Health2010，7，4： | 1 |
| 9 | Surgical resection of the primary tumor is associated with increased long-term survival in pa- tients with Stage IV breast cancer after controlling for site of metas- tasis显示文摘 | Fields R C Jeffe D B Trinkaus K | 2007 | Ann SurgOncol2007，14，12： | 1 |
| 10 | Addition of 1,3, 4-thiadiazole-2, 5-dithiol to Olefinic Compounds显示文摘 | FIELDS E K | 1956 | J Org Chem1956，21，5： | 1 |
| 11 | A practical strategy for analysing multispecies distribution patterns显示文摘 | Field J G Clarke K R Warwick R M | 1982 | Mar Ecol Prog Ser1982，8，1： | 1 |
| 12 | Impacts of fu- ture climate change on California perennial crop yields: model projections with climate and crop uncertainties显示文摘 | Lobell D B Field C B Cahill K N | 2006 | Agricultural and Forest Meteorology2006，141，24： | 1 |
| 13 | Systemic administration of interleukin 2 enhances therapeutic efficacy of dendritic cell-based tumor vaccines显示文摘 | Fields RC Giedlin M | 1999 | Proc Nat Acad Sci USA1999，96，： | 1 |
| 14 | Organophilic pervaporation: an engineering science analysis of component transport and the classification of behaviour with reference to the effect of permeate pressure显示文摘 | Ten P K Field R W | 2000 | Chemical Engineering Science2000，55，14： | 1 |
| 15 | Scale and species richness: towards a general, hierarchical theory of species diversity 显示文摘 | Whittaker R J Willis K J Field R | 2001 | J Biogeo2001，28，： | 1 |
| 16 | Equal-channel angular extrusion of Beryllium显示文摘 | Field R D Hartwig K T | 2002 | ibid2002，33，： | 1 |
| 17 | Preoperative investigations for metastatic staging of colon and rectal cancer across multiple centres- what is current practice显示文摘 | Kosmider S Stella DL Field K | 2009 | Colorectal Dis2009，11，6： | 1 |
| 18 | KIF4 regulates midzone length during cytokinesis 显示文摘 | HU C K COUGHLIN M FIELD C M | 2011 | Curr Biol2011，21，10： | 1 |
| 19 | A PCR assay to discriminate human and ruminant feces on the basis of host differences in Bacteroides- Prevotella genes encoding 16S rRNA 显示文摘 | Bernhard A E Field K G | 2000 | Applied and Environmental Microbiology2000，66，10： | 1 |
| 20 | Genetic alteration in bronchial lavage as a potential marker for individuals with a high risk of developing lung cancer 显示文摘 | Field J K Liloglou T Xinariancs G | 1999 | Cancer Res1999，59，11： | 1 |
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